Dual Function of the NK Cell Receptor 2B4 (CD244) in the Regulation
of HCV-Specific CD8+ T Cells

English version České info

The outcome of viral infections is dependent on the function of CD8+ T cells

which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4

(CD244) is a transmembrane protein belonging to the Ig superfamily which can

also be expressed by CD8+ T cells. The aim of this study was to analyze the

role of 2B4 as an additional costimulatory receptor regulating CD8+ T cell

function and in particular to investigate its implication for exhaustion of

hepatitis C virus (HCV)-specific CD8+ T cells during persistent infection.

We demonstrate that (i) 2B4 is expressed on virus-specific CD8+ T cells

during acute and chronic hepatitis C, (ii) that 2B4 cross-linking can lead to

both inhibition and activation of HCV-specific CD8+ T cell function,

depending on expression levels of 2B4 and the intracellular adaptor molecule SAP

and (iii) that 2B4 stimulation may counteract enhanced proliferation of

HCV-specific CD8+ T cells induced by PD1 blockade. We suggest that 2B4 is

another important molecule within the network of costimulatory/inhibitory

receptors regulating CD8+ T cell function in acute and chronic hepatitis C

and that 2B4 expression levels could also be a marker of CD8+ T cell

dysfunction. Understanding in more detail how 2B4 exerts its differential

effects could have implications for the development of novel immunotherapies of

HCV infection aiming to achieve immune control.

Vyšlo v časopise: Dual Function of the NK Cell Receptor 2B4 (CD244) in the Regulation of HCV-Specific CD8+ T Cells. PLoS Pathog 7(5): e32767. doi:10.1371/journal.ppat.1002045
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1002045

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