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The relevance of U.S. Strategic Highway Safety Plans in a future context
Authors: Brett P. Hughes aff001; Torbjorn Falkmer aff001; Anna Anund aff003; Melissa H. Black aff001
Authors place of work: School of Occupational Therapy, Social Work and Speech Pathology, Curtin University, Perth, Australia aff001; Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden aff002; Swedish Road and Transport Research Institute, VTI, Linkoping, Sweden aff003
Published in the journal: PLoS ONE 14(10)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0223646Summary
While road safety in the United States (U.S.) has been continually improving since the 1970's, there are indications that these improvements are becoming increasingly difficult to sustain. Strategic Highway Safety Plans (SHSPs) are prepared by States to guide road safety management, however assessing the appropriateness of these plans remains a significant challenge, especially for the future in which they are to be applied. This study developed a new methodology to assess SHSPs from the perspectives of comprehensive system-based safety management and relevant future issues that can be applied before SHSPs are implemented, thereby avoiding long periods after implementation before assessing the appropriateness of the plans. A rating scale was developed and applied to assess 48 U.S. SHSPs against two key criteria: 1. a comprehensive framework for road safety, and 2. the anticipated changing, difficult and unpredictable nature of future transport and its context. The analysis concluded that current SHSPs have good national oversight with several strengths but were weak in some areas of content and did not address future challenges. Improvements are suggested to strengthen the plans’ thoroughness by being consistent with systems theory and practice, as well as ways that these SHSPs can be more resilient to future circumstances. Implementing the recommendations in this paper provides the opportunity to adopt a system-based safety management practice that has been successful in other hazardous industries. Doing so is expected to most efficiently and effectively continue the recent improvements to road safety, which is likely to be increasingly difficult otherwise.
Keywords:
Engineering and technology – Behavior – Roads – Transportation – Traffic safety – Decision making – Automation – Highways
Introduction
In the ten years ending 2016, 320,874 people died in traffic crashes in the United States (U.S.), and approximately 100 times as many were injured [1]. Fatality and injury rates resulting from crashes remained reasonably unchanged until 2005 before declining until 2010. Numbers then remained relatively constant until 2014 and have since risen up until 2016 [1], as shown in Fig 1. The total numbers and the rates against population, number of drivers, vehicles and miles travelled followed similar trajectories. The cause for concern is that road safety appears not to have improved in the five years up to 2016 and may even be deteriorating. Improvements in road safety have similarly discontinued in other developed countries [2,3], but it is difficult to determine the reasons underlying these patterns and how road safety can continue to be improved into the future.
Fig. 1. U.S. road fatalities and rates. To qualify for Federal road funds, U.S. States are required to develop, implement, evaluate and update a Strategic Highway Safety Plan (SHSP) that identifies and analyzes road safety problems and opportunities on all public roads [4]. However, assessing the appropriateness of SHSPs in efficiently and effectively achieving their objectives, especially for the future in which they are to be applied, is a key challenge. This paper describes the development and application of a new methodology to assess current SHSPs against two criteria that can be used prior to the SHSPs being implemented. The first set of criteria are the seven elements of a newly developed comprehensive framework for road safety management, based on systems theory and practice [5,6]. The second criteria represent the changes that are expected in the transport system and its context that are likely to affect road safety [4,7,8], including the changing and variable nature of future transport [6,9–11].
Assessing road safety plans
Assessing the effectiveness and efficiency of road safety plans is problematic. The causal effect of a safety plan in achieving its objectives is difficult to demonstrate, partly due to the confounding or contributing factors, such as changes to the economic context [12–14]. Federal legislation requires SHSPs to be evaluated, because “if an SHSP goal or objective is not met, the results may suggest a strategy is ineffective, or in some cases, the process for implementation did not go as planned and needs to be reconsidered.” [15]. Evaluation makes judgments about the activities, characteristics, and outcomes of a program, to improve its effectiveness, and/or inform decisions about future programming, and has three levels of objectives: Process, Output and Outcome [16]. The evolution to current road safety management appears to have been successful in parts of Europe, but the evidence is difficult to interpret [17], because “it is tempting to attribute changes in the time series of road safety measures to contemporary initiatives and intervention. This easy confidence in our ability to link effect to cause may be unrealistic and misdirect our actions.” ([18], p45).
Several limitations exist in the current evaluation frameworks applied to assess the appropriateness, effectiveness, and efficiency of current road safety plans. Quantitative rating to assess safety policy and leadership has found considerable variation between U.S. States in countermeasure adoption and leadership, with each State having different strengths [19]. Furthermore, meaningful causal relationships between road safety management and outcomes were found to be difficult to identify, so it was concluded that there was no reliable relationship between road safety management tools and improved road safety outcomes, despite the obvious rationality and attractiveness of the proposition [20]. Perhaps critically, current SHSPs are evaluated sometime after implementation which may result in considerable funds being allocated to ineffective and inefficient plans. Significant time is required to collect and analyze data which may confound the validity of the assessment and also delays its utility, perhaps by so long that it is not very helpful [17,18]. Given the significant limitations associated with the current assessment of SHSPs, there is a strong case for constructive, critical assessments of the quality and value of SHSPs, as well as recommendations to make improvements to them.
Road safety management development
Early approaches to road safety management focused on the key component parts of drivers, vehicles and roads (1920’s), for which engineering, enforcement and education (1930’s) was developed and applied to reduce crashes [6]. Road safety management subsequently evolved through several paradigms, described for example as i) Control of motorized carriage, ii) Mastering traffic situations, iii) Managing the traffic system, and iv) Managing the transport system [21]. These developments often reflected safety management from other domains, such as the epidemiological ‘host-agent-environment’ [22,23], the ‘human-machine-environment’ or sequence of causal events models [24–26].
Road safety management has evolved by modifying traditional approaches incrementally. U.S. road safety management continues to apply the 4E policy tools of Engineering, Enforcement, Education and Emergency response to road users, vehicles and roads [15], as is used in most developed countries, at least until a few years ago. In Europe and Australasia, road safety management has evolved most recently into Vision Zero or Safe Systems descriptions [27], which have incorporated an underlying moral argument and added the dimension of principles by which countermeasures are developed and applied. Despite these underlying differences, road safety practice at the operational level is the same in all cases, relying primarily on education, enforcement and engineering applied to drivers, vehicles and roads [12].
U.S. road safety management is strongly influenced by Federal legislation and direction, together with other nationally coordinated information [28,29]. The Federal Highway Administration (FHWA) recognizes many diverse issues that guide SHSPs, such as leadership, safety management, program delivery, consultation, coordination, system performance, corporate capacity and evaluation. Other countries have started to apply systems concepts to road safety, in the U.S. commonly known as Toward Zero Deaths (TZD) [3,19,29,30], but these concepts have not yet been thoroughly, widely or consistently applied in the U.S.
Safety management in hazardous industries
Similar to road safety, safety management in hazardous industries evolved through several paradigms and approaches. However, in contrast to road safety, safety management in hazardous industries over the past 20 years has moved away from the human-machine-environment interface model and causal sequence analysis that considered parts in isolation [6,31] and has adopted and applied systems theory [32–36] developed from early applications in industry [5,24,37–40]. A sociotechnical system may be defined as “an interacting combination, at any level of complexity, of people, materials, tools, machines, software, facilities, and procedures designed to work together for some common purpose” ([5], p22). Systems theory was developed to overcome a mechanistic or ‘machine theory’ approach that “attempted to analyse the vital process into particular occurrences proceeding in single parts or mechanisms independently of one another.”, because “the essence of the organism (is seen) in the harmony and co-ordination of the processes among one another” ([34], p177).
Systems-based safety management emerged to counter the limitations of traditional techniques that did not provide sufficient levels of safety [31,38,39], as evidenced by several high profile catastrophes in diverse hazardous industries in the 1980’s. Industrial safety management, particularly in safety-critical industries, such as nuclear, aerospace and offshore petroleum industries found that linear, simplistic and reductionist models were inadequate to deal with complexity and uncertainty [11,31]. Linear models did not recognize all interactions, feedback or the dynamic nature of systems that do not always operate in equilibrium over time or even for short periods. This oversimplification ignored some of the numerous contributing component parts, participants, factors or other influences and neglected broader contributions from standards, regulatory regimes, business practices, economic factors or organizations. Reductionist approaches were found to be inadequate because they focused too narrowly on only a few parts of the system that affected the results, increasingly relying on detailed analyses of individual parts or actions in isolation. Ultimately, these approaches did not provide sufficient levels of safety.
Consequently, hazardous industries have progressively and thoroughly adopted system approaches to manage safety efficiently and effectively. Modern reliability engineering and safety management in complex safety-critical industries have developed and adopted sophisticated, multidimensional and comprehensive approaches based on systems theory [11,31,41–43]. As a result, current safety management in these industries is indeed based on systems theory and best practice that broadens the choice of policy tools that can be applied to all components (or parts) that comprise the system being managed [11,31,44,45]. In contrast to road safety, this approach also specifically recognizes the full range of participants (or actors), the partnerships (or relationships and interactions) within the system, and the necessary processes to efficiently and effectively achieve the purpose. These approaches also recognize the importance of the way that systems and organizations operate (or safety culture and climate) in affecting and improving safety outcomes [46–51].
The dynamic nature of systems has been recognized for some time [11,33], but the changing current and future contexts require new paradigms for policymaking incorporating a systems approach, because “theories, models, philosophies, and methods stemming from an earlier era of scientific thought and developed for simpler, mostly physical systems are largely inapplicable” for current circumstances ([33], p7).
The most dramatic and structural changes that occur to systems are described as ‘disruptions’ affecting society, the economy, industry or business, which are expected to escalate and occur faster in future [7,8,10,31,52–54]. New business models and applications are developing as different sectors interconnect and converge. Some specific changes have already altered transport and further, more substantial changes are expected to transform transport even more, such as automation. As transport changes, so does road safety, which needs to respond to accordingly, either to maximize the opportunities presented by these changes or to mitigate negative impacts. The context of road safety and its greater context has become increasingly volatile, uncertain, complex, and ambiguous (or VUCA) [9,55].
A comprehensive systems-based framework for road safety
The potential for systems theory and practice to be applied to road safety has been recognized for many years but has failed to be thoroughly adopted and implemented [39,56–58]. In response, research to apply modern industrial safety management based on systems theory and practice to strategic road safety management has developed the comprehensive 7P System framework (Fig 2) [6] that can be summarized as: Participants use processes based on principles to apply policy tools to affect contributing component parts, in order to achieve a purpose (improved road safety). These all occur in complex interdependent partnerships or interactions within the system. The framework has similarities with other conceptual frameworks but is unusual in its breadth of content compared to previous conceptual frameworks for road safety [6]. The framework resulted from an extensive literature review of models relevant to road safety, so it incorporates many features of previous safety models [27]. In fact, the 7P System framework incorporates all dimensions of the most significant safety management approaches previously applied, viz. i) traditional road safety management, ii) Haddon’s original ten countermeasures [59], iii) all versions of the Haddon Matrix [60], iv) current U.S. national safety management, v) Vision Zero or Safe Systems and vi) contemporary systems-based safety management.
Fig. 2. The 7P System framework for road safety management. Consequently, this study developed a new methodology to assess SHSPs from the perspectives of comprehensive system-based safety management and relevant future issues while also overcoming the need to wait for long periods after implementation before assessing the appropriateness of the plans.
The 7P System framework incorporates many more policy tools, parts and participants than the content in current U.S. road safety management guidance or traditional road safety management [6,12]. Traditional road safety management has applied the 4E’s (Engineering, Enforcement, Education and Emergency response) to three parts (drivers, vehicles and roads), whereas the 7P System framework extends to ten policy tools applied to nine parts [6,12]. Table 1 summaries the differences between the traditional approach to road safety management that is practiced in the U.S. with the Policy Tools, Parts (or system components) and Participants (or actors) based on systems theory and approaches from other safety domains, as it would be applied to road safety management [6]. It also recognizes the wide range of Participants (or actors) that can affect road safety outcomes that are often neglected in managing road safety [58].
Tab. 1. Policy tools, parts and participants in traditional road safety management compared with the P7 System framework. The 7P System framework incorporates all essential system dimensions including the full range of participants and processes (e.g. risk analysis and implementation) which are explicitly identified. The 7P System framework includes both feedforward and feedback partnerships (interactions or interrelationships) that are particularly numerous and complicated for road safety [61] but are ignored in road safety management. While Vision Zero includes valuable principles, they are not universally accepted or consistent. Vision Zero principles are different to those in other road safety approaches, such as the Dutch Sustainable Safety [62], so the 7P System framework allows for other principles that could be adopted as a basis, such as value for money or community acceptance.
The 7P System framework is consistent with frameworks in more general fields, such as management or community development, which it is intended to augment, not replicate. The framework is also consistent with other common management practices, [63] that cover financial management, strategic planning, operations management, legal issues, project management, communications and human resources. Other general frameworks, such as for community development [64], have clear goals and principles to guide practice, which could be useful if applied to road safety management because they are different to those provided by FHWA, American Association of State Highway and Transportation Officials (AASHTO) or TZD. U.S. Agency International Development (USAID) [64] also has very clear processes that are not included in traditional road safety management, and are recognized as essential in the 7P System framework. The USAID five R’s scope; Results, Roles, Relationships, Rules and Resources is also more extensive and detailed than traditional road safety management [65]. However, these approaches do not clearly describe the full range of policy tools and system parts that are relevant to any specific context or issue. By contrast, the 7P framework includes numerous specific systems components and policy tools that are not described or organized clearly elsewhere. While other frameworks and guidance material provide the opportunity for improving road safety management, the 7P System framework provides a broader overview as well as some detailed content that is not found in other frameworks. The 7P framework considers road safety from a less common, holistic and comprehensive approach which complements micro-level approaches and analyses that are more common, such as those used by Chen et al. [66] and Chen et al. [67]. Salmon and Lenné [58] adapted Rasmussen’s accident causation approach to describe seven predictions specifically relevant to road safety that are consistent with the 7P System framework but are more prominently and clearly stated. These relate to the contributions of many participants and contributing factors rather than a few, and the significance of relationships including vertical communication and feedback. They argue that taking account of these in road safety management requires a paradigm shift, that the 7P System framework is consistent with.
So, while the 7P framework has many similarities with other management and frameworks, some of which could be complementary, it has distinct advantages for this circumstance; i) it is specific to road safety; ii) it is thoroughly based in systems theory and practice, and iii) it incorporates more dimensions and concepts than other frameworks, including those from several other frameworks.
Analytical approach
To counter the existing weaknesses of analyzing the appropriateness of SHSPs for a future context, this study describes a new method for examining and scoring SHSPs. This ex ante analysis overcomes the delay in assessing the appropriateness of SHSP’s which occurs with ex post analyses, examines SHSPs from a comprehensive systems perspective, and considers future contextual issues that will be relevant to the success of SHSPs.
The analytical basis for this study was based on the systems theory paradigm introduced above and the need to respond to future changes that have already been occurring but have accelerated more recently. Therefore, the present paper developed and applied a rating scale to assess 48 U.S. SHSPs against two key criteria: 1. a comprehensive framework for road safety, and 2. the anticipated changing, difficult and unpredictable nature of future transport and its context.
7P System criteria
Rating scales based on the 7P System framework were developed to assess SHSPs against a comprehensive systems approach to manage and improve road safety [6], as described in Table 2.
Tab. 2. Summary of 7P system criteria and scoring. Future changes criteria
SHSP’s need to take account of the future context to ensure they are relevant during the period of their applicability, given the significance and the unpredictability of these changes. The FHWA notes four key changes influencing the future operating environment: Key Influencing Trends, Highway Industry Trends, Highway Transportation Trends and Strategic Issues [68]. While there are numerous commentaries about future changes, several key topics commonly arise, particularly automation and other innovative applications enabled by electronic, information and communications technologies (EICT) [7,8,10,31,52–54].
Automation in road transport has evolved through several phases including Intelligent Vehicle Highway Systems and transport telematics into what is commonly called Intelligent Transport Systems (ITS) [6,69]. Automation in vehicles is not new but the opportunities provided by EICT have resulted in numerous applications for engine and transmission management, comfort, driver information, driver assistance and control systems in modern vehicles. It is widely expected that automation will dramatically change road safety by eliminating many driver errors, but it will also change productivity, ownership, privacy, data, terrorism and other outcomes, as has occurred in other industries. Road transportation automation is currently focused on vehicle control systems that do not have the same applicability across all modes or users, particularly pedestrians and cyclists [70], so the benefits will not be evenly distributed or wide-ranging. Systems theory and practice also suggests that new technologies and applications will introduce new failures that will need to be managed, due to increasing complexity and the fact that technology application maturity takes time [31].
More widely, new business models are disrupting traditional commercial enterprises. The sharing economy (e.g. Airbnb, Uber) and other new information and transaction enterprises have emerged extremely quickly over the last few years [71]. These businesses are responsive to evolving consumer preferences, particularly demands for services that are easier, cheaper and faster. These include transport preferences of younger people, diverse urban lifestyles or different demands of aging populations compared to the past. In transport, new business models are converging with new technologies to service different transport user demands or preferences, one commonly described example of which is Mobility-as-a-Service (MaaS) [8,69,72].
Another aspect of future circumstances is the difficult and variable nature of conditions, which continues to be more changeable, unpredictable and difficult to manage [10,11,73]. The historical environment that has been simple, stable, clear and certain, as mentioned, can no longer be described as such [9,55]; "Organisations today are under stress from a number of dynamic factors in their environment, such as technological changes, globalization, and market conditions. Modern socio-technical systems are characterized by increased complexity and coupling, and are as a consequence increasingly intractable." ([55], p 955). These conditions make intended outcomes more difficult to achieve, requiring more integration and collaboration and thus a more robust and comprehensive framework and practice [31]. Participants, factors, relationships and feedback are not static for predictions and planning for road safety management, but change over time [58], which necessitates a paradigm shift in road safety management that takes these dynamic factors into account.
Modern safety management in safety-critical industries takes into account that the future will be different in nature compared to present circumstances. In road safety, various analyses attempt to determine the impact of actions in isolation, including before-and-after studies, cost-benefit analyses or other micro-level assessments. However, by assessing the impact of road safety plans as a whole, information will be generated that can be used for performance measurement and understanding the success of the plans (or lack thereof). The problem is that these assessments often assume steady-state conditions that are not reasonable in these changing circumstances. Consequently, relying on analysis that is based on historical information and perspectives introduces a risk that a plan will not suit the future conditions [18,20]. Instead, suitable processes need to ensure that plans are relevant to the future, such as alternative analytical techniques [74,75] including real options analysis [76], scenario analysis, systems dynamics and cognitive workplace analysis [31,43,76–78].
Future Changes criteria for the assessment in this study are based on the expected changes in the transport system and its context, that are likely to affect road safety [6,68] as described above and summarized in Table 3.
Tab. 3. Summary of future changes criteria and scoring. Methods
Current SHSPs from the U.S. were downloaded from the States’ websites and assessed according to the seven 7P System criteria and the five Future Changes criteria, similar to previous comparative analysis based on a rating scale [19,79]. Most plans were five years old or less while three plans were older, and two States did not have SHSPs available. Most plans were valid for five years.
A five-point scale was developed and used to rate the extent to which the SHSPs reflect the assessment criteria that are summarized in Tables 2 and 3. Keywords and indicative search terms were selected according to the concepts relevant to each specific criterion, and the basic scoring scale is as follows:
0—keywords or concepts not mentioned (i.e. brief text only),
1—keywords or concepts directly or indirectly mentioned, and not directly discussed (i.e. longer text),
2—keywords or concepts mentioned and briefly discussed or addressed (i.e. including a response to the criteria),
3—keywords or concepts discussed or has actions to address,
4—keywords or concepts thoroughly discussed and have comprehensive actions to address.
A central mark of ‘2’ represents that the SHSP’s inclusion of the criteria was minimally adequate. To maximize the reliability of the scores, the scales were a) explicitly described with keywords and search terms, which minimizes inconsistencies between the rating of different SHSPs, and, b) rated in all cases by the first author who has forty years’ experience in road safety and transportation policy, planning and research. To avoid sampling issues, all 48 available SHSPs were assessed. Each of the SHSPs was individually read and notes taken regarding the content relevant to the criteria to score each criterion and maximize the consistency of analysis and description of qualitative information. Examples of content that resulted in a higher score were noted to illustrate superior quality plans and provide guidance for improvements. The scores were noted, as provided below, before being analyzed and interpreted as a whole group. The analysis involved basic descriptive statistical analysis including calculation of the mean and standard deviation of the ratings provided to each criterion. Qualitative descriptions were also extracted to enable interpretation, discussion, and conclusions. The data, analysis and results were provided to whole study team who are highly qualified and experienced in road safety research and analysis. All scores, the important qualitative descriptive information and the results are provided below.
Results
Seven 7P System criteria were assessed, where a score of '2' represented a minimum acceptable pass consistent with the comprehensive approach based on systems theory and practice described above. This provided 336 individual scores, as summarized in Table 4. A score above a minimum acceptable level of two for these seven framework criteria as a whole was achieved by 21 SHSPs, with an average score of 2.05 for all SHSPs combined. There were only 28 individual maximum scores of four, 68 scores of three and 89 scores less than two. These numbers equate to 28% of scores above a minimum acceptable level, 45% at the minimum acceptable level and 27% below an acceptable level. The highest average scores were 2.46 for purpose and 2.35 for policy tools, while the lowest average scores were 1.13 for principles and 1.92 for processes. Only four SHSPs scored above an average of three for the 7P System criteria, while 27 SHSPs scored below an average of two, indicating they were basic and inadequately described a comprehensive framework.
Tab. 4. Summary of 7P system criteria assessment. Five Future Changes criteria representing future conditions in which the SHSPs are expected to be applied were assessed, where a score of '2' represented a minimum acceptable score relevant to expected future conditions and suitable responses. This provided 240 individual scores, as summarized in Table 5. There were only six scores of four, only five scores of three and 11 scores of two, with the clear majority of scores (218) below a minimum acceptable score. These numbers equate to 4.6% of scores above a minimum acceptable level, 4.6% at the minimum acceptable level and 91% below an acceptable level. Only six of the SHSPs achieved a total average score above one, well below the acceptable level of two for these five criteria, with an average overall score of an extremely low 0.39 for all SHSPs. The highest score of 1.10 was for new technologies, while all other criteria scores averaged below 1.0. None of the SHSPs reflected the future situations to any degree of adequacy, with 33 SHSPs scoring zero in at least four Future Changes criteria.
Tab. 5. Summary of future changes criteria assessment. Fig 3 summarizes the assessment scores for the 7P System criteria and the Future Changes criteria separately, and all criteria together. This illustrates the moderate level of the scores against the 7P System criteria which ranged between 1.13 and 2.46, with an overall average of 2.05. The scores for the Future Changes criteria were much lower, ranging between 0.06 and 1.1, with an average score of 0.40. The scores varied slightly across the years ranging between 1.09 and 1.67. The SHSPs may be improving slightly over time, particularly for Future Changes criteria, but any change is likely to be marginal.
Fig. 3. Average scores for SHSP assessments. Table 6 summarizes the assessment for each individual SHSP which are illustrated in Fig 4. As a total, only four SHSPs achieved a minimum acceptable score of two as an average across all 12 criteria. Of the 576 individual scores overall, this equates to 19% of all individual scores above a minimum acceptable level (3 or 4), 28% at minimum acceptable level (2) and 53% below an acceptable level (0 or 1).
Fig. 4. Individual SHSP assessment scores. Tab. 6. Summary of individual SHSP assessment scores. Discussion
This study developed and applied an assessment framework for SHSPs guided by a comprehensive systems-based framework for road safety and future issues. The application of this framework to 48 existing SHSPs demonstrates the utility of this framework in assessing the appropriateness and indicative effectiveness of future SHSPs using an ex ante approach.
There is a strong national multiagency approach to SHSPs with several sources providing support and guidance which includes Federal legislation, guidelines, oversight, monitoring and review, primarily by the FHWA. AASHTO and other organizations or collaborations, such as TZD, also provide additional support, although a greater vertical and horizontal integration at the individual State SHSP level would be beneficial [58]. Complying with this multiple agency guidance would result in SHSPs that would be at least adequate for most 7P System criteria, however the results of this study suggest that not all SHSPs appear to do so, indicating that many SHSPs are failing to adequately address guidance material. A number of potential factors may influence the application of guidance material in the development of SHSPs. For example, accessibility or knowledge of how to adequately utilize guidance and other supports may hinder its inclusion in SHSPs. In addition, our assessment describes other system criteria that are not well covered by Federal guidance, such as safety principles and processes. There are also other emerging and innovative concepts, such as Safety Culture [6,29,80–82], that are not included in guidance material. So, there is a risk that States could do as little as necessary to comply with Federal requirements to qualify for funds without necessarily producing the most efficient and effective SHSP. If so, strong Federal oversight could actually limit innovation. Continued effort is required to further improve SHSP guidance at the Federal or joint national level collaboratively and at the State level as SHSPs are developed and implemented. Investigating these potential factors was not within the scope of this study but warrants additional exploration in order to address these potential concerns.
Federal requirements include evaluation and implementation processes but are weakly described in the current SHSPs and the FHWA’s four steps for evaluations are not often evident. Previous SHSPs have not demonstrated effectiveness during the development of current SHSPs, partly because of the difficulty associated with assessing cause and effect, and partly because they have not been subject to robust evaluations. Our assessment provides no evidence to contradict the earlier proposition that ex post evaluation is problematic, as there are many factors contributing to road safety 6,13,17] and the value of SHSPs has not been proven [20]. Moreover, thorough implementation is crucial to the success of SHSPs to ensure efficiency and effectiveness in achieving outcomes. FHWA guidelines describe the ‘essential eight’ components for successful implementation: four elements (1. leadership, 2. collaboration, 3. communication, and 4. data collection and analysis) and four steps (1. developing emphasis area action plans, 2. integrating the SHSP into other transportation and safety plans, 3. developing a marketing strategy, and 4. monitoring progress, evaluating results, and establishing a feedback loop to ensure SHSP adjustments and updates are continually incorporating experiences and lessons learned) [83]. Unfortunately, these eight components are not evident in most SHSPs, which consequently threatens their success. SHSPs would benefit from thorough evaluations and robust implementation plans with a commitment to complete delivery to ensure the SHSPs are properly applied. However, the opportunity to apply ex ante assessments would be more timely and therefore beneficial, than ex post evaluations that are subject to lengthy delays.
As for other similar studies [19,79] the analysis presented in this study is limited by the information available and within the scope of the review, i.e., the published SHSPs. Additional SHSP complementary information, such as actions plans, and other supporting information may also be available, but not referred to in the plans, such as in the Highway Safety Improvement Plans, Commercial Vehicle Safety Plans, or broader transport plans. For a comparative assessment, it is important that strategies are assessed on an equal basis, so including additional information, either selectively or unsystematically, can threaten the equivalence of such assessments. The style and purpose are other issues affecting the content of the plans. SHSPs may be written shorter or more simply to to improve readability for the general public. The plans may have alternative purposes, such as to engage and motivate the public, to assist decision making by elected members and agencies, or to clearly guide and direct professionals, practitioners and other participants involved. Therefore, the SHSPs may necessarily need to be written in different ways and include different content.
As this study provides a new methodology for assessing SHSPs, it is subject to further consideration and development. For instance, other assessors may prefer different criteria or different scoring for the criteria used in this study. This study relied on a single assessor to maximize consistency, but not all assessors would necessarily agree with this assessor’s score, even though the relativity of scores should remain consistent even if the nominal values change.
7P System criteria application
The assessment of systems criteria presented in this study (Tables 4 and 5) found that current SHSPs were strongest on one element of best practice from a system perspective (purpose), minimally adequate for some (policy tools, parts, participants, and partnerships) but weak on principles and processes. All SHSPs mentioned education, engineering, enforcement and emergency services, consistent with Federal requirements, although activities to improve emergency services were less common. Some other policy tools were occasionally included, such as incentives, taxation, leadership, integrating techniques, alternative funding and investment (e.g. private sector), subsidies, consumer choice, industry change or innovation. All SHSPs mentioned several types of road users, vehicles (mostly several types) and roads (often with the wider infrastructure). Other parts of the road safety system that affect outcomes were rarely mentioned, such as land use, the economy, social context, and safety management [6]. Emphasis or Focus Areas clearly identified specific aspects for the SHSPs to target and were a mix of parts (e.g. roads or road users), behaviors (e.g. distraction, alcohol) or activities (e.g. data, enforcement and education).
Principles to guide road safety management and practice were adequately described in 17 SHSPs, most often based on AASHTO or TZD, or were generally stated as ways of approaching the problem. However, most SHSPs did not include such clear guidance. Other valuable principles to ensure the SHSPs were cost-effective, acceptable and timely were only occasionally described, such as innovation, administrative efficiency and effectiveness, resilience to future change, national consistency, practicability or operational and commercial efficiency and effectiveness.
Processes that need to be applied in order for the intended road safety outcomes to be achieved were adequately described in 32 SHSPs although there was considerable room for improvement in almost all SHSPs. Consistent with Federal requirements, all SHSPs described the process to develop the plan, implementation and evaluation, although often weakly. Marketing, collaboration or communication was also regularly included, however, other valuable processes for safety management, research, project design and, communications, etc. were rarely or never mentioned. Additional processes to apply best practice safety management that exist in other safety domains were also missing, including in-depth crash investigation, thorough safety and risk management, scenario assessments, benefit-cost assessment, program evaluation, etc. Other contemporary risk analysis and management that could be applied includes fault tree analysis [31], Management Oversight and Risk Tree (MORT) [25], real options analysis [76], Systems Theoretic Accident Modeling and Processes (STAMP) [31,77], SAFETY II [11] and systems dynamics [31,77,78].
The development of all SHSPs involved many stakeholders, often with diverse roles and varied perspectives involving extensive collaborative participation [11,31,77]. However, these stakeholders were generally not carried over into subsequent stages of design and implementation, and other relevant participants were often not included. Implementing the multifaceted programs in the SHSPs to address complex emphasis areas would benefit from the involvement of all participants that can make a positive contribution, at the same time as minimizing interference from participants with conflicting objectives. In the same way, many SHSPs included several complementary activities together in individual emphasis areas, although elsewhere the interrelationships between different policy tools, participants and processes were often not well recognized. Analyzing, describing and understanding these partnerships provides an opportunity to maximize complementary synergies and collaborative efficiency during SHSP implementation.
All SHSPs included education and enforcement, with the primary objective being to change roaduser behavior. Traditional road safety measures rely on education and enforcement as the policy tools to change behavior by increasing compliance with rules, but these alone do not work [84]; they can be useful but are not sufficient: “education alone does not necessarily motivate the safe choice. By contrast, transformative education addresses the cultural attitudes, values and beliefs surrounding a set of behaviors, such as driving-related practices, and tries to motivate change by changing the culture itself.” ([84], p16). More sophisticated behavior change programs have been found to be more successful in health promotion and achieving other objectives in transport [85,86], including the Theory of Planned Behavior (TPB) [87,88] and the Transtheoretical or Stages of Change [89]. These more advanced programs provide an opportunity to improve road safety education and other activities that are intended to change road users’ and other participants’ behaviors.
Twenty-three SHSPs discussed the concept of TZD, while another 14 mentioned it briefly or had numerical 'Toward Zero' goals. While TZD might be a useful label for public engagement, the term has various and different meanings, rather than the concept, principles and practices described in the national dialogue described by TZD, FHWA and others. Often called Vision Zero, TZD has been developed and adopted in several European and Australasian jurisdictions but varies considerably in its description and application [17,27]. Most commonly, TZD includes clear and challenging targets, and the principles that any loss of human life is unacceptable and avoidable, that humans do make mistakes, the system should take account that humans can only absorb limited forces during crashes, and there is a shared responsibility for road safety [3,18,20]. Consequently, TZD is fundamentally a philosophy to influence policy makers, the public and designers. Therefore, TZD can potentially be effective if it is translated into strategies, plans and actions that are consistent with its principles. TZD in the U.S. positively differs from other international jurisdictions by including Safety Culture and systems approaches [83]. In the U.S. and internationally, the translation of TZD into plans continues to rely on road engineering together with driver education and enforcement, which continues the common practice of many years. While some SHSPs included TZD concepts, it was not clearly translated into actions in the SHSPs, so traditional approaches to road safety continued to dominate.
As noted above, Safety Culture is a concept that has been recognized as being valuable in safety-critical industries and has successfully been applied over a long period to change participants' behavior to achieve the intended purposes [46–51]. The application of Safety Culture to road safety has been emerging for some time [6,29,80–82] but has not become intrinsic to U.S. road safety management. Safety Culture is described as "the shared values, actions and behaviors that demonstrate a commitment to safety over competing goals and demands" [90]. Both organizational and public Safety Culture are important to achieve road safety outcomes [90]. Organizational Safety Culture can be achieved through leadership, systems, standards and processes and applies to employers, as well as departments responsible for safety management. Public Safety Culture is more difficult to achieve in the absence of authority to do so. Fifteen SHSPs discuss the concept of Safety Culture, while another 14 SHSPs mention it briefly, so it has not yet been widely applied methodically. Therefore, the application of Safety Culture for road users, professionals, other participants, decision-makers and the general public offers another potential tool to improve road safety.
While systems approaches have been widely and successfully applied in different domains, it might be foolish to assume they are complete or adequate. At the same time, there appears to be little literature that challenges systems approaches; other ways of thinking or practice or details tend to be complementary not contradictory. Once a system is described and understood, it must be recognized that it can change over time, participants and parts can be added or removed, increased or decreased and new policy tools may be developed and applied. The road system is never completely in equilibrium but is constantly changing over time. So, the dynamic nature of the road safety system must be appreciated, and its management framework must be dynamic to remain relevant. This issue is part of the reason that future situation assessment is required. While a systems approach is justifiable theoretically, it can also be difficult to apply in practice, due to its complexity. The number of participants, policy tools, parts and interactions are too numerous to take full account of [6,77], so road safety requires careful management.
Future changes criteria application
Results of this study regarding future changes affecting road safety found that existing SHSPs hardly reflected the anticipated future context, while the changing and variable nature of future conditions was missing almost entirely from consideration and responses. Less than 10% of the SHSPs achieved an acceptable score for Future Changes criteria, with the overwhelming majority of SHSPs did not relate to future circumstances and instead reflected a historical perspective based on past circumstances and practice. Although the transport market, business models and user preferences have been evolving for many years, such changes were barely recognized. SHSPs did not assess or forecast the impact resulting from the implementation of the SHSPs, and there were no processes or techniques described to do so. The most common view of the future was to outline the path to future targets without a justification that the SHSP could achieve that outcome. Even though the future has been becoming continually more changeable, complicated and unpredictable, the SHSPs generally assumed the opposite.
While new technologies were mentioned, the comments were mainly focused on the negative impact of technology on distraction and opportunities for increased automated enforcement. There was little mention about new technologies to improve road safety directly (such as in-vehicle safety systems and driverless technology), and no clear actions to apply such technologies, particularly the introduction of driver assistance systems, to the point that driverless cars were not foreseen. Responses to the introduction of such useful technologies were almost completely absent in SHSPs, despite such technologies being deployed, and sometimes mandated today. Car automation is a major focus of government, transport and general industry and similar technologies are emerging to improve safety outcomes for pedestrians, cycling, heavy vehicle and motorcycles, which also need to be accounted for.
The low scores for Futures Criteria raise the question as to whether the criteria may be too stringent. Since SHSPs have not been subject to assessment regarding future relevance, this issue would benefit from further consideration and development of reasonable measures of acceptable criteria and scores that are broadly agreed.
Recommendations
Based on systems theory and best practice in safety management, the following recommendations are made to improve U.S. SHSPs. Firstly, consistent with systems theory and practice [6], adoption of a comprehensive systems-based framework would include:
clearly describing and applying principles that need to guide SHSPs to be most effective, such as those underpinning the TZD approach, cost efficiency, innovation, best practice and evaluation;
maximizing the contributions of all relevant participants by stimulating participants who can positively contribute to road safety outcomes and minimize the effects of participants who can negatively interfere;
adopting additional alternative policy tools that broaden the range of actions that can be applied. These may include economic incentives, developing Safety Culture and climate, or capability development and standards for participants with poorer skills and knowledge;
identifying other component parts that can be influenced to improve road safety or counteract if they would result in adverse road safety outcomes. These could include aspects of the transport and land-use system, society or economic context including broader government policy;
thoroughly describing and applying the most useful processes required to manage road safety properly, including risk analysis, thorough implementation and evaluation;
identifying and maximizing the positive relationships between participants, policy tools, components and outcomes and minimize the negative influences; and
describing the outcomes or purposes of individual actions in addition to the SHSPs as a whole, and for specific sectors (such as heavy vehicles, geographic areas, road user groups of participants).
The following recommendations are made to ensure that the SHSPs are more suitable for future circumstances:
identifying and taking into account influences and factors that will change in the future and affect road safety outcomes;
developing and applying techniques to manage future influences that are uncertain to ensure that the SHSPs are resilient to alternative future situations caused by changing circumstances;
employing contemporary futures analytical techniques, such as scenario analysis, real options analysis, and Monte Carlo simulation for analysis of future consequences caused by the SHSPs, individual actions, and external factors and participants;
developing actions to maximize the benefits of positive influences and minimize the effects of negative influences of automation and technology, new business models and the effects of changing consumer preferences; and
ensuring an appropriate time that SHSPs should be applied to, so they remain relevant throughout their lifespan.
Finally, the methodology used in this study could be further reviewed and refined in subsequent research.
Summary and conclusions
This study developed a new methodology to assess SHSPs from the perspectives of comprehensive system-based safety management and relevant future issues that can be applied before an SHSP is implemented. This study demonstrates that U.S. SHSPs could be developed to more thoroughly respond to the increasingly difficult challenge to improve road safety and respond to changes in the transport, economic, social and business contexts that are occurring. The SHSPs are most strongly influenced by good processes and practices described by Federal requirements and national collaborative approaches. There is a risk that current SHSPs are developed primarily to comply with Federal requirements, rather than achieving outcomes based on high-quality safety management practices. The SHSPs and national guidance are unfortunately overly reliant on historical perspectives and do not take sufficient account of future situations, including increasing complexity, changeability and unpredictability. They could be improved by applying analytical techniques to assess future situations. Generally, SHSPs are only minimally acceptable at present and could be further improved by applying thorough approaches based on systems theory and best practice safety management that have been successful in hazardous industries. Broader structural elements of a comprehensive safety framework need to be considered more deeply and astutely incorporated. Indeed, the SHSPs should be improved so that they are more likely to be successful and better applicable to the future than current versions. Finally, the concepts and methodology in this study can be applied proactively during the development of SHSPs without waiting for lengthy periods after implementation to examine the appropriateness of plans by which time the evaluation may be out of date. Applying the learnings from this study is expected to more efficiently and effectively continue the improvements to road safety.
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- Increased incidence of age-related macular degeneration in sensorineural hearing loss: A population-based cohort study
- Evaluating the foundations that help avert antimicrobial resistance: Performance of essential water sanitation and hygiene functions in hospitals and requirements for action in Kenya
- Effects of a hot ambient operating theatre on manual dexterity, psychological and physiological parameters in staff during a simulated burn surgery
- Introduction of quality management in a National Reference Laboratory in Germany
- Histopathological investigation of complex gill disease in sea farmed Atlantic salmon
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- Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
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- Interaction of detergents with biological membranes: Comparison of fluorescence assays with filtration protocols and implications for the rates of detergent association, dissociation and flip-flop
- Potential causes of early death among admitted newborns in a rural Tanzanian hospital
- Identification of glomerular and podocyte-specific genes and pathways activated by sera of patients with focal segmental glomerulosclerosis
- Prevalence and correlates of partner violence among adolescent girls and young women: Evidence from baseline data of a cluster randomised trial in Tanzania
- Development of an integrated fingerstick blood self-collection device for radiation countermeasures
- Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease
- Effects of arthroscopic vs. mini-open rotator cuff repair on function, pain & range of motion. A systematic review and meta-analysis
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- Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal
- Nanoaperture fabrication via colloidal lithography for single molecule fluorescence analysis
- A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis
- Sialochemical analysis in polytraumatized patients in intensive care units
- The black sheep effect: The case of the deviant ingroup robot
- No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer’s disease
- Implementation of an international standardized set of outcome indicators in pregnancy and childbirth in Kenya: Utilizing mobile technology to collect patient-reported outcomes
- Breastfeeding support through wet nursing during nutritional emergency: A cross sectional study from Rohingya refugee camps in Bangladesh
- Does route matter? Impact of route of oxytocin administration on postpartum bleeding: A double-blind, randomized controlled trial
- Research on OpenCL optimization for FPGA deep learning application
- Drug therapy problems, medication adherence and treatment satisfaction among diabetic patients on follow-up care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
- Quality of life and symptom intensity over time in people with cancer receiving palliative care: Results from the international European Palliative Care Cancer Symptom study
- The dynamics of Early Celtic consumption practices: A case study of the pottery from the Heuneburg
- Safety and efficacy of artesunate-amodiaquine combined with either methylene blue or primaquine in children with falciparum malaria in Burkina Faso: A randomized controlled trial
- “Cementing” marriages through childbearing in subsequent unions: Insights into fertility differentials among first-time married and remarried women in Ghana
- Single session high definition transcranial direct current stimulation to the cerebellum does not impact higher cognitive function
- The contribution of age structure to the international homicide decline
- Genetic structure of Mexican lionfish populations in the southwest Gulf of Mexico and the Caribbean Sea
- A physiological dose of oral vitamin B-12 improves hematological, biochemical-metabolic indices and peripheral nerve function in B-12 deficient Indian adolescent women
- Nutritional status, cognitive achievement, and educational attainment of children aged 8-11 in rural South India
- Costs and cost-effectiveness analyses of mCARE strategies for promoting care seeking of maternal and newborn health services in rural Bangladesh
- Cause-specific mortality in the general population with transient dipstick-proteinuria
- Assessing hand dysfunction in cervical spondylotic myelopathy
- KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
- Variation in activity rates may explain sex-specific dorsal color patterns in Habronattus jumping spiders
- Adjusting for spatial variation when assessing individual-level risk: A case-study in the epidemiology of snake-bite in Sri Lanka
- Acute sprint exercise transcriptome in human skeletal muscle
- Parenting and personality disorder: An overview and meta-synthesis of systematic reviews
- Female rats release a trapped cagemate following shaping of the door opening response: Opening latency when the restrainer was baited with food, was empty, or contained a cagemate
- Multiplex communities and the emergence of international conflict
- The impact of socioeconomic status on emergency department outcome in a low-income country setting: A registry-based analysis
- Effect of psycho-social support by teachers on improving mental health and hope of adolescents in an earthquake-affected district in Nepal: A cluster randomized controlled trial
- A cluster-randomized controlled trial of the effectiveness of the JUMP Math program of math instruction for improving elementary math achievement
- Transgenic mouse model for conditional expression of influenza hemagglutinin-tagged human SLC20A1/PIT1
- Use of rapid Model for End-Stage Liver Disease (MELD) increases for liver transplant registrant prioritization after MELD-Na and Share 35, an evaluation using data from the United Network for Organ Sharing
- Fishery Improvement Projects as a governance tool for fisheries sustainability: A global comparative analysis
- QRStree: A prefix tree-based model to fetal QRS complexes detection
- Fundraising and vote distribution: A non-equilibrium statistical approach
- Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity
- Gene expression profiling of whole blood: A comparative assessment of RNA-stabilizing collection methods
- Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation
- Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe
- P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
- Using long-term datasets to assess the impacts of dietary exposure to neonicotinoids on farmland bird populations in England
- Genetic mapping of distal femoral, stifle, and tibial radiographic morphology in dogs with cranial cruciate ligament disease
- Optimized bioluminescence analysis of adenosine triphosphate (ATP) released by platelets and its application in the high throughput screening of platelet inhibitors
- Consumer beliefs about healthy foods and diets
- An observational study on intracutaneous sodium storage in intensive care patients and controls
- Recovery when you are on your own: Slow population responses in an isolated marine reserve
- How does the method change what we measure? Comparing virtual reality and text-based surveys for the assessment of moral decisions in traffic dilemmas
- Is recent Afghanistan survey data suitable for fertility analysis? A regional investigation based on fertility inhibiting determinants
- Analytical validation of the Target Selector ctDNA platform featuring single copy detection sensitivity for clinically actionable EGFR, BRAF, and KRAS mutations
- Comparison of two swept-source optical coherence tomography biometers and a partial coherence interferometer
- Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents
- A social media intervention to improve nutrition knowledge and behaviors of low income, pregnant adolescents and adult women
- Detection of vision and /or hearing loss using the interRAI Community Health Assessment aligns well with common behavioral vision/hearing measurements
- E-MOVIE - Experimental MOVies for Induction of Emotions in neuroscience: An innovative film database with normative data and sex differences
- Does self-reported pregnancy loss identify women at risk of an adverse cardiovascular phenotype in later life? Insights from UK Biobank
- An elevated glycemic gap predicts adverse outcomes in diabetic patients with necrotizing fasciitis
- 40-Hz auditory steady-state responses and the complex information processing: An exploratory study in healthy young males
- Highly diverse anaerobe-predominant vaginal microbiota among HIV-infected pregnant women in Zambia
- Decision-based models of the implementation of interventions in systems of healthcare: Implementation outcomes and intervention effectiveness in complex service environments
- Dual number-based variational data assimilation: Constructing exact tangent linear and adjoint code from nonlinear model evaluations
- Ultra-deep sequencing reveals pre-mRNA splicing as a sequence driven high-fidelity process
- Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis
- Lek-associated movement of a putative Ebolavirus reservoir, the hammer-headed fruit bat (Hypsignathus monstrosus), in northern Republic of Congo
- Attenuation correction using 3D deep convolutional neural network for brain 18F-FDG PET/MR: Comparison with Atlas, ZTE and CT based attenuation correction
- Differences in macular capillary parameters between healthy black and white subjects with Optical Coherence Tomography Angiography (OCTA)
- Sealing agent reduces formation of single and dual-species biofilms of Candida albicans and Enterococcus faecalis on screw joints at the abutment/implant interface
- Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species
- What is the optimum time for initiation of early mobilization in mechanically ventilated patients? A network meta-analysis
- Cognitive aptitude, peers, and trajectories of marijuana use from adolescence through young adulthood
- Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study
- Accuracy and interobserver-agreement of respiratory rate measurements by healthcare professionals, and its effect on the outcomes of clinical prediction/diagnostic rules
- Does task delegation to non-physician health professionals improve quality of diabetes care? Results of a scoping review
- The Univariate Flagging Algorithm (UFA): An interpretable approach for predictive modeling
- Profiles and trajectories of impaired social cognition in people with Prader-Willi syndrome
- Effect of pimobendan on physical fitness, lactate and echocardiographic parameters in dogs with preclinical mitral valve disease without cardiomegaly
- Sub-types of safety behaviours and their effects on social anxiety disorder
- Engaging in prosocial behavior explains how high self-control relates to more life satisfaction: Evidence from three Chinese samples
- Artificial fingerprints for cross-comparison of forensic DNA and protein recovery methods
- The organization of Golgi in Drosophila bristles requires microtubule motor protein function and a properly organized microtubule array
- Direct and moderating effects of environmental regulation intensity on enterprise technological innovation: The case of China
- Prevalence and associated factors of depression among Korean adolescents
- Transcriptome analysis of PK-15 cells in innate immune response to porcine deltacoronavirus infection
- Geographic variation in cardiometabolic risk distribution: A cross-sectional study of 256,525 adult residents in the Illawarra-Shoalhaven region of the NSW, Australia
- Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
- Lipid profile changings after switching from rilpivirine/tenofovir disoproxil fumarate/emtricitabine to rilpivirine/tenofovir alafenamide/emtricitabine: Different effects in patients with or without baseline hypercholesterolemia
- A feature selection strategy for gene expression time series experiments with hidden Markov models
- Dissociating the sequential dependency of subjective temporal order from subjective simultaneity
- Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis
- Population-based estimates of engagement in HIV care and mortality using double-sampling methods following home-based counseling and testing in western Kenya
- Vaginal temperature as indicative of thermoregulatory response in Nellore heifers under different microclimatic conditions
- Galectin-9 gene (LGALS9) polymorphisms are associated with rheumatoid arthritis in Brazilian patients
- The association of brightness with number/duration in human newborns
- Microslit on a chip: A simplified filter to capture circulating tumor cells enlarged with microbeads
- Integrating continuous differential evolution with discrete local search for meander line RFID antenna design
- The impact of the French soda tax on prices and purchases. An ex post evaluation
- Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications
- Structural characterization of a novel polysaccharide from Sargassum thunbergii and its antioxidant and anti-inflammation effects
- Potential biomarker identification for Friedreich’s ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion
- Major drug resistance mutations to HIV-1 protease inhibitors (PI) among patients exposed to PI class failing antiretroviral therapy in São Paulo State, Brazil
- Chile (Capsicum annuum) plants transformed with the RB gene from Solanum bulbocastanum are resistant to Phytophthora capsici
- Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
- Analysis of gene co-expression networks of phosphate starvation and aluminium toxicity responses in Populus spp.
- Risk factors associated with IgA vasculitis with nephritis (Henoch–Schönlein purpura nephritis) progressing to unfavorable outcomes: A meta-analysis
- The prediction model of suicidal thoughts in Korean adults using Decision Tree Analysis: A nationwide cross-sectional study
- A multidimensional understanding of prosperity and well-being at country level: Data-driven explorations
- Factors associated with muscle mass in community-dwelling older people in Singapore: Findings from the SHIELD study
- The prevalence and risk of non-infectious comorbidities in HIV-infected and non-HIV infected men attending general practice in Australia
- Vibrio cholerae strains with inactivated cqsS gene overproduce autoinducer-2 which enhances resuscitation of dormant environmental V. cholerae
- Myocardial function in patients with anomalous left coronary artery from the pulmonary artery syndrome: A long-term speckle tracking echocardiographic study
- Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo
- Joint distribution for number of crossings and longest run in independent Bernoulli observations. The R package crossrun
- Learning to play badminton altered resting-state activity and functional connectivity of the cerebellar sub-regions in adults
- Children’s dietary diversity and related factors in Rwanda and Burundi: A multilevel analysis using 2010 Demographic and Health Surveys
- Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease
- Precluding rare outcomes by predicting their absence
- Tidal inlet seafloor changes induced by recently built hard structures
- A further study on Franciscobasis Machado & Bedê, 2016 (Odonata: Coenagrionidae), a newly described genus from Minas Gerais, Brazil
- Associative responses to visual shape stimuli in the mouse auditory cortex
- Extracellular matrix turnover and inflammation in chemically-induced TMJ arthritis mouse models
- LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure
- Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases
- Separating the effects of temperature and carbon allocation on the diel pattern of soil respiration in the different phenological stages in dry grasslands
- Unweaving tangled mortality and antibiotic consumption data to detect disease outbreaks – Peaks, growths, and foresight in swine production
- Factors associated with exclusive breast-feeding: A cross-sectional survey in Kaiyuan, Yunnan, Southwest China
- The Model of Mortality with Incident Cirrhosis (MoMIC) and the model of Long-term Outlook of Mortality in Cirrhosis (LOMiC)
- Burden of treatment-resistant depression in Medicare: A retrospective claims database analysis
- Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates
- Sharing the filmic experience - The physiology of socio-emotional processes in the cinema
- A super-SILAC based proteomics analysis of diffuse large B-cell lymphoma-NOS patient samples to identify new proteins that discriminate GCB and non-GCB lymphomas
- Pneumoproteins are associated with pulmonary function in HIV-infected persons
- Tissue-specific expression of IgG receptors by human macrophages ex vivo
- Electrical impedance myography for the detection of muscle inflammation induced by λ-carrageenan
- Clustering of the structures by using “snakes-&-dragons” approach, or correlation matrix as a signal
- Asymmetric valuation of gains and losses in effort-based decision making
- Genomic and metabolic differences between Pseudomonas putida populations inhabiting sugarcane rhizosphere or bulk soil
- Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis
- Gender linked fate explains lower legal abortion support among white married women
- L-3,3’,5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors
- eQTL mapping of rare variant associations using RNA-seq data: An evaluation of approaches
- Cell fishing: A similarity based approach and machine learning strategy for multiple cell lines-compound sensitivity prediction
- Macrogeographic genetic structure of Lutzomyia longipalpis complex populations using Next Generation Sequencing
- Dual-career through the elite university student-athletes’ lenses: The international FISU-EAS survey
- Machine learning prediction of emesis and gastrointestinal state in ferrets
- Impact of bitter tastant sub-qualities on retronasal coffee aroma perception
- Head orientation and electrode placement potentially influence fetal scalp ECG waveform
- Clinical outcomes associated with the use of the NexSite hemodialysis catheter with new exit barrier technology: Results from a prospective, observational multi-center registry study
- Geospatial correlates of early marriage and union formation in Ghana
- Disruption of white matter connectivity in chronic obstructive pulmonary disease
- Integrated evaluation of clinical, pathological and radiological prognostic factors in squamous cell carcinoma of the lung
- Saliva enhances infection of gingival fibroblasts by herpes simplex virus 1
- Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions
- An alternative approach for estimating the number needed to treat for survival endpoints
- Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines
- Can telemedicine initiative be an effective intervention strategy for improving treatment compliance for pediatric HIV patients: Evidences on costs and improvement in treatment compliance from Maharashtra, India
- Trial registration as a safeguard against outcome reporting bias and spin? A case study of randomized controlled trials of acupuncture
- Multi-disciplinary interventions for chronic pain involving education: A systematic review
- Impact of climate change on the integrity of the superstructure of deteriorated U.S. bridges
- Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
- Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials
- Testing gene by community disadvantage moderation of sexual health outcomes among urban women
- The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review
- Evaluation of a screening algorithm using the Strengths and Difficulties Questionnaire to identify children with mental health problems: A five-year register-based follow-up on school performance and healthcare use
- Optimized fast GPU implementation of robust artificial-neural-networks for k-space interpolation (RAKI) reconstruction
- The cost of illness and economic burden of endometriosis and chronic pelvic pain in Australia: A national online survey
- Refined distributed emotion vector representation for social media sentiment analysis
- Enhancing timeliness of drug overdose mortality surveillance: A machine learning approach
- A real-time gesture recognition system using near-infrared imagery
- Alcohol use and its association with sexual risk behaviors in the Armed Forces of the Republic of the Congo
- Improved survival rates in patients with H1N1 acute respiratory failure in Korea between 2009 and 2016
- Electroencephalographic features of discontinuous activity in anesthetized infants and children
- Tumor stromal type is associated with stromal PD-L1 expression and predicts outcomes in breast cancer
- Mutant prevention concentration of ozenoxacin for quinolone-susceptible or -resistant Staphylococcus aureus and Staphylococcus epidermidis
- The Echobot: An automated system for stimulus presentation in studies of human echolocation
- Evaluation of clinical manifestations, health risks, and quality of life among women with polycystic ovary syndrome
- Magnetic resonance imaging presentation of deep infiltrating endometriosis nodules before and after pregnancy: A case series
- Agrobacterium tumefaciens-mediated transformation of a hevein-like gene into asparagus leads to stem wilt resistance
- Effect of a Mentor Mother Programme on retention of mother-baby pairs in HIV care: A secondary analysis of programme data in Uganda
- Utilizing multiplex fluor LAMPs to illuminate multiple gene expressions in situ
- Genetic relationships between the RACK1 homolog cpc-2 and heterotrimeric G protein subunit genes in Neurospora crassa
- Is latent tuberculosis infection challenging in Iranian health care workers? A systematic review and meta-analysis
- A comparison of the risk of congestive heart failure-related hospitalizations in patients receiving hemodialysis and peritoneal dialysis - A retrospective propensity score-matched study
- A tailored approach to fusion transcript identification increases diagnosis of rare inherited disease
- Experiences, needs, and preferences for follow-up after stroke perceived by people with stroke and healthcare professionals: A focus group study
- Iodine supplementation of lactating women and assessment of infant visual information processing and maternal and infant thyroid function: A randomized trial
- The Nordic Maintenance Care Program: Does psychological profile modify the treatment effect of a preventive manual therapy intervention? A secondary analysis of a pragmatic randomized controlled trial
- Within-subject variability in human retinal nerve fiber bundle width
- Motivation for alcohol consumption or abstinence during pregnancy: A clinical-qualitative study in Brazil
- Comparison of conventional BLUP and single-step genomic BLUP evaluations for yearling weight and carcass traits in Hanwoo beef cattle using single trait and multi-trait models
- Do cognitive and non-cognitive abilities mediate the relationship between air pollution exposure and mental health?
- Molecular phylogeny and morphology reveal a new epiphytic species of Habenaria (Orchidaceae; Orchideae; Orchidinae) from Nepal
- Nitrogen nutrition is a key modulator of the sugar and organic acid content in citrus fruit
- Understanding variation in health service coverage and maternal health outcomes among districts in Rwanda – A qualitative study of local health workers’ perceptions
- Biased cognition in East Asian and Western cultures
- Physical fitness and physical self-concept of male and female young adults in Qatar
- Robust policy evaluation from large-scale observational studies
- Improved semi-supervised autoencoder for deception detection
- Delineation of high resolution climate regions over the Korean Peninsula using machine learning approaches
- Are spasticity, weakness, selectivity, and passive range of motion related to gait deviations in children with spastic cerebral palsy? A statistical parametric mapping study
- ProphET, prophage estimation tool: A stand-alone prophage sequence prediction tool with self-updating reference database
- Conspicuous and cryptic reef fishes from a unique and economically important region in the northern Red Sea
- Time scale of resilience loss: Implications for managing critical transitions in water quality
- Effectiveness of physical and cognitive-behavioural intervention programmes for chronic musculoskeletal pain in adults: A systematic review and meta-analysis of randomised controlled trials
- Relationship between feed efficiency indexes and performance, body measurements, digestibility, energy partitioning, and nitrogen partitioning in pre-weaning dairy heifers
- Long-stay patients in pediatric intensive care unit: Diagnostic-specific definition and predictors
- Evidence of ritual breakage of a ground stone tool at the Late Natufian site of Hilazon Tachtit cave (12,000 years ago)
- Whole genome sequencing to identify predictive markers for the risk of drug-induced interstitial lung disease
- A systematic review and thematic synthesis of Canada’s LGBTQ2S+ employment, labour market and earnings literature
- The occurrence of ‘Sleeping Beauty’ publications in medical research: Their scientific impact and technological relevance
- Analysis of the protein composition of the spindle pole body during sporulation in Ashbya gossypii
- Assessing undergraduate student and faculty views on animal research: What do they know, whom do they trust, and how much do they care?
- The views and experiences of general dental practitioners (GDP’s) in West Yorkshire who used the International Caries Detection and Assessment System (ICDAS) in research
- Compare HIV/syphilis infections between age groups and explore associated factors of HIV/syphilis co-infections among men who have sex with men in Shenzhen, China, from 2009 to 2017
- Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers
- Effect of exclusive breastfeeding cessation time on childhood morbidity and adverse nutritional outcomes in Ethiopia: Analysis of the demographic and health surveys
- Dual antiplatelet therapy in patients with cirrhosis and acute myocardial infarction – A 13-year nationwide cohort study
- Relationships between electrolyte and amino acid compositions in sweat during exercise suggest a role for amino acids and K+ in reabsorption of Na+ and Cl- from sweat
- A simplified vocal tract model for articulation of [s]: The effect of tongue tip elevation on [s]
- Management and glycemic control of patients with type 2 diabetes mellitus at primary care level in Kedah, Malaysia: A statewide evaluation
- Anabolic steroids among resistance training practitioners
- Factors associated with unsafe abortion practices in Nepal: Pooled analysis of the 2011 and 2016 Nepal Demographic and Health Surveys
- New methods of removing debris and high-throughput counting of cyst nematode eggs extracted from field soil
- Vehicle configurations associated with anatomical-specific severe injuries resulting from traffic collisions
- What has reproductive health decision-making capacity got to do with unintended pregnancy? Evidence from the 2014 Ghana Demographic and Health Survey
- Circulating levels of CD34+ cells predict long-term cardiovascular outcomes in patients on maintenance hemodialysis
- Penetration of linezolid into bone tissue 24 h after administration in patients with multidrug-resistant spinal tuberculosis
- Prosthesis design of animal models of periprosthetic joint infection following total knee arthroplasty: A systematic review
- Coherent diversification in corporate technological portfolios
- Technology opportunity discovery by structuring user needs based on natural language processing and machine learning
- Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage
- Factors associated with the use of diet and the use of exercise for prostate cancer by long-term survivors
- Congenital Zika Syndrome in a Brazil-Paraguay-Bolivia border region: Clinical features of cases diagnosed between 2015 and 2018
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- Malawian children with uncomplicated and cerebral malaria have decreased activated Vγ9Vδ2 γδ T cells which increase in convalescence
- Predictors of mortality within the first year of initiating antiretroviral therapy in urban and rural Kenya: A prospective cohort study
- The investment case as a mechanism for addressing the NCD burden: Evaluating the NCD institutional context in Jamaica, and the return on investment of select interventions
- Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection
- Bringing fear into focus: The intersections of HIV and masculine gender norms in Côte d’Ivoire
- Scientific output scales with resources. A comparison of US and European universities
- Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis
- Effect of host genotype and Eimeria acervulina infection on the metabolome of meat-type chickens
- Gravity influences bevacizumab distribution in an undisturbed balanced salt solution in vitro
- Agrobacterium tumefaciens-mediated transformation and expression of GFP in Ascochyta lentis to characterize ascochyta blight disease progression in lentil
- Proteomic changes of aryl hydrocarbon receptor (AhR)-silenced porcine granulosa cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
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- Improving the forecasting performance of temporal hierarchies
- Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building
- Relatives’ attachment anxiety mediates the association between perceived loss and expressed emotion in early psychosis
- The impact of PEPFAR transition on HIV service delivery at health facilities in Uganda
- Impact of peri-intraventricular haemorrhage and periventricular leukomalacia in the neurodevelopment of preterms: A systematic review and meta-analysis
- Correction: Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
- Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection
- Determination of factors affecting medication adherence in type 2 diabetes mellitus patients using a nationwide claim-based database in Japan
- Beyond the metabolic syndrome: Visceral and marrow adipose tissues impair bone quantity and quality in Cushing’s disease
- Clade II Candida auris possess genomic structural variations related to an ancestral strain
- Effect of aging on the association between ankle muscle strength and the control of bipedal stance
- Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
- Kinematic and electromyographic analysis of variations in Nordic hamstring exercise
- Comparison of transcriptomes of an orthotospovirus vector and non-vector thrips species
- Trabeculectomy followed by phacoemulsification versus trabeculectomy alone: The Collaborative Bleb-Related Infection Incidence and Treatment Study
- Whole genome resequencing of watermelons to identify single nucleotide polymorphisms related to flesh color and lycopene content
- Religious practices and long-term survival after hospital discharge for an acute coronary syndrome
- Behavioral recovery and spinal motoneuron remodeling after polyethylene glycol fusion repair of singly cut and ablated sciatic nerves
- Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation
- Comparative characterization of bacterial communities in geese consuming of different proportions of ryegrass
- Temperature sensitivity patterns of carbon and nitrogen processes in decomposition of boreal organic soils – Quantification in different compounds and molecule sizes based on a multifactorial experiment
- Cows painted with zebra-like striping can avoid biting fly attack
- The intriguing effect of ethanol and nicotine on acetylcholine-sensitive potassium current IKAch: Insight from a quantitative model
- The accumulation of deficits approach to describe frailty
- Botulinum toxin A injection into the entopeduncular nucleus improves dynamic locomotory parameters in hemiparkinsonian rats
- Turing complete neural computation based on synaptic plasticity
- Influence of mydriasis on optical coherence tomography angiography imaging in patients with age-related macular degeneration
- Specialized care improves outcomes for patients with cirrhosis who require general surgical operations
- Association between plural legal systems and sexual and reproductive health outcomes for women and girls in Nigeria: A state-level ecological study
- 3D analysis of human islet amyloid polypeptide crystalline structures in Drosophila melanogaster
- Utility of qSOFA and modified SOFA in severe malaria presenting as sepsis
- Correction: Perspectives of general dental practitioners on preventive, patient-centred, and evidence-based oral healthcare—A Q-methodology study
- Early detection and differential serodiagnosis of Mycoplasma hyorhinis and Mycoplasma hyosynoviae infections under experimental conditions
- No evidence of associations between ADHD and event-related brain potentials from a continuous performance task in a population-based sample of adolescent twins
- Antibiotic resistance of blood cultures in regional and tertiary hospital settings of Tyrol, Austria (2006-2015): Impacts & trends
- Simultaneous cardiac and respiratory inhibition during seizure precedes death in the DBA/1 audiogenic mouse model of SUDEP
- Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
- Cell-free DNA levels of twins and sibling pairs indicate individuality and possible use as a personalized biomarker
- Dinosaur ichnology and sedimentology of the Chignik Formation (Upper Cretaceous), Aniakchak National Monument, southwestern Alaska; Further insights on habitat preferences of high-latitude hadrosaurs
- Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation – A finite element modeling study
- Catastrophic factors involved in road accidents: Underlying causes and descriptive analysis
- Seroprevalence of anti-Toxoplasma gondii antibodies in wild boars (Sus scrofa), hunting dogs, and hunters of Brazil
- Detection and determination of stability of the antibiotic residues in cow’s milk
- Neural minimization methods (NMM) for solving variable order fractional delay differential equations (FDDEs) with simulated annealing (SA)
- Maternal and perinatal outcomes among women with hypertensive disorders in pregnancy in Kumasi, Ghana
- Characteristics and costs in adults with acute poisoning admitted to the emergency department of a university hospital in Belgium
- War pact model of shrinking networks
- Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease?
- Effect of an intensive 3-day social cognitive treatment (can do treatment) on control self-efficacy in patients with relapsing remitting multiple sclerosis and low disability: A single-centre randomized controlled trial
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- Postural changes in optic nerve and optic nerve sheath diameters in postural orthostatic tachycardia syndrome and spontaneous intracranial hypotension: A cohort study
- Attitudes and referral practices for pre-exposure prophylaxis (PrEP) among HIV rapid testers and case managers in Philadelphia: A mixed methods study
- The landscape for HIV pre-exposure prophylaxis during pregnancy and breastfeeding in Malawi and Zambia: A qualitative study
- Endovascular therapy of direct dural carotid cavernous fistulas – A therapy assessment study including long-term follow-up patient interviews
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- An extinction event in planktonic Foraminifera preceded by stabilizing selection
- Optimal seismic retrofitting techniques for URM school buildings located in the southwestern Iberian peninsula
- The effect of a hiding box on stress levels and body weight in Dutch shelter cats; a randomized controlled trial
- Early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: A systematic review and meta-analysis
- Deep brain activation patterns involved in virtual gait without and with a doorway: An fMRI study
- Infant dietary intake of yogurt and cheese and gastroenteritis at 1 year of age: The Japan Environment and Children’s Study
- Attenuation of renal fibrosis after unilateral ureteral obstruction in mice lacking the N-type calcium channel
- Anesthesia during deployment of a military forward surgical unit in low income countries: A register study of 1547 anesthesia cases
- CsBZIP40, a BZIP transcription factor in sweet orange, plays a positive regulatory role in citrus bacterial canker response and tolerance
- Differences in perceived popularity and social preference between bullying roles and class norms
- Identity and pathogenicity of some fungi associated with hazelnut (Corylus avellana L.) trunk cankers in Oregon
- Fermented cereal-based Munkoyo beverage: Processing practices, microbial diversity and aroma compounds
- Associations between focus constructions and levels of exhaustivity: An experimental investigation of Chinese
- Measurement invariance tests of revisions to archaically worded items in the Mach IV scale
- Give science and peace a chance: Speeches by Nobel laureates in the sciences, 1901-2018
- The effect of food anticipation on cognitive function: An eye tracking study
- Adaptation of H3N2 canine influenza virus to feline cell culture
- A meta-analysis of crop response patterns to nitrogen limitation for improved model representation
- Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer’s mouse model are associated with hippocampal synaptic deficits in an age-dependent manner
- Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models
- Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
- Hepatic disease and the risk of mortality of Vibrio vulnificus necrotizing skin and soft tissue infections: A systematic review and meta-analysis
- Diagnostic accuracy of midkine on hepatocellular carcinoma: A meta-analysis
- Phosphorus-mediated alleviation of aluminum toxicity revealed by the iTRAQ technique in Citrus grandis roots
- Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization
- Management strategies for vaccinated animals after an outbreak of foot-and-mouth disease and the impact on return to trade
- RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida
- SpliceHetero: An information theoretic approach for measuring spliceomic intratumor heterogeneity from bulk tumor RNA-seq
- Large-scale phylogenomic analysis suggests three ancient superclades of the WUSCHEL-RELATED HOMEOBOX transcription factor family in plants
- Plasma sCD36 as non-circadian marker of chronic circadian disturbance in shift workers
- A cross sectional comparison of drug use indicators using WHO methodology in primary level hospitals participating in an Auditable Pharmaceutical Transactions and Services program versus non-APTS primary hospitals in Southern Ethiopia
- Trends in NBA and Euroleague basketball: Analysis and comparison of statistical data from 2000 to 2017
- Liquid biopsies for omics-based analysis in sentinel mussels
- Reporting biases in self-assessed physical and cognitive health status of older Europeans
- Trends in the characteristics of acute primary angle closure in Korea over the past 10-years
- Obesity-associated insulin resistance adversely affects skin function
- First-line treatments in EGFR-mutated advanced non-small cell lung cancer: A network meta-analysis
- In vivo human lower limb muscle architecture dataset obtained using diffusion tensor imaging
- Tobacco smoke exposure as a risk factor for human papillomavirus infections in women 18-26 years old in the United States
- The trigger-information-response model: Exploring health literacy during the first six months following a kidney transplantation
- Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance
- The development of an evidence-based street food vending model within a socioecological framework: A guide for African countries
- Sociodemographic changes and trends in the rates of new perinatal HIV diagnoses and transmission in Spain from 1997 to 2015
- Patient navigation services for cancer care in low-and middle-income countries: A scoping review
- Weather extremes and perinatal mortality – Seasonal and ethnic differences in northern Sweden, 1800-1895
- Cognitive, relational and task crafting: Spanish adaptation and analysis of psychometric properties of the Job Crafting Questionnaire
- Maternal and perinatal death surveillance and response in Ethiopia: Achievements, challenges and prospects
- Identification and characterisation of capidermicin, a novel bacteriocin produced by Staphylococcus capitis
- Joint emulation of Earth System Model temperature-precipitation realizations with internal variability and space-time and cross-variable correlation: fldgen v2.0 software description
- Extensive culturomics of 8 healthy samples enhances metagenomics efficiency
- Macroepidemiological aspects of porcine reproductive and respiratory syndrome virus detection by major United States veterinary diagnostic laboratories over time, age group, and specimen
- Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
- Correction: Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants
- Myofibrillar function differs markedly between denervated and dexamethasone-treated rat skeletal muscles: Role of mechanical load
- Quantitation of eumelanin and pheomelanin markers in diverse biological samples by HPLC-UV-MS following solid-phase extraction
- Kinetics of mean platelet volume predicts mortality in patients with septic shock
- An integrated epigenome and transcriptome analysis identifies PAX2 as a master regulator of drug resistance in high grade pancreatic ductal adenocarcinoma
- Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity
- Association of Medicaid expansion with health insurance coverage by marital status and sex
- Are current approaches for measuring access to clean water and sanitation inclusive of people with disabilities? Comparison of individual- and household-level access between people with and without disabilities in the Tanahun district of Nepal
- A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage
- Monitoring Universal Health Coverage (UHC) in high Tuberculosis burden countries: Tuberculosis mortality an important tracer of UHC service coverage
- RCT evaluation of Skhokho: A holistic school intervention to prevent gender-based violence among South African Grade 8s
- On the use of Action Units and fuzzy explanatory models for facial expression recognition
- A systematic review of complementary and alternative medicine in oncology: Psychological and physical effects of manipulative and body-based practices
- What factors best explain attitudes to snow leopards in the Nepal Himalayas?
- Determinants of temperature sensitivity of soil respiration with the decline of a foundation species
- Mindfulness meditation, time judgment and time experience: Importance of the time scale considered (seconds or minutes)
- Regional, institutional, and departmental factors associated with gender diversity among BS-level chemical and electrical engineering graduates
- Transepithelial transport of P-glycoprotein substrate by the Malpighian tubules of the desert locust
- Sex affects immunolabeling for histone 3 K27me3 in the trophectoderm of the bovine blastocyst but not labeling for histone 3 K18ac
- A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan
- Replacing plasma membrane outer leaflet lipids with exogenous lipid without damaging membrane integrity
- Accurate dried blood spots collection in the community using non-medically trained personnel could support scaling up routine viral load testing in resource limited settings
- Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study
- Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review
- The motility-based swim-up technique separates bull sperm based on differences in metabolic rates and tail length
- Synbiotic supplementation to decrease Salmonella colonization in the intestine and carcass contamination in broiler birds
- Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease
- States with higher minimum wages have lower STI rates among women: Results of an ecological study of 66 US metropolitan areas, 2003-2015
- Weakening the subjective sensation of own hand ownership does not interfere with rapid finger movements
- Identification of DNA methyltransferases and demethylases in Solanum melongena L., and their transcription dynamics during fruit development and after salt and drought stresses
- Environmental conditions for Jamestown Canyon virus correlated with population-level resource selection by white-tailed deer in a suburban landscape
- The contribution of linear perspective cues and texture gradients in the perceptual rescaling of stimuli inside a Ponzo illusion corridor
- Cerebral blood flow imbalance is associated with motor outcome after pediatric arterial ischemic stroke
- Particularly neglected in countries with other challenges: High Toxoplasma gondii seroprevalence in pregnant women in Kabul, Afghanistan, while a low proportion know about the parasite
- Implementing advance care planning in routine nursing home care: The development of the theory-based ACP+ program
- Identifying genetic lineages through shape: An example in a cosmopolitan marine turtle species using geometric morphometrics
- The causality of borrowing: Lexical loans in Eurasian languages
- The uptake of the pharmacy-dispensed naloxone kit program in Ontario: A population-based study
- Gaze and body cues interplay during interactive requests
- Acetylcholine-mediated top-down attention improves the response to bottom-up inputs by deformation of the attractor landscape
- Deep architectures for long-term stock price prediction with a heuristic-based strategy for trading simulations
- Vaccination status of patients using anti-TNF therapy and the physicians’ behavior shaping the phenomenon: Mixed-methods approach
- Organizational justice and illness reporting among Japanese employees with chronic diseases
- CavBench: A benchmark for protein cavity detection methods
- Antimicrobial resistance (AMR) and molecular characterization of Neisseria gonorrhoeae in Ghana, 2012-2015
- Prevalence of methicillin-resistant Staphylococcus aureus in healthy Chinese population: A system review and meta-analysis
- Suppression treatment differentially influences the microbial community and the occurrence of broad host range plasmids in the rhizosphere of the model cover crop Avena sativa L.
- Risk of pneumonia among residents living near goat and poultry farms during 2014-2016
- Lipid levels after childbirth and association with number of children: A population-based cohort study
- Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study
- ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
- Effects of dietary intake and nutritional status on cerebral oxygenation in patients with chronic kidney disease not undergoing dialysis: A cross-sectional study
- Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
- Flexible learning spaces facilitate interaction, collaboration and behavioural engagement in secondary school
- Clinical significance and prognostic role of hypoxia-induced microRNA 382 in gastric adenocarcinoma
- Genome-wide investigation of superoxide dismutase (SOD) gene family and their regulatory miRNAs reveal the involvement in abiotic stress and hormone response in tea plant (Camellia sinensis)
- Classifying recurrent Mycobacterium tuberculosis cases in Georgia using MIRU-VNTR typing
- Prevalence of Trypanosoma cruzi infection in active military population of The Colombian National Army gathered in five departments
- An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway
- Sarcopenia as a prognostic factor for survival in patients with locally advanced gastroesophageal adenocarcinoma
- Increased aggression and reduced aversive learning in honey bees exposed to extremely low frequency electromagnetic fields
- Attending to design when developing complex health interventions: A qualitative interview study with intervention developers and associated stakeholders
- Increased fecundity of Aphis fabae on Vicia faba plants following seed or leaf inoculation with the entomopathogenic fungus Beauveria bassiana
- Is summer food intake a limiting factor for boreal browsers? Diet, temperature, and reproduction as drivers of consumption in female moose
- Characterization of sound scattering layers in the Bay of Biscay using broadband acoustics, nets and video
- Conducting human challenge studies in LMICs: A survey of researchers and ethics committee members in Thailand
- eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization
- Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy
- The interplay of personality and attitudes toward own aging across two decades of later life
- Robust automated reading of the skin prick test via 3D imaging and parametric surface fitting
- Reconstructing the population history of the sandy beach amphipod Haustorioides japonicus using the calibration of demographic transition (CDT) approach
- A psychoacoustic application for the adjustment of electrical hearing thresholds in cochlear implant patients
- Correction: Blue light-dependent human magnetoreception in geomagnetic food orientation
- Re-evaluation of a Tn5::gacA mutant of Pseudomonas syringae pv. tomato DC3000 uncovers roles for uvrC and anmK in promoting virulence
- Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study
- Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma
- The impact of shared knowledge on speakers’ prosody
- Effects of insecticides, fipronil and imidacloprid, on the growth, survival, and behavior of brown shrimp Farfantepenaeus aztecus
- Prevalence of pectus excavatum (PE), pectus carinatum (PC), tracheal hypoplasia, thoracic spine deformities and lateral heart displacement in thoracic radiographs of screw-tailed brachycephalic dogs
- Validation of the vignette-based German Exercise Causality Orientation Scale (G-ECOS)
- Hierarchical classification of snowmelt episodes in the Pyrenees using seismic data
- A national survey of videolaryngoscopes and alternative intubation devices in Hungary
- The relevance of U.S. Strategic Highway Safety Plans in a future context
- Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs
- Anti-inflammatory effects induced by ultralow concentrations of bupivacaine in combination with ultralow concentrations of sildenafil (Viagra) and vitamin D3 on inflammatory reactive brain astrocytes
- Access to unauthorized hepatitis C generics: Perception and knowledge of physicians, pharmacists, patients and non-healthcare professionals
- Urban commuting dynamics in response to public transit upgrades: A big data approach
- Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-κB pathways
- When resolution does matter: Modelling indirect contacts in dairy farms at different levels of detail
- Molecular epidemiology of Mycoplasma hyorhinis porcine field isolates in the United States
- Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation
- Adolescents living with HIV are at higher risk of death and loss to follow up from care: Analysis of cohort data from eight health facilities in Ethiopia
- Identification of social relation within pedestrian dyads
- Blood donation and health status based on SF-36: The mediating effect of cognition in blood donation
- The cost-effectiveness of controlling cervical cancer using a new 9-valent human papillomavirus vaccine among school-aged girls in Australia
- Inactivation of chronic wasting disease prions using sodium hypochlorite
- Analysing linear multivariate pattern transformations in neuroimaging data
- Ecological aesthetic assessment of a rebuilt wetland restored from farmland and management implications for National Wetland Parks
- A method for predicting background advertisement exposure parameters in sporting events: Televised football game approach
- Self-reported and experimentally induced self-disgust is heightened in Parkinson’s disease: Contribution of behavioural symptoms
- Associations between nocturnal sleep duration, midday nap duration and body composition among adults in Southwest China
- Short-term effects of video gaming on brain response during working memory performance
- Molecular detection and genetic characterization of Bartonella species from rodents and their associated ectoparasites from northern Tanzania
- Estimation of the number of HCV-positive patients in Italy
- Comparative cost analysis of point-of-care versus laboratory-based testing to initiate and monitor HIV treatment in South Africa
- Insights into the behavior of six rationally designed peptides based on Escherichia coli’s OmpA at the water-dodecane interface
- Identification of muscle-specific candidate genes in Simmental beef cattle using imputed next generation sequencing
- A game theoretic setting of capitation versus fee-for-service payment systems
- In utero exposure to economic fluctuations and birth outcomes: An analysis of the relevance of the local unemployment rate in Brazilian state capitals
- QTL mapping for aluminum tolerance in RIL population of soybean (Glycine max L.) by RAD sequencing
- Establishing an infrastructure for collaboration in primate cognition research
- Evaluation of left ventricular dimension and systolic function by standard transthoracic echocardiography before and 24-hours after percutaneous closure of patent ductus arteriosus in 120 dogs
- Modeling environmental variability and network formation among pastoral nomadic households: Implications for the rise of the Mongol Empire
- Changes in real-life practice for hepatocellular carcinoma patients in the Republic of Korea over a 12-year period: A nationwide random sample study
- Correction: Homology analysis of malware based on ensemble learning and multifeatures
- Illness beliefs and emotional responses in mildly disabled stroke survivors: A qualitative study
- Extended-wavelength diffuse reflectance spectroscopy with a machine-learning method for in vivo tissue classification
- Modeling the natural history of fatty liver using lifestyle–related risk factors: Effects of body mass index (BMI) on the life–course of fatty liver
- Development of a recombinant replication-deficient rabies virus-based bivalent-vaccine against MERS-CoV and rabies virus and its humoral immunogenicity in mice
- Educational achievement at age 9.5 years of children born to mothers maintained on methadone during pregnancy
- Comparative transcriptome analysis of galls from four different host plants suggests the molecular mechanism of gall development
- Experiences with peer support for breastfeeding in Beirut, Lebanon: A qualitative study
- Elucidating optical field directed hierarchical self-assembly of homogenous versus heterogeneous nanoclusters with femtosecond optical tweezers
- Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer
- Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality
- Correction: Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation
- Correction: Estimating Body Composition in Adolescent Sprint Athletes: Comparison of Different Methods in a 3 Years Longitudinal Design
- Quality of labor and birth care in Sindh Province, Pakistan: Findings from direct observations at health facilities
- A comparison of sLASER and MEGA-sLASER using simultaneous interleaved acquisition for measuring GABA in the human brain at 7T
- Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis
- Intrabladder pressure as predictor of intra-abdominal pressure in horses
- Pollock avoided hydrodynamic instabilities to paint with his dripping technique
- Metabolomic analysis of the occurrence of bitter fruits on grafted oriental melon plants
- Photo-degradation dynamics of five neonicotinoids: Bamboo vinegar as a synergistic agent for improved functional duration
- Use of acoustic emission to identify novel candidate biomarkers for knee osteoarthritis (OA)
- Cetacean biodiversity, spatial and temporal trends based on stranding records (1920-2016), Victoria, Australia
- Neutrophil elastase inhibitor purification strategy from cowpea seeds
- Correction: Hafting of Middle Paleolithic tools in Latium (central Italy): New data from Fossellone and Sant’Agostino caves
- Coherent poly propagation materials with 3-dimensional photonic control over visible light
- Characterization of Worldwide Olive Germplasm Banks of Marrakech (Morocco) and Córdoba (Spain): Towards management and use of olive germplasm in breeding programs
- Can non-pharmacological interventions reduce hospital admissions in people with dementia? A systematic review
- Metarhizium robertsii ammonium permeases (MepC and Mep2) contribute to rhizoplane colonization and modulates the transfer of insect derived nitrogen to plants
- Genotyping and antimicrobial resistance of Streptococcus uberis isolated from bovine clinical mastitis
- Isotopic compositions of ground ice in near-surface permafrost in relation to vegetation and microtopography at the Taiga–Tundra boundary in the Indigirka River lowlands, northeastern Siberia
- Financial inclusion and intimate partner violence: What does the evidence suggest?
- Are intestinal helminths playing a positive role in tuberculosis risk? A systematic review and meta-analysis
- Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition
- Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer
- Take one step backward to move forward: Assessment of genetic diversity and population structure of captive Asian woolly-necked storks (Ciconia episcopus)
- Money doesn’t matter! Householders’ intentions to reduce standby power are unaffected by personalised pecuniary feedback
- Validating a scale to measure engineers’ perceived self-efficacy for engineering education outreach
- Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder
- Nursing students and nurses’ knowledge and attitudes regarding children’s pain: A comparative cross-sectional study
- Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum
- Knowledge, attitudes and medical practice regarding hepatitis B prevention and management among healthcare workers in Northern Vietnam
- Development and validation of a symptom assessment tool for postmicturition dribble: A prospective, multicenter, observational study in Korea
- Identification of closely related Ixodes species by protein profiling with MALDI-TOF mass spectrometry
- When calculators lie: A demonstration of uncritical calculator usage among college students and factors that improve performance
- Socio-economic characteristics and career intentions of the WiSDOM health professional cohort in South Africa
- Correction: Neural computational model GrowthEstimate: A model for studying living resources through digestive efficiency
- Social proximity in dairy calves is affected by differences in pessimism
- Amphibian skin-associated Pigmentiphaga: Genome sequence and occurrence across geography and hosts
- Expanded consumer niche widths may signal an early response to spatial protection
- Moral grandstanding in public discourse: Status-seeking motives as a potential explanatory mechanism in predicting conflict
- Adipose stem cells in reparative goat mastitis mammary gland
- Seventy-five mosses and liverworts found frozen with the late Neolithic Tyrolean Iceman: Origins, taphonomy and the Iceman’s last journey
- Hyaluronic acid and epidermal growth factor improved the bovine embryo quality by regulating the DNA methylation and expression patterns of the focal adhesion pathway
- Associations among knowledge, attitudes, and practices toward palliative care consultation service in healthcare staffs: A cross-sectional study
- A novel, wearable, electronic visual aid to assist those with reduced peripheral vision
- Genetic diversity and population structure of the Mediterranean sesame core collection with use of genome-wide SNPs developed by double digest RAD-Seq
- Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression
- Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Factors influencing cultivated ginseng (Panax ginseng C. A. Meyer) bioactive compounds
- Estimation of soil pH with geochemical indices in forest soils
- Multiplexed editing of a begomovirus genome restricts escape mutant formation and disease development
- Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures
- Collaboration and followership: A stochastic model for activities in social networks
- Evaluating access to oral anti-diabetic medicines: A cross-sectional survey of prices, availability and affordability in Shaanxi Province, Western China
- Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles
- Use of a pressure-sensing walkway system for biometric assessment of gait characteristics in goats
- Current status and direct medical cost of amyotrophic lateral sclerosis in the region of Catalonia: A population-based analysis
- Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
- Can work climate foster pro-environmental behavior inside and outside of the workplace?
- Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA
- Pelvic alignment changes during the perinatal period
- Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
- Life-course trajectories of body mass index and subsequent cardiovascular risk among Chinese population
- Inhibitory interaction networks among coevolved Streptomyces populations from prairie soils
- Exploiting contextual information to improve call prediction
- Visual inputs decrease brain activity in frontal areas during silent lipreading
- The synergistic effects of TaAGP.L-B1 and TaSSIVb-D mutations in wheat lead to alterations of gene expression patterns and starch content in grain development
- Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets
- Robust, real-time generic detector based on a multi-feature probabilistic method
- Maize leaves drought-responsive genes revealed by comparative transcriptome of two cultivars during the filling stage
- Xenon lamps used for fruit surface sterilization can increase the content of total flavonols in leaves of Lactuca sativa L. without any negative effect on net photosynthesis
- An alternative procedure to obtain the mortality rate with non-linear functions: Application to the case of the Spanish population
- Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
- Longitudinal assessment of post-surgical physical activity in endometrial and ovarian cancer patients
- THINGS: A database of 1,854 object concepts and more than 26,000 naturalistic object images
- Evaluation of ranibizumab and aflibercept for the treatment of diabetic macular edema in daily clinical practice
- Proteomic analysis of Escherichia coli detergent-resistant membranes (DRM)
- Correction: Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor
- Correction: Predicting childhood obesity using electronic health records and publicly available data
- Correction: Estimating the value of tropical coastal wetland habitats to fisheries: Caveats and assumptions
- Correction: The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- Determinants of frailty development and progression using a multidimensional frailty index: Evidence from the English Longitudinal Study of Ageing
- Supporting informed clinical trial decisions: Results from a randomized controlled trial evaluating a digital decision support tool for those with intellectual disability
- BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin
- Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Hepatopulmonary syndrome has low prevalence of pulmonary vascular abnormalities on chest computed tomography
- Early and long-term outcomes of coronary artery bypass surgery with and without use of heart-lung machine and with special respect to renal function - A retrospective study
- Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
- The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population
- Expression of Concern: The Coordination of Cell Growth during Fission Yeast Mating Requires Ras1-GTP Hydrolysis
- Correction: Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells
- Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
- Remarkable cell recovery from cerebral ischemia in rats using an adaptive escalator-based rehabilitation mechanism
- Integrating environmental and neighborhood factors in MaxEnt modeling to predict species distributions: A case study of Aedes albopictus in southeastern Pennsylvania
- Post-overdose interventions triggered by calling 911: Centering the perspectives of people who use drugs (PWUDs)
- The prevalence of intimate partner violence among couples signing up for universally offered parent preparation
- Analysis of gear surface morphology based on gray level co-occurrence matrix and fractal dimension
- Abiotic, present-day and historical effects on species, functional and phylogenetic diversity in dry grasslands of different age
- Clonality analysis of pulmonary tumors by genome-wide copy number profiling
- A relictual troglomorphic harvestman discovered in a volcanic cave of western Argentina: Otilioleptes marcelae, new genus, new species, and Otilioleptidae, new family (Arachnida, Opiliones, Gonyleptoidea)
- HIV drug resistance in persons who inject drugs enrolled in an HIV prevention trial in Indonesia, Ukraine, and Vietnam: HPTN 074
- Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery
- Regulation of nitrogen availability results in changes in grain protein content and grain storage subproteomes in barley (Hordeum vulgare L.)
- Diagnostic test evaluation methodology: A systematic review of methods employed to evaluate diagnostic tests in the absence of gold standard – An update
- Longitudinal trends of and factors associated with inappropriate antibiotic prescribing for non-bacterial acute respiratory tract infection in Japan: A retrospective claims database study, 2012–2017
- Revealing users’ experience and social interaction outcomes following a web-based smoking prevention intervention for adolescents: A qualitative study
- Coordination of human movements resulting in motor strategies exploited by skilled players during a throwing task
- Impact of pericardiectomy on exercise capacity and sleep of patients with chronic constrictive pericarditis
- Blue-violet light decreases VEGFa production in an in vitro model of AMD
- Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach
- Speed of processing training and depression in assisted and independent living: A randomized controlled trial
- Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient
- What happens in the brain of meditators when perception changes but not the stimulus?
- Comparison of HIV-1 Vif and Vpu accessory proteins for delivery of polyepitope constructs harboring Nef, Gp160 and P24 using various cell penetrating peptides
- Are degree of urbanisation and travel times to healthcare services associated with the processes of care and outcomes of heart failure? A retrospective cohort study based on administrative data
- A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing
- Influence of transcutaneous vagus nerve stimulation on cardiac vagal activity: Not different from sham stimulation and no effect of stimulation intensity
- Co-prescription network reveals social dynamics of opioid doctor shopping
- Contractile properties of superficial skeletal muscle affect postural control in healthy young adults: A test of the rambling and trembling hypothesis
- Does intrauterine crowding affect the force generating capacity and muscle composition of the piglet front limb?
- Correction: Measuring compassionate healthcare with the 12-item Schwartz Center Compassionate Care Scale
- Facilitators and barriers to traditional medicine use among cancer patients in Malawi
- Expression of CMV protein pp65 in cutaneous malignant melanoma
- The evolution of mental health outcomes across a combat deployment cycle: A longitudinal study of a Guam-based National Guard unit
- Caesarean section delivery and childhood obesity in a British longitudinal cohort study
- Incidence, characteristics, and mortality of infective endocarditis in France in 2011
- Pfcyp51 exclusively determines reduced sensitivity to 14α-demethylase inhibitor fungicides in the banana black Sigatoka pathogen Pseudocercospora fijiensis
- Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin
- Histological and developmental insights into the herbivorous dentition of tapinocephalid therapsids
- Differential immunomodulation of T-cells by immunoglobulin replacement therapy in primary and secondary antibody deficiency
- A longitudinal study on perceived health in cardiovascular patients: The role of conscientiousness, subjective wellbeing and cardiac self-efficacy
- The effectiveness of interferon beta versus glatiramer acetate and natalizumab versus fingolimod in a Polish real-world population
- Interactions of Streptococcus suis serotype 9 with host cells and role of the capsular polysaccharide: Comparison with serotypes 2 and 14
- Honey bee and native solitary bee foraging behavior in a crop with dimorphic parental lines
- A flexible formula for incorporating distributive concerns into cost-effectiveness analyses: Priority weights
- Correction: Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- A reconnaissance survey of farmers’ awareness of hypomagnesaemic tetany in UK cattle and sheep farms
- Health workers’ perception of malaria rapid diagnostic test and factors influencing compliance with test results in Ebonyi state, Nigeria
- Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods
- The increasing importance of fellowships and career development awards in the careers of early-stage biomedical academic researchers
- Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components
- Auxin driven indoleamine biosynthesis and the role of tryptophan as an inductive signal in Hypericum perforatum (L.)
- Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development
- Distance to large rivers affects fish diversity patterns in highly dynamic streams of Central Amazonia
- Real vs. immersive-virtual emotional experience: Analysis of psycho-physiological patterns in a free exploration of an art museum
- Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study
- Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses
- Modeling ENSO impact on rice production in the Mekong River Delta
- The feasibility of a behavioral group intervention after weight-loss surgery: A randomized pilot trial
- EMR-integrated minimal core dataset for routine health care and multiple research settings: A case study for neuroinflammatory demyelinating diseases
- A review of a 13-month period of FilmArray Meningitis/Encephalitis panel implementation as a first-line diagnosis tool at a university hospital
- Increased BMI has a linear association with late-onset preeclampsia: A population-based study
- Autoantibody production significantly decreased with APRIL/BLyS blockade in murine chronic rejection kidney transplant model
- Vancomycin-resistance gene cluster, vanC, in the gut microbiome of acute leukemia patients undergoing intensive chemotherapy
- Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
- Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP
- Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn’s disease and ulcerative colitis
- Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells
- Autophagy is important to the acidogenic metabolism of Aspergillus niger
- Continuous ratings of movie watching reveal idiosyncratic dynamics of aesthetic enjoyment
- Sensitivity and specificity of serum soluble interleukin-2 receptor for diagnosing sarcoidosis in a population of patients suspected of sarcoidosis
- Enhancing genomic selection by fitting large-effect SNPs as fixed effects and a genotype-by-environment effect using a maize BC1F3:4 population
- Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry
- Microbial induced solidification and stabilization of municipal solid waste incineration fly ash with high alkalinity and heavy metal toxicity
- Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses
- A fault-tolerant aware scheduling method for fog-cloud environments
- Correction: BCG vaccination and tuberculosis prevention: A forty years cohort study, Monastir, Tunisia
- Correction: Perceptions among transgender women of factors associated with the access to HIV/AIDS-related health services in Yogyakarta, Indonesia
- Assessing the convergent validity between the automated emotion recognition software Noldus FaceReader 7 and Facial Action Coding System Scoring
- Deep learning based banana plant detection and counting using high-resolution red-green-blue (RGB) images collected from unmanned aerial vehicle (UAV)
- Comparison of cardiorespiratory fitness between preschool children with normal and excess body adipose ~ An observational study
- Intraregional differences in renal function in the Northern Netherlands: The Lifelines Cohort Study
- Effects of MCHM on yeast metabolism
- Signaling impacts of GMO labeling on fruit and vegetable demand
- Dietary specialization depending on ecological context and sexual differences in Asiatic black bears
- Electronic device use and beverage related sugar and caffeine intake in US adolescents
- Isolation and characterization of five novel probiotic strains from Korean infant and children faeces
- Correction: Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Correction: Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Endothelial nitric oxide synthase limits host immunity to control disseminated Candida albicans infections in mice
- Lack of detection of Candida nivariensis and Candida bracarensis among 440 clinical Candida glabrata sensu lato isolates in Kuwait
- Nonlinear dynamics captures brain states at different levels of consciousness in patients anesthetized with propofol
- Visual encounters on line transect surveys under-detect carnivore species: Implications for assessing distribution and conservation status
- Menstrual health communication among Indian adolescents: A mixed-methods study
- Fast fluorescence in situ hybridisation for the enhanced detection of MET in non-small cell lung cancer
- The influence of personality on the effect of iTBS after being stressed on cortisol secretion
- Parental and peer support and modelling in relation to domain-specific physical activity participation in boys and girls from Germany
- Oral delivery of water-soluble compounds to the phytoseiid mite Neoseiulus californicus (Acari: Phytoseiidae)
- Force perceptual bias caused by muscle activity in unimanual steering
- Correction: Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Correction: Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium
- Providencia entomophila sp. nov., a new bacterial species associated with major olive pests in Tunisia
- Safety of intravitreal ziv-aflibercept in choroido-retinal vascular diseases: A randomised double-blind intervention study
- A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic
- Reduction of the rocuronium-induced withdrawal reflex by MR13A10A, a generic rocuronium with a novel solution: A randomized, controlled study
- Emotionally expressed voices are retained in memory following a single exposure
- Megabenthic communities of the Ligurian deep continental shelf and shelf break (NW Mediterranean Sea)
- Election forensics: Using machine learning and synthetic data for possible election anomaly detection
- A randomized crossover trial comparing the Nifty cup to a medicine cup in preterm infants who have difficulty breastfeeding at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana
- The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease
- Genomic impact of severe population decline in a nomadic songbird
- Evolution of high-sensitivity troponin-T and echocardiography parameters in patients undergoing high efficiency on-line hemodiafiltration versus conventional low-flux hemodialysis
- Full genome characterization of 12 citrus tatter leaf virus isolates for the development of a detection assay
- Intake of myo-inositol hexaphosphate and urinary excretion of inositol phosphates in Wistar rats: Gavage vs. oral administration with sugar
- Enhancing financial security of female sex workers through a community-led intervention in India: Evidence from a longitudinal survey
- In-silico prediction of novel genes responsive to drought and salinity stress tolerance in bread wheat (Triticum aestivum)
- Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America
- Partitioning the risk of tuberculosis transmission in household contact studies
- Recommendation system in social networks with topical attention and probabilistic matrix factorization
- Using satellite-measured relative humidity for prediction of Metisa plana’s population in oil palm plantations: A comparative assessment of regression and artificial neural network models
- A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects
- Emotional and behavioral problems, social competence and risk factors in 6–16-year-old students in Beijing, China
- Clinicopathologic and prognostic significance of tumor-associated macrophages in patients with hepatocellular carcinoma: A meta-analysis
- Involution of retinopathy of prematurity and neurodevelopmental outcomes after intravitreal bevacizumab treatment
- Travel demand and distance analysis for free-floating car sharing based on deep learning method
- Genome-wide identification, characterization, expression and enzyme activity analysis of coniferyl alcohol acetyltransferase genes involved in eugenol biosynthesis in Prunus mume
- Population analysis of D6-like plasmid prophage variants associated with specific IncC plasmid types in the emerging Salmonella Typhimurium ST213 genotype
- The high resource impact of reformatting requirements for scientific papers
- Egg yolk-free cryopreservation of bull semen
- Fine epitope mapping of glycoprotein Gn in Guertu virus
- Are hospital nurse staffing practices associated with postoperative cardiac events and death? A systematic review
- Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction
- Aging and the wandering brain: Age-related differences in the neural correlates of stimulus-independent thoughts
- Elucidating stygofaunal trophic web interactions via isotopic ecology
- Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases
- Scientist and data architect collaborate to curate and archive an inner ear electrophysiology data collection
- No effect of triple-pulse TMS medial to intraparietal sulcus on online correction for target perturbations during goal-directed hand and foot reaches
- Correction: Controlling Social Stress in Virtual Reality Environments
- TNF-α is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement
- Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
- Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease
- To tweet or not to tweet, that is the question: A randomized trial of Twitter effects in medical education
- Visualizing a field of research: A methodology of systematic scientometric reviews
- True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential
- Impact of the detection of ζ-globin chains and hemoglobin Bart’s using immunochromatographic strip tests for α0-thalassemia (--SEA) differential diagnosis
- Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort
- Correction: Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Correction: Lower prevalence of Blastocystis sp. infections in HIV positive compared to HIV negative adults in Ghana
- Correction: Precision public health: Mapping socioeconomic disparities in opioid dispensations at Swedish pharmacies by Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA)
- Epidemiological, clinical and laboratory characteristics of the measles resurgence in the Republic of Serbia in 2014-2015
- Macro-charcoal accumulation in floodplain wetlands: Problems and prospects for reconstruction of fire regimes and environmental conditions
- Stage at diagnosis and stage-specific survival of breast cancer in Latin America and the Caribbean: A systematic review and meta-analysis
- Correction: Retraction: Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway
- TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo
- Clinical impact of intraoperative hyperlactatemia during craniotomy
- Intubation with channeled versus non-channeled video laryngoscopes in simulated difficult airway by junior doctors in an out-of-hospital setting: A crossover manikin study
- Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates
- Sex-specific differences in risk factors of lymph node metastasis in patients with early gastric cancer
- The impact of electroconvulsive therapy on the spatial QRS-T angle and cardiac troponin T concentration in psychiatric patients
- BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss
- Investigation on the hereditary basis of colorectal cancers in an African population with frequent early onset cases
- Comparison of cancer prevalence between patients with glomerulonephritis and the general population at the time of kidney biopsy
- Predictors of time to unfavorable treatment outcomes among patients with multidrug resistant tuberculosis in Oromia region, Ethiopia
- Experimentally validated simulation of coronary stents considering different dogboning ratios and asymmetric stent positioning
- The membrane effects of melittin on gastric and colorectal cancer
- Exclusive breastfeeding policy, practice and influences in South Africa, 1980 to 2018: A mixed-methods systematic review
- Hippocampal subfield volumes and pre-clinical Alzheimer’s disease in 408 cognitively normal adults born in 1946
- Uncorrected low hyperopia in young subjects induces postural instability even in those with clear visual acuity
- Membrane associated proteins of two Trichomonas gallinae clones vary with the virulence
- Awareness, current use of electronic cigarettes and associated smoking factors in Zhejiang Chinese adolescents
- Associations between pre-pregnancy BMI, gestational weight gain, and prenatal diet quality in a national sample
- Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children
- Optofluidic laser speckle image decorrelation analysis for the assessment of red blood cell storage
- Complete chloroplast genome sequence and phylogenetic analysis of Spathiphyllum 'Parrish'
- Strategic science communication as planned behavior: Understanding scientists’ willingness to choose specific tactics
- Understanding spatial patterns of soils for sustainable agriculture in northern Ethiopia’s tropical mountains
- Does Japan’s national nutrient-based dietary guideline improve lifestyle-related disease outcomes? A retrospective observational cross-sectional study
- Agitation near the end of life with dementia: An ethnographic study of care
- Tick-borne encephalitis virus infections in Germany. Seasonality and in-year patterns. A retrospective analysis from 2001-2018
- Encouraging perspective taking: Using narrative writing to induce empathy for others engaging in negative health behaviors
- Considerations of target surface area and the risk of radiosurgical toxicity
- Correction: A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
- Effect of using immobilization device in fluoroscopic study in pediatric patient: Focused on radiation dose reduction in voiding cystourethrogram
- Temporal trends in breast cancer survival by race and ethnicity: A population-based cohort study
- Contamination of hospital surfaces with respiratory pathogens in Bangladesh
- The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver
- Association between hospital interval and survival in patients with oral cancer: A waiting time paradox
- Translating a stress management intervention for rural Latina breast cancer survivors: The Nuevo Amanecer-II
- Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial
- Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning
- Harnessing therapeutic viruses as a delivery vehicle for RNA-based therapy
- Korean soybean core collection: Genotypic and phenotypic diversity population structure and genome-wide association study
- Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- Measurement of structural integrity of the spinal cord in patients with amyotrophic lateral sclerosis using diffusion tensor magnetic resonance imaging
- Typological analysis of public-private partnerships in the veterinary domain
- Improved clinical outcome after medial open-wedge osteotomy despite cartilage lesions in the lateral compartment
- Rapid and structure-specific cellular uptake of selected steroids
- Avoiding gambling harm: An evidence-based set of safe gambling practices for consumers
- Epidemiology of chronic pain in Ukraine: Findings from the World Mental Health Survey
- PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target
- Double triage to identify poorly annotated genes in maize: The missing link in community curation
- N-acetyl cysteine restores the fertility of vitrified–warmed mouse oocytes derived through ultrasuperovulation
- Architecture of population-differentiated polymorphisms in the human genome
- Linguistic neutrosophic power Muirhead mean operators for safety evaluation of mines
- Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes
- Exercise intensity-dependent effects of arm and leg-cycling on cognitive performance
- How information about perpetrators’ nature and nurture influences assessments of their character, mental states, and deserved punishment
- Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis
- In silico assessment of human Calprotectin subunits (S100A8/A9) in presence of sodium and calcium ions using Molecular Dynamics simulation approach
- Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging
- Measurable residual disease monitoring for patients with acute myeloid leukemia following hematopoietic cell transplantation using error corrected hybrid capture next generation sequencing
- Characteristics of complementary medicine therapists in Switzerland: A cross-sectional study
- Lack of generalization between explicit and implicit visuomotor learning
- Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population
- Effects of temperature and salinity on respiratory losses and the ratio of photosynthesis to respiration in representative Antarctic phytoplankton species
- Self-reported non-receipt of HIV test results: A silent barrier to HIV epidemic control in Mozambique
- Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature
- Echocardiography overestimates LV mass in the elderly as compared to cardiac CT
- Efficacy of cotrimoxazole (Sulfamethoxazole-Trimethoprim) as a salvage therapy for the treatment of bone and joint infections (BJIs)
- Molecular mechanism of antimicrobial activity of chlorhexidine against carbapenem-resistant Acinetobacter baumannii
- First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides
- Green synthesis of silver nanoparticles using Solanum mammosum L. (Solanaceae) fruit extract and their larvicidal activity against Aedes aegypti L. (Diptera: Culicidae)
- Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007
- Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
- 13C and 15N NMR identification of product compound classes from aqueous and solid phase photodegradation of 2,4,6-trinitrotoluene
- Off-target effects of CRISPRa on interleukin-6 expression
- Exploring the antimicrobial properties of dark-operating ceramic-based nanocomposite materials for the disinfection of indoor air
- Experienced males recognise and avoid mating with non-virgin females in the western flower thrips
- Liver transplantation in patients with a history of migration—A German single center comparative analysis
- Retraction: The Different Role of Notch1 and Notch2 in Astrocytic Gliomas
- Correction: Understanding climate change from a global analysis of city analogues
- Comparison of 4D Flow MRI to 2D Flow MRI in the pulmonary arteries in healthy volunteers and patients with pulmonary hypertension
- The relationship between sleep quality, inappropriate medication use and frailty among older adults in aged care homes in Malaysia
- Clonal diversity and spatial genetic structure in the long-lived herb, Prairie trillium
- Medication histories documentation at the community pharmacy setting: A study from Jordan
- Population dynamics of an invasive bird parasite, Philornis downsi (Diptera: Muscidae), in the Galapagos Islands
- Because you had a bad day: General and daily relations between reactive temperament, emotion regulation, and depressive symptoms in youth
- Socioeconomic status and alcohol use disorders across the lifespan: A co-relative control study
- Generation of deletions and precise point mutations in Dictyostelium discoideum using the CRISPR nickase
- Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation
- Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study
- Validation and perception of a key feature problem examination in neurology
- Gender affirmative HIV care framework: Decisions on feminizing hormone therapy (FHT) and antiretroviral therapy (ART) among transgender women
- Quantifying international human mobility patterns using Facebook Network data
- Localization and characterization of thyroid microcalcifications: A histopathological study
- Young children are the main victims of fast food induced obesity in Brazil
- Understanding self-reported importance of religion/spirituality in a North American sample of individuals at risk for familial depression: A principal component analysis
- Standing balance of professional ballet dancers and non-dancers under different conditions
- 30-day unplanned readmission rate in otolaryngology patients: A population-based study in Thuringia, Germany
- Physical exercise stimulates salivary secretion of cystatins
- Vintage electronics for trusted radiation measurements and verified dismantlement of nuclear weapons
- Keepin’ it real: Linguistic models of authenticity judgments for artificially generated rap lyrics
- Carbon emission reduction and profit distribution mechanism of construction supply chain with fairness concern and cap-and-trade
- Modulations of microbehaviour by associative memory strength in Drosophila larvae
- Changes in peak expiratory flow rates using two head-tilt/chin-lift maneuver angles in young healthy conscious volunteers
- 3D image analysis reveals differences of CD30 positive cells and network formation in reactive and malignant human lymphoid tissue (classical Hodgkin Lymphoma)
- Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- 2-methylquinazoline derivative F7 as a potent and selective HDAC6 inhibitor protected against rhabdomyolysis-induced acute kidney injury
- Correction: Reducing growth and developmental problems in children: Development of an innovative postnatal risk assessment
- Comparative analysis of the vertebral pneumatization in pterosaurs (Reptilia: Pterosauria) and extant birds (Avialae: Neornithes)
- Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults
- Retraction: MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1
- Comparing growth patterns of three species: Similarities and differences
- Iron is increased in the brains of ageing mice lacking the neurofilament light gene
- Economic evaluation of community acquired pneumonia management strategies: A systematic review of literature
- A participatory community case study of periurban coastal flood vulnerability in southern Ecuador
- Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL
- Mitochondrial dysfunctions in leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL)
- MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex
- Knowledge, attitudes, and practices related to anthrax and animal care: A case-control study in Georgia
- Information diffusion in signed networks
- Nurses’ perspectives on their communication with patients in busy oncology wards: A qualitative study
- Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS
- ART is key to clearing oncogenic HPV genotypes (HR-HPV) in anal mucosa of HIV-positive MSM
- Retraction: Fluid–Structure Interaction-Based Biomechanical Perception Model for Tactile Sensing
- Correction: Role of Caveolin-1 in Atrial Fibrillation as an Anti-Fibrotic Signaling Molecule in Human Atrial Fibroblasts
- The French adaptation and validation of the Partners in Health (PIH) scale among patients with chronic conditions seen in primary care
- Depth inversion with a 3D structure influences brightness perception
- Analysis of group evolution prediction in complex networks
- Effect of aridity and dune type on rhizosphere soil bacterial communities of Caragana microphylla in desert regions of northern China
- Knowledge, attitudes, and practices related to TB among the general population of Ethiopia: Findings from a national cross-sectional survey
- Correction: Personality traits in companion dogs—Results from the VIDOPET
- MANET 3.0: Hierarchy and modularity in evolving metabolic networks
- Agreement study on gait assessment using a video-assisted rating method in patients with idiopathic normal-pressure hydrocephalus
- Single fixed low-dose rituximab as induction therapy suppresses de novo donor-specific anti-HLA antibody production in ABO compatible living kidney transplant recipients
- Myomesin is part of an integrity pathway that responds to sarcomere damage and disease
- Acute normobaric hypoxia does not affect the simultaneous exercise-induced increase in circulating BDNF and GDNF in young healthy men: A feasibility study
- Systematic investigation on quad-metallic AgAuPdPt and tri-metallic AuPdPt NPs through the solid-state dewetting of quad-layer Ag/Au/Pd/Pt thin films on c-plane sapphire
- Video lecturing in Clicker-assisted English flipped class
- Significant changes of the choroid in patients with ocular ischemic syndrome and symptomatic carotid artery stenosis
- Skewed T cell responses to Epstein-Barr virus in long-term asymptomatic kidney transplant recipients
- Candidate genes expression profiling during wilting in chickpea caused by Fusarium oxysporum f. sp. ciceris race 5
- Host plants influence the composition of the gut bacteria in Henosepilachna vigintioctopunctata
- ‘We are all serving the same Ugandans’: A nationwide mixed-methods evaluation of private sector surgical capacity in Uganda
- The association between flavor capsule cigarette use and sociodemographic variables: Evidence from Chile
- Relations between gross motor skills and executive functions, controlling for the role of information processing and lapses of attention in 8-10 year old children
- Linalool acts as a fast and reversible anesthetic in Hydra
- Double burden of maternal and child malnutrition and socioeconomic status in urban Sri Lanka
- Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles
- Adherence to general medical checkup and cancer screening guidelines according to self-reported smoking status: Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2012
- Do older English adults exhibit day-to-day compensation in sedentary time and in prolonged sedentary bouts? An EPIC-Norfolk cohort analysis
- Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue
- Correction: Factors associated with hospitalization and death among TB/HIV co-infected persons in Porto Alegre, Brazil
- An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patterns
- Reporting adverse events related to medical devices: A single center experience from a tertiary academic hospital
- Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism
- Estimating biodiversity changes in the Camargue wetlands: An expert knowledge approach
- Decreased risk of Parkinson’s disease in diabetic patients with thiazolidinediones therapy: An exploratory meta-analysis
- Retraction: Carboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis
- Lipoarabinomannan from Mycobacterium indicus pranii shows immunostimulatory activity and induces autophagy in macrophages
- A measure of inconsistencies in intertemporal choice
- A novel radiopaque tissue marker for soft tissue localization and in vivo length and area measurements
- Anatomical, histological and computed tomography comparisons of the eye and adnexa of crab-eating fox (Cerdocyon thous) to domestic dogs
- Subpopulation augmentation among habitat patches as a tool to manage an endangered Mojave Desert wetlands-dependent rodent during anthropogenic restricted water climate regimes
- Characteristics of CD5-positive diffuse large B-cell lymphoma among Koreans: High incidence of BCL2 and MYC double-expressors
- Fossil tabulate corals reveal outcrops of Paleozoic sandstones in the Atlantic Coastal Plain Province, Southeastern USA
- Coming and going – Historical distributions of the European oyster Ostrea edulis Linnaeus, 1758 and the introduced slipper limpet Crepidula fornicata Linnaeus, 1758 in the North Sea
- Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter
- Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation
- Can emotional intelligence be improved? A randomized experimental study of a business-oriented EI training program for senior managers
- Genetic variability in landraces populations and the risk to lose genetic variation. The example of landrace ‘Kyperounda’ and its implications for ex situ conservation
- Sleep problems are a strong predictor of stress-related metabolic changes in police officers. A prospective study
- Age, sex and primary care setting differences in patients’ perception of community healthcare seeking behaviour towards health services
- Kinematic analyses including finite helical axes of drop jump landings demonstrate decreased knee control long after anterior cruciate ligament injury
- Effects of model inaccuracies on reaching movements with intermittent control
- C-reactive protein to albumin ratio predicts the outcome in renal cell carcinoma: A meta-analysis
- A new synthetic lure for management of the invasive giant African snail, Lissachatina fulica
- Bridging solvent molecules mediate RNase A – Ligand binding
- Variation in methods, results and reporting in electronic health record-based studies evaluating routine care in gout: A systematic review
- The use of prophylactic intra-aortic balloon pump in high-risk patients undergoing coronary artery bypass grafting
- Compliance with clinical guidelines for breast cancer management: A population-based study of quality-of-care indicators in France
- Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis
- Acute effects of differential learning on football kicking performance and in countermovement jump
- Escherichia coli and Salmonella spp. isolated from Australian meat chickens remain susceptible to critically important antimicrobial agents
- Play like me: Similarity in playfulness promotes social play
- Awareness of family health history in a predominantly young adult population
- Care pathways during a child’s final illness in rural South Africa: Findings from a social autopsy study
- Intranasal lidocaine for acute migraine: A meta-analysis of randomized controlled trials
- Evaluating case management as a complex intervention: Lessons for the future
- Allele-specific enhancer interaction at the Peg3 imprinted domain
- Has the “M” word been framed? Marijuana, cannabis, and public opinion
- Is spontaneous normalization of systolic blood pressure within 24 hours after ischemic stroke onset related with favorable outcomes?
- Mixotrophic cultivation of Spirulina platensis in dairy wastewater: Effects on the production of biomass, biochemical composition and antioxidant capacity
- Constitutive expression of an A-5 subgroup member in the DREB transcription factor subfamily from Ammopiptanthus mongolicus enhanced abiotic stress tolerance and anthocyanin accumulation in transgenic Arabidopsis
- Stable carbon isotope diagnostics of mammalian metabolism, a high-resolution isotomics approach using amino acid carboxyl groups
- Factors associated with depressive symptoms in patients with ankylosing spondylitis in Northern Taiwan
- A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
- Retraction: Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1
- Potential role for microRNA-16 (miR-16) and microRNA-93 (miR-93) in diagnosis and prediction of disease progression in mycosis fungoides in Egyptian patients
- Rapid visual categorization is not guided by early salience-based selection
- Relative contribution of climate and non-climate drivers in determining dynamic rates of boreal birds at the edge of their range
- A simple-to-use nomogram to predict long term survival of patients undergoing coronary artery bypass grafting (CABG) using bilateral internal thoracic artery grafting technique
- Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model
- Antenatal and intrapartum interventions for reducing caesarean section, promoting vaginal birth, and reducing fear of childbirth: An overview of systematic reviews
- Relative species abundance successfully predicts nestedness and interaction frequency of monthly pollination networks in an alpine meadow
- Correction: RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
- Amphibians on the hotspot: Molecular biology and conservation in the South American Atlantic Rainforest
- Role of psychosocial status in predicting health-related quality of life at 1-year follow-up among newly diagnosed people living with HIV
- Application of national pollutant inventories for monitoring trends on dioxin emissions from stationary industrial sources in Australia, Canada and European Union
- The association between vaccination confidence, vaccination behavior, and willingness to recommend vaccines among Finnish healthcare workers
- Retraction: Interleukin-1β-Induced Autophagy-Related Gene 5 Regulates Proliferation of Embryonic Stem Cell-Derived Odontoblastic Cells
- A localized sanitation status index as a proxy for fecal contamination in urban Maputo, Mozambique
- E2 protein is the major determinant of specificity at the human papillomavirus origin of replication
- “You’re kind of at war with yourself as a nurse”: Perspectives of inpatient nurses on treating people who present with a comorbid opioid use disorder
- A refinement approach in a mouse model of rehabilitation research. Analgesia strategy, reduction approach and infrared thermography in spinal cord injury
- Circulating cell-free DNA from plasma undergoes less fragmentation during bisulfite treatment than genomic DNA due to low molecular weight
- Understanding fatigue in adults with visual impairment: A path analysis study of sociodemographic, psychological and health-related factors
- Retraction: Mouse-Induced Pluripotent Stem Cells Differentiate into Odontoblast-Like Cells with Induction of Altered Adhesive and Migratory Phenotype of Integrin
- A novel analytical method to assess the effect of imipenem/cilastatin on liver function laboratory indexes in Chinese underage inpatients: Probability distribution curve
- The cause of anorexia and proportion of its recovery in older adults without underlying disease: Results of a retrospective study
- Referral and admission to intensive care: A qualitative study of doctors’ practices in a Tanzanian university hospital
- Agreement between clinical and non-clinical digital manometer for assessing maximal respiratory pressures in healthy subjects
- Heads or tails? Differential translational regulation in cercarial heads and tails of schistosome worms
- Horizontal seed dispersal by dung beetles reduced seed and seedling clumping, but did not increase short-term seedling establishment
- The coupling of the M2 muscarinic receptor to its G protein is voltage dependent
- Subsidy strategy of pharmaceutical e-commerce platform based on two-sided market theory
- Shoulder girdle injuries involving the medial clavicle differ from lateral clavicle injuries with a focus on concomitant injuries and management strategies: A retrospective study based on nationwide routine data
- Unraveling middle childhood attachment-related behavior sequences using a micro-coding approach
- Divergence history and hydrothermal vent adaptation of decapod crustaceans: A mitogenomic perspective
- Duration of solid fuel cookstove use is associated with increased risk of acute lower respiratory infection among children under six months in rural central India
- Evolving flocking in embodied agents based on local and global application of Reynolds’ rules
- Non-invasive contrast enhanced ultrasound molecular imaging of inflammation in autoimmune myocarditis for prediction of left ventricular fibrosis and remodeling
- Care coordination for chronic and complex health conditions: An experienced based co-design study engaging consumer and clinician groups for service improvement
- Association between socioeconomic status and diet quality in Mexican men and women: A cross-sectional study
- Surveillance of panicle positions by unmanned aerial vehicle to reveal morphological features of rice
- Is Betula carpatica genetically distinctive? A morphometric, cytometric and molecular study of birches in the Bohemian Massif with a focus on Carpathian birch
- Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance
- The genome of the migratory nematode, Radopholus similis, reveals signatures of close association to the sedentary cyst nematodes
- Factors associated with pneumococcal carriage and density in infants and young children in Laos PDR
- Overlap between telangiectasia and photoreceptor loss increases with progression of macular telangiectasia type 2
- The role of hope for health professionals in rehabilitation: A qualitative study on unfavorable prognosis communication
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