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Technology opportunity discovery by structuring user needs based on natural language processing and machine learning
Authors: Taeyeoun Roh aff001; Yujin Jeong aff001; Hyejin Jang aff001; Byungun Yoon aff001
Authors place of work: Department of Industrial & Systems Engineering, School of Engineering, Dongguk University, Seoul, South Korea aff001
Published in the journal: PLoS ONE 14(10)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0223404Summary
Discovering technology opportunities from the opinion of users can promote successful technological development by satisfying the needs of users. However, although previous approaches using opinion mining only have classified various needs of users into positive or negative categories, they cannot derive the main reasons for their opinion. To solve this problem, this research proposes an approach to exploring technology opportunity by structuring user needs with a concept of opinion trigger of objects and functions of the technology-based products. To discover technology opportunity, first, an opinion trigger is identified from review data using Naïve Base classifier and natural language processing. Second, the opinion triggers and patent keywords that have a similar meaning in context are clustered to discover the needs of the user and need-related technology. Then, the sentimental values of needs are calculated through graph-based semi-supervised learning. Finally, the needs of the user are classified in resolving the problem of vacant technology to discover technology opportunity. Then, an R&D strategy of each opportunity is suggested based on opinion triggers, patent keywords, and their property. Based on the concept of opinion trigger-based methodology, a case study is conducted on automobile—related reviews, extracting the customer needs and presenting important R&D projects such as an extracted need (cargo transportation) and its R&D strategy (resolving contradiction). The proposed approach can analyze the needs of user at a functional level to discover new technology opportunities.
Keywords:
Transportation – Natural language processing – Linguistic morphology – Semantics – Patents – Vector spaces – Text mining – Brakes
Introduction
Technology innovation has accelerated the growth of the economy by enabling the development of new products and services. Thus, discovering new technology opportunities can be regarded as a fundamental activity of government, as well as companies. Basically, since two opposite approaches, such as technology push and demand pull, are the main sources of innovation, most traditional studies on technology forecasting started their arguments by choosing their position in two approaches. While technology push means that a new technology catalyzes impactful innovation by utilizing and commercializing the technology, the demand-pull approach refers to needs of users for a product or technology that brings in innovation to satisfy their needs. Conventional studies on technology innovation highlight the role of technology push, because a technological breakthrough is regarded as the only driving force for innovation. However, other researchers advocating a demand-pull approach concentrate on user needs, investigating a diverse set of market features [1]. While users do not always need a high technology product, they just want to satisfy their needs at a reasonable price and performance. Thus, it is suggested that user-oriented experiences and designs are a leading factor in the competitive marketing environment [2]. In addition, previous studies proposed an R&D framework that reflects users’ needs through opinion mining [3, 4].
However, there are two limitations to the previous studies about TOD using opinion mining. First, they just profile the user, or classify their opinion. In other words, they do not focus on discovering “what they want” and “how it works” in a structured manner. Although classified opinions can provide the information on how a user thinks about their products and services, existing approaches cannot suggest a way to satisfy users by developing new technology, or by modifying current technology. Second, the characteristics of technology and user needs are not directly connected. Since patent assignees might be experts in specific technology, they write a patent script in their technical terminology. In contrast, reviews of users are written in simple words, because users do not have scientific knowledge. Due to these differences, user opinions can hardly be reflected in the R&D process, even when they express their opinions with objective information in words. Thus, previous researches are limited to a specific technology area in which only the pre-defined area can be analyzed.
Since previous studies on opinion mining concentrate on classifying the opinions of users into positive or negative categories, they cannot derive the main reasons for their opinions. Thus, they cannot be actively utilized to suggest new technology opportunity to satisfy user needs. To solve this problem, this paper defines an opinion trigger as an object that users express their feeling towards products or services. In other words, an opinion trigger means the main reason for user opinion. The opinion trigger can be interpreted as “what the user wants, or “how it works”. Furthermore, user needs can be constructed by the opinion trigger. In this research, each component of product/technology is discovered as needs that a user wants to be satisfied. The property of needs and related technology can be used to build a technology strategy to satisfy user needs in designing products and services. In addition, the word-embedded matrix is used to find a relationship between user needs and technology information. Based on their relationship, the words that express differently but have the same meaning can be derived. Thus, an R&D process can be efficiently managed, because the proposed approach can reduce a pre-defining process, or expert advice.
This paper is organized as follows. Section 2 presents the theoretical background, which contains technology opportunity discovery (TOD), which is the main purpose of this research, opinion mining analyzing the needs of the user, and technology backgrounds, which are natural language processing and Word2Vec. Section 3 presents the research concept and framework, and explains the details of the research process. Section 4 conducts a case study in the car industry, to illustrate the proposed approach. Finally, Section 5 discusses the contribution of this research, its limitations, and the possibility of future research.
Theoretical background
Technology opportunity discovery (TOD)
The purpose of technology opportunity discovery (TOD) is to identify significant trends in society, culture, and science to discover the most promising technology [5]. Technology opportunity includes the possibility that may be applied in various industries, not confined within a specific industry [6]. Previous TOD approaches based on patents and papers use bibliographic information and their text data. Since patent information contains a variety of technology information, important properties of a technology field can be extracted by patent mining. Promising technology fields are identified [7], while the relationship between various technologies using a citation network is derived [8]. Technology trends are analyzed based on the number of registered patents each year [9, 10], while IPC code is used to find the core technology in an environmental ecology field [11]. RFID technology is forecasted in China through clustering and patent portfolios [12], while exploring promising technology sectors by using patent networks and promising patent index [13].
In addition, various text mining techniques and statistical analysis are employed to discovery emerging or promising technology fields. Text mining, which is the main method of extracting significant information from patent qualitative data, is highly dependent on keyword extraction. To increase text mining performance and prediction accuracy, many methodologies, such as Latent Semantic Analysis and Latent Dirichlet allocation, have been proposed. Core keywords are identified in the parts of summary and claims, then identify the targets of mergers and acquisitions or patent infringements [14, 15]. Technology development is analyzed in shale gas development in China and the United States, using the abstracts of patent documents [16]. In addition, novel patents are find to predict technology convergence based on keyword similarity [17]. In particular, technology opportunity is identified through subject-action-object (SAO) text mining and morphology analysis [18]. Product features that customers want are grouped by using LDA [19], while opinion mining and clustering is conducted to characterize products [20]. In addition, product ranks and their features are suggested based on opinions and the interests of users [21].
The TOD, which has the perspective of technology push, can obtain competitive priority based on high technology ability [22]. However, innovative or high-performance technology does not always get competitive priority from a customer choice. Some technology or product has higher technology ability than is necessary, and the price is too expensive to pay for it. In addition, R&D activities without market prediction may result in useless technology for users. Furthermore, the development of social network services and Internet shopping services allows users to easily express and share their opinion. Based on other user opinions, they can choose the products and services that they truly want, forcing technologists to reflect their opinions in developing a product, and even a technology.
Opinion mining
Opinion mining extracts quantitative and qualitative data from user opinion data through natural language processing (NLP), linguistics, and text mining [23]. The technique is also called sentimental analysis, by deriving positive, neutral, and negative opinion. This drives sentimental value, meaning the quantitative value of opinion. A positive value means a positive opinion about an object, while a negative value means a negative opinion about an object. Opinion mining can be divided into sentimental analysis and contents analysis. Sentimental analysis derives sentimental value from sentences or documents. Pre-defined opinion dictionaries, such as Semantria and SentiWordNet, are used as an opinion dictionary for sentimental analysis. Well-expressed opinions are extracted by analyzing movie review data [24]. Sentimental value prediction models are developed through analyzing opinion text data and user profiles, such as age, sex, and religion [3]. Technology opportunities are discovered by analyzing user reviews and patents through sLDA [25]. Opinion mining is used to quantify the degree of positive or negative opinions about products or services [4, 26]. Also, posts on social network service such like Twitter are used for opinion mining to identify and monitor the development trends of emerging technologies including patent analysis [27]. Not only user opinions are used to form text; various factors are used together to improve the reliability of analysis. Complaints are analyzed by using reviews containing a grade [3], and user information, such as age and gender, is used to predict user needs [28]. Using machine learning algorithm, many studies to improve accuracy and extract more useful information have been conducted. Extracting multiple linguistic features is suggested in an automatic learning system to summarize many reviews [29]. Deep learning models are applied such as recurrent neural network and convolutional neural network, for more accurate sentimental analysis and features of opinions [30–32].
In the R&D process, the needs of users are identified through opinion mining, and can be reflected in technology attributes, or specification to satisfy users. User reviews are analyzed with their profile and predict future users [28], while needs of users are extracted by analyzing relationships with each word, sentence structure, and specific words occurrence [33, 34].
Natural language processing (NLP)
NLP is linguistics based on computer science that studies the interaction between computer and human. Its theoretical base resides in supervised machine learning. NLP machines learn from the linguistic information of each sentence or document, such as phrase, part-of-speech (POS), and sentence structures, and analyze new input sentences or documents based on learned information, and derive linguistic information. NLP can extract more linguistic information from texts than simply using the meaning of each text. Its function can be divided into chunking and POS tagging. Chunking is also known as parsing, extracting phrases expressing one object with other words. POS tagging is tagging a part-of-speech, which means the linguistic function of each word in a sentence.
Chunking is conducted in an automatic translation area. A translation algorithm is suggested by dividing complex sentences into single sentences, and chunking various sentences, then translating texts at a phrase level [35]. The effectiveness of the phrase level translation machine is proved by comparing with word level or sentence level translation [36, 37]. POS tagging is used in many areas that need more detailed information about text. Text mining is divided into keywords-based and key function-based approaches [38]. Nouns and verbs of each sentence are extracted from the perspectives of subject-action-object (SAO), and collected patents are analyzed based on SAO structure. Nouns and verbs are interpreted as functions and objects, and then construct a technology tree based on a patent’s function and object [39]. An inventive design method is extracted, based on TRIZ and patent semantic similarity [40]. Furthermore, technology information is structured in patent documents, using their linguistic character and patent law [41].
In this research, chunking is used to divide a complicated sentence into single sentences. Then, POS-tagging is used to identify components of needs structure. Users express their opinion in the adverbial and adjectival forms, thus these words are defined as sentimental keywords. Using sentimental keywords, sentences from user opinion are classified into opinion sentences and non-opinion sentences. In addition, opinion triggers are classified into object-related opinion triggers and function-related opinion triggers based on their POSs, which are verb or noun.
Word2Vec
Word2vec is a word embedding method that can rapidly calculate more than a billion words [42]. Word embedding is a methodology to represent texts in a vector space by reducing the dimensions of the text vector that form its own vector space. Many embedding models have been suggested based on the neural network; feedforward neural net language [43], and Recurrent Neural Net language Model [44]. Word2vec uses a continuous bag of words (CBOW) and a skip-gram learning model. CBOW predicts which word appears next to or between texts, when various words appear through learning. Skip-gram predicts words that appear next to previously appearing words through learning. Using these learning models, Word2Vec has the advantage of word embedding that learns a lot of data into a vector space with a short learning time, compared to other word embedding methodology.
Word2Vec has two specific functions. One is semantic similarity being represented in a vector space, and the other is a vector calculation that can be done between words in a vector space. Semantic similarity reflects the synonyms and derivatives of a word. Using the property of word occurrence representing their semantic similarity, similar words can be identified in a vector space without a predefined dictionary, such as Wordnet. Based on this character of Word2Vec, user opinion is classified using clustering methodology [45].
In this research, a combination of the words is identified as needs, using features that words having semantic similarity occur nearby. Each word having semantic similarity can be clustered using clustering methodology, and interpreted as needs. Patent and user opinions are embedded in the same vector space to word gap between expert and users. Fig 1 shows concepts of identifying the needs of user by Word2vec and clustering methodology.
Fig. 1. Concept of identifying needs in vector space. Underlined word, blue color word and red colored word expressing sentiment, object and function, respectively. Methodology
Research framework
To discover technology opportunity based on opinion triggers, a framework that consists of three modules is suggested. In the first module, an opinion trigger is identified as an object or a function opinion trigger by Naïve Bayes classifier to detect an ‘opinion sentence’, which contains one of the sentimental keywords among all review sentences. The second module constructs the structure of user needs for each type of opinion trigger from both user needs and related technology points of view. Needs are analyzed by clustering combinational text data on both user reviews and patents through word2vec and partitioning around medoids (PAM). Sentimental value for each need is calculated by graph-based semi-supervised learning. Then the relationship between the needs and technologies is interpreted based on the structure of the opinion trigger and additionally, the technology ability is analyzed. The last module of discovering technology opportunity makes suggestions of technology opportunity types and technology strategies. Fig 2 shows the framework of this study.
Fig. 2. Research framework. Module construction (outer flow chart), detailed processes for each module (inner flow chart), and methodologies (tagged by right side boxes). Detailed process of framework
Module 1: Identifying opinion trigger
In Module 1, the opinion trigger is identified as the source of needs. Despite the user expressing their opinion using various words, these opinions have the same linguistic characteristics. Those characteristics have the same linguistic structure—adjective or adverb + verb + noun. Based on the characteristics, opinion triggers are identified using natural language processing and naïve Bayes classifier. The POS-tagging function can be used to derive each part of speech in an opinion. POS-tagged words can be suggested as candidates of opinion triggers. In addition, naïve Bayes classifiers suggest the probability of each word usage when users express their opinions, and this probability is used to identify opinion triggers.
The first step of identifying opinion trigger is to crawl review data. Review data on a website express various user opinions. To identify opinion triggers, review data are collected from several websites that collect and show expert review data for users. Expert reviews consist of multiple sentences and detailed information about products. Since their purposes are to re-provide information for users, they have to explain detailed information, such as components, modules, and attributes of products in simple words that users can readily understand. Thus, it can be the best source of opinion mining and word2vec. The review data are collected on several websites, not on a specific website. Since some websites might have biased reviews about user propensities or specific products/companies, review data in websites are crawled by web crawling. This research uses a web crawler based on R using “httr”, “rvest”, and the “RSelenium” package.
In the review data, there is much information beyond the reviewer’s opinion about product/technology. For example, the data could contain product specifications or their purpose of purchasing the product. This information does not express an opinion. A difference between such information and user opinion is the occurrence of adjectives or adverbs. In the case of user opinion, users express their feeling by using adjectival or adverbial phrases, such as “great design!”, “the best wheel”, and “handles turns smoothly”. Since this research focuses on investigating these linguistic characteristics of user opinion, sentimental keywords are defined as words that are used when users express their opinion using natural language processing.
As mentioned above, sentimental keywords are formed as adjectives or adverbs. Based on natural language processing, candidates of sentimental keywords can be extracted. Then, the sentimental keywords can be classified based on their usage. For example, ‘good’, ‘best’, and ‘bad’ can be clearly interpreted by being combined with an object like examples such as “bad cargo!”, “bad handle” and “bad efficiency”. Thus, it can be defined as a global sentimental keyword (GSK), meaning a keyword that can express their sentiment in a global situation. On the other hand, words such as ‘smoothly’, ‘wide’, and ‘immediately’ cannot be significantly interpreted, when they are used with an object. For example, while the “stop immediately” is a reasonable opinion, the “immediately cargo” cannot be interpreted and does not a reasonable opinion. The word “stop” has the word “immediately” as an attribute like “quick” and “fast”, whereas the “cargo” does not. Therefore, “immediately cargo” cannot be interpreted. Thus, these words that can be interpreted with a specific object are defined as a static sentimental keyword (SSK), meaning a keyword that can express their sentiment in a static environment. The two types of sentimental keywords have the same meaning as a global variable and static variable in a programming language. Sentimental keywords are used to identify opinion triggers, and the two types of sentimental keywords are used to calculate the sentimental value of needs based on their attribute.
An opinion trigger is defined as words that users use to express their opinion directly. Based on the definition of a sentimental keyword, the opinion sentence has to include sentimental keywords. Using this character of user opinion, an opinion trigger can be identified from user opinion, as follows. First, user opinions that consist of several long sentences in review data are partitioned into multiple single sentences. Second, each sentence is classified into opinion sentence and non-opinion sentence, based on the occurrence of sentimental keywords in the sentence. If a sentence has a sentimental keyword, this means that the sentence can be classified as user opinion. On the other hand, if not, the sentence can be classified as a non-opinion sentence. This means that there is no opinion in the sentence. Third, opinion triggers are identified using naïve Bayes classifier.
Naïve Bayes classifier is a supervised machine learning methodology based on the assumption that each probability distribution is independent of each other. Bayes theory, which is a theoretical base of Naïve Bayes classifier is used to calculate the conditional probability that is hard to calculate using other conditional probability. Eq (1) shows the basic formula of Bayes theory:
According to the definition of opinion trigger, the words used when users express their opinions can be an opinion trigger. It can be defined as P(Words | Opinion Sentence). In Bayes formula, P(Words | Opinion Sentence) and P(Words | Non-opinion Sentence) could be obtained using Eqs (2) and (3). If a word has a higher P(Word | Opinion sentence) than P(Word | Non-opinion Sentence), the word can be identified as an opinion trigger. This means that the word occurs more frequently in opinion sentences than non-opinion sentences. Logically, sentimental keywords always have high probability. However, sentimental keywords do not contain “what they want” or “how it works”. Thus, except sentimental keywords, the keyword that has high P(Word |Opinion sentence) can be identified as an opinion trigger.
Fourth, the identified opinion triggers are classified into function opinion trigger (FOT) and object opinion trigger (OOT). As mentioned above, the needs of users can be constructed with adjective/adverb, verb, and noun. Since adjective or adverb are defined as a sentimental keyword, verb and noun should be defined to construct user opinions. As an opinion trigger is defined using the probability of each word, POS-tagging in natural language processing can be used to define the verb and noun in opinions. Thus, an opinion trigger formed as a verb can be defined as FOT, while an opinion trigger formed as a noun can be defined as OOT.
Module 2: Identifying needs and related technology
In Module 2, needs and related technology are identified based on opinion triggers using Word2Vec and PAM. Then, the sentimental values of needs and technology ability are analyzed by using graph-based semi-supervised learning and patent index. Sentimental value means how a user is satisfied by each need, and the related technology ability means the ability to satisfy the needs of a user. Based on these properties, technology opportunity is classified in Module 3.
At first, patents are collected to analyze technology information and their technology ability in the United States Patent and Trademark Office (USPTO) database. Patents that are issued in the USPTO are approved by patent law, and have technology information in a clearly explained sentence, with no grammatical or linguistic errors [46]. Thus, review data and patents could be a source of analysis, reducing the words-gap in the same vector by reflecting the opinions of users and technology information. To collect patent documents, a query is used that restricts time period and the scope of industry. On average, a patent takes two years from application to issue. Thus, this research analyzes patents applied from two years ago for 10 years. To collect patents in a specific industry, this research uses simple keywords that represent the industry. Since specialized keywords, such as component or module, cannot drive the technology information about an industry, they are excluded in this research.
Needs of users could be discovered through a combination of opinion triggers and sentimental keywords. The basic formula of the needs of the user can be defined as OOT + FOT + (sentimental keywords). For example, in “handle turns smoothly”, “handle” is the main object of needs, “turns” is a function of how the handle works, and “smoothly” expresses the sentiment that the user feels. Even if there is no sentimental keyword, two types of opinion trigger can structure the user needs itself. “Gear downshift” can be an example of user need that is structured without a sentimental keyword. Also, several needs can be discovered by a modified formula: OOT / FOT + sentimental keyword. “Great downshift!” and “wide cargo space” can identify needs about a downshift and cargo. Each need can be examples of FOT (downshift) + sentimental keyword (great) and OOT (cargo space) + sentimental keyword (wide).
To find their combination of words, Word2vec and PAM are conducted. Word2vec is used to analyze the relationship between words based on review data and patent data, and then suggest the vector source of each keyword as their relationship. Based on these vector sources, PAM is conducted to cluster opinion triggers and sentimental keywords to discover the needs of the user. PAM, also known as k-medoids clustering, is a clustering methodology based on nodes. The center nodes of a cluster are called medoids, and the number of medoids can be selected by several criteria. PAM is more robust from outliers than k-means clustering. Furthermore, besides the number of medoids, each medoid that is a starting point to calculate in an iteration that can be selected by the analyst. It can make an opinion trigger as a center of the cluster, enabling an opinion trigger to be derived—a weighted cluster. This research conducts PAM, using the same number of clusters as opinion triggers to analyze the most related keywords in a vector space.
Fig 3 and Table 1 show an example of word2vec and PAM results. In Fig 3, several types of words are embedded in a vector space. The distance of each word means the degree of meaningful relationship, and in this case, four clusters are constructed by PAM. Needs #1 and #2 are formed by the basic formula, and they are constructed by OOT and FOT. Although need #2 does not have a sentimental keyword, the need can be discovered based on OOT and FOT. Need #2 has two FOTs expressed by different words; however, they have the same meaning. Thus, they can be suggested as the same needs. Needs #3 and #4 are formed by the modified formula, discovered by only one type of need. Although Need #3 has two different object triggers, they have the same meaning. Need #4 has normal keywords that are neither a sentimental keyword, nor an opinion trigger. These keywords that come from the opinions of users or patents can be used to analyze detailed information of needs. For instance, need no 4. has “mountain” and “road” as normal keywords and it can be useful information to discover detailed needs such as “driving in mountain or road”.
Fig. 3. Identifying needs using combination of trigger (example). Underlined word, bold word and italics word expressing sentiment, object and function, respectively. Tab. 1. Identifying needs using needs formula. The sentimental value of each need is calculated by using the property of the sentimental keyword. The sentimental value of needs can be derived from the sentimental value of the opinion trigger. The sentimental keyword is a word by which users express their feeling, and each keyword has sentimental value. However, an opinion trigger does not have its own sentimental value. To solve the problem, this research uses a structure of needs that is constructed with sentimental keywords and opinion triggers. That is, users express their opinions using sentimental keywords and opinion triggers together. Thus, each opinion trigger can have sentimental value based on co-occurrence with positive or negative sentimental keywords.
To calculate the sentimental value of the opinion trigger, the sentimental value of the sentimental keyword is propagated to each opinion trigger that forms user needs. For this, a graph-based semi-supervised learning technique that is one of the network analysis methodologies is employed. The specific value of one node is propagated to neighboring nodes, and it can derive the missing or empty value of the other nodes. In this research, the graph-based semi-supervised learning that is mainly used for network analysis is modified to apply to clustering analysis. Several types of keywords, such as opinion triggers and sentimental keywords, are embedded in a vector space, and clustered based on their relativeness. This means each keyword in the same cluster has a meaningful relationship. Thus, the graph-based semi-supervised learning can be conducted in cluster analysis, because each cluster can substitute a network as a group of a meaningful relationship.
Based on the graph-based semi-supervised learning, two types of sentimental keywords are propagated to the opinion trigger in different ways. First, the sentimental value of each sentimental keyword is calculated using Semantria. Semantria analyzes the sentimental value of documents, sentences, or words based on a pre-defined sentimental dictionary and their own algorithm. Many opinion minings have been conducted to calculate the sentimental value based on Semantria [25, 47]. Second, the distances between opinion triggers and sentimental keywords are calculated depending on the sentimental keywords type. SSK can express their opinion about a restricted opinion trigger. Thus, if an SSK does not belong to a cluster, its distance to an opinion trigger equals infinity. This means there is no relationship between the opinion trigger and the sentimental keyword. The GSK can express its opinion about all the opinion triggers, and its distance to an opinion trigger can be used in calculating sentimental keywords as a weight. The third step is to multiply the sentimental value of sentimental keywords by the inverse distance opinion trigger and sentimental keywords, to calculate the sentimental value of the opinion trigger using Eq (4). Since the distance between two types of words means their semantic similarity, it can be used as a weight in graph-based semi-supervised learning. Finally, the sentimental value of needs can be derived from the sum of the sentimental value of the opinion trigger using Eq (5). Fig 4 shows the process for calculating the sentimental value of needs.
Fig. 4. Process to calculate sentimental value of needs. A conceptual example of needs with SK and OT (left box) and flow chart of calculating s-value based on SK and OT (right flow chart). User needs related technology is identified based on patent keywords in a cluster formed by needs. Using the POS-tagging function in NLP, keywords in patent documents are classified into noun, verb, and others. In this research, noun and verb words are suggested to be object patent words (OPWs) and function patent words (FPWs). Each word can be interpreted by patent object and patent function. Using these two types of patent words, user needs and related technology can be identified. Based on the opinion trigger structure of needs, related patent words are allocated in each need. In the case of need #1 that has both OOT and FOT, FPW and OPW in the same cluster can be interpreted to mean that the FPW and OPW have a relationship with need #1. Hence, patents containing those FPWs and OPWs are allocated in needs-related patents. Then, the group of patents can be suggested as needs-related technology. Fig 5 shows the process of identifying needs related technology.
Fig. 5. Process of identify needs-related technology. A conceptual example of needs with OT and related words (left rounded box), needs with trigger and related word (middle top table), patent list with related OT word lists (middle bottom table) and need list with related patents (right table). The technological ability of needs-related technology can be analyzed using patent index. Patents have their own quantitative value, such as the number of cited patents, the number of citing patents and the number of independent claims, and the number of INPADOC family patents. These indices can be interpreted by their own meaning. The number of cited patents means how many other patents cite the patent to apply for a new patent, indicating that their technology information is used by other patents. Thus, the number of cited patents can be interpreted as the impact on other patents. The number of citing index means how many other patents are cited to apply for their patent. Thus, a high number in the citing index means that the novelty of patents is low, showing the number of citing patents can be interpreted as innovativeness. The claim is a right to legal protection of their novel invention from others. Many claims of a patent mean that it has a lot of technology information that can be protected by patent law. The INPADOC family number is their legal right in other countries. Once a patent has been issued in a country, its right can be protected in other countries included in the INPADOC family. Thus, the INPADOC family number can be interpreted as the marketability of the patent.
These patent indices show capability from various perspectives [13, 25, 48] impact, innovativeness, authorization, and market ability. Thus, the average value of the indices can be the technology ability containing various perspectives. Table 2 shows each formula of index and their meanings. Since each index has other meanings about technology property, the average of the four indexes is suggested as the technological ability. Then, the difference between the ability of each index and average index of the whole technology is derived as the technology ability of each needs-related technology.
Tab. 2. Meaning of patent index and formula. Module 3: Analyzing technology opportunity
The needs of the user are classified into four types by the property of needs and their related technology ability. There are two criteria to classify technology opportunity, which are the sentimental value of needs, and the ability of related technology. Table 3 shows the four types of needs based on sentimental value and technology ability.
Tab. 3. Four types of needs. In the case of type 1 and 2, the needs of users are satisfied. Thus, these types of needs can be used for a marketing strategy or a low-cost strategy to gain more consumers. These strategies are dependent on the environment of each company or developer. However, this research discovers technology opportunity from needs based on user opinions and the properties of technology. The patent index used in this research, such as sentimental value, technology ability, and keywords, cannot consider the properties and strategies of companies or developers. Thus, technology opportunities of need type 1 and 2 could not be formulated. In the case of type 3, although the ability of technology is higher than others, users are not satisfied with the satisfaction level of their needs. This means there are some gaps between the needs and related technology. Thus, this type of need can be defined as technology opportunity for resolving the gap. The gap can be analyzed from the opinion trigger and the structure of needs. Finally, in type 4, the needs of users are not satisfied, and the ability of their technology is relatively low. This means there is no specified technology for the needs of users. Thus, this case can be defined as the technology opportunity for vacant technology. Their vacancy can be analyzed from the difference between opinion triggers in user opinion and technology ecology.
Technology strategies of type 3 and 4 should be implemented, in order to resolve the contradiction, and develop the vacant technology. Detailed strategy about technology opportunity is suggested using their opinion trigger, patent keywords, and other keywords. Type 3 opportunities to resolve contradiction (RC) can be suggested based on the gap between the structure of needs and related technology. Needs that are associated with a specific function, and related technology that focuses on an object can contradict one another. In this case, a technology strategy to resolve the contradiction can be suggested using opinion triggers. Type 4 opportunities to develop vacant technology (VT) can be proposed using an opinion trigger. Based on an opinion trigger, which function of an object should be developed to satisfy users can be suggested. In addition, the sentimental value of each need and the detailed technology property of each technology are used as the source of strategy.
Case study
This research concentrates on the car industry to extract opinion triggers, and discover technology opportunity. Since the car industry is one of the most active areas in which users express their opinion in the web, many opinion mining studies target this industry to extract user opinion [25]. The car industry has various types of users, and their needs vary, depending on the purpose. Therefore, in order to interpret their needs accurately, needs should have to be analyzed in what they want, and how it works.
Module 1: Identifying opinion triggers
Dataset
Review data is collected in four websites, which are ‘amazon.com’, ‘cars.com’, ‘car and driver (www.caranddriver.com)’ and ‘the car connection (www.thecarconnection.com)’. The ‘amazon.com’ has the biggest customers and products among internet shopping malls and other websites are nominated in J.D. Power top 10 car review sites. During 2007–2016, 38,748 reviews are collected without limiting the specific model. Data fields include review title (year, make, and model), review year, review body and type of data source. Using Rselenium, the html sources from review pages are automatically crawled. Then, the html sources are partitioned to collect review data through rvest’ and ‘httr’ package. Data that does not include the review body or has a length of 10 or less in words is excluded for the analysis of word2vec and clustering. The final dataset consists of 37,697 reviews (32,260 from Amazon.com, 1,452 from Car and driver, 2,881 from Car connection, and 1,104 from Car.com).
Extracting opinion triggers
Prior to the case study for the suggested opinion trigger structuring, the information on raw data needs to be described. Table 4 shows the result of keyword frequency in the review data after eliminating stop-words such as ‘a’, ‘the’ and ‘and’. Consequently, keywords such as ‘car’, ‘great’ and ‘like’ mostly appeared in reviews. In addition, Table 5 shows top 5 frequency-based needs by manually interpreting user’s opinion including one of the top keywords (fuel, engine, mileage and so on), accounting for over 80% of the entire keyword frequency, as user’s needs. The needs ratio indicates the percentage of review document corresponding to each frequency-based. The extracted keywords have a limitation when it comes to analyzing user needs for technology opportunity. They hardly reflect how people satisfy/dissatisfy, which object or function it is and so on. Thus, this paper suggests novel methods to structure users’ needs as an opinion trigger by using the combination of existing techniques which cannot be analyzed through keyword frequencies.
Tab. 4. Keyword frequency in review data. Tab. 5. Needs ratio based on keywords and documents. Collected reviews are partitioned into 228,900 sentences, and used to extract opinion triggers. Using POS-tagging, POSs are tagged to each sentence. 2,860 words, which are formed in adverbs and adjectives, are selected as the candidates of sentimental keywords. Among the candidates, sentimental keywords with frequency in the review of higher than 100 are selected. According to the accuracy of NLP, a proper noun can be tagged as an adverb or adjective. Furthermore, some tagged words are wrong. To resolve these problems, words that are tagged as adjective or adverb more than 100 times are selected as accurately tagged candidates. Selected sentimental keywords are sorted into global sentimental keyword and static sentimental keyword by their meaning. Table 6 shows 424 selected sentimental keywords and their type.
Tab. 6. Extracted sentimental keywords from opinions. Review sentences are divided into opinion sentences (OS) and non-opinion sentences (NOS), to identify opinion triggers based on sentimental keywords. In all, 115,277 sentences are sorted into OS, while 113,623 sentences are sorted into NOS. Using the word frequency of each sentence and Naïve Bayes classifier, the appearance probability of each word in an opinion sentence can be calculated. Based on this probability, 368 opinion triggers are identified. In addition, in order to analyze an opinion trigger’s property in the structure of needs, each word’s POS is tagged. Then, an opinion trigger formed as a verb is sorted in the function opinion trigger. In addition, an opinion trigger formed as a noun is sorted in the object opinion trigger. Table 7 shows each opinion triggered type and probability.
Tab. 7. Identified opinion triggers (part). Module 2: Analyzing the needs of user & related technology
Patents are collected from wisdomain.com, which provides search and download services for registering United States patents and the trademark office. Using queries structured by car and related to car, such as vehicle, automobile, and automotive, 63,358 patents that are registered in 2007 through 2016 are collected. Based on the Word2Vec algorithm, the title, abstract, and claim in patents and user reviews are embedded in a two-dimensional vector space. In Word2Vec, 1,500 words that occur more than 100 times are used. The window size that interprets contextual relationship with each other is set as 4. Then, 200,000 times repeated training is conducted. To analyze the relationship and contextual similarity between each word, PAM is conducted to make 308 clusters, the same as the number of triggers. After clustering, the contents of clusters are interpreted by opinion triggers, sentimental keyword, and normal keywords.
Then, 51 clusters containing at least one trigger in the cluster are interpreted as the needs of the user. Among the derived needs, 22 needs that could not be satisfied by technology development, such as design and price, are excluded. Since this paper focuses on technology-related user need that can be handled with R&D activities, opinions distant to technology problem such as ‘satisfaction of moon-roof style and design’ are eliminated manually. Table 8 shows 6 representative needs of users among 51 total needs.
Tab. 8. Discovered needs of users (part). Sentimental keywords are used to extract the sentimental value of each need that is targeted to discover technology opportunity. Based on the graph-based semi-supervised learning, the sentimental values of needs are calculated using sentimental keywords and opinion triggers. The sentimental value of 424 sentimental keywords is calculated in Semantria. Their sentimental values are propagated in different ways, depending on the sentimental keywords type. Table 9 shows the sentimental value of candidate needs for technology opportunity; 65 percent of needs are positive, while 35 percent of needs are negative.
Tab. 9. Sentimental value of needs for candidate technology opportunity. To identify the relationship between needs and technology, patents are allocated based on their keywords type. If needs are structured with function and object opinion trigger, patents that have object keywords or function keywords are allocated in needs. If needs are structured with one type of trigger, patents that have the same type of keyword are allocated in needs. Then, the technology ability is analyzed by calculating the number of cited/citing patents, the number of INPADOC family countries, and the number of independent claims. Table 10 shows the relationship between needs and their normalized technology ability in relative value.
Tab. 10. Needs-technology relationship and technology ability. Module 3: Discovering technology opportunity
Using the sentimental value of needs and technology ability, all identified needs are classified into four types, as in Table 11. Type 1 needs have positive user opinion and high technology ability. These are related to the driving environment and core hardware, such as road-holding, acceleration ability, suspension, and acceleration pedals. Since their ability can be expressed by an objective index, the results could be interpreted by high technology ability derived high user satisfaction. Type 2 needs have positive user opinion; however, their technology ability is low. These are related to passenger or driver feeling, such as being comfortable while driving, hardware manipulation system, fuel efficiency, safety driving, and backseat and back of the seat. Driver or passenger feeling could not be calculated by quantitative value, and personal preferences are too diverse to calculate one criterion. Thus, although their technology ability is low, the user feels satisfaction about the needs. Type 1 and 2 needs have to be interpreted by product or company property, such as marketing property, development strategy, and industrial environment. Though various indices used in this study, such as sentimental value, opinion trigger, and needs–technology relationship, they cannot reflect their property related to marketing property or industrial environment. Thus, this research focuses on type 3 and 4, which can be resolved by investigating the contradiction type and vacant technology type. Table 12 shows the target of this research to formulate a technology strategy.
Tab. 11. Classified needs and technology opportunity. Tab. 12. Property of technology opportunity. The technology opportunity (Type 3) for resolving contradiction has high technology ability, but users are not satisfied with their needs. In other words, their technology properties cannot satisfy user needs. Need #1, for ‘cargo transportation’ has a high relationship with transportation, which is a functional opinion trigger. But in the user opinion, there are many keywords related to safety, such as stable, parallel, and horizontal. Thus, transportation technology that aims to improve cargo safety has to be developed. Need #2, the ‘noise using brake’ is constructed by functional opinion trigger. There are many keywords related to rapid brake systems, such as immediate, response, and deliver. On the other hand, there are no keywords related to noise that occurs in opinion. That is, a brake system that aims to facilitate rapid operation cannot satisfy user needs for a quiet brake system. To satisfy the needs of users, the brake system has to develop a quieter operating method. Need #6, for ‘audio’, is constructed by object opinion trigger. Although technology related to the need is just installed in the speaker or audio in a car, it does not have special characteristics for the car. In particular, a user wants a great sub-woofer. However, few patents tackle the sub-woofer part. Thus, audio (speaker) for a car should have to focus on a superior sub-woofer and specialized property for a car. Need #11, concerning ‘charging noise for electric vehicle’ is constructed by function opinion trigger. Patent keywords in the cluster are related not to sounds and noise, but to efficiency. On the other hand, keywords from opinions said that the user wants a silent charging system. Thus, noise-free charging technology, or another technology that can reduce noise from charging, should be developed.
Technology opportunity for vacant technology means they do not have the needs-related technology, or low technology ability fails to satisfy the needs of the user. This type (Type 4) of need should have new technology developed, or be as specialized as the user wants. Need #3, concerning ‘control using handle’ has the related technology. However, their technology ability is low. Furthermore, they do not have keywords related to sensitivity. Since the notion of more sensitive and sophisticated control systems is derived from user opinion, more accurate vehicle handling technology needs to be developed. Need #4, ‘warning for battery’ has various patents related to battery, power, warning, and alarm. However, although each keyword is included in different patents, the combination of keywords that is relevant to user needs does not occur in a single patent. In addition, the ability of each technology is low. Thus, a technology that can warn of the remaining level of battery has to be developed. Need #5, about ‘adjusting seat’ has many patents that are related to the seat. However, there are few patents related to adjusting. In addition, automatic and personalization occur in user opinions. Consequently, car seat technology has to be developed to enhance the adjusting function, and automatic and personalization option. Need #7, about ‘downshift’ is related to a gear that is the object of need. However, downshift that is in the gear functional side is not emphasized in the patent. Therefore, downshift technology has to be developed, aiming at the function itself. Need #8, about ‘tablet mounted in car’ has many patents related to a tablet that is the object of needs. However, touch or recognition-related patents that are functions of need are relatively small, and their technology ability is low. Thus, tablet-related patents focusing on touch and recognition have to be developed. Need #9, ‘navigation, does not have specialized keywords. Therefore, a technology strategy could not be formulated.
Verification
At first, this research compares the proposed approach with conventional methods to show the validity of the main methodologies based on word2vec and PAM. Identical data that was used in the proposed approach is analyzed by using Document Term Matrix (DTM) and k-means clustering algorithm, which both are frequently used in text mining and clustering. DTM is used to text mining analysis such as Latent Semantic Analysis (LSA) and Latent Dirichlet allocation (LDA) and has a limitation of a frequency-based approach. K-means clustering is also one of the traditionally popular clustering methods. Table 13 shows the list of keywords in five groups of clusters which 308 clusters derived by DTM and k-means clustering algorithm are assigned into. The result that the ‘brand’ cluster type includes most of the clusters (176 clusters) shows that most people who wrote down their own opinion on the website mentioned a particular brand name. Thus, the result is subject to provide insignificant information on customer needs. In addition, document clustering has the limitation that it can rarely derive detailed and concrete needs because there are various opinions in one review document. In these reasons, this paper has a contribution that can define segmented needs by starting from an ‘opinion trigger’ and structuring opinion text data.
Tab. 13. Cluster type based on DTM & K-means clustering. In addition, the main results of discovering user needs are compared with reliable and actual data. The complaints data provided by Office of Defects Investigation (ODI) of National Highway Traffic Safety Administration (NHTSA), which is a part of the Department of Transportation of the Executive Branch of the U.S. government is employed for the comparison. The ODI complaints data is utilized to help make decisions of recall or other safety-related problems, containing over than 1.5 million safety-related defect complaints received by NHTSA since January 1, 1995 (https://www-odi.nhtsa.dot.gov/downloads/). Among all fields of data, the ‘description of the complaint’ is analyzed to derive the main issues that users have reported dangerous and problematic when they use a car. Although the description is revised by a recorder and mainly focuses on safety-related problems, the ODI complaints data is suitable to convince the identified needs for verification. Table 14 shows the frequency and example of ODI complaints data related to the identified user needs. The needs of ‘control using handle’ has the highest record in ODI complains 94,168 times and the complaints linked to the needs accounts for around 10% of total ODI complaints. It reveals that the needs extracted by the proposed approach reflect consumers’ actual discontents and opinions.
Tab. 14. ODI complaints data related to the needs. The accuracy of machine learning techniques has been verified through repetitive analyses of 100 times in order to show the consistency of the analysis results. Table 15 illustrates the accuracy of conducting word2vec and PAM for 10 needs that were identified from the ODI complaints data. The hyper-parameters such as ‘skip_window’, ‘batch size’ and ‘embedding size’ of the machine learning technique need to be defined by conducting experiments to make combined words like Benz* (Benz C-class) be closely positioned in a word map. In this paper, consequently, the values of ‘skip_window’, ‘batch size’ and ‘embedding size’ become 8, 128 and 64, respectively after the repetitive experiments. On average, the learning accuracy on the 10 needs is 78.1%, which means that the 10 needs are consistently derived in 78.1 times out of 100 tests on average. Five needs (Noise in brake system, Control using handle, Audio, Downshift, Noise in charging for electric car) among the 10 needs are perfectly extracted on every trial by the proposed approach. On the other hand, warning for battery (7%) and cargo transportation (18%) show low accuracy. However, such needs that have low accuracy can be interpreted as new needs. The suggested machine learning algorithm reflects both pre-defined needs for technology opportunities and newly derived users’ needs, reflecting the objectives of this paper to explore potential users’ needs. The results of the verification will be discussed in the section of discussion.
Tab. 15. Machine learning (Word2vec + PAM clustering) accuracy. In this research, technology opportunities are derived from the needs of the user. To verify the opportunities, two-step verification is conducted. First, the needs of the user are verified by their persistence. Since technology development for the temporary needs of users brings small profit, the persistence of needs should be verified before R&D planning. Second, technology opportunities are verified by interests. If many competitors have interests in the same technology, this can promote a highly competitive environment. Thus, a developed technology cannot survive in this environment and gain competitive advantage. First, needs that users continue to express their opinion to others can be interpreted as a criterion for their choice. Thus, persistent needs should have to be satisfied by developing specialized technology. To compare the persistence of needs, Table 16 shows the average needs growth rate from 2009 to 2016, and 2016 to 2017. Needs # 2, 3, 7, 8, 9 have a higher growth rate from 2016 to 2017, than from 2009 to 2016. This means these needs have to be satisfied to get user choice and competitive advantage.
Tab. 16. Annual growth rate of needs. Technology interest can be analyzed by the patent registration rate. In this research, whole technology fields patent growth rates and needs-related technology growth rates are compared. If the needs-related technology growth rate is low, this means that other competitors do not have interests in satisfying the needs of the user. In other words, needs-oriented technology can easily be chosen by the user. Because there is no technology, it can satisfy their needs. To show the technology interests, Table 17 shows the annual patent growth rate of needs-related technology. The annual patent growth rate of the whole technology is analyzed as 9.33%, while the patent growth rate of needs # 2, 5, 6, 7, 8 and 9 are lower than 9.33%. In addition, their growth rate ranks in 29 valid relationships between needs and technology are low. This means these needs have low interest in car technology. That is, needs-oriented technology gets more choices from users and high competitive advantage.
Tab. 17. Annual patent growth rate of needs. Discussion
This paper has proposed a novel opinion mining methodology to structure user needs through the concept of Opinion Trigger focusing on objects and functions in user review data in the automotive area as Table 8. User needs have been derived through the proposed methodology and explored the technology opportunities based on the needs as Tables 12 and 13. Also, the result of the study was verified using comparison with time interval, ODI complaint data which shows ground truth, and the accuracy of machine learning methods as Tables 14, 15, 16 and 17. Based on these results, this study discusses in a view of comparison with related studies and actual/current issues in the automotive filed.
At first, the accuracy of machine learning is discussed based on Table 15. The accuracy of the study was verified in terms of the consistency of the consecutive analysis results of word2vec and PAM clustering. The 10 user needs derived from the study have a large range of accuracy according to each need. Needs with high accuracy are generally concerned with the purchase of a car or with a complaint of actual use. Indeed, needs with high accuracy of 90% or more tend to occupy high frequency of 1,000 or more data in ODI complains data including ‘noise in brake system’, ‘control using handle’, ‘seat adjusting’, ‘audio’, ‘downshift’, and ‘tablet mounted in car’. Handle control and noise in brake system have had a big issue in the real industry such as recall, and the accuracy of needs related to this problem is very high. Those needs are dealt with previous related study. ODI and amazon review data are analyzed and indicated that the issues on power steering failure on Cobalt 2006 and rear brake issues on Honda Accord 2008 are directly related to the results of topic modeling of online review data [49, 50]. In addition, the users’ need of power steering failure is shown as one the main results using topic modeling for review data on specific car model [51]. On the other hand, needs with low accuracy including cargo transportation, warning for battery and navigation (direction) can be interpreted as potential needs, which are not yet manifested as general needs such like high accuracy needs. In this study, word embedding vector considers relations between similar words before clustering for extracting user needs. Based on vector similarity, potential needs are derived by considering potential inter-word connectivity. Thus, although the frequency is low and does not appear with high accuracy in 100 times of test analyses, new needs can be derived from a potential perspective. ‘Cargo transportation’ and ‘Seat adjusting’ have been an issue in the actual automotive industry, which is verified by an industry player who is one of domain experts in Hyundai motor group. Cargo transportation needs can be interpreted as significant needs because the general user is interested in a freight transport (such as outdoor items) along with the increase in purchases of SUVs and CUV vehicles [52, 53]. The need on battery can be described that many companies are currently competing to gain technological advantage such as hybrid, full hybrid and plugged-in hybrid. In other words, low-accuracy needs reflect the needs of users who have recently become an issue, which has never been derived from previous studies.
Moreover, this study has compared the growth rate by dividing into the last 2 years and the previous years in the total data collection period, as shown in Table 16. In the case of the need of audio, which decreases most from the past, it can be interpreted that the high-performance technology has already been completed or that the user has reached its limit utility [54, 55]. On the other hand, the need of control using handle can be interpreted as an increase in the variety of automobile types such as sports cars and SUVs, as well as the increasing interest in handling an advanced driving assistance system (ADAS) among the automobile options that have recently become an issue [56, 57].
Conclusion
The study proposes a novel concept of ‘opinion trigger’ to extract user's needs from review data, in order to structure unstructured review data for technology opportunity discovery. This research defines an opinion trigger as an object towards which users directly express their needs. Based on the opinion trigger, the needs of the user are analyzed into object and function, rather than positive or negative feelings about a product. The object opinion trigger and function opinion trigger could be interpreted as what they want, and how it works, respectively. In addition, the word gap between users and technicians could be removed, and related technology can be derived without any additional process, through using the opinion trigger and Word2vec algorithm. Using the needs and the related technology index, two technology opportunities are derived. The first opportunity has resolved the contradiction between technology ability and sentimental value. Using technology-related ratios and opinion triggers, the reason for contradiction can be analyzed. The second opportunity is the vacant technology that has low technology ability to satisfy the needs of the user. The needs of the user were investigated through the opinion triggers, sentimental keywords, and keywords from opinions. Thus, a technology strategy for the two types of opportunities was suggested. Finally, the suggested strategy was verified by the insight on the increasing ratio of needs and technology competitors.
This research has several theoretical contributions. First, a feature of word2vec that words with high semantic similarity appear in adjacent vector space is used as a clustering methodology. Since previous studies have focused on just the vector source of each word, they use vector calculation or distance between words to interpret a single word. However, this research interprets the needs of users through a combination of words using the clustering methodology. Second, the proposed methodology uses linguistic information based on natural language processing. Though previous text mining methodology uses the meaning of words and their frequency, this methodology can bring a multi-dimensional text mining approach. Using opinion mining, the sentimental value is propagated to neutral words in the existing methodology. In addition, single words are structured by user needs, using their relationship and part of speech. The suggested methodology using both word2vec and K-medoid clustering has a contribution point that extracts potential information by considering the inter-word relationship based on word embedded vector unlike traditional topic modeling of LDA, which simply have a statistical approach to documents and words.
This research can produce efficiency in R&D management and industry fields in various ways. First, the suggested systematic approach can explore the user’s needs that are freely presented by the user and updated in real time without the large-scale survey for user satisfaction, which needs a lot of time and money. The main reasons for user opinions can be extracted, and a strategy made to increase users satisfaction with their products. From the case study of the car industry in this research, user needs for a speaker and navigation module are extracted. The speaker and navigation are not the main components of the car. However, users actively express their opinions about the speaker and navigation. In other words, even if the needs of the user are not the main component of their industry, they can be analyzed through the proposed methodology. Second, there is no additional process to reflect user opinions in the R&D process. The minimized R&D process can generate more economic profits, and make the R&D management process more flexible. The proposed methodology can present the structured needs result through the concept of opinion trigger structured by object and function, and it can utilize the result itself without additional work of analysis result unlike existing topic modeling. Third, a contradiction that high technology ability sometimes does not bring users high satisfaction can be resolved. Based on an opinion trigger, the main reason for user opinion and related technology can be clearly identified. By analyzing the relationship between needs and technology, the reason why technology cannot satisfy the needs of the user is suggested. An effective way to satisfy the needs of the user by developing exact technology attributes is suggested by analyzing those reasons.
However, this research has several limitations. First, one trigger can derive only one need. For example, an opinion trigger ‘design’ could be interpreted by ‘window design’, ‘roof design’, and ‘tire design’. However, since the PAM allows one keyword to one cluster, one trigger cannot form various needs. Second, the suggested methodology discovers technology opportunities in a specific technology. Various technology innovation insights, such as heterogeneous technology fields or technology fusion, cannot be reflected in the opportunities. To resolve these limitations, a new clustering methodology, such as overlapping k-means clustering, can be adopted for the suggested approach. Since the overlapping k-means clustering can assign one trigger to various clusters, it can derive more reasonable results. In addition, patents in more various technology fields should be collected, to reflect various technology innovation ideas.
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- A low latency and low power indirect topology for on-chip communication
- Development and application of a framework to estimate health care costs in China: The cervical cancer example
- New oral anti-coagulants versus vitamin K antagonists in high thromboembolic risk patients
- Enriched taxa were found among the gut microbiota of centenarians in East China
- Model-based QTL detection is sensitive to slight modifications in model formulation
- Modeling the residential distribution of enrolled students to assess boundary-induced disparities in public school access
- A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial
- Associations of MGMT promoter hypermethylation with squamous intraepithelial lesion and cervical carcinoma: A meta-analysis
- Differences in energy and nutritional content of menu items served by popular UK chain restaurants with versus without voluntary menu labelling: A cross-sectional study
- The association between disordered eating and health-related quality of life among children and adolescents: A systematic review of population-based studies
- Prescribing patterns of polypharmacy in Korean pediatric patients
- Factors associated with directly observed treatment in tuberculosis/HIV coinfection cases in Porto Alegre, 2009-2013: A retrospective cohort
- Evaluation of date palm pollen (Phoenix dactylifera L.) encapsulation, impact on the nutritional and functional properties of fortified yoghurt
- Association between maternal fermented food consumption and infant sleep duration: The Japan Environment and Children's Study
- Discerning the functional networks behind processing of music and speech through human vocalizations
- Preference-based serial decisions are counterintuitively influenced by emotion regulation and conscientiousness
- Subgenotyping and genetic variability of hepatitis C virus in Palestine
- Supra-threshold perception and neural representation of tones presented in noise in conditions of masking release
- Measuring sustainability of seed-funded earth science informatics projects
- Contrast-enhanced spectral mammography with a compact synchrotron source
- Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions
- Inequality in income change among cancer survivors five years after diagnosis: Evidence from a French national survey
- A novel fast-slow model of diabetes progression: Insights into mechanisms of response to the interventions in the Diabetes Prevention Program
- Integrated HIV surveillance finds recent adult hepatitis B virus (HBV) transmission and intermediate HBV prevalence among military in uncharacterized Caribbean country
- Declared impact of the US President’s statements and campaign statements on Latino populations’ perceptions of safety and emergency care access
- Two novel and correlated CF-causing insertions in the (TG)mTn tract of the CFTR gene
- Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis
- Practice and factors associated with active management of third stage of labor among obstetric care providers in Amhara region referral hospitals, North Ethiopia, 2018: A cross sectional study
- Animal-assisted therapy for patients in a minimally conscious state: A randomized two treatment multi-period crossover trial
- Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)
- Rice bran oil ameliorates inflammatory responses by enhancing mitochondrial respiration in murine macrophages
- Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs
- The effect of ‘Traffic-Light’ nutritional labelling in carbonated soft drink purchases in Ecuador
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- A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients
- Framework for rational donor selection in fecal microbiota transplant clinical trials
- HLA high-resolution typing by next-generation sequencing in Pandemrix-induced narcolepsy
- Health assessment of Conolophus subcristatus, Conolophus pallidus, and C. subcristatus X Amblyrhynchus cristatus hybrid (Galápagos land iguanas)
- Prognostic value of post-induction chemotherapy 18F-FDG PET-CT in stage II/III non-small cell lung cancer before (chemo-) radiation
- Risk factor-based subphenotyping of heart failure in the community
- An efficient and adaptive data-hiding scheme based on secure random matrix
- Endovascular treatment of different types of iliac occlusions—Results from an observational study
- Variation in pickleweed root-associated microbial communities at different locations of a saline solid waste management unit contaminated with petroleum hydrocarbons
- Consumption of rice, acceptability and sensory qualities of fortified rice amongst consumers of social safety net rice in Nepal
- Quantitative analysis of the bilateral coordination and gait asymmetry using inertial measurement unit-based gait analysis
- Application of metagenomic shotgun sequencing to detect vector-borne pathogens in clinical blood samples
- Higher underestimation of tumour size post-neoadjuvant chemotherapy with breast magnetic resonance imaging (MRI)—A concordance comparison cohort analysis
- Wealth accumulation in rotation forestry – Failure of the net present value optimization?
- Increased incidence of age-related macular degeneration in sensorineural hearing loss: A population-based cohort study
- Evaluating the foundations that help avert antimicrobial resistance: Performance of essential water sanitation and hygiene functions in hospitals and requirements for action in Kenya
- Effects of a hot ambient operating theatre on manual dexterity, psychological and physiological parameters in staff during a simulated burn surgery
- Introduction of quality management in a National Reference Laboratory in Germany
- Histopathological investigation of complex gill disease in sea farmed Atlantic salmon
- Common variants in glyoxalase I do not increase chronic pancreatitis risk
- Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types
- Interaction of detergents with biological membranes: Comparison of fluorescence assays with filtration protocols and implications for the rates of detergent association, dissociation and flip-flop
- Potential causes of early death among admitted newborns in a rural Tanzanian hospital
- Identification of glomerular and podocyte-specific genes and pathways activated by sera of patients with focal segmental glomerulosclerosis
- Prevalence and correlates of partner violence among adolescent girls and young women: Evidence from baseline data of a cluster randomised trial in Tanzania
- Development of an integrated fingerstick blood self-collection device for radiation countermeasures
- Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease
- Effects of arthroscopic vs. mini-open rotator cuff repair on function, pain & range of motion. A systematic review and meta-analysis
- Broiler welfare trade-off: A semi-quantitative welfare assessment for optimised welfare improvement based on an expert survey
- Engagement in care among women and their infants lost to follow-up under Option B+ in eSwatini
- Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal
- Nanoaperture fabrication via colloidal lithography for single molecule fluorescence analysis
- A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis
- Sialochemical analysis in polytraumatized patients in intensive care units
- The black sheep effect: The case of the deviant ingroup robot
- No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer’s disease
- Implementation of an international standardized set of outcome indicators in pregnancy and childbirth in Kenya: Utilizing mobile technology to collect patient-reported outcomes
- Breastfeeding support through wet nursing during nutritional emergency: A cross sectional study from Rohingya refugee camps in Bangladesh
- Does route matter? Impact of route of oxytocin administration on postpartum bleeding: A double-blind, randomized controlled trial
- Research on OpenCL optimization for FPGA deep learning application
- Drug therapy problems, medication adherence and treatment satisfaction among diabetic patients on follow-up care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
- Quality of life and symptom intensity over time in people with cancer receiving palliative care: Results from the international European Palliative Care Cancer Symptom study
- The dynamics of Early Celtic consumption practices: A case study of the pottery from the Heuneburg
- Safety and efficacy of artesunate-amodiaquine combined with either methylene blue or primaquine in children with falciparum malaria in Burkina Faso: A randomized controlled trial
- “Cementing” marriages through childbearing in subsequent unions: Insights into fertility differentials among first-time married and remarried women in Ghana
- Single session high definition transcranial direct current stimulation to the cerebellum does not impact higher cognitive function
- The contribution of age structure to the international homicide decline
- Genetic structure of Mexican lionfish populations in the southwest Gulf of Mexico and the Caribbean Sea
- A physiological dose of oral vitamin B-12 improves hematological, biochemical-metabolic indices and peripheral nerve function in B-12 deficient Indian adolescent women
- Nutritional status, cognitive achievement, and educational attainment of children aged 8-11 in rural South India
- Costs and cost-effectiveness analyses of mCARE strategies for promoting care seeking of maternal and newborn health services in rural Bangladesh
- Cause-specific mortality in the general population with transient dipstick-proteinuria
- Assessing hand dysfunction in cervical spondylotic myelopathy
- KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
- Variation in activity rates may explain sex-specific dorsal color patterns in Habronattus jumping spiders
- Adjusting for spatial variation when assessing individual-level risk: A case-study in the epidemiology of snake-bite in Sri Lanka
- Acute sprint exercise transcriptome in human skeletal muscle
- Parenting and personality disorder: An overview and meta-synthesis of systematic reviews
- Female rats release a trapped cagemate following shaping of the door opening response: Opening latency when the restrainer was baited with food, was empty, or contained a cagemate
- Multiplex communities and the emergence of international conflict
- The impact of socioeconomic status on emergency department outcome in a low-income country setting: A registry-based analysis
- Effect of psycho-social support by teachers on improving mental health and hope of adolescents in an earthquake-affected district in Nepal: A cluster randomized controlled trial
- A cluster-randomized controlled trial of the effectiveness of the JUMP Math program of math instruction for improving elementary math achievement
- Transgenic mouse model for conditional expression of influenza hemagglutinin-tagged human SLC20A1/PIT1
- Use of rapid Model for End-Stage Liver Disease (MELD) increases for liver transplant registrant prioritization after MELD-Na and Share 35, an evaluation using data from the United Network for Organ Sharing
- Fishery Improvement Projects as a governance tool for fisheries sustainability: A global comparative analysis
- QRStree: A prefix tree-based model to fetal QRS complexes detection
- Fundraising and vote distribution: A non-equilibrium statistical approach
- Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity
- Gene expression profiling of whole blood: A comparative assessment of RNA-stabilizing collection methods
- Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation
- Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe
- P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
- Using long-term datasets to assess the impacts of dietary exposure to neonicotinoids on farmland bird populations in England
- Genetic mapping of distal femoral, stifle, and tibial radiographic morphology in dogs with cranial cruciate ligament disease
- Optimized bioluminescence analysis of adenosine triphosphate (ATP) released by platelets and its application in the high throughput screening of platelet inhibitors
- Consumer beliefs about healthy foods and diets
- An observational study on intracutaneous sodium storage in intensive care patients and controls
- Recovery when you are on your own: Slow population responses in an isolated marine reserve
- How does the method change what we measure? Comparing virtual reality and text-based surveys for the assessment of moral decisions in traffic dilemmas
- Is recent Afghanistan survey data suitable for fertility analysis? A regional investigation based on fertility inhibiting determinants
- Analytical validation of the Target Selector ctDNA platform featuring single copy detection sensitivity for clinically actionable EGFR, BRAF, and KRAS mutations
- Comparison of two swept-source optical coherence tomography biometers and a partial coherence interferometer
- Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents
- A social media intervention to improve nutrition knowledge and behaviors of low income, pregnant adolescents and adult women
- Detection of vision and /or hearing loss using the interRAI Community Health Assessment aligns well with common behavioral vision/hearing measurements
- E-MOVIE - Experimental MOVies for Induction of Emotions in neuroscience: An innovative film database with normative data and sex differences
- Does self-reported pregnancy loss identify women at risk of an adverse cardiovascular phenotype in later life? Insights from UK Biobank
- An elevated glycemic gap predicts adverse outcomes in diabetic patients with necrotizing fasciitis
- 40-Hz auditory steady-state responses and the complex information processing: An exploratory study in healthy young males
- Highly diverse anaerobe-predominant vaginal microbiota among HIV-infected pregnant women in Zambia
- Decision-based models of the implementation of interventions in systems of healthcare: Implementation outcomes and intervention effectiveness in complex service environments
- Dual number-based variational data assimilation: Constructing exact tangent linear and adjoint code from nonlinear model evaluations
- Ultra-deep sequencing reveals pre-mRNA splicing as a sequence driven high-fidelity process
- Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis
- Lek-associated movement of a putative Ebolavirus reservoir, the hammer-headed fruit bat (Hypsignathus monstrosus), in northern Republic of Congo
- Attenuation correction using 3D deep convolutional neural network for brain 18F-FDG PET/MR: Comparison with Atlas, ZTE and CT based attenuation correction
- Differences in macular capillary parameters between healthy black and white subjects with Optical Coherence Tomography Angiography (OCTA)
- Sealing agent reduces formation of single and dual-species biofilms of Candida albicans and Enterococcus faecalis on screw joints at the abutment/implant interface
- Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species
- What is the optimum time for initiation of early mobilization in mechanically ventilated patients? A network meta-analysis
- Cognitive aptitude, peers, and trajectories of marijuana use from adolescence through young adulthood
- Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study
- Accuracy and interobserver-agreement of respiratory rate measurements by healthcare professionals, and its effect on the outcomes of clinical prediction/diagnostic rules
- Does task delegation to non-physician health professionals improve quality of diabetes care? Results of a scoping review
- The Univariate Flagging Algorithm (UFA): An interpretable approach for predictive modeling
- Profiles and trajectories of impaired social cognition in people with Prader-Willi syndrome
- Effect of pimobendan on physical fitness, lactate and echocardiographic parameters in dogs with preclinical mitral valve disease without cardiomegaly
- Sub-types of safety behaviours and their effects on social anxiety disorder
- Engaging in prosocial behavior explains how high self-control relates to more life satisfaction: Evidence from three Chinese samples
- Artificial fingerprints for cross-comparison of forensic DNA and protein recovery methods
- The organization of Golgi in Drosophila bristles requires microtubule motor protein function and a properly organized microtubule array
- Direct and moderating effects of environmental regulation intensity on enterprise technological innovation: The case of China
- Prevalence and associated factors of depression among Korean adolescents
- Transcriptome analysis of PK-15 cells in innate immune response to porcine deltacoronavirus infection
- Geographic variation in cardiometabolic risk distribution: A cross-sectional study of 256,525 adult residents in the Illawarra-Shoalhaven region of the NSW, Australia
- Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
- Lipid profile changings after switching from rilpivirine/tenofovir disoproxil fumarate/emtricitabine to rilpivirine/tenofovir alafenamide/emtricitabine: Different effects in patients with or without baseline hypercholesterolemia
- A feature selection strategy for gene expression time series experiments with hidden Markov models
- Dissociating the sequential dependency of subjective temporal order from subjective simultaneity
- Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis
- Population-based estimates of engagement in HIV care and mortality using double-sampling methods following home-based counseling and testing in western Kenya
- Vaginal temperature as indicative of thermoregulatory response in Nellore heifers under different microclimatic conditions
- Galectin-9 gene (LGALS9) polymorphisms are associated with rheumatoid arthritis in Brazilian patients
- The association of brightness with number/duration in human newborns
- Microslit on a chip: A simplified filter to capture circulating tumor cells enlarged with microbeads
- Integrating continuous differential evolution with discrete local search for meander line RFID antenna design
- The impact of the French soda tax on prices and purchases. An ex post evaluation
- Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications
- Structural characterization of a novel polysaccharide from Sargassum thunbergii and its antioxidant and anti-inflammation effects
- Potential biomarker identification for Friedreich’s ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion
- Major drug resistance mutations to HIV-1 protease inhibitors (PI) among patients exposed to PI class failing antiretroviral therapy in São Paulo State, Brazil
- Chile (Capsicum annuum) plants transformed with the RB gene from Solanum bulbocastanum are resistant to Phytophthora capsici
- Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
- Analysis of gene co-expression networks of phosphate starvation and aluminium toxicity responses in Populus spp.
- Risk factors associated with IgA vasculitis with nephritis (Henoch–Schönlein purpura nephritis) progressing to unfavorable outcomes: A meta-analysis
- The prediction model of suicidal thoughts in Korean adults using Decision Tree Analysis: A nationwide cross-sectional study
- A multidimensional understanding of prosperity and well-being at country level: Data-driven explorations
- Factors associated with muscle mass in community-dwelling older people in Singapore: Findings from the SHIELD study
- The prevalence and risk of non-infectious comorbidities in HIV-infected and non-HIV infected men attending general practice in Australia
- Vibrio cholerae strains with inactivated cqsS gene overproduce autoinducer-2 which enhances resuscitation of dormant environmental V. cholerae
- Myocardial function in patients with anomalous left coronary artery from the pulmonary artery syndrome: A long-term speckle tracking echocardiographic study
- Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo
- Joint distribution for number of crossings and longest run in independent Bernoulli observations. The R package crossrun
- Learning to play badminton altered resting-state activity and functional connectivity of the cerebellar sub-regions in adults
- Children’s dietary diversity and related factors in Rwanda and Burundi: A multilevel analysis using 2010 Demographic and Health Surveys
- Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease
- Precluding rare outcomes by predicting their absence
- Tidal inlet seafloor changes induced by recently built hard structures
- A further study on Franciscobasis Machado & Bedê, 2016 (Odonata: Coenagrionidae), a newly described genus from Minas Gerais, Brazil
- Associative responses to visual shape stimuli in the mouse auditory cortex
- Extracellular matrix turnover and inflammation in chemically-induced TMJ arthritis mouse models
- LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure
- Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases
- Separating the effects of temperature and carbon allocation on the diel pattern of soil respiration in the different phenological stages in dry grasslands
- Unweaving tangled mortality and antibiotic consumption data to detect disease outbreaks – Peaks, growths, and foresight in swine production
- Factors associated with exclusive breast-feeding: A cross-sectional survey in Kaiyuan, Yunnan, Southwest China
- The Model of Mortality with Incident Cirrhosis (MoMIC) and the model of Long-term Outlook of Mortality in Cirrhosis (LOMiC)
- Burden of treatment-resistant depression in Medicare: A retrospective claims database analysis
- Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates
- Sharing the filmic experience - The physiology of socio-emotional processes in the cinema
- A super-SILAC based proteomics analysis of diffuse large B-cell lymphoma-NOS patient samples to identify new proteins that discriminate GCB and non-GCB lymphomas
- Pneumoproteins are associated with pulmonary function in HIV-infected persons
- Tissue-specific expression of IgG receptors by human macrophages ex vivo
- Electrical impedance myography for the detection of muscle inflammation induced by λ-carrageenan
- Clustering of the structures by using “snakes-&-dragons” approach, or correlation matrix as a signal
- Asymmetric valuation of gains and losses in effort-based decision making
- Genomic and metabolic differences between Pseudomonas putida populations inhabiting sugarcane rhizosphere or bulk soil
- Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis
- Gender linked fate explains lower legal abortion support among white married women
- L-3,3’,5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors
- eQTL mapping of rare variant associations using RNA-seq data: An evaluation of approaches
- Cell fishing: A similarity based approach and machine learning strategy for multiple cell lines-compound sensitivity prediction
- Macrogeographic genetic structure of Lutzomyia longipalpis complex populations using Next Generation Sequencing
- Dual-career through the elite university student-athletes’ lenses: The international FISU-EAS survey
- Machine learning prediction of emesis and gastrointestinal state in ferrets
- Impact of bitter tastant sub-qualities on retronasal coffee aroma perception
- Head orientation and electrode placement potentially influence fetal scalp ECG waveform
- Clinical outcomes associated with the use of the NexSite hemodialysis catheter with new exit barrier technology: Results from a prospective, observational multi-center registry study
- Geospatial correlates of early marriage and union formation in Ghana
- Disruption of white matter connectivity in chronic obstructive pulmonary disease
- Integrated evaluation of clinical, pathological and radiological prognostic factors in squamous cell carcinoma of the lung
- Saliva enhances infection of gingival fibroblasts by herpes simplex virus 1
- Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions
- An alternative approach for estimating the number needed to treat for survival endpoints
- Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines
- Can telemedicine initiative be an effective intervention strategy for improving treatment compliance for pediatric HIV patients: Evidences on costs and improvement in treatment compliance from Maharashtra, India
- Trial registration as a safeguard against outcome reporting bias and spin? A case study of randomized controlled trials of acupuncture
- Multi-disciplinary interventions for chronic pain involving education: A systematic review
- Impact of climate change on the integrity of the superstructure of deteriorated U.S. bridges
- Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
- Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials
- Testing gene by community disadvantage moderation of sexual health outcomes among urban women
- The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review
- Evaluation of a screening algorithm using the Strengths and Difficulties Questionnaire to identify children with mental health problems: A five-year register-based follow-up on school performance and healthcare use
- Optimized fast GPU implementation of robust artificial-neural-networks for k-space interpolation (RAKI) reconstruction
- The cost of illness and economic burden of endometriosis and chronic pelvic pain in Australia: A national online survey
- Refined distributed emotion vector representation for social media sentiment analysis
- Enhancing timeliness of drug overdose mortality surveillance: A machine learning approach
- A real-time gesture recognition system using near-infrared imagery
- Alcohol use and its association with sexual risk behaviors in the Armed Forces of the Republic of the Congo
- Improved survival rates in patients with H1N1 acute respiratory failure in Korea between 2009 and 2016
- Electroencephalographic features of discontinuous activity in anesthetized infants and children
- Tumor stromal type is associated with stromal PD-L1 expression and predicts outcomes in breast cancer
- Mutant prevention concentration of ozenoxacin for quinolone-susceptible or -resistant Staphylococcus aureus and Staphylococcus epidermidis
- The Echobot: An automated system for stimulus presentation in studies of human echolocation
- Evaluation of clinical manifestations, health risks, and quality of life among women with polycystic ovary syndrome
- Magnetic resonance imaging presentation of deep infiltrating endometriosis nodules before and after pregnancy: A case series
- Agrobacterium tumefaciens-mediated transformation of a hevein-like gene into asparagus leads to stem wilt resistance
- Effect of a Mentor Mother Programme on retention of mother-baby pairs in HIV care: A secondary analysis of programme data in Uganda
- Utilizing multiplex fluor LAMPs to illuminate multiple gene expressions in situ
- Genetic relationships between the RACK1 homolog cpc-2 and heterotrimeric G protein subunit genes in Neurospora crassa
- Is latent tuberculosis infection challenging in Iranian health care workers? A systematic review and meta-analysis
- A comparison of the risk of congestive heart failure-related hospitalizations in patients receiving hemodialysis and peritoneal dialysis - A retrospective propensity score-matched study
- A tailored approach to fusion transcript identification increases diagnosis of rare inherited disease
- Experiences, needs, and preferences for follow-up after stroke perceived by people with stroke and healthcare professionals: A focus group study
- Iodine supplementation of lactating women and assessment of infant visual information processing and maternal and infant thyroid function: A randomized trial
- The Nordic Maintenance Care Program: Does psychological profile modify the treatment effect of a preventive manual therapy intervention? A secondary analysis of a pragmatic randomized controlled trial
- Within-subject variability in human retinal nerve fiber bundle width
- Motivation for alcohol consumption or abstinence during pregnancy: A clinical-qualitative study in Brazil
- Comparison of conventional BLUP and single-step genomic BLUP evaluations for yearling weight and carcass traits in Hanwoo beef cattle using single trait and multi-trait models
- Do cognitive and non-cognitive abilities mediate the relationship between air pollution exposure and mental health?
- Molecular phylogeny and morphology reveal a new epiphytic species of Habenaria (Orchidaceae; Orchideae; Orchidinae) from Nepal
- Nitrogen nutrition is a key modulator of the sugar and organic acid content in citrus fruit
- Understanding variation in health service coverage and maternal health outcomes among districts in Rwanda – A qualitative study of local health workers’ perceptions
- Biased cognition in East Asian and Western cultures
- Physical fitness and physical self-concept of male and female young adults in Qatar
- Robust policy evaluation from large-scale observational studies
- Improved semi-supervised autoencoder for deception detection
- Delineation of high resolution climate regions over the Korean Peninsula using machine learning approaches
- Are spasticity, weakness, selectivity, and passive range of motion related to gait deviations in children with spastic cerebral palsy? A statistical parametric mapping study
- ProphET, prophage estimation tool: A stand-alone prophage sequence prediction tool with self-updating reference database
- Conspicuous and cryptic reef fishes from a unique and economically important region in the northern Red Sea
- Time scale of resilience loss: Implications for managing critical transitions in water quality
- Effectiveness of physical and cognitive-behavioural intervention programmes for chronic musculoskeletal pain in adults: A systematic review and meta-analysis of randomised controlled trials
- Relationship between feed efficiency indexes and performance, body measurements, digestibility, energy partitioning, and nitrogen partitioning in pre-weaning dairy heifers
- Long-stay patients in pediatric intensive care unit: Diagnostic-specific definition and predictors
- Evidence of ritual breakage of a ground stone tool at the Late Natufian site of Hilazon Tachtit cave (12,000 years ago)
- Whole genome sequencing to identify predictive markers for the risk of drug-induced interstitial lung disease
- A systematic review and thematic synthesis of Canada’s LGBTQ2S+ employment, labour market and earnings literature
- The occurrence of ‘Sleeping Beauty’ publications in medical research: Their scientific impact and technological relevance
- Analysis of the protein composition of the spindle pole body during sporulation in Ashbya gossypii
- Assessing undergraduate student and faculty views on animal research: What do they know, whom do they trust, and how much do they care?
- The views and experiences of general dental practitioners (GDP’s) in West Yorkshire who used the International Caries Detection and Assessment System (ICDAS) in research
- Compare HIV/syphilis infections between age groups and explore associated factors of HIV/syphilis co-infections among men who have sex with men in Shenzhen, China, from 2009 to 2017
- Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers
- Effect of exclusive breastfeeding cessation time on childhood morbidity and adverse nutritional outcomes in Ethiopia: Analysis of the demographic and health surveys
- Dual antiplatelet therapy in patients with cirrhosis and acute myocardial infarction – A 13-year nationwide cohort study
- Relationships between electrolyte and amino acid compositions in sweat during exercise suggest a role for amino acids and K+ in reabsorption of Na+ and Cl- from sweat
- A simplified vocal tract model for articulation of [s]: The effect of tongue tip elevation on [s]
- Management and glycemic control of patients with type 2 diabetes mellitus at primary care level in Kedah, Malaysia: A statewide evaluation
- Anabolic steroids among resistance training practitioners
- Factors associated with unsafe abortion practices in Nepal: Pooled analysis of the 2011 and 2016 Nepal Demographic and Health Surveys
- New methods of removing debris and high-throughput counting of cyst nematode eggs extracted from field soil
- Vehicle configurations associated with anatomical-specific severe injuries resulting from traffic collisions
- What has reproductive health decision-making capacity got to do with unintended pregnancy? Evidence from the 2014 Ghana Demographic and Health Survey
- Circulating levels of CD34+ cells predict long-term cardiovascular outcomes in patients on maintenance hemodialysis
- Penetration of linezolid into bone tissue 24 h after administration in patients with multidrug-resistant spinal tuberculosis
- Prosthesis design of animal models of periprosthetic joint infection following total knee arthroplasty: A systematic review
- Coherent diversification in corporate technological portfolios
- Technology opportunity discovery by structuring user needs based on natural language processing and machine learning
- Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage
- Factors associated with the use of diet and the use of exercise for prostate cancer by long-term survivors
- Congenital Zika Syndrome in a Brazil-Paraguay-Bolivia border region: Clinical features of cases diagnosed between 2015 and 2018
- Trends and impact of antimicrobial resistance on older inpatients with urinary tract infections (UTIs): A national retrospective observational study
- Malawian children with uncomplicated and cerebral malaria have decreased activated Vγ9Vδ2 γδ T cells which increase in convalescence
- Predictors of mortality within the first year of initiating antiretroviral therapy in urban and rural Kenya: A prospective cohort study
- The investment case as a mechanism for addressing the NCD burden: Evaluating the NCD institutional context in Jamaica, and the return on investment of select interventions
- Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection
- Bringing fear into focus: The intersections of HIV and masculine gender norms in Côte d’Ivoire
- Scientific output scales with resources. A comparison of US and European universities
- Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis
- Effect of host genotype and Eimeria acervulina infection on the metabolome of meat-type chickens
- Gravity influences bevacizumab distribution in an undisturbed balanced salt solution in vitro
- Agrobacterium tumefaciens-mediated transformation and expression of GFP in Ascochyta lentis to characterize ascochyta blight disease progression in lentil
- Proteomic changes of aryl hydrocarbon receptor (AhR)-silenced porcine granulosa cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
- Localization and dynamic change of saponins in Cyclocarya paliurus (Batal.) Iljinskaja
- Improving the forecasting performance of temporal hierarchies
- Prevalence of surgically correctable conditions among children in a mixed urban-rural community in Nigeria using the SOSAS survey tool: Implications for paediatric surgical capacity-building
- Relatives’ attachment anxiety mediates the association between perceived loss and expressed emotion in early psychosis
- The impact of PEPFAR transition on HIV service delivery at health facilities in Uganda
- Impact of peri-intraventricular haemorrhage and periventricular leukomalacia in the neurodevelopment of preterms: A systematic review and meta-analysis
- Correction: Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
- Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection
- Determination of factors affecting medication adherence in type 2 diabetes mellitus patients using a nationwide claim-based database in Japan
- Beyond the metabolic syndrome: Visceral and marrow adipose tissues impair bone quantity and quality in Cushing’s disease
- Clade II Candida auris possess genomic structural variations related to an ancestral strain
- Effect of aging on the association between ankle muscle strength and the control of bipedal stance
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- Kinematic and electromyographic analysis of variations in Nordic hamstring exercise
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- The accumulation of deficits approach to describe frailty
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- Utility of qSOFA and modified SOFA in severe malaria presenting as sepsis
- Correction: Perspectives of general dental practitioners on preventive, patient-centred, and evidence-based oral healthcare—A Q-methodology study
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- Give science and peace a chance: Speeches by Nobel laureates in the sciences, 1901-2018
- The effect of food anticipation on cognitive function: An eye tracking study
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- The trigger-information-response model: Exploring health literacy during the first six months following a kidney transplantation
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- Joint emulation of Earth System Model temperature-precipitation realizations with internal variability and space-time and cross-variable correlation: fldgen v2.0 software description
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- Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
- Correction: Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants
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- A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage
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- RCT evaluation of Skhokho: A holistic school intervention to prevent gender-based violence among South African Grade 8s
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- A systematic review of complementary and alternative medicine in oncology: Psychological and physical effects of manipulative and body-based practices
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- Determinants of temperature sensitivity of soil respiration with the decline of a foundation species
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- Regional, institutional, and departmental factors associated with gender diversity among BS-level chemical and electrical engineering graduates
- Transepithelial transport of P-glycoprotein substrate by the Malpighian tubules of the desert locust
- Sex affects immunolabeling for histone 3 K27me3 in the trophectoderm of the bovine blastocyst but not labeling for histone 3 K18ac
- A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan
- Replacing plasma membrane outer leaflet lipids with exogenous lipid without damaging membrane integrity
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- Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study
- Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review
- The motility-based swim-up technique separates bull sperm based on differences in metabolic rates and tail length
- Synbiotic supplementation to decrease Salmonella colonization in the intestine and carcass contamination in broiler birds
- Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease
- States with higher minimum wages have lower STI rates among women: Results of an ecological study of 66 US metropolitan areas, 2003-2015
- Weakening the subjective sensation of own hand ownership does not interfere with rapid finger movements
- Identification of DNA methyltransferases and demethylases in Solanum melongena L., and their transcription dynamics during fruit development and after salt and drought stresses
- Environmental conditions for Jamestown Canyon virus correlated with population-level resource selection by white-tailed deer in a suburban landscape
- The contribution of linear perspective cues and texture gradients in the perceptual rescaling of stimuli inside a Ponzo illusion corridor
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- Particularly neglected in countries with other challenges: High Toxoplasma gondii seroprevalence in pregnant women in Kabul, Afghanistan, while a low proportion know about the parasite
- Implementing advance care planning in routine nursing home care: The development of the theory-based ACP+ program
- Identifying genetic lineages through shape: An example in a cosmopolitan marine turtle species using geometric morphometrics
- The causality of borrowing: Lexical loans in Eurasian languages
- The uptake of the pharmacy-dispensed naloxone kit program in Ontario: A population-based study
- Gaze and body cues interplay during interactive requests
- Acetylcholine-mediated top-down attention improves the response to bottom-up inputs by deformation of the attractor landscape
- Deep architectures for long-term stock price prediction with a heuristic-based strategy for trading simulations
- Vaccination status of patients using anti-TNF therapy and the physicians’ behavior shaping the phenomenon: Mixed-methods approach
- Organizational justice and illness reporting among Japanese employees with chronic diseases
- CavBench: A benchmark for protein cavity detection methods
- Antimicrobial resistance (AMR) and molecular characterization of Neisseria gonorrhoeae in Ghana, 2012-2015
- Prevalence of methicillin-resistant Staphylococcus aureus in healthy Chinese population: A system review and meta-analysis
- Suppression treatment differentially influences the microbial community and the occurrence of broad host range plasmids in the rhizosphere of the model cover crop Avena sativa L.
- Risk of pneumonia among residents living near goat and poultry farms during 2014-2016
- Lipid levels after childbirth and association with number of children: A population-based cohort study
- Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study
- ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
- Effects of dietary intake and nutritional status on cerebral oxygenation in patients with chronic kidney disease not undergoing dialysis: A cross-sectional study
- Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
- Flexible learning spaces facilitate interaction, collaboration and behavioural engagement in secondary school
- Clinical significance and prognostic role of hypoxia-induced microRNA 382 in gastric adenocarcinoma
- Genome-wide investigation of superoxide dismutase (SOD) gene family and their regulatory miRNAs reveal the involvement in abiotic stress and hormone response in tea plant (Camellia sinensis)
- Classifying recurrent Mycobacterium tuberculosis cases in Georgia using MIRU-VNTR typing
- Prevalence of Trypanosoma cruzi infection in active military population of The Colombian National Army gathered in five departments
- An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway
- Sarcopenia as a prognostic factor for survival in patients with locally advanced gastroesophageal adenocarcinoma
- Increased aggression and reduced aversive learning in honey bees exposed to extremely low frequency electromagnetic fields
- Attending to design when developing complex health interventions: A qualitative interview study with intervention developers and associated stakeholders
- Increased fecundity of Aphis fabae on Vicia faba plants following seed or leaf inoculation with the entomopathogenic fungus Beauveria bassiana
- Is summer food intake a limiting factor for boreal browsers? Diet, temperature, and reproduction as drivers of consumption in female moose
- Characterization of sound scattering layers in the Bay of Biscay using broadband acoustics, nets and video
- Conducting human challenge studies in LMICs: A survey of researchers and ethics committee members in Thailand
- eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization
- Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy
- The interplay of personality and attitudes toward own aging across two decades of later life
- Robust automated reading of the skin prick test via 3D imaging and parametric surface fitting
- Reconstructing the population history of the sandy beach amphipod Haustorioides japonicus using the calibration of demographic transition (CDT) approach
- A psychoacoustic application for the adjustment of electrical hearing thresholds in cochlear implant patients
- Correction: Blue light-dependent human magnetoreception in geomagnetic food orientation
- Re-evaluation of a Tn5::gacA mutant of Pseudomonas syringae pv. tomato DC3000 uncovers roles for uvrC and anmK in promoting virulence
- Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study
- Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma
- The impact of shared knowledge on speakers’ prosody
- Effects of insecticides, fipronil and imidacloprid, on the growth, survival, and behavior of brown shrimp Farfantepenaeus aztecus
- Prevalence of pectus excavatum (PE), pectus carinatum (PC), tracheal hypoplasia, thoracic spine deformities and lateral heart displacement in thoracic radiographs of screw-tailed brachycephalic dogs
- Validation of the vignette-based German Exercise Causality Orientation Scale (G-ECOS)
- Hierarchical classification of snowmelt episodes in the Pyrenees using seismic data
- A national survey of videolaryngoscopes and alternative intubation devices in Hungary
- The relevance of U.S. Strategic Highway Safety Plans in a future context
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- Anti-inflammatory effects induced by ultralow concentrations of bupivacaine in combination with ultralow concentrations of sildenafil (Viagra) and vitamin D3 on inflammatory reactive brain astrocytes
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- Urban commuting dynamics in response to public transit upgrades: A big data approach
- Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-κB pathways
- When resolution does matter: Modelling indirect contacts in dairy farms at different levels of detail
- Molecular epidemiology of Mycoplasma hyorhinis porcine field isolates in the United States
- Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation
- Adolescents living with HIV are at higher risk of death and loss to follow up from care: Analysis of cohort data from eight health facilities in Ethiopia
- Identification of social relation within pedestrian dyads
- Blood donation and health status based on SF-36: The mediating effect of cognition in blood donation
- The cost-effectiveness of controlling cervical cancer using a new 9-valent human papillomavirus vaccine among school-aged girls in Australia
- Inactivation of chronic wasting disease prions using sodium hypochlorite
- Analysing linear multivariate pattern transformations in neuroimaging data
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- A method for predicting background advertisement exposure parameters in sporting events: Televised football game approach
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- Associations between nocturnal sleep duration, midday nap duration and body composition among adults in Southwest China
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- Molecular detection and genetic characterization of Bartonella species from rodents and their associated ectoparasites from northern Tanzania
- Estimation of the number of HCV-positive patients in Italy
- Comparative cost analysis of point-of-care versus laboratory-based testing to initiate and monitor HIV treatment in South Africa
- Insights into the behavior of six rationally designed peptides based on Escherichia coli’s OmpA at the water-dodecane interface
- Identification of muscle-specific candidate genes in Simmental beef cattle using imputed next generation sequencing
- A game theoretic setting of capitation versus fee-for-service payment systems
- In utero exposure to economic fluctuations and birth outcomes: An analysis of the relevance of the local unemployment rate in Brazilian state capitals
- QTL mapping for aluminum tolerance in RIL population of soybean (Glycine max L.) by RAD sequencing
- Establishing an infrastructure for collaboration in primate cognition research
- Evaluation of left ventricular dimension and systolic function by standard transthoracic echocardiography before and 24-hours after percutaneous closure of patent ductus arteriosus in 120 dogs
- Modeling environmental variability and network formation among pastoral nomadic households: Implications for the rise of the Mongol Empire
- Changes in real-life practice for hepatocellular carcinoma patients in the Republic of Korea over a 12-year period: A nationwide random sample study
- Correction: Homology analysis of malware based on ensemble learning and multifeatures
- Illness beliefs and emotional responses in mildly disabled stroke survivors: A qualitative study
- Extended-wavelength diffuse reflectance spectroscopy with a machine-learning method for in vivo tissue classification
- Modeling the natural history of fatty liver using lifestyle–related risk factors: Effects of body mass index (BMI) on the life–course of fatty liver
- Development of a recombinant replication-deficient rabies virus-based bivalent-vaccine against MERS-CoV and rabies virus and its humoral immunogenicity in mice
- Educational achievement at age 9.5 years of children born to mothers maintained on methadone during pregnancy
- Comparative transcriptome analysis of galls from four different host plants suggests the molecular mechanism of gall development
- Experiences with peer support for breastfeeding in Beirut, Lebanon: A qualitative study
- Elucidating optical field directed hierarchical self-assembly of homogenous versus heterogeneous nanoclusters with femtosecond optical tweezers
- Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer
- Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality
- Correction: Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation
- Correction: Estimating Body Composition in Adolescent Sprint Athletes: Comparison of Different Methods in a 3 Years Longitudinal Design
- Quality of labor and birth care in Sindh Province, Pakistan: Findings from direct observations at health facilities
- A comparison of sLASER and MEGA-sLASER using simultaneous interleaved acquisition for measuring GABA in the human brain at 7T
- Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis
- Intrabladder pressure as predictor of intra-abdominal pressure in horses
- Pollock avoided hydrodynamic instabilities to paint with his dripping technique
- Metabolomic analysis of the occurrence of bitter fruits on grafted oriental melon plants
- Photo-degradation dynamics of five neonicotinoids: Bamboo vinegar as a synergistic agent for improved functional duration
- Use of acoustic emission to identify novel candidate biomarkers for knee osteoarthritis (OA)
- Cetacean biodiversity, spatial and temporal trends based on stranding records (1920-2016), Victoria, Australia
- Neutrophil elastase inhibitor purification strategy from cowpea seeds
- Correction: Hafting of Middle Paleolithic tools in Latium (central Italy): New data from Fossellone and Sant’Agostino caves
- Coherent poly propagation materials with 3-dimensional photonic control over visible light
- Characterization of Worldwide Olive Germplasm Banks of Marrakech (Morocco) and Córdoba (Spain): Towards management and use of olive germplasm in breeding programs
- Can non-pharmacological interventions reduce hospital admissions in people with dementia? A systematic review
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- Genotyping and antimicrobial resistance of Streptococcus uberis isolated from bovine clinical mastitis
- Isotopic compositions of ground ice in near-surface permafrost in relation to vegetation and microtopography at the Taiga–Tundra boundary in the Indigirka River lowlands, northeastern Siberia
- Financial inclusion and intimate partner violence: What does the evidence suggest?
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- Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition
- Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer
- Take one step backward to move forward: Assessment of genetic diversity and population structure of captive Asian woolly-necked storks (Ciconia episcopus)
- Money doesn’t matter! Householders’ intentions to reduce standby power are unaffected by personalised pecuniary feedback
- Validating a scale to measure engineers’ perceived self-efficacy for engineering education outreach
- Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder
- Nursing students and nurses’ knowledge and attitudes regarding children’s pain: A comparative cross-sectional study
- Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum
- Knowledge, attitudes and medical practice regarding hepatitis B prevention and management among healthcare workers in Northern Vietnam
- Development and validation of a symptom assessment tool for postmicturition dribble: A prospective, multicenter, observational study in Korea
- Identification of closely related Ixodes species by protein profiling with MALDI-TOF mass spectrometry
- When calculators lie: A demonstration of uncritical calculator usage among college students and factors that improve performance
- Socio-economic characteristics and career intentions of the WiSDOM health professional cohort in South Africa
- Correction: Neural computational model GrowthEstimate: A model for studying living resources through digestive efficiency
- Social proximity in dairy calves is affected by differences in pessimism
- Amphibian skin-associated Pigmentiphaga: Genome sequence and occurrence across geography and hosts
- Expanded consumer niche widths may signal an early response to spatial protection
- Moral grandstanding in public discourse: Status-seeking motives as a potential explanatory mechanism in predicting conflict
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- Hyaluronic acid and epidermal growth factor improved the bovine embryo quality by regulating the DNA methylation and expression patterns of the focal adhesion pathway
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- A novel, wearable, electronic visual aid to assist those with reduced peripheral vision
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- Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Factors influencing cultivated ginseng (Panax ginseng C. A. Meyer) bioactive compounds
- Estimation of soil pH with geochemical indices in forest soils
- Multiplexed editing of a begomovirus genome restricts escape mutant formation and disease development
- Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures
- Collaboration and followership: A stochastic model for activities in social networks
- Evaluating access to oral anti-diabetic medicines: A cross-sectional survey of prices, availability and affordability in Shaanxi Province, Western China
- Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles
- Use of a pressure-sensing walkway system for biometric assessment of gait characteristics in goats
- Current status and direct medical cost of amyotrophic lateral sclerosis in the region of Catalonia: A population-based analysis
- Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
- Can work climate foster pro-environmental behavior inside and outside of the workplace?
- Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA
- Pelvic alignment changes during the perinatal period
- Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
- Life-course trajectories of body mass index and subsequent cardiovascular risk among Chinese population
- Inhibitory interaction networks among coevolved Streptomyces populations from prairie soils
- Exploiting contextual information to improve call prediction
- Visual inputs decrease brain activity in frontal areas during silent lipreading
- The synergistic effects of TaAGP.L-B1 and TaSSIVb-D mutations in wheat lead to alterations of gene expression patterns and starch content in grain development
- Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets
- Robust, real-time generic detector based on a multi-feature probabilistic method
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- Xenon lamps used for fruit surface sterilization can increase the content of total flavonols in leaves of Lactuca sativa L. without any negative effect on net photosynthesis
- An alternative procedure to obtain the mortality rate with non-linear functions: Application to the case of the Spanish population
- Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
- Longitudinal assessment of post-surgical physical activity in endometrial and ovarian cancer patients
- THINGS: A database of 1,854 object concepts and more than 26,000 naturalistic object images
- Evaluation of ranibizumab and aflibercept for the treatment of diabetic macular edema in daily clinical practice
- Proteomic analysis of Escherichia coli detergent-resistant membranes (DRM)
- Correction: Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor
- Correction: Predicting childhood obesity using electronic health records and publicly available data
- Correction: Estimating the value of tropical coastal wetland habitats to fisheries: Caveats and assumptions
- Correction: The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
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- Supporting informed clinical trial decisions: Results from a randomized controlled trial evaluating a digital decision support tool for those with intellectual disability
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- Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Hepatopulmonary syndrome has low prevalence of pulmonary vascular abnormalities on chest computed tomography
- Early and long-term outcomes of coronary artery bypass surgery with and without use of heart-lung machine and with special respect to renal function - A retrospective study
- Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
- The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population
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- Correction: Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells
- Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
- Remarkable cell recovery from cerebral ischemia in rats using an adaptive escalator-based rehabilitation mechanism
- Integrating environmental and neighborhood factors in MaxEnt modeling to predict species distributions: A case study of Aedes albopictus in southeastern Pennsylvania
- Post-overdose interventions triggered by calling 911: Centering the perspectives of people who use drugs (PWUDs)
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- Analysis of gear surface morphology based on gray level co-occurrence matrix and fractal dimension
- Abiotic, present-day and historical effects on species, functional and phylogenetic diversity in dry grasslands of different age
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- HIV drug resistance in persons who inject drugs enrolled in an HIV prevention trial in Indonesia, Ukraine, and Vietnam: HPTN 074
- Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery
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- Longitudinal trends of and factors associated with inappropriate antibiotic prescribing for non-bacterial acute respiratory tract infection in Japan: A retrospective claims database study, 2012–2017
- Revealing users’ experience and social interaction outcomes following a web-based smoking prevention intervention for adolescents: A qualitative study
- Coordination of human movements resulting in motor strategies exploited by skilled players during a throwing task
- Impact of pericardiectomy on exercise capacity and sleep of patients with chronic constrictive pericarditis
- Blue-violet light decreases VEGFa production in an in vitro model of AMD
- Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach
- Speed of processing training and depression in assisted and independent living: A randomized controlled trial
- Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient
- What happens in the brain of meditators when perception changes but not the stimulus?
- Comparison of HIV-1 Vif and Vpu accessory proteins for delivery of polyepitope constructs harboring Nef, Gp160 and P24 using various cell penetrating peptides
- Are degree of urbanisation and travel times to healthcare services associated with the processes of care and outcomes of heart failure? A retrospective cohort study based on administrative data
- A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing
- Influence of transcutaneous vagus nerve stimulation on cardiac vagal activity: Not different from sham stimulation and no effect of stimulation intensity
- Co-prescription network reveals social dynamics of opioid doctor shopping
- Contractile properties of superficial skeletal muscle affect postural control in healthy young adults: A test of the rambling and trembling hypothesis
- Does intrauterine crowding affect the force generating capacity and muscle composition of the piglet front limb?
- Correction: Measuring compassionate healthcare with the 12-item Schwartz Center Compassionate Care Scale
- Facilitators and barriers to traditional medicine use among cancer patients in Malawi
- Expression of CMV protein pp65 in cutaneous malignant melanoma
- The evolution of mental health outcomes across a combat deployment cycle: A longitudinal study of a Guam-based National Guard unit
- Caesarean section delivery and childhood obesity in a British longitudinal cohort study
- Incidence, characteristics, and mortality of infective endocarditis in France in 2011
- Pfcyp51 exclusively determines reduced sensitivity to 14α-demethylase inhibitor fungicides in the banana black Sigatoka pathogen Pseudocercospora fijiensis
- Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin
- Histological and developmental insights into the herbivorous dentition of tapinocephalid therapsids
- Differential immunomodulation of T-cells by immunoglobulin replacement therapy in primary and secondary antibody deficiency
- A longitudinal study on perceived health in cardiovascular patients: The role of conscientiousness, subjective wellbeing and cardiac self-efficacy
- The effectiveness of interferon beta versus glatiramer acetate and natalizumab versus fingolimod in a Polish real-world population
- Interactions of Streptococcus suis serotype 9 with host cells and role of the capsular polysaccharide: Comparison with serotypes 2 and 14
- Honey bee and native solitary bee foraging behavior in a crop with dimorphic parental lines
- A flexible formula for incorporating distributive concerns into cost-effectiveness analyses: Priority weights
- Correction: Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- A reconnaissance survey of farmers’ awareness of hypomagnesaemic tetany in UK cattle and sheep farms
- Health workers’ perception of malaria rapid diagnostic test and factors influencing compliance with test results in Ebonyi state, Nigeria
- Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods
- The increasing importance of fellowships and career development awards in the careers of early-stage biomedical academic researchers
- Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components
- Auxin driven indoleamine biosynthesis and the role of tryptophan as an inductive signal in Hypericum perforatum (L.)
- Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development
- Distance to large rivers affects fish diversity patterns in highly dynamic streams of Central Amazonia
- Real vs. immersive-virtual emotional experience: Analysis of psycho-physiological patterns in a free exploration of an art museum
- Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study
- Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses
- Modeling ENSO impact on rice production in the Mekong River Delta
- The feasibility of a behavioral group intervention after weight-loss surgery: A randomized pilot trial
- EMR-integrated minimal core dataset for routine health care and multiple research settings: A case study for neuroinflammatory demyelinating diseases
- A review of a 13-month period of FilmArray Meningitis/Encephalitis panel implementation as a first-line diagnosis tool at a university hospital
- Increased BMI has a linear association with late-onset preeclampsia: A population-based study
- Autoantibody production significantly decreased with APRIL/BLyS blockade in murine chronic rejection kidney transplant model
- Vancomycin-resistance gene cluster, vanC, in the gut microbiome of acute leukemia patients undergoing intensive chemotherapy
- Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
- Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP
- Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn’s disease and ulcerative colitis
- Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells
- Autophagy is important to the acidogenic metabolism of Aspergillus niger
- Continuous ratings of movie watching reveal idiosyncratic dynamics of aesthetic enjoyment
- Sensitivity and specificity of serum soluble interleukin-2 receptor for diagnosing sarcoidosis in a population of patients suspected of sarcoidosis
- Enhancing genomic selection by fitting large-effect SNPs as fixed effects and a genotype-by-environment effect using a maize BC1F3:4 population
- Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry
- Microbial induced solidification and stabilization of municipal solid waste incineration fly ash with high alkalinity and heavy metal toxicity
- Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses
- A fault-tolerant aware scheduling method for fog-cloud environments
- Correction: BCG vaccination and tuberculosis prevention: A forty years cohort study, Monastir, Tunisia
- Correction: Perceptions among transgender women of factors associated with the access to HIV/AIDS-related health services in Yogyakarta, Indonesia
- Assessing the convergent validity between the automated emotion recognition software Noldus FaceReader 7 and Facial Action Coding System Scoring
- Deep learning based banana plant detection and counting using high-resolution red-green-blue (RGB) images collected from unmanned aerial vehicle (UAV)
- Comparison of cardiorespiratory fitness between preschool children with normal and excess body adipose ~ An observational study
- Intraregional differences in renal function in the Northern Netherlands: The Lifelines Cohort Study
- Effects of MCHM on yeast metabolism
- Signaling impacts of GMO labeling on fruit and vegetable demand
- Dietary specialization depending on ecological context and sexual differences in Asiatic black bears
- Electronic device use and beverage related sugar and caffeine intake in US adolescents
- Isolation and characterization of five novel probiotic strains from Korean infant and children faeces
- Correction: Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Correction: Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Endothelial nitric oxide synthase limits host immunity to control disseminated Candida albicans infections in mice
- Lack of detection of Candida nivariensis and Candida bracarensis among 440 clinical Candida glabrata sensu lato isolates in Kuwait
- Nonlinear dynamics captures brain states at different levels of consciousness in patients anesthetized with propofol
- Visual encounters on line transect surveys under-detect carnivore species: Implications for assessing distribution and conservation status
- Menstrual health communication among Indian adolescents: A mixed-methods study
- Fast fluorescence in situ hybridisation for the enhanced detection of MET in non-small cell lung cancer
- The influence of personality on the effect of iTBS after being stressed on cortisol secretion
- Parental and peer support and modelling in relation to domain-specific physical activity participation in boys and girls from Germany
- Oral delivery of water-soluble compounds to the phytoseiid mite Neoseiulus californicus (Acari: Phytoseiidae)
- Force perceptual bias caused by muscle activity in unimanual steering
- Correction: Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Correction: Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium
- Providencia entomophila sp. nov., a new bacterial species associated with major olive pests in Tunisia
- Safety of intravitreal ziv-aflibercept in choroido-retinal vascular diseases: A randomised double-blind intervention study
- A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic
- Reduction of the rocuronium-induced withdrawal reflex by MR13A10A, a generic rocuronium with a novel solution: A randomized, controlled study
- Emotionally expressed voices are retained in memory following a single exposure
- Megabenthic communities of the Ligurian deep continental shelf and shelf break (NW Mediterranean Sea)
- Election forensics: Using machine learning and synthetic data for possible election anomaly detection
- A randomized crossover trial comparing the Nifty cup to a medicine cup in preterm infants who have difficulty breastfeeding at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana
- The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease
- Genomic impact of severe population decline in a nomadic songbird
- Evolution of high-sensitivity troponin-T and echocardiography parameters in patients undergoing high efficiency on-line hemodiafiltration versus conventional low-flux hemodialysis
- Full genome characterization of 12 citrus tatter leaf virus isolates for the development of a detection assay
- Intake of myo-inositol hexaphosphate and urinary excretion of inositol phosphates in Wistar rats: Gavage vs. oral administration with sugar
- Enhancing financial security of female sex workers through a community-led intervention in India: Evidence from a longitudinal survey
- In-silico prediction of novel genes responsive to drought and salinity stress tolerance in bread wheat (Triticum aestivum)
- Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America
- Partitioning the risk of tuberculosis transmission in household contact studies
- Recommendation system in social networks with topical attention and probabilistic matrix factorization
- Using satellite-measured relative humidity for prediction of Metisa plana’s population in oil palm plantations: A comparative assessment of regression and artificial neural network models
- A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects
- Emotional and behavioral problems, social competence and risk factors in 6–16-year-old students in Beijing, China
- Clinicopathologic and prognostic significance of tumor-associated macrophages in patients with hepatocellular carcinoma: A meta-analysis
- Involution of retinopathy of prematurity and neurodevelopmental outcomes after intravitreal bevacizumab treatment
- Travel demand and distance analysis for free-floating car sharing based on deep learning method
- Genome-wide identification, characterization, expression and enzyme activity analysis of coniferyl alcohol acetyltransferase genes involved in eugenol biosynthesis in Prunus mume
- Population analysis of D6-like plasmid prophage variants associated with specific IncC plasmid types in the emerging Salmonella Typhimurium ST213 genotype
- The high resource impact of reformatting requirements for scientific papers
- Egg yolk-free cryopreservation of bull semen
- Fine epitope mapping of glycoprotein Gn in Guertu virus
- Are hospital nurse staffing practices associated with postoperative cardiac events and death? A systematic review
- Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction
- Aging and the wandering brain: Age-related differences in the neural correlates of stimulus-independent thoughts
- Elucidating stygofaunal trophic web interactions via isotopic ecology
- Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases
- Scientist and data architect collaborate to curate and archive an inner ear electrophysiology data collection
- No effect of triple-pulse TMS medial to intraparietal sulcus on online correction for target perturbations during goal-directed hand and foot reaches
- Correction: Controlling Social Stress in Virtual Reality Environments
- TNF-α is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement
- Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
- Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease
- To tweet or not to tweet, that is the question: A randomized trial of Twitter effects in medical education
- Visualizing a field of research: A methodology of systematic scientometric reviews
- True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential
- Impact of the detection of ζ-globin chains and hemoglobin Bart’s using immunochromatographic strip tests for α0-thalassemia (--SEA) differential diagnosis
- Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort
- Correction: Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Correction: Lower prevalence of Blastocystis sp. infections in HIV positive compared to HIV negative adults in Ghana
- Correction: Precision public health: Mapping socioeconomic disparities in opioid dispensations at Swedish pharmacies by Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA)
- Epidemiological, clinical and laboratory characteristics of the measles resurgence in the Republic of Serbia in 2014-2015
- Macro-charcoal accumulation in floodplain wetlands: Problems and prospects for reconstruction of fire regimes and environmental conditions
- Stage at diagnosis and stage-specific survival of breast cancer in Latin America and the Caribbean: A systematic review and meta-analysis
- Correction: Retraction: Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway
- TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo
- Clinical impact of intraoperative hyperlactatemia during craniotomy
- Intubation with channeled versus non-channeled video laryngoscopes in simulated difficult airway by junior doctors in an out-of-hospital setting: A crossover manikin study
- Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates
- Sex-specific differences in risk factors of lymph node metastasis in patients with early gastric cancer
- The impact of electroconvulsive therapy on the spatial QRS-T angle and cardiac troponin T concentration in psychiatric patients
- BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss
- Investigation on the hereditary basis of colorectal cancers in an African population with frequent early onset cases
- Comparison of cancer prevalence between patients with glomerulonephritis and the general population at the time of kidney biopsy
- Predictors of time to unfavorable treatment outcomes among patients with multidrug resistant tuberculosis in Oromia region, Ethiopia
- Experimentally validated simulation of coronary stents considering different dogboning ratios and asymmetric stent positioning
- The membrane effects of melittin on gastric and colorectal cancer
- Exclusive breastfeeding policy, practice and influences in South Africa, 1980 to 2018: A mixed-methods systematic review
- Hippocampal subfield volumes and pre-clinical Alzheimer’s disease in 408 cognitively normal adults born in 1946
- Uncorrected low hyperopia in young subjects induces postural instability even in those with clear visual acuity
- Membrane associated proteins of two Trichomonas gallinae clones vary with the virulence
- Awareness, current use of electronic cigarettes and associated smoking factors in Zhejiang Chinese adolescents
- Associations between pre-pregnancy BMI, gestational weight gain, and prenatal diet quality in a national sample
- Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children
- Optofluidic laser speckle image decorrelation analysis for the assessment of red blood cell storage
- Complete chloroplast genome sequence and phylogenetic analysis of Spathiphyllum 'Parrish'
- Strategic science communication as planned behavior: Understanding scientists’ willingness to choose specific tactics
- Understanding spatial patterns of soils for sustainable agriculture in northern Ethiopia’s tropical mountains
- Does Japan’s national nutrient-based dietary guideline improve lifestyle-related disease outcomes? A retrospective observational cross-sectional study
- Agitation near the end of life with dementia: An ethnographic study of care
- Tick-borne encephalitis virus infections in Germany. Seasonality and in-year patterns. A retrospective analysis from 2001-2018
- Encouraging perspective taking: Using narrative writing to induce empathy for others engaging in negative health behaviors
- Considerations of target surface area and the risk of radiosurgical toxicity
- Correction: A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
- Effect of using immobilization device in fluoroscopic study in pediatric patient: Focused on radiation dose reduction in voiding cystourethrogram
- Temporal trends in breast cancer survival by race and ethnicity: A population-based cohort study
- Contamination of hospital surfaces with respiratory pathogens in Bangladesh
- The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver
- Association between hospital interval and survival in patients with oral cancer: A waiting time paradox
- Translating a stress management intervention for rural Latina breast cancer survivors: The Nuevo Amanecer-II
- Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial
- Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning
- Harnessing therapeutic viruses as a delivery vehicle for RNA-based therapy
- Korean soybean core collection: Genotypic and phenotypic diversity population structure and genome-wide association study
- Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- Measurement of structural integrity of the spinal cord in patients with amyotrophic lateral sclerosis using diffusion tensor magnetic resonance imaging
- Typological analysis of public-private partnerships in the veterinary domain
- Improved clinical outcome after medial open-wedge osteotomy despite cartilage lesions in the lateral compartment
- Rapid and structure-specific cellular uptake of selected steroids
- Avoiding gambling harm: An evidence-based set of safe gambling practices for consumers
- Epidemiology of chronic pain in Ukraine: Findings from the World Mental Health Survey
- PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target
- Double triage to identify poorly annotated genes in maize: The missing link in community curation
- N-acetyl cysteine restores the fertility of vitrified–warmed mouse oocytes derived through ultrasuperovulation
- Architecture of population-differentiated polymorphisms in the human genome
- Linguistic neutrosophic power Muirhead mean operators for safety evaluation of mines
- Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes
- Exercise intensity-dependent effects of arm and leg-cycling on cognitive performance
- How information about perpetrators’ nature and nurture influences assessments of their character, mental states, and deserved punishment
- Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis
- In silico assessment of human Calprotectin subunits (S100A8/A9) in presence of sodium and calcium ions using Molecular Dynamics simulation approach
- Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging
- Measurable residual disease monitoring for patients with acute myeloid leukemia following hematopoietic cell transplantation using error corrected hybrid capture next generation sequencing
- Characteristics of complementary medicine therapists in Switzerland: A cross-sectional study
- Lack of generalization between explicit and implicit visuomotor learning
- Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population
- Effects of temperature and salinity on respiratory losses and the ratio of photosynthesis to respiration in representative Antarctic phytoplankton species
- Self-reported non-receipt of HIV test results: A silent barrier to HIV epidemic control in Mozambique
- Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature
- Echocardiography overestimates LV mass in the elderly as compared to cardiac CT
- Efficacy of cotrimoxazole (Sulfamethoxazole-Trimethoprim) as a salvage therapy for the treatment of bone and joint infections (BJIs)
- Molecular mechanism of antimicrobial activity of chlorhexidine against carbapenem-resistant Acinetobacter baumannii
- First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides
- Green synthesis of silver nanoparticles using Solanum mammosum L. (Solanaceae) fruit extract and their larvicidal activity against Aedes aegypti L. (Diptera: Culicidae)
- Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007
- Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
- 13C and 15N NMR identification of product compound classes from aqueous and solid phase photodegradation of 2,4,6-trinitrotoluene
- Off-target effects of CRISPRa on interleukin-6 expression
- Exploring the antimicrobial properties of dark-operating ceramic-based nanocomposite materials for the disinfection of indoor air
- Experienced males recognise and avoid mating with non-virgin females in the western flower thrips
- Liver transplantation in patients with a history of migration—A German single center comparative analysis
- Retraction: The Different Role of Notch1 and Notch2 in Astrocytic Gliomas
- Correction: Understanding climate change from a global analysis of city analogues
- Comparison of 4D Flow MRI to 2D Flow MRI in the pulmonary arteries in healthy volunteers and patients with pulmonary hypertension
- The relationship between sleep quality, inappropriate medication use and frailty among older adults in aged care homes in Malaysia
- Clonal diversity and spatial genetic structure in the long-lived herb, Prairie trillium
- Medication histories documentation at the community pharmacy setting: A study from Jordan
- Population dynamics of an invasive bird parasite, Philornis downsi (Diptera: Muscidae), in the Galapagos Islands
- Because you had a bad day: General and daily relations between reactive temperament, emotion regulation, and depressive symptoms in youth
- Socioeconomic status and alcohol use disorders across the lifespan: A co-relative control study
- Generation of deletions and precise point mutations in Dictyostelium discoideum using the CRISPR nickase
- Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation
- Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study
- Validation and perception of a key feature problem examination in neurology
- Gender affirmative HIV care framework: Decisions on feminizing hormone therapy (FHT) and antiretroviral therapy (ART) among transgender women
- Quantifying international human mobility patterns using Facebook Network data
- Localization and characterization of thyroid microcalcifications: A histopathological study
- Young children are the main victims of fast food induced obesity in Brazil
- Understanding self-reported importance of religion/spirituality in a North American sample of individuals at risk for familial depression: A principal component analysis
- Standing balance of professional ballet dancers and non-dancers under different conditions
- 30-day unplanned readmission rate in otolaryngology patients: A population-based study in Thuringia, Germany
- Physical exercise stimulates salivary secretion of cystatins
- Vintage electronics for trusted radiation measurements and verified dismantlement of nuclear weapons
- Keepin’ it real: Linguistic models of authenticity judgments for artificially generated rap lyrics
- Carbon emission reduction and profit distribution mechanism of construction supply chain with fairness concern and cap-and-trade
- Modulations of microbehaviour by associative memory strength in Drosophila larvae
- Changes in peak expiratory flow rates using two head-tilt/chin-lift maneuver angles in young healthy conscious volunteers
- 3D image analysis reveals differences of CD30 positive cells and network formation in reactive and malignant human lymphoid tissue (classical Hodgkin Lymphoma)
- Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- 2-methylquinazoline derivative F7 as a potent and selective HDAC6 inhibitor protected against rhabdomyolysis-induced acute kidney injury
- Correction: Reducing growth and developmental problems in children: Development of an innovative postnatal risk assessment
- Comparative analysis of the vertebral pneumatization in pterosaurs (Reptilia: Pterosauria) and extant birds (Avialae: Neornithes)
- Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults
- Retraction: MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1
- Comparing growth patterns of three species: Similarities and differences
- Iron is increased in the brains of ageing mice lacking the neurofilament light gene
- Economic evaluation of community acquired pneumonia management strategies: A systematic review of literature
- A participatory community case study of periurban coastal flood vulnerability in southern Ecuador
- Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL
- Mitochondrial dysfunctions in leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL)
- MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex
- Knowledge, attitudes, and practices related to anthrax and animal care: A case-control study in Georgia
- Information diffusion in signed networks
- Nurses’ perspectives on their communication with patients in busy oncology wards: A qualitative study
- Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS
- ART is key to clearing oncogenic HPV genotypes (HR-HPV) in anal mucosa of HIV-positive MSM
- Retraction: Fluid–Structure Interaction-Based Biomechanical Perception Model for Tactile Sensing
- Correction: Role of Caveolin-1 in Atrial Fibrillation as an Anti-Fibrotic Signaling Molecule in Human Atrial Fibroblasts
- The French adaptation and validation of the Partners in Health (PIH) scale among patients with chronic conditions seen in primary care
- Depth inversion with a 3D structure influences brightness perception
- Analysis of group evolution prediction in complex networks
- Effect of aridity and dune type on rhizosphere soil bacterial communities of Caragana microphylla in desert regions of northern China
- Knowledge, attitudes, and practices related to TB among the general population of Ethiopia: Findings from a national cross-sectional survey
- Correction: Personality traits in companion dogs—Results from the VIDOPET
- MANET 3.0: Hierarchy and modularity in evolving metabolic networks
- Agreement study on gait assessment using a video-assisted rating method in patients with idiopathic normal-pressure hydrocephalus
- Single fixed low-dose rituximab as induction therapy suppresses de novo donor-specific anti-HLA antibody production in ABO compatible living kidney transplant recipients
- Myomesin is part of an integrity pathway that responds to sarcomere damage and disease
- Acute normobaric hypoxia does not affect the simultaneous exercise-induced increase in circulating BDNF and GDNF in young healthy men: A feasibility study
- Systematic investigation on quad-metallic AgAuPdPt and tri-metallic AuPdPt NPs through the solid-state dewetting of quad-layer Ag/Au/Pd/Pt thin films on c-plane sapphire
- Video lecturing in Clicker-assisted English flipped class
- Significant changes of the choroid in patients with ocular ischemic syndrome and symptomatic carotid artery stenosis
- Skewed T cell responses to Epstein-Barr virus in long-term asymptomatic kidney transplant recipients
- Candidate genes expression profiling during wilting in chickpea caused by Fusarium oxysporum f. sp. ciceris race 5
- Host plants influence the composition of the gut bacteria in Henosepilachna vigintioctopunctata
- ‘We are all serving the same Ugandans’: A nationwide mixed-methods evaluation of private sector surgical capacity in Uganda
- The association between flavor capsule cigarette use and sociodemographic variables: Evidence from Chile
- Relations between gross motor skills and executive functions, controlling for the role of information processing and lapses of attention in 8-10 year old children
- Linalool acts as a fast and reversible anesthetic in Hydra
- Double burden of maternal and child malnutrition and socioeconomic status in urban Sri Lanka
- Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles
- Adherence to general medical checkup and cancer screening guidelines according to self-reported smoking status: Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2012
- Do older English adults exhibit day-to-day compensation in sedentary time and in prolonged sedentary bouts? An EPIC-Norfolk cohort analysis
- Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue
- Correction: Factors associated with hospitalization and death among TB/HIV co-infected persons in Porto Alegre, Brazil
- An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patterns
- Reporting adverse events related to medical devices: A single center experience from a tertiary academic hospital
- Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism
- Estimating biodiversity changes in the Camargue wetlands: An expert knowledge approach
- Decreased risk of Parkinson’s disease in diabetic patients with thiazolidinediones therapy: An exploratory meta-analysis
- Retraction: Carboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis
- Lipoarabinomannan from Mycobacterium indicus pranii shows immunostimulatory activity and induces autophagy in macrophages
- A measure of inconsistencies in intertemporal choice
- A novel radiopaque tissue marker for soft tissue localization and in vivo length and area measurements
- Anatomical, histological and computed tomography comparisons of the eye and adnexa of crab-eating fox (Cerdocyon thous) to domestic dogs
- Subpopulation augmentation among habitat patches as a tool to manage an endangered Mojave Desert wetlands-dependent rodent during anthropogenic restricted water climate regimes
- Characteristics of CD5-positive diffuse large B-cell lymphoma among Koreans: High incidence of BCL2 and MYC double-expressors
- Fossil tabulate corals reveal outcrops of Paleozoic sandstones in the Atlantic Coastal Plain Province, Southeastern USA
- Coming and going – Historical distributions of the European oyster Ostrea edulis Linnaeus, 1758 and the introduced slipper limpet Crepidula fornicata Linnaeus, 1758 in the North Sea
- Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter
- Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation
- Can emotional intelligence be improved? A randomized experimental study of a business-oriented EI training program for senior managers
- Genetic variability in landraces populations and the risk to lose genetic variation. The example of landrace ‘Kyperounda’ and its implications for ex situ conservation
- Sleep problems are a strong predictor of stress-related metabolic changes in police officers. A prospective study
- Age, sex and primary care setting differences in patients’ perception of community healthcare seeking behaviour towards health services
- Kinematic analyses including finite helical axes of drop jump landings demonstrate decreased knee control long after anterior cruciate ligament injury
- Effects of model inaccuracies on reaching movements with intermittent control
- C-reactive protein to albumin ratio predicts the outcome in renal cell carcinoma: A meta-analysis
- A new synthetic lure for management of the invasive giant African snail, Lissachatina fulica
- Bridging solvent molecules mediate RNase A – Ligand binding
- Variation in methods, results and reporting in electronic health record-based studies evaluating routine care in gout: A systematic review
- The use of prophylactic intra-aortic balloon pump in high-risk patients undergoing coronary artery bypass grafting
- Compliance with clinical guidelines for breast cancer management: A population-based study of quality-of-care indicators in France
- Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis
- Acute effects of differential learning on football kicking performance and in countermovement jump
- Escherichia coli and Salmonella spp. isolated from Australian meat chickens remain susceptible to critically important antimicrobial agents
- Play like me: Similarity in playfulness promotes social play
- Awareness of family health history in a predominantly young adult population
- Care pathways during a child’s final illness in rural South Africa: Findings from a social autopsy study
- Intranasal lidocaine for acute migraine: A meta-analysis of randomized controlled trials
- Evaluating case management as a complex intervention: Lessons for the future
- Allele-specific enhancer interaction at the Peg3 imprinted domain
- Has the “M” word been framed? Marijuana, cannabis, and public opinion
- Is spontaneous normalization of systolic blood pressure within 24 hours after ischemic stroke onset related with favorable outcomes?
- Mixotrophic cultivation of Spirulina platensis in dairy wastewater: Effects on the production of biomass, biochemical composition and antioxidant capacity
- Constitutive expression of an A-5 subgroup member in the DREB transcription factor subfamily from Ammopiptanthus mongolicus enhanced abiotic stress tolerance and anthocyanin accumulation in transgenic Arabidopsis
- Stable carbon isotope diagnostics of mammalian metabolism, a high-resolution isotomics approach using amino acid carboxyl groups
- Factors associated with depressive symptoms in patients with ankylosing spondylitis in Northern Taiwan
- A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
- Retraction: Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1
- Potential role for microRNA-16 (miR-16) and microRNA-93 (miR-93) in diagnosis and prediction of disease progression in mycosis fungoides in Egyptian patients
- Rapid visual categorization is not guided by early salience-based selection
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- Correction: RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
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- The association between vaccination confidence, vaccination behavior, and willingness to recommend vaccines among Finnish healthcare workers
- Retraction: Interleukin-1β-Induced Autophagy-Related Gene 5 Regulates Proliferation of Embryonic Stem Cell-Derived Odontoblastic Cells
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- E2 protein is the major determinant of specificity at the human papillomavirus origin of replication
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- Understanding fatigue in adults with visual impairment: A path analysis study of sociodemographic, psychological and health-related factors
- Retraction: Mouse-Induced Pluripotent Stem Cells Differentiate into Odontoblast-Like Cells with Induction of Altered Adhesive and Migratory Phenotype of Integrin
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- The coupling of the M2 muscarinic receptor to its G protein is voltage dependent
- Subsidy strategy of pharmaceutical e-commerce platform based on two-sided market theory
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- Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance
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- Correction: Bioactivity-guided isolation of rosmarinic acid as the principle bioactive compound from the butanol extract of Isodon rugosus against the pea aphid, Acyrthosiphon pisum
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- Consequences of chronic bacterial infection in Drosophila melanogaster
- The effects of environmental parameters on the microbial activity in peat-bog lakes
- Differences in protein structural regions that impact functional specificity in GT2 family β-glucan synthases
- Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan
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- Correction: Nitrogen starvation induces distinct photosynthetic responses and recovery dynamics in diatoms and prasinophytes
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- Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli
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- Deep-learning-based risk stratification for mortality of patients with acute myocardial infarction
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- The association between socioeconomic status, psychopathological symptom burden in mothers, and early childhood caries of their children
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- Parallels between stream and coastal water quality associated with groundwater discharge
- Determinants of anemia among pregnant women attending antenatal care in Horo Guduru Wollega Zone, West Ethiopia: Unmatched case-control study
- Depression and anxiety among pregnant women living with HIV in Kilimanjaro region, Tanzania
- Shift in trophic niches of soil microarthropods with conversion of tropical rainforest into plantations as indicated by stable isotopes (15N, 13C)
- On the development of sleep states in the first weeks of life
- CCR5 receptor antagonism inhibits hepatitis C virus (HCV) replication in vitro
- Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise
- Correction: Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts
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- Correction: Evidence for plant-derived xenomiRs based on a large-scale analysis of public small RNA sequencing data from human samples
- Correction: Prognostic impact of systolic blood pressure variability in people with diabetes
- Retraction: Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis
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- Shipworm bioerosion of lithic substrates in a freshwater setting, Abatan River, Philippines: Ichnologic, paleoenvironmental and biogeomorphical implications
- Genetic codes optimized as a traveling salesman problem
- Effect of antenatal detection of small-for-gestational-age newborns in a risk stratified retrospective cohort
- Using family network data in child protection services
- Transcriptome sequencing reveals the effect of biochar improvement on the development of tobacco plants before and after topping
- Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials
- Cumulative fluid balance predicts mortality and increases time on mechanical ventilation in ARDS patients: An observational cohort study
- Stated-preference research in HIV: A scoping review
- Correction: Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Antinociceptive compounds and LC-DAD-ESIMSn profile from Dictyoloma vandellianum leaves
- Time series experimental design under one-shot sampling: The importance of condition diversity
- Evaluation of protocols for rRNA depletion-based RNA sequencing of nanogram inputs of mammalian total RNA
- Prevalence and predictors of primary postpartum hemorrhage: An implication for designing effective intervention at selected hospitals, Southern Ethiopia
- Correction: Stillbirths in urban Guinea-Bissau: A hospital- and community-based study
- Correction: Method for spike detection from microelectrode array recordings contaminated by artifacts of simultaneous two-photon imaging
- Correction: Peripheral blood mononuclear cells extracts VEGF protein levels and VEGF mRNA: Associations with inflammatory molecules in a healthy population
- Correction: Novel site-specific PEGylated L-asparaginase
- Effect of caffeine ingestion on competitive rifle shooting performance
- Correction: Color adaptation induced from linguistic description of color
- MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity
- Correction: A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Correction: A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing
- Measurement of horizontal ocular deviation on magnetic resonance imaging in various disease with acute vertigo
- Clinical outcomes of early gastric cancer with non-curative resection after pathological evaluation based on the expanded criteria
- Detection of quantitative trait loci associated with drought tolerance in St. Augustinegrass
- An examination of the Kuleshov effect using still photographs
- Correction: Relationship between non-communicable diseases and background characteristics among homeless people in Nagoya City, Japan
- An exploration of automated narrative analysis via machine learning
- Correction: Frozen by stress: Stress increases scope insensitivity
- The pragmatic role of trust in young children’s interpretation of unfamiliar signals
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- Mathematical modeling of cardiac function to evaluate clinical cases in adults and children
- Correction: Forecasting the impact of population ageing on tuberculosis incidence
- “The car is my extra legs” – Experiences of outdoor mobility amongst immigrants in Sweden with late effects of polio
- Correction: Multilevel analyses of on-demand medication data, with an application to the treatment of Female Sexual Interest/Arousal Disorder
- Correction: The world’s user-generated road map is more than 80% complete
- Correction: Predictors of opioid efficacy in patients with chronic pain: A prospective multicenter observational cohort study
- Correction: Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Correction: Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases
- Correction: Effect of early measles vaccine on pneumococcal colonization: A randomized trial from Guinea-Bissau
- Correction: Tuberculosis patients in an Indian mega-city: Where do they live and where are they diagnosed?
- Correction: Priority Queue Based Reactive Buffer Management Policy for Delay Tolerant Network under City Based Environments
- Correction: Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma
- Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
- Correction: Evolution and study of a copycat effect in intimate partner homicides: A lesson from Spanish femicides
- Correction: Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
- Correction: Congenital Zika Syndrome in a Brazil-Paraguay-Bolivia border region: Clinical features of cases diagnosed between 2015 and 2018
- Correction: Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression
- Correction: Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance
- Correction: Nonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight
- Retraction: Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery
- Retraction: Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-κB and ERK Signaling Pathways in BV2 Cells
- Correction: Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient
- Correction: Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents
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