Translational approaches to coagulopathy after trauma: Towards targeted treatment

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Mitchell J.
Cohen discusses why trauma care must go beyond restoring perfusion to target disorders of inflammation and coagulation in severely injured patients.

Vyšlo v časopise: Translational approaches to coagulopathy after trauma: Towards targeted treatment. PLoS Med 14(7): e32767. doi:10.1371/journal.pmed.1002359
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002359

Souhrn

Mitchell J.
Cohen discusses why trauma care must go beyond restoring perfusion to target disorders of inflammation and coagulation in severely injured patients.

Zdroje

1. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54(6):1127–30. doi: 10.1097/01.TA.0000069184.82147.06 12813333

2. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55(1):39–44. doi: 10.1097/01.TA.0000075338.21177.EF 12855879

3. Cohen MJ, Kutcher M, Redick B, Nelson M, Call M, Knudson MM, et al. Clinical and mechanistic drivers of acute traumatic coagulopathy. The journal of trauma and acute care surgery. 2013;75(1 Suppl 1):S40–7. doi: 10.1097/TA.0b013e31828fa43d 23778510

4. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63(4):805–13. doi: 10.1097/TA.0b013e3181271ba3 18090009

5. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13(6):680–5. doi: 10.1097/MCC.0b013e3282f1e78f 17975390

6. Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64(5):1211–7; discussion 7. doi: 10.1097/TA.0b013e318169cd3c 18469643

7. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al, for the PROPPR Study Group. Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma The PROPPR Randomized Clinical Trial. JAMA. 2015;313(5):471–482. doi: 10.1001/jama.2015.12 25647203

8. Menezes AA, Vilardi RF, Arkin AP, Cohen MJ. Targeted clinical control of trauma patient coagulation through a thrombin dynamics model. Sci Transl Med. 2017;9(371).

9. Cohen MJ, Grossman AD, Morabito D, Knudson MM, Butte AJ, Manley GT. Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care. 2010;14(1):R10. doi: 10.1186/cc8864 20122274

10. Diaz I, Hubbard A, Decker A, Cohen M. Variable importance and prediction methods for longitudinal problems with missing variables. PLoS ONE. 2015;10(3):e0120031. doi: 10.1371/journal.pone.0120031 25815719

11. Hubbard A, Munoz ID, Decker A, Holcomb JB, Schreiber MA, Bulger EM, et al. Time-dependent prediction and evaluation of variable importance using superlearning in high-dimensional clinical data. J Trauma Acute Care Surg. 2013;75(1 Suppl 1):S53–60. doi: 10.1097/TA.0b013e3182914553 23778512

12. Kutcher ME, Ferguson AR, Cohen MJ. A principal component analysis of coagulation after trauma. The journal of trauma and acute care surgery. 2013;74(5):1223–9; discussion 9–30. doi: 10.1097/TA.0b013e31828b7fa1 23609271