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Time for trauma immunology


Timothy Billiar summarizes the role of the innate immune response in the clinical course following severe injury and envisions a field of "trauma immunology."


Vyšlo v časopise: Time for trauma immunology. PLoS Med 14(7): e32767. doi:10.1371/journal.pmed.1002342
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002342

Souhrn

Timothy Billiar summarizes the role of the innate immune response in the clinical course following severe injury and envisions a field of "trauma immunology."


Zdroje

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2. Namas RA, Vodovotz Y, Almahmoud K, Abdul-Malak O, Zaaqoq A, Namas R, et al. Temporal patterns of circulating inflammation biomarker networks differentiate susceptibility to nosocomial infection following blunt trauma in humans. Ann Surg. 2016 Jan; 263(1): 191–198. doi: 10.1097/SLA.0000000000001001. 25371118

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7. Mollen KP, Anand RJ, Tsung A, Prince JM, Levy RM, Billiar TR. Emerging paradigm: Toll-like receptor 4-sentinel for the detection of tissue damage. Shock. 2006 Nov; 26(5):430–437. doi: 10.1097/01.shk.0000228797.41044.08. 17047512

8. Gill R, Ruan X, Menzel CJ, Namkoong S, Loughran PA, Hackam DJ, et al. Systemic Inflammation and Liver Injury following Hemorrhagic Shock And Peripheral Tissue Trauma Involve Functional TLR9 Signaling on Bone Marrow-Derived Cells and Parenchymal Cells. Shock. 2011 Feb; 35(2):164–70. doi: 10.1097/SHK.0b013e3181eddcab. 20577143.

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10. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010 Mar 4; 464: 104–107. doi: 10.1038/nature08780. 20203610

11. Abboud AN, Namas RA, Ramadan M, Mi Q, Almahmoud K, Abdul-Malak O, et al. Computational analysis supports an early, type 17 cell-associated divergence of blunt trauma survival and mortality. Crit Care Med. 2016 Nov; 44(11): e1074–e1081. doi: 10.1097/CCM.0000000000001951. 27513538

12. Brown D, Namas RA, Almahmoud K, Zaaqoq A, Sarkar J, Barclay DA, et al. Trauma in silico: individual-specific mathematical models and virtual clinical populations. Sci Transl Med. 2015 Apr 29; 7:(285):285ra261. doi: 10.1126/scitranslmed.aaa3636. 25925680

Štítky
Interné lekárstvo

Článok vyšiel v časopise

PLOS Medicine


2017 Číslo 7
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