Hope for HIV control in southern Africa: The continued quest for a vaccine

In a Perspective, Linda-Gail Bekker and Glenda Gray discuss HIV vaccine development.

Vyšlo v časopise: Hope for HIV control in southern Africa: The continued quest for a vaccine. PLoS Med 14(2): e32767. doi:10.1371/journal.pmed.1002241
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002241

Souhrn

In a Perspective, Linda-Gail Bekker and Glenda Gray discuss HIV vaccine development.

Zdroje

1. The Prevention Gap Report: 2016. UNAIDS http://www.unaids.org/en/resources/documents/2016/prevention-gap. Accessed 16 January 2017.

2. Philips AN, Cambiano V, Nakagawa F, Ford D, Lundgren JD, Roset-Bahmanyar E, et al. Potential future impact of a partially effective HIV vaccine in a Southern Africa setting. PLoS ONE. 2014;9(9):e107214. doi: 10.1371/journal.pone.0107214 25207973

3. Fauci AS, Martson HD. Ending AIDS—Is an HIV Vaccine Necessary? N Engl J Med. 2014;370(6):495–498. doi: 10.1056/NEJMp1313771 24499210

4. Rawlings K, et al. (McCallister S presenting) FTC/TDF (Truvada) for HIV pre-exposure prophylaxis (PrEP) utilization in the United States: 2013–2015. 21st International AIDS Conference, Durban, abstract TUAX0105LB, 2016.

5. Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, Paris R, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med. 2009;361(23):2209–2220. doi: 10.1056/NEJMoa0908492 19843557

6. Gray GE, Andersen-Nissen E, Grunenberg N, Huang Y, Roux S, Laher F, et al. HVTN 097: Evaluation of the RV144 Vaccine Regimen in HIV Uninfected South African Adults. AIDS Research and Human Retroviruses. October 2014, 30(S1): A33–A34.

7. Bekker L-G. Meeting the “Go” criteria: immunogenicity from HVTN100, a phase 1–2 randomized, double-blind, placebo-controlled trial of clade C ALVAC-® (vCP2438) and bivalent subtype C gp120/MF59®in HIV-uninfected South African adults. 21st International AIDS Conference, Durban, abstract TUAX0102LB, 2016.

8. Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South Africa (HVTN702). Clinical Trials.Gov. https://clinicaltrials.gov/show/NCT02968849.

9. Pitisuttithum P, Gilbert O, Gurwith M, Heyward W, Martin M, van Griensven F, et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis. 2006;194 : 1661–1671. doi: 10.1086/508748 17109337

10. Nitayaphan S, Pitisuttithum P, Karnasuta C, Eamsila C, de Souza M, Morgan P, et al. Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults. J Infect Dis. 2004;190 : 702–706. doi: 10.1086/422258 15272397

11. Burton DR, Hangartner L. Broadly neutralizing antibodies to HIV and their role in vaccine design. Annu Rev Immunol. 2016;34 : 635–659. doi: 10.1146/annurev-immunol-041015-055515 27168247

12. National Institute of Allergy and Infectious Diseases. NIH Launches Large Clinical Trials of Antibody-Based HIV Prevention: Studies on Three Continents Could Have Broad Implications for HIV Prevention Research. https://www.niaid.nih.gov/news-events/nih-launches-large-clinical-trials-antibody-based-hiv-prevention. Accessed 19 January 2017.