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Leveraging Genetics to Advance Type 2 Diabetes Prevention


In this Perspective, Jose Florez discusses how information from genetics and genomics may be able to contribute to prevention of type 2 diabetes and predicting individual responses to behavioral and other interventions.


Vyšlo v časopise: Leveraging Genetics to Advance Type 2 Diabetes Prevention. PLoS Med 13(7): e32767. doi:10.1371/journal.pmed.1002102
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002102

Souhrn

In this Perspective, Jose Florez discusses how information from genetics and genomics may be able to contribute to prevention of type 2 diabetes and predicting individual responses to behavioral and other interventions.


Zdroje

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21. Pollin TI, Jablonski KA, McAteer JB, Saxena R, Kathiresan S, Kahn SE, et al. Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. J Clin Endocrinol Metab. 2011;96(7):E1142–E1147. 21525158; PubMed Central PMCID: PMC3205512. doi: 10.1210/jc.2010-2324.

22. Pollin TI, Isakova T, Jablonski KA, de Bakker PI, Taylor A, McAteer J, et al. Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: The Diabetes Prevention Program. PLoS Genet. 2012;8(8):e1002895. 22951888; PubMed Central PMCID: PMC3431328.

23. Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, et al. Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials. Diabetes. 2015;64(12):4312–4321. Epub 2015/08/09. doi: 10.2337/db15-0441 26253612; PubMed Central PMCID: PMC4657576.

24. Becker ML, Visser LE, van Schaik RHN, Hofman A, Uitterlinden AG, Stricker BHC. Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: A preliminary study. Diabetes. 2009;58(3):745–749. doi: 10.2337/db08-1028 19228809.

25. Zhou K, Bellenguez C, Spencer CC, Bennett AJ, Coleman RL, Tavendale R, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet. 2011;43(2):117–120. Epub 2010/12/28. ng.735 [pii] doi: 10.1038/ng.735 21186350; PubMed Central PMCID: PMC3030919.

26. Florez JC, Jablonski KA, Taylor A, Mather K, Horton E, White NH, et al. The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program. Diabetes Care. 2012;35(9):1864–1867. 22751958; PubMed Central PMCID: PMC3425006.

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