Why Treatment Fails in Type 2 Diabetes

1. TurnerRC

1998

The U.K. Prospective Diabetes Study. A review.

Diabetes Care

21

Suppl 3

C35

C38

2. McCarthyMIZegginiE

2007

Genome-wide association scans for Type 2 diabetes: New insights into biology and therapy.

Trends Pharmacol Sci

28

598

601

3. AshcroftFMGribbleFM

1998

Correlating structure and function in ATP-sensitive K+ channels.

Trends Neurosci

21

288

294

4. TrubeGRorsmanPOhno-ShosakuT

1986

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.

Pflugers Arch

407

493

499

5. [No authors listed]

1998

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.

Lancet

352

837

853

6. MatthewsDRCullCAStrattonIMHolmanRRTurnerRC

1998

UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group.

Diabet Med

15

297

303

7. MaedlerKCarrRDBoscoDZuelligRABerneyT

2005

Sulfonylurea induced beta-cell apoptosis in cultured human islets.

J Clin Endocrinol Metab

90

501

506

8. LupiRDel PratoS

2008

Beta-cell apoptosis in type 2 diabetes: Quantitative and functional consequences.

Diabetes Metab

34

Suppl 2

S56

S64

9. RemediMSRocheleauJVTongAPattonBLMcDanielML

2006

Hyperinsulinism in mice with heterozygous loss of K(ATP) channels.

Diabetologia

49

2368

2378

10. MikiTNagashimaKTashiroFKotakeKYoshitomiH

1998

Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

Proc Natl Acad Sci U S A

95

10402

10406

11. ShiotaCLarssonOSheltonKDShiotaMEfanovAM

2002

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.

J Biol Chem

277

37176

37183

12. SeghersVNakazakiMDeMayoFAguilar-BryanLBryanJ

2000

Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion.

J Biol Chem

275

9270

9277

13. RemediMSNicholsCG

2008

Chronic antidiabetic sulfonylureas in vivo: Reversible effects on mouse pancreatic β-cells.

PLoS Med

5

e206

doi:10.1371/journal.pmed.0050206