Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis

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Previous studies on cattle recombination largely focused on males. Using a large Holstein sample from the USDA national database, we studied both male and female recombination by assembling paternal and maternal recombination events in at least three generations. This unique data set provides unprecedented statistical power to study cattle genome recombination in the two sexes: (1) We report for the first time that bulls have more recombination than cows, contrary to the common perception that females have more recombination than males as observed in many mammalian species including humans and mice, and that the sex difference in recombination primarily occurs near the subtelomeric regions of all bovine autosomes; (2) We identify several genes associated with cattle recombination in both females and males, and genes affecting female recombination only; (3) We define putative recombination hotspots and find the cattle PRDM9 gene to be associated with recombination hotspot usage. These results provide new insights for understanding cattle and mammalian genome recombination.

Vyšlo v časopise: Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis. PLoS Genet 11(11): e32767. doi:10.1371/journal.pgen.1005387
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005387

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