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Post-Embryonic Nerve-Associated Precursors to Adult Pigment Cells:
Genetic Requirements and Dynamics of Morphogenesis and
Differentiation


The pigment cells of vertebrates serve a variety of functions and generate a

stunning variety of patterns. These cells are also implicated in human

pathologies including melanoma. Whereas the events of pigment cell development

have been studied extensively in the embryo, much less is known about

morphogenesis and differentiation of these cells during post-embryonic stages.

Previous studies of zebrafish revealed genetically distinct populations of

embryonic and adult melanophores, the ectotherm homologue of amniote

melanocytes. Here, we use molecular markers, vital labeling, time-lapse imaging,

mutational analyses, and transgenesis to identify peripheral nerves as a niche

for precursors to adult melanophores that subsequently migrate to the skin to

form the adult pigment pattern. We further identify genetic requirements for

establishing, maintaining, and recruiting precursors to the adult melanophore

lineage and demonstrate novel compensatory behaviors during pattern regulation

in mutant backgrounds. Finally, we show that distinct populations of latent

precursors having differential regenerative capabilities persist into the adult.

These findings provide a foundation for future studies of post-embryonic pigment

cell precursors in development, evolution, and neoplasia.


Vyšlo v časopise: Post-Embryonic Nerve-Associated Precursors to Adult Pigment Cells: Genetic Requirements and Dynamics of Morphogenesis and Differentiation. PLoS Genet 7(5): e32767. doi:10.1371/journal.pgen.1002044
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1002044

Souhrn

The pigment cells of vertebrates serve a variety of functions and generate a

stunning variety of patterns. These cells are also implicated in human

pathologies including melanoma. Whereas the events of pigment cell development

have been studied extensively in the embryo, much less is known about

morphogenesis and differentiation of these cells during post-embryonic stages.

Previous studies of zebrafish revealed genetically distinct populations of

embryonic and adult melanophores, the ectotherm homologue of amniote

melanocytes. Here, we use molecular markers, vital labeling, time-lapse imaging,

mutational analyses, and transgenesis to identify peripheral nerves as a niche

for precursors to adult melanophores that subsequently migrate to the skin to

form the adult pigment pattern. We further identify genetic requirements for

establishing, maintaining, and recruiting precursors to the adult melanophore

lineage and demonstrate novel compensatory behaviors during pattern regulation

in mutant backgrounds. Finally, we show that distinct populations of latent

precursors having differential regenerative capabilities persist into the adult.

These findings provide a foundation for future studies of post-embryonic pigment

cell precursors in development, evolution, and neoplasia.


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