Perineurálna diferenciácia v ganglioneurómoch. Súbor 8 prípadov s imunohistochemickou expresiou perineurálnych markerov

V súbore 8 ganglioneurómov bola zisťovaná prítomnosť perineurálnej diferenciácie pomocou 3 imunohistochemických perineurálnych markerov: epitelového membránového antigénu (EMA), klaudínu-1 a GLUT-1. Priemerný vek pacientov bol 42,3 rokov (rozsah 26–68 rokov), 6 tumorov bolo u žien a 2 prípady u mužov. Päť tumorov bolo v nadobličke a 3 v retroperitoneu. Morfológia tumorov bola typická, t.j. tvorená neuroidnou vretenobunkovou populáciou a zrelými gangliovými bunkami. Vretenovité bunky pozitívne na perineurálne markery klaudín-1 a GLUT-1 boli nájdené vo všetkých tumoroch. EMA-pozitívne bunky boli v 2 léziach. Bunky s perineurálnou diferenciáciou boli často usporiadané organoidne v periférii neuroidných fasciklov alebo okolo ciev. Náš nález ukazuje, že perineurálna diferenciácia je bežne prítomná v ganglioneurómoch.

Kľúčové slová:
ganglioneuróm – perineurióm – EMA – klaudín-1 – GLUT-1

Autoři: M. Zámečník ¹; M. Staník ²; A. Chlumská ^3,4; P. Mukenšnabl ⁴; F. Ondriaš ¹
Působiště autorů: Alpha Medical Pathology, s. r. o., Bratislava, Slovak Republic ¹; Department of Pathology, Suedharz Hospital, Nordhausen, Germany ²; Šikl’s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic ³; Laboratory of Surgical Pathology, Pilsen, Czech Republic ⁴
Vyšlo v časopise: Čes.-slov. Patol., 48, 2012, No. 4, p. 215-217
Kategorie: Původní práce

Souhrn

Kľúčové slová:
ganglioneuróm – perineurióm – EMA – klaudín-1 – GLUT-1

Zdroje

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