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Phenotypic Screens, Chemical Genomics, and Antimalarial Lead Discovery
article has not abstract
Vyšlo v časopise: Phenotypic Screens, Chemical Genomics, and Antimalarial Lead Discovery. PLoS Pathog 7(8): e32767. doi:10.1371/journal.ppat.1002156
Kategorie: Opinion
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1002156Souhrn
article has not abstract
Zdroje
1. GamoFJSanzLMVidalJde CozarCAlvarezE 2010 Thousands of chemical starting points for antimalarial lead identification. Nature 465 305 310
2. GuiguemdeWAShelatAABouckDDuffySCrowtherGJ 2010 Chemical genetics of Plasmodium falciparum. Nature 465 311 315
3. PlouffeDBrinkerAMcNamaraCHensonKKatoN 2008 In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A 105 9059 9064
4. LipinskiCA 2000 Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods 44 235 249
5. LipinskiCALombardoFDominyBWFeeneyPJ 2001 Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46 3 26
6. StrobelGLArnoldJ 2004 Essential eukaryotic core. Evolution 58 441 446
7. BajorathJ 2008 Computational analysis of ligand relationships within target families. Curr Opin Chem Biol 12 352 358
8. KolbPFerreiraRSIrwinJJShoichetBK 2009 Docking and chemoinformatic screens for new ligands and targets. Curr Opin Biotechnol 20 429 436
9. KeiserMJSetolaVIrwinJJLaggnerCAbbasAI 2009 Predicting new molecular targets for known drugs. Nature 462 175 181
10. CrowtherGJNapuliAJGilliganJHGagaringKBorboaR 2011 Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds. Mol Biochem Parasitol 175 21 29
11. DujonB 1998 European Functional Analysis Network (EUROFAN) and the functional analysis of the Saccharomyces cerevisiae genome. Electrophoresis 19 617 624
Štítky
Hygiena a epidemiológia Infekčné lekárstvo Laboratórium
Článek Crystal Structure of Reovirus Attachment Protein σ1 in Complex with Sialylated OligosaccharidesČlánek A Protein Thermometer Controls Temperature-Dependent Transcription of Flagellar Motility Genes inČlánek Modulation of NKp30- and NKp46-Mediated Natural Killer Cell Responses by Poxviral Hemagglutinin
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Všetky články tohto čísla
- Phenotypic Screens, Chemical Genomics, and Antimalarial Lead Discovery
- Characterisation of Regulatory T Cells in Nasal Associated Lymphoid Tissue in Children: Relationships with Pneumococcal Colonization
- Crystal Structure of Reovirus Attachment Protein σ1 in Complex with Sialylated Oligosaccharides
- Absence of Cross-Presenting Cells in the Salivary Gland and Viral Immune Evasion Confine Cytomegalovirus Immune Control to Effector CD4 T Cells
- Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein
- A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes
- Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus
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- Histo-Blood Group Antigens Act as Attachment Factors of Rabbit Hemorrhagic Disease Virus Infection in a Virus Strain-Dependent Manner
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- Disruption of PML Nuclear Bodies Is Mediated by ORF61 SUMO-Interacting Motifs and Required for Varicella-Zoster Virus Pathogenesis in Skin
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- Viral Infection Induces Expression of Novel Phased MicroRNAs from Conserved Cellular MicroRNA Precursors
- Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4 T Cells and Is Reverted by CD8 Cell Depletion
- Recruitment of the Major Vault Protein by InlK: A Strategy to Avoid Autophagy
- The Steroid Catabolic Pathway of the Intracellular Pathogen Is Important for Pathogenesis and a Target for Vaccine Development
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Najčítanejšie v tomto čísle- Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus
- Two Group A Streptococcal Peptide Pheromones Act through Opposing Rgg Regulators to Control Biofilm Development
- Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species
- Recruitment of the Major Vault Protein by InlK: A Strategy to Avoid Autophagy
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