#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-17 Immunity by Dectin-1 and Dectin-2


C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of TH1 and TH-17 cellular responses. Fungal recognition by dectin-1 on human dendritic cells engages the CARD9-Bcl10-Malt1 module to activate NF-κB. Here we demonstrate that Malt1 recruitment is pivotal to TH-17 immunity by selective activation of NF-κB subunit c-Rel, which induces expression of TH-17-polarizing cytokines IL-1β and IL-23p19. Malt1 inhibition abrogates c-Rel activation and TH-17 immunity to Candida species. We found that Malt1-mediated activation of c-Rel is similarly essential to induction of TH-17-polarizing cytokines by dectin-2. Whereas dectin-1 activates all NF-κB subunits, dectin-2 selectively activates c-Rel, signifying a specialized TH-17-enhancing function for dectin-2 in anti-fungal immunity by human dendritic cells. Thus, dectin-1 and dectin-2 control adaptive TH-17 immunity to fungi via Malt1-dependent activation of c-Rel.


Vyšlo v časopise: Selective C-Rel Activation via Malt1 Controls Anti-Fungal T-17 Immunity by Dectin-1 and Dectin-2. PLoS Pathog 7(1): e32767. doi:10.1371/journal.ppat.1001259
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1001259

Souhrn

C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of TH1 and TH-17 cellular responses. Fungal recognition by dectin-1 on human dendritic cells engages the CARD9-Bcl10-Malt1 module to activate NF-κB. Here we demonstrate that Malt1 recruitment is pivotal to TH-17 immunity by selective activation of NF-κB subunit c-Rel, which induces expression of TH-17-polarizing cytokines IL-1β and IL-23p19. Malt1 inhibition abrogates c-Rel activation and TH-17 immunity to Candida species. We found that Malt1-mediated activation of c-Rel is similarly essential to induction of TH-17-polarizing cytokines by dectin-2. Whereas dectin-1 activates all NF-κB subunits, dectin-2 selectively activates c-Rel, signifying a specialized TH-17-enhancing function for dectin-2 in anti-fungal immunity by human dendritic cells. Thus, dectin-1 and dectin-2 control adaptive TH-17 immunity to fungi via Malt1-dependent activation of c-Rel.


Zdroje

1. RomaniL

2008 Cell mediated immunity to fungi: a reassessment. Med Mycol 46 515 529

2. OuyangW

KollsJK

ZhengY

2008 The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28 454 467

3. LoutenJ

BonifaceK

de Waal MalefytR

2009 Development and function of TH17 cells in health and disease. J Allergy Clin Immunol 123 1004 1011

4. RomaniL

2004 Immunity to fungal infections. Nat Rev Immunol 4 11 23

5. GeijtenbeekTBH

GringhuisSI

2009 Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol 9 465 479

6. MedzhitovR

2007 Recognition of microorganisms and activation of the immune response. Nature 449 819 826

7. van BeelenAJ

ZelinkovaZ

Taanman-KueterEW

MullerFJ

HommesDW

2007 Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27 660 669

8. WeaverCT

HattonRD

2009 Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol 9 883 889

9. MurphyKM

ReinerSL

2002 The lineage decisions of helper T cells. Nat Rev Immunol 2 933 944

10. GringhuisSI

den DunnenJ

LitjensM

van der VlistM

WeversB

2009 Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-[kappa]B activation through Raf-1 and Syk. Nat Immunol 10 203 213

11. NeteaMG

BrownGD

KullbergBJ

GowNAR

2008 An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Micro 6 67 78

12. SatoK

YangXL

YudateT

ChungJS

WuJ

2006 Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J Biol Chem 281 38854 38866

13. GrossO

GewiesA

FingerK

SchaferM

SparwasserT

2006 Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442 651 656

14. LeibundGut-LandmannS

GrossO

RobinsonMJ

OsorioF

SlackEC

2007 Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8 630 638

15. RogersNC

SlackEC

EdwardsAD

NolteMA

SchulzO

2005 Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22 507 517

16. GlockerEO

HennigsA

NabaviM

SchafferAA

WoellnerC

2009 A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med 361 1727 1735

17. FerwerdaB

FerwerdaG

PlantingaTS

WillmentJA

van SprielAB

2009 Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med 361 1760 1767

18. McGrealEP

RosasM

BrownGD

ZamzeS

WongSY

2006 The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16 422 430

19. SaijoS

IkedaS

YamabeK

KakutaS

IshigameH

2010 Dectin-2 Recognition of [alpha]-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans. Immunity 32 681 691

20. RobinsonMJ

OsorioF

RosasM

FreitasRP

SchweighofferE

2009 Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med 206 2037 2051

21. HaydenMS

GhoshS

2008 Shared principles in NF-[kappa]B signaling. Cell 132 344 362

22. RebeaudF

HailfingerS

Posevitz-FejfarA

TapernouxM

MoserR

2008 The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol 9 272 281

23. CoornaertB

BaensM

HeyninckK

BekaertT

HaegmanM

2008 T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-[kappa]B inhibitor A20. Nat Immunol 9 263 271

24. ButlerG

RasmussenMD

LinMF

SantosMA

SakthikumarS

2009 Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459 657 662

25. PfallerMA

DiekemaDJ

2007 Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20 133 163

26. BormanAM

PetchR

LintonCJ

PalmerMD

BridgePD

2008 Candida nivariensis, an emerging pathogenic fungus with multidrug resistance to antifungal agents. J Clin Microbiol 46 933 938

27. UnderhillDM

RossnagleE

LowellCA

SimmonsRM

2005 Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106 2543 2550

28. RawlingsDJ

SommerK

Moreno-GarciaME

2006 The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes. Nat Rev Immunol 6 799 812

29. FerchU

BuschenfeldeCMz

GewiesA

WegenerE

RauserS

2007 MALT1 directs B cell receptor-induced canonical nuclear factor-[kappa]B signaling selectively to the c-Rel subunit. Nat Immunol 8 984 991

30. TuscheMW

WardLA

VuF

McCarthyD

Quintela-FandinoM

2009 Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets. J Exp Med 206 2671 2683

31. GantnerBN

SimmonsRM

CanaveraSJ

AkiraS

UnderhillDM

2003 Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 197 1107 1117

32. SaccaniS

PantanoS

NatoliG

2003 Modulation of NF-kappaB activity by exchange of dimers. Mol Cell 11 1563 74

33. GringhuisSI

den DunnenJ

LitjensM

HofBV

van KooykY

2007 C-type lectin DC-SIGN modulates toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappa B. Immunity 26 605 616

34. SaijoS

FujikadoN

FurutaT

ChungSH

KotakiH

2007 Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol 8 39 46

35. TaylorPR

TsoniSV

WillmentJA

DennehyKM

RosasM

2007 Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 8 31 38

36. Hertz-FowlerC

PainA

2009 Unity in diversity: lessons from Candida. Nat Rev Micro 7 763

37. ChaffinWL

Lopez-RibotJL

CasanovaM

GozalboD

MartinezJP

1998 Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Microbiol Mol Biol Rev 62 130 180

38. BernardM

LatgeJP

2001 Aspergillus fumigatus cell wall: composition and biosynthesis. Med Mycol 39 Suppl 1 9 17

39. HohlTM

Van EppsHL

RiveraA

MorganLA

ChenPL

2005 Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog 1 e30

40. SorgiCA

SecattoA

FontanariC

TuratoWM

BelangerC

2009 Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and Dectin-1 receptors: correlation with leukotriene B4 generation and Role in HIV-1 Infection. J Immunol 182 4025 4035

41. ViriyakosolS

FiererJ

BrownGD

KirklandTN

2005 Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and dectin-1. Infect Immun 73 1553 1560

42. AshbeeHR

EvansEG

2002 Immunology of diseases associated with Malassezia species. Clin Microbiol Rev 15 21 57

43. BoseI

ReeseAJ

OryJJ

JanbonG

DoeringTL

2003 A Yeast under cover: the capsule of Cryptococcus neoformans. Eukaryot Cell 2 655 663

44. KleinschekMA

MullerU

BrodieSJ

StenzelW

KohlerG

2006 IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J Immunol 176 1098 1106

45. NakamuraK

KinjoT

SaijoS

MiyazatoA

AdachiY

2007 Dectin-1 is not required for the host defense to Cryptococcus neoformans. Microbiol Immunol 51 1115 1119

46. CooperAM

KhaderSA

2008 The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis. Immunol Rev 226 191 204

47. de JongMA

VriendLE

TheelenB

TaylorME

FluitsmaD

2010 C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi. Mol Immunol 47 1216 1225

Štítky
Hygiena a epidemiológia Infekčné lekárstvo Laboratórium

Článok vyšiel v časopise

PLOS Pathogens


2011 Číslo 1
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Získaná hemofilie - Povědomí o nemoci a její diagnostika
nový kurz

Eozinofilní granulomatóza s polyangiitidou
Autori: doc. MUDr. Martina Doubková, Ph.D.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#