Temperature is a critical environmental factor that affects ageing in both cold-blooded and warm-blooded species. In invertebrate animals, lifespan varies inversely with temperature, with higher temperature resulting in faster development but shorter lifespan. This phenomenon has been usually attributed to passive changes in metabolic rate, but recent work suggests that this process is regulated. In this study, we identify the co-chaperone protein p23 in the nematode C. elegans as an important modulator of longevity in response to temperature. Co-chaperones bind to client proteins to assist in their folding or stabilize their shape, thereby regulating their activity. Remarkably, deletion of p23 results in animals that are long lived at high temperatures and short lived at low temperatures relative to normal wild type animals. Our experiments indicate that p23 regulates lifespan through the neurosensory apparatus. These in turn impinge on key longevity regulators that mediate the transcriptional outputs of insulin/IGF, heat shock response and steroidal signaling. These studies suggest that complexes formed by p23 play a central role in regulating longevity in response to temperature.
Vyšlo v časopise: Co-chaperone p23 Regulates . Lifespan in Response to Temperature. PLoS Genet 11(4): e32767. doi:10.1371/journal.pgen.1005023 Kategorie: Research Article prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005023
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