Break to Make a Connection

1. HassoldTHuntP 2001 To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2 280 291

2. KeeneySGirouxCNKlecknerN 1997 Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88 375 384

3. BergeratAde MassyBGadelleDVaroutasPCNicolasA 1997 An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature 386 414 417

4. LakeCMNielsenRJHawleyRS 2011 The Drosophila zinc finger protein Trade Embargo is required for double strand break formation in meiosis. PLoS Genet 7 e1002005 doi:10.1371/journal.pgen.1002005

5. KeeneyS 2007 Spo11 and the formation of DNA double-strand breaks in meiosis. EgelRLankenauDH  Berlin Springer 81 123

6. SasanumaHHirotaKFukudaTKakushoNKugouK 2008 Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. Genes Dev 22 398 410

7. WanLNiuHFutcherBZhangCShokatKM 2008 Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev 22 386 397

8. HendersonKAKeeKMalekiSSantiniPAKeeneyS 2006 Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell 125 1321 1332

9. KumarRBourbonHMde MassyB 2010 Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev 24 1266 1280

10. BaudatFBuardJGreyCFledel-AlonAOberC 2010 PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 327 836 840

11. MyersSBowdenRTumianABontropREFreemanC 2010 Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science 327 876 879

12. ParvanovEDPetkovPMPaigenK 2010 Prdm9 controls activation of mammalian recombination hotspots. Science 327 835

13. HayashiKYoshidaKMatsuiY 2005 A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature 438 374 378

14. ReddyKCVilleneuveAM 2004 C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination. Cell 118 439 452

15. LibbyBJReinholdtLGSchimentiJC 2003 Positional cloning and characterization of Mei1, a vertebrate-specific gene required fornormal meiotic chromosome synapsis in mice. Proc Natl Acad Sci U S A 100 15706 15711

16. MercierRArmstrongSJHorlowCJacksonNPMakaroffCA 2003 The meiotic protein SWI1 is required for axial element formation and recombination initiation in Arabidopsis. Development 130 3309 3318

17. PageSLNielsenRJTeeterKLakeCMOngS 2007 A germline clone screen for meiotic mutants in Drosophila melanogaster. Fly (Austin) 1 172 181

18. CarpenterAT 1975 Recombination nodules and synaptonemal complex in recombination-defective females of Drosophila melanogaster. Chromosoma 75 259 292

19. LiuHJangJKKatoNMcKimKS 2002 mei-P22 encodes a chromosome-associated protein required for the initiation of meiotic recombination in Drosophila melanogaster. Genetics 162 245 258

20. MehrotraSMcKimKS 2006 Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila females. PLoS Genet 2 e200 doi:10.1371/journal.pgen.0020200