Contributions of Status and Allele Expression, But Not Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys

English version České info

CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 acquisition and with both viral load and disease progression following infection with HIV-1. An association has also been reported between CCL3L CNV and clinical sequelae of the simian immunodeficiency virus (SIV) infection in vivo in rhesus monkeys. The present study was initiated to explore the possibility of an association of CCL3L CNV with the control of virus replication and AIDS progression in a carefully defined cohort of SIVmac251-infected, Indian-origin rhesus monkeys. Although we demonstrated extensive variation in copy number of CCL3L in this cohort of monkeys, CCL3L CNV was not significantly associated with either peak or set-point plasma SIV RNA levels in these monkeys when MHC class I allele Mamu-A*01 was included in the models or progression to AIDS in these monkeys. With 66 monkeys in the study, there was adequate power for these tests if the correlation of CCL3L and either peak or set-point plasma SIV RNA levels was 0.34 or 0.36, respectively. These findings call into question the premise that CCL3L CNV is important in HIV/SIV pathogenesis.

Vyšlo v časopise: Contributions of Status and Allele Expression, But Not Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys. PLoS Genet 6(6): e32767. doi:10.1371/journal.pgen.1000997
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1000997

Souhrn

Zdroje

1. KaslowRA

CarringtonM

AppleR

ParkL

MuñozA

1996 Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat Med 2 405 411

2. FellayJ

ShiannaKV

GeD

ColomboS

2007 A whole-genome association study of major determinants for host control of HIV-1. Science 317 944 947

3. MartinMP

GaoX

LeeJH

NelsonGW

DetelsR

2002 Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 31 429 434

4. DeanM

CarringtonM

WinklerC

HuttleyGA

SmithMW

1996 Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273 1856 1862

5. HuangY

PaxtonWA

WolinskySM

NeumannAU

ZhangL

1996 The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 2 1240 1243

6. SmithMW

DeanM

CarringtonM

WinklerC

HuttleyGA

1997 Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science 277 959 965

7. GonzalezE

KulkarniH

BolivarH

ManganoA

SanchezR

2005 The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 307 1434 1440

8. AhujaSK

KulkarniH

CatanoG

AganBK

CamargoJF

2008 CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals. Nat Med 14 413 420

9. DolanMJ

KulkarniH

CamargoJF

HeW

SmithA

2007 CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat Immunol 8 1324 1336

10. BaileyJA

GuZ

ClarkRA

ReinertK

SamonteRV

2002 Recent segmental duplications in the human genome. Science 297 1003 1007

11. TownsonJR

BarcellosLF

NibbsRJ

2002 Gene copy number regulates the production of the human chemokine CCL3-L1. Eur J Immunol 32 3016 3026

12. UrbanTJ

WeintrobAC

FellayJ

ColomboS

ShiannaKV

2009 CCL3L 1 and HIV/AIDS susceptibility. Nat Med 15 1110 1112

13. BhattacharyaT

StantonJ

KimEY

KunstmanKJ

PhairJP

2009 CCL3L1 and HIV/AIDS susceptibility. Nat Med 15 1112 1115

14. FieldSF

HowsonJM

MaierLM

WalkerS

WalkerNM

2009 Experimental aspects of copy number variant assays at CCL3L1. Nat Med 15 1115 1117

15. DegenhardtJD

de CandiaP

ChabotA

SchwartzS

HendersonL

2009 Copy number variation of CCL3-like genes affects rate of progression to simian-AIDS in Rhesus Macaques (Macaca mulatta). PLoS Genet 5 e1000346 doi:10.1371/journal.pgen.1000346

16. Reimann KA ParkerRA

SeamanMS

BeaudryK

BeddallM

2005 Pathogenicity of simian-human immunodeficiency virus SHIV-89.6P and SIVmac is attenuated in cynomolgus macaques and associated with early T-lymphocyte responses. J Virol 79 8878 8885

17. YasutomiY

ReimannKA

LordCI

MillerMD

LetvinNL

1993 Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys. J Virol 67 1707 1711

18. PalR

VenzonD

LetvinNL

SantraS

MontefioriDC

2002 ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency. J Virol 76 292 302

19. MothéBR

WeinfurterJ

WangC

RehrauerW

WilsonN

2003 Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication. J Virol 77 2736 2740

20. LimSY

RogersT

ChanT

WhitneyJB

KimJH

2010 TRIM5α Modulates Immunodeficiency Virus Control in Rhesus Monkeys. PLoS Pathog 6 e1000738 doi:10.1371/journal.ppat.1000738

21. LifsonJD

NowakMA

GoldsteinS

RossioJL

KinterA

1997 The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection. J Virol 71(12) 9508 9514

22. LetvinNL

MascolaJR

SuY

GorgoneDA

BuzbyAP

2006 Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys. Science 312 1530 1533

23. BurdoTH

MarcondesMC

LaniganCM

PenedoMC

FoxHS

2005 Susceptibility of Chinese rhesus monkeys to SIV infection. AIDS 19 1704 1706

24. ZhangY

LouB

LalRB

GettieA

MarxPA

2000 Use of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and human immunodeficiency virus type 2 in primary cells. J Virol 74 6893 6910

25. ModiWS

2004 CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12. Genomics 83 735 738

26. LetvinNL

MascolaJR

SuY

GorgoneDA

BuzbyAP

2006 Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys. Science 312 1530 1533

27. ZelenM

1971 The analysis of several 2×2 contingency tables. Biometrika 58 129 137