Absence of Evidence for MHC–Dependent Mate Selection within HapMap Populations
The major histocompatibility complex (MHC) of immunity genes has been reported to influence mate choice in vertebrates, and a recent study presented genetic evidence for this effect in humans. Specifically, greater dissimilarity at the MHC locus was reported for European-American mates (parents in HapMap Phase 2 trios) than for non-mates. Here we show that the results depend on a few extreme data points, are not robust to conservative changes in the analysis procedure, and cannot be reproduced in an equivalent but independent set of European-American mates. Although some evidence suggests an avoidance of extreme MHC similarity between mates, rather than a preference for dissimilarity, limited sample sizes preclude a rigorous investigation. In summary, fine-scale molecular-genetic data do not conclusively support the hypothesis that mate selection in humans is influenced by the MHC locus.
Vyšlo v časopise:
Absence of Evidence for MHC–Dependent Mate Selection within HapMap Populations. PLoS Genet 6(4): e32767. doi:10.1371/journal.pgen.1000925
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pgen.1000925
Souhrn
The major histocompatibility complex (MHC) of immunity genes has been reported to influence mate choice in vertebrates, and a recent study presented genetic evidence for this effect in humans. Specifically, greater dissimilarity at the MHC locus was reported for European-American mates (parents in HapMap Phase 2 trios) than for non-mates. Here we show that the results depend on a few extreme data points, are not robust to conservative changes in the analysis procedure, and cannot be reproduced in an equivalent but independent set of European-American mates. Although some evidence suggests an avoidance of extreme MHC similarity between mates, rather than a preference for dissimilarity, limited sample sizes preclude a rigorous investigation. In summary, fine-scale molecular-genetic data do not conclusively support the hypothesis that mate selection in humans is influenced by the MHC locus.
Zdroje
1. de BakkerPIW
McVeanG
SabetiPC
MirettiMM
GreenT
2006 A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 38 1166 72 doi:10.1038/ng1885
2. PottsWK
2002 Wisdom through immunogenetics. Nat Genet 30 130 1 doi:10.1038/ng0202-130
3. Garver-ApgarCE
GangestadSW
ThornhillR
MillerRD
OlpJJ
2006 Major histocompatibility complex alleles, sexual responsivity, and unfaithfulness in romantic couples. Psychol Sci 17 830 5 doi:10.1111/j.1467-9280.2006.01789.x
4. WedekindC
SeebeckT
BettensF
PaepkeAJ
1995 MHC-dependent mate preferences in humans. Proc Biol Sci 260 245 9 doi:10.1098/rspb.1995.0087
5. JacobS
McClintockMK
ZelanoB
OberC
2002 Paternally inherited HLA alleles are associated with women's choice of male odor. Nat Genet 30 175 9 doi:10.1038/ng830
6. RobertsSC
GoslingLM
CarterV
PetrieM
2008 MHC-correlated odour preferences in humans and the use of oral contraceptives. Proc Biol Sci 275 2715 22 doi:10.1098/rspb.2008.0825
7. OberC
WeitkampLR
CoxN
DytchH
KostyuD
1997 HLA and mate choice in humans. Am J Hum Genet 61 497 504 doi:10.1086/515511
8. ThompsonRN
McMillonR
NapierA
WekesaKS
2007 Pregnancy block by MHC class I peptides is mediated via the production of inositol 1,4,5-trisphosphate in the mouse vomeronasal organ. J Exp Biol 210 1406 12 doi:10.1242/jeb.02753
9. WyattTD
2009 Fifty years of pheromones. Nature 457 262 3 doi:10.1038/457262a
10. NuzzoR
2008 Ah, love at first whiff - An online matchmaking site tries to predict attraction based on people's genes. The Los Angeles Times: F.1
11. HavlicekJ
RobertsSC
2009 MHC-correlated mate choice in humans: a review. Psychoneuroendocrinology 34 497 512 doi:10.1016/j.psyneuen.2008.10.007
12. RobertsSC
LittleAC
GoslingLM
JonesBC
PerrettDI
2005 MHC-assortative facial preferences in humans. Biol Lett 1 400 3 doi:10.1098/rsbl.2005.0343
13. ChaixR
CaoC
DonnellyP
2008 Is mate choice in humans MHC-dependent? PLoS Genet 4 e1000184 doi:10.1371/journal.pgen.1000184
14. A haplotype map of the human genome 2005 Nature 437 1299 320 doi:10.1038/nature04226
15. HayterAJ
1996 Probability and Statistics for Engineers and Scientists. Har/Dsk. Wadsworth Publishing Company
16. MarchiniJ
CutlerD
PattersonN
StephensM
EskinE
2006 A comparison of phasing algorithms for trios and unrelated individuals. Am J Hum Genet 78 437 50 doi:10.1086/500808
17. SokalRR
RohlfFJ
1994 Biometry: The Principles and Practices of Statistics in Biological Research. Third Edition. W. H. Freeman
18. RülickeT
ChapuisatM
HombergerFR
MacasE
WedekindC
1998 MHC-genotype of progeny influenced by parental infection. Proc Biol Sci 265 711 6 doi:10.1098/rspb.1998.0351
Štítky
Genetika Reprodukčná medicínaČlánok vyšiel v časopise
PLOS Genetics
2010 Číslo 4
- Je „freeze-all“ pro všechny? Odborníci na fertilitu diskutovali na virtuálním summitu
- Gynekologové a odborníci na reprodukční medicínu se sejdou na prvním virtuálním summitu
Najčítanejšie v tomto čísle
- Admixture Mapping Scans Identify a Locus Affecting Retinal Vascular Caliber in Hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) Study
- Whole-Genome SNP Association in the Horse: Identification of a Deletion in Myosin Va Responsible for Lavender Foal Syndrome
- Genetic Tests for Ecological and Allopatric Speciation in Anoles on an Island Archipelago
- Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair