Výpis čísla časopisu 8/2013 PLOS Genetics

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Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations

Re-Ranking Sequencing Variants in the Post-GWAS Era for Accurate Causal Variant Identification

Histone Variant HTZ1 Shows Extensive Epistasis with, but Does Not Increase Robustness to, New Mutations

Functional Characterisation of Alpha-Galactosidase A Mutations as a Basis for a New Classification System in Fabry Disease

A Flexible Approach for the Analysis of Rare Variants Allowing for a Mixture of Effects on Binary or Quantitative Traits

Masculinization of Gene Expression Is Associated with Exaggeration of Male Sexual Dimorphism

Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes

Endogenous Stress Caused by Faulty Oxidation Reactions Fosters Evolution of 2,4-Dinitrotoluene-Degrading Bacteria

Comparative Anatomy of Chromosomal Domains with Imprinted and Non-Imprinted Allele-Specific DNA Methylation

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence

Depletion of Retinoic Acid Receptors Initiates a Novel Positive Feedback Mechanism that Promotes Teratogenic Increases in Retinoic Acid

Bypass of 8-oxodG

Calpain-6 Deficiency Promotes Skeletal Muscle Development and Regeneration

ATM Release at Resected Double-Strand Breaks Provides Heterochromatin Reconstitution to Facilitate Homologous Recombination

Generation of Tandem Direct Duplications by Reversed-Ends Transposition of Maize Elements

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

Integrated Model of and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes

High-Throughput Genetic and Gene Expression Analysis of the RNAPII-CTD Reveals Unexpected Connections to SRB10/CDK8

Dynamic Rewiring of the Retinal Determination Network Switches Its Function from Selector to Differentiation

β-Catenin-Independent Activation of TCF1/LEF1 in Human Hematopoietic Tumor Cells through Interaction with ATF2 Transcription Factors

Genetic Mapping of Specific Interactions between Mosquitoes and Dengue Viruses

A Highly Redundant Gene Network Controls Assembly of the Outer Spore Wall in

Origin and Functional Diversification of an Amphibian Defense Peptide Arsenal

Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in

Integrative Modeling of eQTLs and Cis-Regulatory Elements Suggests Mechanisms Underlying Cell Type Specificity of eQTLs

Species and Population Level Molecular Profiling Reveals Cryptic Recombination and Emergent Asymmetry in the Dimorphic Mating Locus of

Ras-Induced Changes in H3K27me3 Occur after Those in Transcriptional Activity

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

Global Analysis of Fission Yeast Mating Genes Reveals New Autophagy Factors

Deficiency Suppresses Intestinal Tumorigenesis

Introns Regulate Gene Expression in in a Pab2p Dependent Pathway

Meiotic Recombination Initiation in and around Retrotransposable Elements in

Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

Comparative Genomic and Functional Analysis of 100 Strains and Their Comparison with Strain GG

A Model-Based Analysis of GC-Biased Gene Conversion in the Human and Chimpanzee Genomes

Masculinization of the X Chromosome in the Pea Aphid

The Architecture of a Prototypical Bacterial Signaling Circuit Enables a Single Point Mutation to Confer Novel Network Properties

Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements

The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress

Mediator Directs Co-transcriptional Heterochromatin Assembly by RNA Interference-Dependent and -Independent Pathways

The Genome of and the Basis of Host-Microsporidian Interactions

Regulation of Sister Chromosome Cohesion by the Replication Fork Tracking Protein SeqA

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

A Nuclear Calcium-Sensing Pathway Is Critical for Gene Regulation and Salt Stress Tolerance in

Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma

: A Mouse Strain with an Ift140 Mutation That Results in a Skeletal Ciliopathy Modelling Jeune Syndrome

The Relative Contribution of Proximal 5′ Flanking Sequence and Microsatellite Variation on Brain Vasopressin 1a Receptor () Gene Expression and Behavior

Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen

Computational Identification of Diverse Mechanisms Underlying Transcription Factor-DNA Occupancy

GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm

H2A.Z Acidic Patch Couples Chromatin Dynamics to Regulation of Gene Expression Programs during ESC Differentiation

Identification of DSB-1, a Protein Required for Initiation of Meiotic Recombination in , Illuminates a Crossover Assurance Checkpoint

Binding of TFIIIC to SINE Elements Controls the Relocation of Activity-Dependent Neuronal Genes to Transcription Factories

Global Analysis of the Sporulation Pathway of

Genetic Circuits that Govern Bisexual and Unisexual Reproduction in

Deletion of microRNA-80 Activates Dietary Restriction to Extend Healthspan and Lifespan

The Enhancer Landscape during Early Neocortical Development Reveals Patterns of Dense Regulation and Co-option

Sociogenomics of Cooperation and Conflict during Colony Founding in the Fire Ant

The Intronic Long Noncoding RNA Recruits PRC2 to the Promoter, Reducing the Expression of and Increasing Cell Proliferation

The , p.E318G Variant Increases the Risk of Alzheimer's Disease in -ε4 Carriers

The Wilms Tumor Gene, , Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans

Reversible and Rapid Transfer-RNA Deactivation as a Mechanism of Translational Repression in Stress

QTL Analysis of High Thermotolerance with Superior and Downgraded Parental Yeast Strains Reveals New Minor QTLs and Converges on Novel Causative Alleles Involved in RNA Processing

Genome Wide Association Identifies Novel Loci Involved in Fungal Communication

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, , Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

Causal and Synthetic Associations of Variants in the Gene Cluster with Alpha1-antitrypsin Serum Levels

Hard Selective Sweep and Ectopic Gene Conversion in a Gene Cluster Affording Environmental Adaptation

Brittle Culm1, a COBRA-Like Protein, Functions in Cellulose Assembly through Binding Cellulose Microfibrils

Chromosomal Copy Number Variation, Selection and Uneven Rates of Recombination Reveal Cryptic Genome Diversity Linked to Pathogenicity

The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1

Ras1 Acts through Duplicated Cdc42 and Rac Proteins to Regulate Morphogenesis and Pathogenesis in the Human Fungal Pathogen

The DSB-2 Protein Reveals a Regulatory Network that Controls Competence for Meiotic DSB Formation and Promotes Crossover Assurance

Recurrent Modification of a Conserved -Regulatory Element Underlies Fruit Fly Pigmentation Diversity

Associations of Mitochondrial Haplogroups B4 and E with Biliary Atresia and Differential Susceptibility to Hydrophobic Bile Acid

The Conditional Nature of Genetic Interactions: The Consequences of Wild-Type Backgrounds on Mutational Interactions in a Genome-Wide Modifier Screen

A Critical Function of Mad2l2 in Primordial Germ Cell Development of Mice

A Role for CF1A 3′ End Processing Complex in Promoter-Associated Transcription

Vitellogenin Underwent Subfunctionalization to Acquire Caste and Behavioral Specific Expression in the Harvester Ant

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The Innocence Project at Twenty: An Interview with Barry Scheck

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Past Visits Present: TCF/LEFs Partner with ATFs for β-Catenin–Independent Activity

Fifty Years On: GWAS Confirms the Role of a Rare Variant in Lung Disease

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Chromatin Sampling—An Emerging Perspective on Targeting Polycomb Repressor Proteins

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Transposon Domestication versus Mutualism in Ciliate Genome Rearrangements

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

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