News from on the Meiotic Roles of Blap75/Rmi1 and Top3α

1. ChangMBellaouiMZhangCDesaiRMorozovP 2005 RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J 24 2024 2033

2. LohmanTMTomkoEJWuCG 2008 Non-hexameric DNA helicases and translocases: mechanisms and regulation. Nat Rev Mol Cell Biol 9 391 401

3. WuLHicksonID 2003 The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 426 870 874

4. MeeteiARSechiSWallischMYangDYoungMK 2003 A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol 23 3417 3426

5. YinJSobeckAXuCMeeteiARHoatlinM 2005 BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. EMBO J 24 1465 1476

6. MullenJRNallasethFSLanYQSlagleCEBrillSJ 2005 Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mol Cell Biol 25 4476 4487

7. SinghTRAliAMBusyginaVRaynardSFanQ 2008 BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev 22 2856

8. XuDGuoRSobeckABachratiCZYangJ 2008 RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev 22 2843

9. LiuYWestSC 2008 More complexity to the Bloom's syndrome complex. Genes Dev 22 2737 2742

10. BussenWRaynardSBusyginaVSinghAKSungP 2007 Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex. J Biol Chem 282 31484 31492

11. RaynardSBussenWSungP 2006 A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J Biol Chem 281 13861 13864

12. WuLBachratiCZOuJXuCYinJ 2006 BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc Natl Acad Sci U S A 103 4068 4073

13. BachratiCZBortsRHHicksonID 2006 Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase. Nucleic Acids Res 34 2269 2279

14. BugreevDVYuXEgelmanEHMazinAV 2007 Novel pro- and anti-recombination activities of the Bloom's syndrome helicase. Genes Dev 21 3085 3094

15. MankouriHWNgoHPHicksonID 2007 Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3. Mol Biol Cell 18 4062 4073

16. GravelSChapmanJRMagillCJacksonSP 2008 DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev 22 2767 2772

17. Bagherieh-NajjarMBde VriesOMHilleJDijkwelPP 2005 Arabidopsis RecQI4A suppresses homologous recombination and modulates DNA damage responses. Plant J 43 789 798

18. HartungFPlchováHPuchtaH 2000 Molecular characterisation of RecQ homologues in Arabidopsis thaliana. Nucleic Acids Res 28 4275 4282

19. HartungFSuerSPuchtaH 2007 Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana. Proc Natl Acad Sci U S A 104 18836 18841

20. ChelyshevaLVezonDBelcramKGendrotGGrelonM 2008 The Arabidopsis BLAP75/RMI1 homologue plys crucial roles in meiotic double strand break repair. PLoS Genet 4(12) e1000309 doi:10.1371/journal.pgen.1000309

21. HartungFSuerSKnollAWurz-WildersinnRPuchtaH 2008 Topoisomerase 3a and RMI1 Are Not Only Required for the Suppression of Somatic Crossovers but Are Also Essential for the Resolution of Meiotic Recombination Intermediates in Arabidopsis thaliana. PLoS Genet 4(12) e1000285 doi:10.1371/journal.pgen.1000285

22. AllersTLichtenM 2001 Differential timing and control of noncrossover and crossover recombination during meiosis. Cell 106 47 57

23. BerchowitzLECopenhaverGP 2008 Division of labor among meiotic genes. Nat Genet 40 266 267

24. BishopDKZicklerD 2004 Early decision; meiotic crossover interference prior to stable strand exchange and synapsis. Cell 117 9 15

25. BornerGVKlecknerNHunterN 2004 Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell 117 29 45

26. HunterNKlecknerN 2001 The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination. Cell 106 59 70

27. JonesGHFranklinFC 2006 Meiotic crossing-over: obligation and interference. Cell 126 246 248

28. MezardCVignardJDrouaudJMercierR 2007 The road to crossovers: plants have their say. Trends Genet 23 91 99

29. JessopLLichtenM 2008 Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol Cell 31 313 323

30. OhSDLaoJPTaylorAFSmithGRHunterN 2008 RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol Cell 31 324 336

31. CouteauFBelzileFHorlowCGrandjeanOVezonD 1999 Random chromosome segregation without meiotic arrest in both male and female meiocytes of a dmc1 mutant of Arabidopsis. Plant Cell 11 1623 1634

32. BleuyardJGallegoMEWhiteCI 2004 Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination. Chromosoma 113 197 203

33. LiWChenCMarkmann-MulischUTimofejevaLSchmelzerE 2004 The Arabidopsis AtRAD51 gene is dispensable for vegetative development but required for meiosis. Proc Natl Acad Sci U S A 101 10596 10601

34. HigginsJVignardJMercierRPughAGFranklinFC 2008 AtMSH5 partners AtMSH4 in the class I meiotic crossover pathway in Arabidopsis thaliana, but is not required for synapsis. Plant J 55 28 39

35. LuXLiuXAnLZhangWSunJ 2008 The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis. Cell Res 18 589 599

36. MercierRJolivetSVezonDHuppeEChelyshevaL 2005 Two meiotic crossover classes cohabit in Arabidopsis: one is dependent on MER3,whereas the other one is not. Curr Biol 15 692 701

37. GangloffSde MassyBArthurLRothsteinRFabreF 1999 The essential role of yeast topoisomerase III in meiosis depends on recombination. EMBO J 18 1701 1711

38. WattPMLouisEJBortsRHHicksonID 1995 Sgs1: a eukaryotic homologue of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81 253 260

39. HartungFSuerSBergmannTPuchtaH 2006 The role of AtMUS81 in DNA repair and its genetic interaction with the helicase AtRecQ4A. Nucleic Acids Res 34 4438 4448

40. LuoGSantoroIMMcDanielLDNishijimaIMillsM 2000 Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat Genet 26 424 429

41. BerchowitzLEFrancisKEBeyALCopenhaverGP 2007 The role of AtMUS81 in interference-insensitive crossovers in A. thaliana. PLoS Genet 3 e132 doi:10.1371/journal.pgen.0030285