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DYNAMICAL CHARACTERISTICS OF SPEECH APPARATUS IN HUNTINGTON’S DISEASE


This paper presents new approach to measuring dynamical characteristics of the articulation and phonation apparatus in Huntington's disease (HD). This study utilizes the rhythm task in unusual way. Each repetition of the syllable is explored as unique measurement of dynamical characteristics of speech apparatus. The evaluation of dynamical characteristics was implemented into fully automatic algorithm. The database is gender balanced and consists of 43 Czech native participants including 20 healthy control (HC) and 23 HD subjects. The evaluation is based on recently designed segmentation method with very high accuracy of syllable detection and set of 6 descriptive features. All features of the set showed significant statistical difference (p<0.05) between HC and HD group. Longer duration of syllables and longer volume increase time reflect the decline of coordination of vocal and articulatory muscles. Higher instability in volume increase time and instability of reproduction are related to ataxic movements of vocal muscles in HD. Instability of duration of syllables and pauses corresponds with all motor manifestations in HD include vocal, articulatory and respiratory system dysfunction.

Keywords:
Huntington's disease, syllable detection, rhythm test, speech disorders, speech assessment.


Autoři: Jan Hlavnička
Působiště autorů: Czech Republic ;  Dept. of Circuit theory, Faculty of Electrical Engineering, Czech Technical University, Prague
Vyšlo v časopise: Lékař a technika - Clinician and Technology No. 3, 2015, 45, 88-92
Kategorie: Původní práce

Souhrn

This paper presents new approach to measuring dynamical characteristics of the articulation and phonation apparatus in Huntington's disease (HD). This study utilizes the rhythm task in unusual way. Each repetition of the syllable is explored as unique measurement of dynamical characteristics of speech apparatus. The evaluation of dynamical characteristics was implemented into fully automatic algorithm. The database is gender balanced and consists of 43 Czech native participants including 20 healthy control (HC) and 23 HD subjects. The evaluation is based on recently designed segmentation method with very high accuracy of syllable detection and set of 6 descriptive features. All features of the set showed significant statistical difference (p<0.05) between HC and HD group. Longer duration of syllables and longer volume increase time reflect the decline of coordination of vocal and articulatory muscles. Higher instability in volume increase time and instability of reproduction are related to ataxic movements of vocal muscles in HD. Instability of duration of syllables and pauses corresponds with all motor manifestations in HD include vocal, articulatory and respiratory system dysfunction.

Keywords:
Huntington's disease, syllable detection, rhythm test, speech disorders, speech assessment.


Zdroje

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[2] Martin, J.B., and Gusella, J.F. Huntington’s disease. Pathogenesis and management. The New England Journal of Medicine, 1986, vol. 19, p. 1267-1276.

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[4] Ballard, K.J., Savage, S., Leyton, C.E., Vogel, A.P., Hornberger, M., et al. Logopenic and Nonfluent Variants of Primary Progressive Aphasia Are Differentiated by Acoustic Measures of Speech Production. PLOS ONE, 2014, vol. 9, e89864.

[5] Tjaden, K., and Willding, G. Speech and pause characteristics associated with voluntary rate reduction in Parkinson’s disease and Multiple Sclerosis. Journal of Communication Disorders, 2011, vol. 44, p. 655-665.

[6] Duffy, J.R. Motor Speech Disorders: Substrates, Differential Diagnosis and Management, 2nd edition. Mosby, 2005, p. 592.

[7] Rusz, J., Saft, C., Schliegel, U., Hoffman R., Skodda, S. Phonatory Dysfunction as a Preclinical Symptom of Huntington Disease. PLOS ONE, 2014, vol. 9, p. 1-7.

[8] Rusz, J., Hlavnička, J., Čmejla, R., and Růžička, E. Automatic evaluation of speech rhythm instability and acceleration in dysarthrias associated with basal ganglia dysfunction. Frontiers in Bioengineering and Biotechnology, 2015, vol. 3, p. 1-11.

[9] Rusz, J., Klempíř, J., Tykalová, T., Baborová, E., Čmejla, R., Růžička, E., and Roth, J. Characteristics and occurrence of speech impairment in Huntington’s disease: possible influence of antipsychotic medication. Journal of Neural Transmission, 2014, vol. 121, p. 655-664.

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