Plasticity between MyoC- and MyoA-Glideosomes: An Example of Functional Compensation in Invasion

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Toxoplasma gondii can infect most warm-blooded animals, and is an important opportunistic pathogen for humans. This obligate intracellular parasite is able to invade virtually all nucleated cells, and as with most parasites of the Apicomplexa phylum, relies on a substrate-dependent gliding motility to actively penetrate into host cells and egress from infected cells. The conserved molecular machine (named glideosome) powering motility is located at the periphery of the parasite and involves the molecular motor, myosin A (MyoA). The glideosome exists in three flavors, exhibiting the same overall organization and sharing some common components while being spatially restricted to the central IMC, the apical cap and the basal pole of the parasite, respectively. The central and apical glideosomes are associated with MyoA (MyoA-glideosome) whereas the basal complex recruits myosin C (MyoC). Deleting components of the MyoC-glideosome uncovers the existence of complementary and compensatory mechanisms that ensure successful establishment of infection. This study highlights a higher degree of complexity and plasticity of the gliding machinery.

Vyšlo v časopise: Plasticity between MyoC- and MyoA-Glideosomes: An Example of Functional Compensation in Invasion. PLoS Pathog 10(11): e32767. doi:10.1371/journal.ppat.1004504
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004504

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