News from the Fungal Front: Wall Proteome Dynamics and Host–Pathogen Interplay

1. KlisFM, de KosterCG, BrulS (2011) A mass spectrometric view of the fungal wall proteome. Future Microbiol 6 : 941–951.

2. HeilmannCJ, SorgoAG, SiliakusAR, DekkerHL, BrulS, et al. (2011) Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile. Microbiology 157 : 2297–2307.

3. SorgoAG, HeilmannCJ, DekkerHL, BekkerM, BrulS, et al. (2011) Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans. Eukaryot Cell 10 : 1071–1081.

4. SosinskaGJ, de KoningLJ, de GrootPW, MandersEM, DekkerHL, et al. (2011) Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH. Microbiology 157 : 136–146.

5. StaabJF, BradwaySD, FidelPL, SundstromP (1999) Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 283 : 1535–1538.

6. HoyerLL, GreenCB, OhSH, ZhaoX (2008) Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family–a sticky pursuit. Med Mycol 46 : 1–15.

7. BoisrameA, CornuA, Da CostaG, RichardML (2011) Unexpected role for a serine/threonine-rich domain in the Candida albicans Iff protein family. Eukaryot Cell 10 : 1317–1330.

8. SalgadoPS, YanR, TaylorJD, BurchellL, JonesR, et al. (2011) Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans. Proc Natl Acad Sci U S A 108 : 15775–15779.

9. LipkePN, GarciaMC, AlsteensD, RamsookCB, KlotzSA, et al. (2012) Strengthening relationships: amyloids create adhesion nanodomains in yeasts. Trends Microbiol 20 : 59–65.

10. AlmeidaRS, BrunkeS, AlbrechtA, ThewesS, LaueM, et al. (2008) the hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog 4: e1000217.

11. LiuY, FillerSG (2011) Candida albicans Als3, a multifunctional adhesin and invasin. Eukaryot Cell 10 : 168–173.

12. LuoG, IbrahimAS, SpellbergB, NobileCJ, MitchellAP, et al. (2010) Candida albicans Hyr1p confers resistance to neutrophil killing and is a potential vaccine target. J Infect Dis 201 : 1718–1728.

13. KulkarniRD, KelkarHS, DeanRA (2003) An eight-cysteine-containing CFEM domain unique to a group of fungal membrane proteins. Trends Biochem Sci 28 : 118–121.

14. SorgoAG, HeilmannCJ, DekkerHL, BrulS, de KosterCG, et al. (2010) Mass spectrometric analysis of the secretome of Candida albicans. Yeast 27 : 661–672.

15. SosinskaGJ, de GrootPW, Teixeira de MattosMJ, DekkerHL, de KosterCG, et al. (2008) Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology 154 : 510–520.

16. WeissmanZ, ShemerR, ConibearE, KornitzerD (2008) An endocytic mechanism for haemoglobin-iron acquisition in Candida albicans. Mol Microbiol 69 : 201–217.

17. WeissmanZ, KornitzerD (2004) A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization. Mol Microbiol 53 : 1209–1220.

18. BraunV, HantkeK (2011) Recent insights into iron import by bacteria. Curr Opin Chem Biol 15 : 328–334.

19. BrownGD, NeteaMG (2012) Exciting developments in the immunology of fungal infections. Cell Host Microbe 11 : 422–424.

20. FrohnerIE, BourgeoisC, YatsykK, MajerO, KuchlerK (2009) Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance. Mol Microbiol 71 : 240–252.

21. Szafranski-SchneiderE, SwidergallM, CottierF, TielkerD, RomanE, et al. (2012) Msb2 shedding protects Candida albicans against antimicrobial peptides. PLoS Pathog 8: e1002501.

22. PuriS, KumarR, ChadhaS, TatiS, ContiHR, et al. (2012) Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis. PLoS One 7: e46020.

23. AlbrechtA, FelkA, PichovaI, NaglikJR, SchallerM, et al. (2006) Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem 281 : 688–694.

24. SchildL, HeykenA, de GrootPW, HillerE, MockM, et al. (2010) Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryot Cell 10 : 98–109.

25. EneIV, HeilmannCJ, SorgoAG, WalkerLA, de KosterCG, et al. (2012) Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans. Proteomics doi: 10.1002/pmic.201200228.

26. VecchiarelliA, PericoliniE, GabrielliE, PietrellaD (2012) New approaches in the development of a vaccine for mucosal candidiasis: progress and challenges. Front Microbiol 3 : 294.

27. SpellbergB, IbrahimAS, YeamanMR, LinL, FuY, et al. (2008) The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus. Infect Immun 76 : 4574–4580.