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preLekára.sk / Odborné časopisy / PLOS Genetics / 2013 - 3

Tdp2: A Means to Fixing the Ends

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Vyšlo v časopise: Tdp2: A Means to Fixing the Ends. PLoS Genet 9(3): e32767. doi:10.1371/journal.pgen.1003370
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1003370

Souhrn

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Zdroje

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8. NitissKC, MalikM, HeX, WhiteSW, NitissJL (2006) Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A 103: 8953–8958.

9. InterthalH, ChenHJ, Kehl-FieTE, ZotzmannJ, LeppardJB, et al. (2005) SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity. EMBO J 24: 2224–2233.

10. MuraiJ, HuangSY, DasBB, DexheimerTS, TakedaS, et al. (2012) Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells. J Biol Chem 287: 12848–12857.

11. Gómez-HerrerosF, Romero-GranadosR, ZengZ, Álvarez-QuilónA, QuinteroC, et al. (2013) TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet 9: e1003226 doi:10.1371/journal.pgen.1003226.

12. Cortes-LedesmaF, El KhamisySF, ZumaMC, OsbornK, CaldecottKW (2009) A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature 461: 674–678.

13. PypeS, DeclercqW, IbrahimiA, MichielsC, Van RietschotenJG, et al. (2000) TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. J Biol Chem 275: 18586–18593.

14. ZengZ, Cortes-LedesmaF, El KhamisySF, CaldecottKW (2011) TDP2/TTRAP is the major 5′-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. J Biol Chem 286: 403–409.

15. ZengZ, SharmaA, JuL, MuraiJ, UmansL, et al. (2012) TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Res 40: 8371–8380.

16. ShiK, KurahashiK, GaoR, TsutakawaSE, TainerJA, et al. (2012) Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2. Nat Struct Mol Biol 19: 1372–7.

17. SchellenbergMJ, AppelCD, AdhikariS, RobertsonPD, RamsdenDA, et al. (2012) Mechanism of repair of 5′-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2. Nat Struct Mol Biol 19: 1363–71.

18. GaoR, HuangSY, MarchandC, PommierY (2012) Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes. J Biol Chem 287: 30842–30852.

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21. HamiltonNK, MaizelsN (2010) MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break repair in Saccharomyces cerevisiae. PLoS ONE 5: e15387 doi:10.1371/journal.pone.0015387.

22. MaoY, DesaiSD, TingCY, HwangJ, LiuLF (2001) 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes. J Biol Chem 276: 40652–40658.

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