Classical Genetics Meets Next-Generation Sequencing: Uncovering a Genome-Wide Recombination Map in

1. SternC (1926) An effect of temperature and age on crossing over in the first chromosome of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America 12 : 530–532.

2. SmithHF (1936) Influence of temperature on crossing-over in Drosophila. Nature 138 : 329–330.

3. PloughHH (1917) The effect of temperature on crossingover in Drosophila. Journal of Experimental Zoology 24 : 147–209.

4. PloughHH (1921) Further studies on the effect of temperature on crossing over. Journal of Experimental Zoology 32 : 187–202.

5. BrooksLD, MarksRW (1986) The organization of genetic variation for recombination in Drosophila melanogaster. Genetics 114 : 525–547.

6. NishantKT, RaoMRS (2006) Molecular features of meiotic recombination hot spots. Bioessays 28 : 45–56.

7. AxelssonE, WebsterMT, RatnakumarA, PontingCP, Lindblad-TohK, et al. (2012) Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Research 22 : 51–63.

8. MyersS, BottoloL, FreemanC, McVeanG, DonnellyP (2005) A fine-scale map of recombination rates and hotspots across the human genome. Science 310 : 321–324.

9. MackayTFC, RichardsS, StoneEA, BarbadillaA, AyrolesJF, et al. (2012) The Drosophila melanogaster Genetic Reference Panel. Nature 482 : 173–178.

10. SellaG, PetrovDA, PrzeworskiM, AndolfattoP (2009) Pervasive Natural Selection in the Drosophila Genome? PLoS Genet 5: e1000495 doi:10.1371/journal.pgen.1000495.

11. SinghND, AquadroCF, ClarkAG (2009) Estimation of fine-scale recombination intensity variation in the white-echinus interval of D. melanogaster. Journal of Molecular Evolution 69 : 42–53.

12. CirulliET, KlimanRM, NoorMAF (2007) Fine-scale crossover rate heterogeneity in Drosophila pseudoobscura. Journal of Molecular Evolution 64 : 129–135.

13. KulathinalRJ, BennetttSM, FitzpatrickCL, NoorMAF (2008) Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence. Proceedings of the National Academy of Sciences of the United States of America 105 : 10051–10056.

14. StevisonLS, NoorMAF (2010) Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis. Journal of Molecular Evolution 71 : 332–345.

15. ComeronJM, RatnappanR, BailinS (2012) The many landscapes of recombination in Drosophila melanogaster. PLoS Genet 8: e1002905 doi:10.1371/journal.pgen.1002905.

16. ManceraE, BourgonR, BrozziA, HuberW, SteinmetzLM (2008) High-resolution mapping of meiotic crossovers and non-crossovers in yeast. Nature 454 : 479–U471.

17. JeffreysAJ, MayCA (2004) Intense and highly localized gene conversion activity in human meiotic crossover hot spots. Nature Genetics 36 : 151–156.

18. ChenJM, CooperDN, ChuzhanovaN, FerecC, PatrinosGP (2007) Gene conversion: mechanisms, evolution and human disease. Nature Reviews Genetics 8 : 762–775.

19. MyersS, BowdenR, TumianA, BontropRE, FreemanC, et al. (2010) Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination. Science 327 : 876–879.

20. ParvanovED, PetkovPM, PaigenK (2010) Prdm9 Controls Activation of Mammalian Recombination Hotspots. Science 327 : 835–835.

21. BaudatF, BuardJ, GreyC, Fledel-AlonA, OberC, et al. (2010) PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 327 : 836–840.

22. OliverPL, GoodstadtL, BayesJJ, BirtleZ, RoachKC, et al. (2009) Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet 5 : 1000753 doi:10.1371/journal.pgen.1000753.

23. ReedFA, TishkoffSA (2006) Positive selection can create false hotspots of recombination. Genetics 172 : 2011–2014.

24. O'ReillyPF, BirneyE, BaldingDJ (2008) Confounding between recombination and selection, and the Ped/Pop method for detecting selection. Genome Research 18 : 1304–1313.