A Sustained Dietary Change Increases Epigenetic Variation in Isogenic
Mice
Epigenetic changes can be induced by adverse environmental exposures, such as
nutritional imbalance, but little is known about the nature or extent of these
changes. Here we have explored the epigenomic effects of a sustained nutritional
change, excess dietary methyl donors, by assessing genomic CpG methylation
patterns in isogenic mice exposed for one or six generations. We find stochastic
variation in methylation levels at many loci; exposure to methyl donors
increases the magnitude of this variation and the number of variable loci.
Several gene ontology categories are significantly overrepresented in genes
proximal to these methylation-variable loci, suggesting that certain pathways
are susceptible to environmental influence on their epigenetic states. Long-term
exposure to the diet (six generations) results in a larger number of loci
exhibiting epigenetic variability, suggesting that some of the induced changes
are heritable. This finding presents the possibility that epigenetic variation
within populations can be induced by environmental change, providing a vehicle
for disease predisposition and possibly a substrate for natural selection.
Vyšlo v časopise:
A Sustained Dietary Change Increases Epigenetic Variation in Isogenic
Mice. PLoS Genet 7(4): e32767. doi:10.1371/journal.pgen.1001380
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pgen.1001380
Souhrn
Epigenetic changes can be induced by adverse environmental exposures, such as
nutritional imbalance, but little is known about the nature or extent of these
changes. Here we have explored the epigenomic effects of a sustained nutritional
change, excess dietary methyl donors, by assessing genomic CpG methylation
patterns in isogenic mice exposed for one or six generations. We find stochastic
variation in methylation levels at many loci; exposure to methyl donors
increases the magnitude of this variation and the number of variable loci.
Several gene ontology categories are significantly overrepresented in genes
proximal to these methylation-variable loci, suggesting that certain pathways
are susceptible to environmental influence on their epigenetic states. Long-term
exposure to the diet (six generations) results in a larger number of loci
exhibiting epigenetic variability, suggesting that some of the induced changes
are heritable. This finding presents the possibility that epigenetic variation
within populations can be induced by environmental change, providing a vehicle
for disease predisposition and possibly a substrate for natural selection.
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