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Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants#


Objective:
This clinical study aimed to evaluate effectiveness of a commercially available toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite as well as antioxidants phloretin, ferulic acid and silymarin in reducing dental hypersensitivity in adults.

Methods:
The clinical trial enrolled patients with a history of dentin hypersensitivity. A test toothpaste was introduced into the daily routine, which included initial instruction on usage. Patients completed a five-question visual analog scale (VAS) at the inception/baseline, after two days and after two weeks of using the toothpaste to determine their level of tooth sensitivity at baseline with the use of the toothpaste over time.

Results:
Patients that had significant sensitivity at baseline had a range of 52% to 76 % improvement after 48 hours and a range of 70% to 84% improvement after two weeks.

Conclusion:
A toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin applied daily significantly decreased tooth pain of dentin hypersensitivity within a two-day and two-week time period.

Clinical Significance:
Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate, sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly and quickly reduce tooth pain of dentin hypersensitivity.

Keywords:
Antioxidants, dentin hypersensitivity, hydroxyapatite, polyphenol.


Autoři: Samuel B. Low 1,4,*;  Edward P. Allen 2;  Elias D. Kontogiorgos 3
Působiště autorů: Department of Periodontics, University of Florida College of Dentistry, University of Florida, Gainesville, Florida 32610, USA 1;  Department of Periodontics, Texas A&M University, Baylor College of Dentistry, Dallas, Texas 75246, USA 2;  Department of Restorative Sciences, Texas A&M, Baylor University, College of Dentistry, Dallas, Texas 75246, USA 3;  Department of Restorative Sciences, Texas A&M, Baylor University, College of Dentistry, Dallas, Texas 75246, USA 4
Vyšlo v časopise: The Open Dentistry Journal, 2015, 9, 92-97
prolekare.web.journal.doi_sk: https://doi.org/10.2174/1874364101509010092

© Low et al.; Licensee Bentham Open.
Open-Access License: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The electronic version of this article is the complete one and can be found online at: http://benthamopen.com/FULLTEXT/TODENTJ-9-92.

Souhrn

Objective:
This clinical study aimed to evaluate effectiveness of a commercially available toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite as well as antioxidants phloretin, ferulic acid and silymarin in reducing dental hypersensitivity in adults.

Methods:
The clinical trial enrolled patients with a history of dentin hypersensitivity. A test toothpaste was introduced into the daily routine, which included initial instruction on usage. Patients completed a five-question visual analog scale (VAS) at the inception/baseline, after two days and after two weeks of using the toothpaste to determine their level of tooth sensitivity at baseline with the use of the toothpaste over time.

Results:
Patients that had significant sensitivity at baseline had a range of 52% to 76 % improvement after 48 hours and a range of 70% to 84% improvement after two weeks.

Conclusion:
A toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin applied daily significantly decreased tooth pain of dentin hypersensitivity within a two-day and two-week time period.

Clinical Significance:
Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate, sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly and quickly reduce tooth pain of dentin hypersensitivity.

Keywords:
Antioxidants, dentin hypersensitivity, hydroxyapatite, polyphenol.


Zdroje

[1] Addy M. Dentine hypersensitivity new perspectives on an old problem Int Dental J 2002; 52(5): 367-75.

[2] Irvine JH. Root surface sensitivity a review of aetiology and management J N Z Soc Periodontol 1988; 66: 15-8.

[3] Miglani S, Aggarwal V, Ahuja B. Dentine hypersensitivity recent trends in management J Conserv Dent 2010; 13(4): 218-4.

[4] Brännström M. Etiology of dentin hypersensitivity Proc Finn Dent Soc 1992; 88(1): 7-13.

[5] Absi EG, Addy M, Adams D. Dentin hypersensitivity a study of the patency of dentinal tubules in sensitive and non-sensitive cervical dentine J Clin Periodontol 1987; 14: 280-4.

[6] Davari AR, Ataei E, Assarzadeh H. Dentin hypersensitivity etiology, diagnosis and treatment; a lit-erature review J Dent Shiraz Uni Med Sci 2013; 14(3): 136-45.

[7] Cummins D. Recent advances in dentin hypersensitivity CLINICALLY proven treatments for instant and lasting sensitivity relief Am J Dent 2010; 23(Spe Issue): A 3A-13A.

[8] Huang SB, Gao SS, Yu HY. Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro Biomed Mater 2009; 4(3): 034104.

[9] Tschoppe P, Zandim DL, Martus P, Kielbassa AM. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes J Dent 2011; 39(6): 430-7.

[10] Li L, Pan H, Tao J , et al. Repair of enamel by using hydroxyapatite nanoparticles as the building blocks J Mater Chem 2008; 18: 4079-84.

[11] Browning WD, Cho SD, Deschepper EJ. Effect of a nano-hydroxyapatite paste on bleaching-related tooth sensitivity J Esthet Restorat Dent 2012; 24(4): 268-76.

[12] Walsh LJ. Contemporary technologies for remineralization therapies a review Int Dent SA 2009; 11(6): 6-16.

[13] Pashley DH. Dentin permeability, dentin sensitivity, and treatment through tubule occlusion J En-dodont 1986; 12(10): 465-74.

[14] Nahri M, Haegerstam G. Intradental nerve activity induced by reduced pressure applied to exposed dentine in the cat Acta Physiologica 1983; 119: 381-6.

[15] Tarbet WJ, Silverman G, Stolman JM, Fratareangelo PA. An evaluation of two methods for the quantitation of dentinal hypersensitivity J Am Dental Assoc 1979; 98: 914-8.

[16] Hodosh MA. A superior desensitizer, potassium nitrate JAm Dental Assoc 1974; 88: 831-3.

[17] Tarbet WJ, Silverman G, Fratareangelo PS, Kauapka JA. Home treatment for dentinal hypersensitity a comparative study J Am Dental Assoc 1982; 105: 227-30.

[18] Roveri N, Battistella E, Bianchi CL , et al. Surface enamel remineralization Biomimetic apatite nanocrystals and fluoride ions different effects J Nanomaterials 2009; 2009: 9.

[19] Hannig M, Hannig C. Nanomaterials in preven-tive dentistry Nat Nanotechnol 2010; 5: 565-9.

[20] Shetty S, Kohad R, Yeltiwar R. Hydroxyap-atite as an in-office agent for tooth hypersensitivity a clinical and scanning electron microscopic study J Periodontol 2010; 81: 1781-9.

[21] Shetty S, Kohad R, Yeltiwar R, Shetty K. Comparative evaluation of hydroxyapatite, potassium nitrate and sodium monofluorophosphate as in-office desensitizing agents a double-blinded randomized controlled clinical trial Oral Hyg Health 2013; 1(1): 104.

[22] Slósarczyk A, Zofia KK, Stobierska E, Paszkiewicz A. Cracow hydroxyapatite ceramics a product report Med Sci Monitor 1998; 4: 172-5.

[23] Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S. The role of matrix metalloproteinases (MMPs) in human caries J Dental Res 2006; 85(1): 22-32.

[24] Sorsa T, Tjaderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases Oral Dis 2004; 10(6): 311-8.

[25] Hannas AR, Pereira JC, Granjeiro JM, Tjäderhane L. The role of matrix metalloproteinases in the oral environment Acta Odontol Scandinavia 2007; 65(1): 1-13.

[26] Kato MT, Leite AL, Hannas AR, Buzalef MAR. Gels containing MMP inhibitors prevent dental erosion in situ J Dental Res 2010; 89(5): 468-72.

[27] Sang Q-XA, Jin Y, Newcomer RG , et al. Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases Curr Top Med Chem 2006; 6: 289-316.

[28] Southward K. The systemic theory of dental car-ies Gen Dent 2011; 59(5): 367-73.

[29] Hurlbutt M, Novy B, Young D. Dental Caries a pH-mediated disease CDHA J 2010; 25(1): 9-15.

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