Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants#


Objective:
This clinical study aimed to evaluate effectiveness of a commercially available toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite as well as antioxidants phloretin, ferulic acid and silymarin in reducing dental hypersensitivity in adults.

Methods:
The clinical trial enrolled patients with a history of dentin hypersensitivity. A test toothpaste was introduced into the daily routine, which included initial instruction on usage. Patients completed a five-question visual analog scale (VAS) at the inception/baseline, after two days and after two weeks of using the toothpaste to determine their level of tooth sensitivity at baseline with the use of the toothpaste over time.

Results:
Patients that had significant sensitivity at baseline had a range of 52% to 76 % improvement after 48 hours and a range of 70% to 84% improvement after two weeks.

Conclusion:
A toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin applied daily significantly decreased tooth pain of dentin hypersensitivity within a two-day and two-week time period.

Clinical Significance:
Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate, sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly and quickly reduce tooth pain of dentin hypersensitivity.

Keywords:
Antioxidants, dentin hypersensitivity, hydroxyapatite, polyphenol.


Autoři: Samuel B. Low 1,4,*;  Edward P. Allen 2;  Elias D. Kontogiorgos 3
Působiště autorů: Department of Periodontics, University of Florida College of Dentistry, University of Florida, Gainesville, Florida 32610, USA 1;  Department of Periodontics, Texas A&M University, Baylor College of Dentistry, Dallas, Texas 75246, USA 2;  Department of Restorative Sciences, Texas A&M, Baylor University, College of Dentistry, Dallas, Texas 75246, USA 3;  Department of Restorative Sciences, Texas A&M, Baylor University, College of Dentistry, Dallas, Texas 75246, USA 4
Vyšlo v časopise: The Open Dentistry Journal, 2015, 9, 92-97
prolekare.web.journal.doi_sk: 10.2174/1874364101509010092

© Low et al.; Licensee Bentham Open.
Open-Access License: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The electronic version of this article is the complete one and can be found online at: http://benthamopen.com/FULLTEXT/TODENTJ-9-92.

Souhrn

Objective:
This clinical study aimed to evaluate effectiveness of a commercially available toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite as well as antioxidants phloretin, ferulic acid and silymarin in reducing dental hypersensitivity in adults.

Methods:
The clinical trial enrolled patients with a history of dentin hypersensitivity. A test toothpaste was introduced into the daily routine, which included initial instruction on usage. Patients completed a five-question visual analog scale (VAS) at the inception/baseline, after two days and after two weeks of using the toothpaste to determine their level of tooth sensitivity at baseline with the use of the toothpaste over time.

Results:
Patients that had significant sensitivity at baseline had a range of 52% to 76 % improvement after 48 hours and a range of 70% to 84% improvement after two weeks.

Conclusion:
A toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin applied daily significantly decreased tooth pain of dentin hypersensitivity within a two-day and two-week time period.

Clinical Significance:
Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate, sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly and quickly reduce tooth pain of dentin hypersensitivity.

Keywords:
Antioxidants, dentin hypersensitivity, hydroxyapatite, polyphenol.


Zdroje

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