Novinky v patologii močového měchýře

Různé histologické podtypy karcinomu močového měchýře mají výrazně rozdílný klinický význam. Identifikací rozdílné architektoniky nádorového růstu lze označit vysoce rizikové pacienty s horší prognózou onemocnění, kteří vyžadují odpovídající léčbu. Tento přehledový článek se věnuje jednotlivým histologickým variantám karcinomu močového měchýře a problémům s jejich diagnostikou.

Klíčová slova:
uroteliální karcinom - histologie - histologické varianty - „nested“ karcinom - mikropapilární karcinom - invertovaný růst

Autoři: Eva Compérat
Působiště autorů: La Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris VI
Vyšlo v časopise: Čes.-slov. Patol., 50, 2014, No. 4, p. 129-136
Kategorie: Přehledové články - Uropatologie

Souhrn

Klíčová slova:
uroteliální karcinom - histologie - histologické varianty - „nested“ karcinom - mikropapilární karcinom - invertovaný růst

Zdroje

1. Eble JN, Sauter G, Epstein JI, Sesterhenn IA, (eds). Pathology and genetics of tumours of the urinary system and male genital organs. World Health Organization Classification of Tumours. Lyon: IARC Press; 2004: 250-257.

2. Amin MB, Ro JY, el-Sharkawy T, Lee K. Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma. Am J Surg Pathol 1994; 18(12): 1224-1232.

3. Johansson SL, Borghede G, Holmäng S. Micropapillary bladder carcinoma: a clinicopathological study of 20 cases. J Urol 1999; 161(6): 1798-1802.

4. Samaratunga H, Khoo K. Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical study. Histopathology 2004; 45(1): 55-64.

5. Compérat E, Roupret M, Yaxley J, et al. Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. Pathology 2010; 42(7): 650-654.

6. Kamat AM, Dinney CP, Gee JR, et al. Micropapillary bladder cancer: a review of the University of Texas M. D. Anderson Cancer Center experience with 100 consecutive patients. Cancer 2007; 110(1): 62-67.

7. Sangoi AR, Beck AH, Amin MB, et al. Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists. Am J Surg Pathol 2010; 34(9): 1367-1376.

8. Amin MB. Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. Mod Pathol 2009; 22 Suppl 2: S96-S118.

9. Ricardo-Gonzalez RR, Nguyen M, Gokden N, Sangoi AR, Presti JC Jr, McKenney JK. Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread. J Urol 2012; 187(3): 852-855.

10. Keck B, Wach S, Kunath F, et al. Nuclear E-cadherin expression is associated with the loss of membranous E-cadherin, plasmacytoiddifferentiation and reduced overall survival in urothelial carcinoma of the bladder. Ann Surg Oncol 2013; 20(7): 2440-2445.

11. Keck B, Wach S, Stoehr R, et al. Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy. BMC Cancer 2013; 13: 71.

12. Carvalho JC, Thomas DG, McHugh JB, Shah RB, Kunju LP. p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system. Histopathology 2012; 60(4): 597-608.

13. Tamas EF, Nielsen ME, Schoenberg MP, Epstein JI. Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. Mod Pathol 2007; 20(8): 828-834.

14. Oliva E, Amin MB, Jimenez R, Young RH. Clear cell carcinoma of the urinary bladder: a report and comparison of four tumors of mullerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems. Am J Surg Pathol 2002; 26(2): 190-197.

15. Leroy X, Gonzalez S, Zini L, Aubert S. Lipoid-cell variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of five cases. Am J Surg Pathol 2007; 31(5): 770-773.

16. Stern JB. Unusual benign bladder tumor of Brunn nest origin. Urology 1979; 14(3): 288-289.

17. Talbert ML, Young RH. Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. Am J Surg Pathol 1989; 13(5): 374-381.

18. Beltran AL, Cheng L, Montironi R, Blanca A, et al. Clinicopathological characteristics and outcome of nested carcinoma of the urinary bladder. Virchows Arch. In press 2014.

19. Holmäng S, Johansson SL. The nested variant of transitional cell carcinoma--a rare neoplasm with poor prognosis. Scand J Urol Nephrol 2001; 35(2): 102-105.

20. Linder BJ, Frank I, Cheville JC, et al. Outcomes following radical cystectomy for nested variant of urothelial carcinoma: a matched cohort analysis. J Urol 2013; 189(5): 1670-1675.

21. Lopez Beltran A, Montironi R, Cheng L. Microcystic urothelial carcinoma: morphology, immunohistochemistry and clinical behaviour. Histopathology 2014; 64(6): 872-879.

22. Lopez-Beltran A, Cheng L, Comperat E, et al. Large cell undifferentiated carcinoma of the urinary bladder. Pathology 2010; 42(4): 364-368.

23. Cox R, Epstein JI. Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. Am J Surg Pathol 2011; 35(9): 1337-1342.

24. Hodges KB, Lopez-Beltran A, Maclennan GT, Montironi R, Cheng L. Urothelial lesions with inverted growth patterns: histogenesis, molecular genetic findings, differential diagnosis and clinical management. BJU Int 2011; 107(4): 532-537.

25. Armstrong AB, Wang M, Eble JN, et al. TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder. Mod Pathol 2009; 22(1): 113-118.

26. Kawano H, Tanaka S, Ishii A, Cui D, Eguchi S, Hashimoto O, Ikeda E. Osteoclast-rich undifferentiated carcinoma of the urinary bladder: an immunohistochemical study. Pathol Res Pract 2011; 207(11): 722-727.

27. Harik LR, Merino C, Coindre JM, Amin MB, Pedeutour F,Weiss SW. Pseudosarcomatous myofibroblastic proliferations of the bladder: a clinicopathologic study of 42 cases. Am J Surg Pathol 2006; 30(7): 787-794.

28. Hansel DE, Zhang Z, Petillo D, Teh BT. Gene profiling suggests a common evolution of bladder cancer subtypes. BMC Med Genomics 2013; 6: 42.

29. Xylinas E, Rink M, Robinson BD, et al. Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of thebladder treated with radical cystectomy. Eur J Cancer 2013; 49(8): 1889-1897.

30. Makise N, Morikawa T, Takeshima Y, Homma Y, Fukayama M. A case of urinary bladder urothelial carcinoma with squamous, glandular, and plasmacytoid differentiation. Case Rep Oncol 2014; 7(2): 362-368.

31. Chu PG, Chung L, Weiss LM, Lau SK. Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases. Am J Surg Pathol 2011; 35(12): 1830-1836.

32. Wang J, Wang FW, Kessinger A. The impact of signet-ring cell carcinoma histology on bladder cancer outcome. World J Urol 2012; 30(6): 777-783.

33. Paner GP, Barkan GA, Mehta V, et al. Urachal carcinomas of the nonglandular type: salient features and considerations in pathologic diagnosis. Am J Surg Pathol 2012; 36(3): 432-442.

34. Gopalan A, Sharp DS, Fine SW, et al. Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation. Am J Surg Pathol 2009; 33(5): 659-668.

35. Molina JR, Quevedo JF, Furth AF, Richardson RL, Zincke H, Burch PA. Predictors of survival from urachal cancer: a Mayo Clinic study of 49 cases. Cancer 2007; 110(11): 2434-2440.

36. Sheldon CA, Clayman RV, Gonzalez R, Williams RD, Fraley EE. Malignant urachal lesions. J Urol 1984; 131(1): 1-8.

37. Herr HW, Bochner BH, Sharp D, Dalbagni G, Reuter VE. Urachal carcinoma: contemporary surgical outcomes. J Urol 2007; 178(1): 74-78.

38. Paner GP, Annaiah C, Gulmann C, et al. Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder. Hum Pathol 2014; 45(7): 1473-1482.