Spatial Distribution and Risk Factors of Highly Pathogenic Avian Influenza (HPAI) H5N1 in China

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Highly pathogenic avian influenza (HPAI) H5N1 was first encountered in 1996 in Guangdong province (China) and started spreading throughout Asia and the western Palearctic in 2004–2006. Compared to several other countries where the HPAI H5N1 distribution has been studied in some detail, little is known about the environmental correlates of the HPAI H5N1 distribution in China. HPAI H5N1 clinical disease outbreaks, and HPAI virus (HPAIV) H5N1 isolated from active risk-based surveillance sampling of domestic poultry (referred to as HPAIV H5N1 surveillance positives in this manuscript) were modeled separately using seven risk variables: chicken, domestic waterfowl population density, proportion of land covered by rice or surface water, cropping intensity, elevation, and human population density. We used bootstrapped logistic regression and boosted regression trees (BRT) with cross-validation to identify the weight of each variable, to assess the predictive power of the models, and to map the distribution of HPAI H5N1 risk. HPAI H5N1 clinical disease outbreak occurrence in domestic poultry was mainly associated with chicken density, human population density, and elevation. In contrast, HPAIV H5N1 infection identified by risk-based surveillance was associated with domestic waterfowl density, human population density, and the proportion of land covered by surface water. Both models had a high explanatory power (mean AUC ranging from 0.864 to 0.967). The map of HPAIV H5N1 risk distribution based on active surveillance data emphasized areas south of the Yangtze River, while the distribution of reported outbreak risk extended further North, where the density of poultry and humans is higher. We quantified the statistical association between HPAI H5N1 outbreak, HPAIV distribution and post-vaccination levels of seropositivity (percentage of effective post-vaccination seroconversion in vaccinated birds) and found that provinces with either outbreaks or HPAIV H5N1 surveillance positives in 2007–2009 appeared to have had lower antibody response to vaccination. The distribution of HPAI H5N1 risk in China appears more limited geographically than previously assessed, offering prospects for better targeted surveillance and control interventions.

Vyšlo v časopise: Spatial Distribution and Risk Factors of Highly Pathogenic Avian Influenza (HPAI) H5N1 in China. PLoS Pathog 7(3): e32767. doi:10.1371/journal.ppat.1001308
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1001308

Souhrn

Zdroje

1. XuX

SubbaraoK

CoxNJ

GuoY

1999 Genetic Characterization of the Pathogenic Influenza A/Goose/Guangdong/1/96 (H5N1) Virus: Similarity of Its Hemagglutinin Gene to Those of H5N1 Viruses from the 1997 Outbreaks in Hong Kong. Virology 261 15 19

2. LiKS

GuanY

WangJ

SmithGJD

XuKM

2004 Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430 209 213

3. ShortridgeKF

1995 The next pandemic influenza virus? The Lancet 346 1210 1212

4. FangLQ

de VlasSJ

LiangS

LoomanCW

GongP

2008 Environmental factors contributing to the spread of H5N1 avian influenza in mainland China. PLoS ONE 3 e2268

5. GilbertM

ChaitaweesubP

ParakarnawongsaT

PremashthiraS

TiensinT

2006 Free-grazing ducks and highly pathogenic avian influenza, Thailand. Emerg Infect Dis 12 227 234

6. GilbertM

XiaoX

PfeifferDU

EpprechtM

BolesS

2008 Mapping H5N1 highly pathogenic avian influenza risk in Southeast Asia. Proc Natl Acad Sci USA 105 4769 4774

7. PfeifferDU

MinhPQ

MartinV

EpprechtM

OtteMJ

2007 An analysis of the spatial and temporal patterns of highly pathogenic avian influenza occurrence in Vietnam using national surveillance data. Vet J 174 302 309

8. TiensinT

AhmedSSU

RojanasthienS

SongsermT

RatanakornP

2009 Ecologic Risk Factor Investigation of Clusters of Avian Influenza A (H5N1) Virus Infection in Thailand. J Infect Dis 199 1735 1743

9. LothL

GilbertM

OsmaniM

KalamM

XiaoX

2010 Risk Factors and Clusters of Highly Pathogenic Avian Influenza H5N1 in Bangladesh. Prev Vet Med 96 104 113

10. PaulM

TavornpanichS

AbrialD

GasquiP

Charras-GarridoM

2010 Anthropogenic factors and the risk of highly pathogenic avian influenza H5N1: prospects from a spatial-based model. Vet Res 41 14

11. BiswasPK

ChristensenJP

AhmedSSU

DasA

RahmanMH

2009 Risk for Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Backyard Chickens, Bangladesh. Emerg Infect Dis 15 1931 1936

12. WardMP

MafteiD

ApostuC

SuruA

2008 Environmental and anthropogenic risk factors for highly pathogenic avian influenza subtype H5N1 outbreaks in Romania, 2005–2006. Vet Res Commun 32 627 634

13. WilliamsRAJ

PetersonAT

2009 Ecology and geography of avian influenza (HPAI H5N1) transmission in the Middle East and northeastern Africa. Int J Health Geogr 8 47

14. HenningJ

PfeifferDU

VuLT

2008 Risk factors and characteristics of H5N1 Highly Pathogenic Avian Influenza (HPAI) post-vaccination outbreaks. Vet Res 40 15

15. ElithJ

LeathwickJR

HastieT

2008 A working guide to boosted regression trees. J Anim Ecol 77 802 813

16. ElithJ

GrahamCH

AndersonRP

DudíkM

FerrierS

2006 Novel methods improve prediction of species' distributions from occurrence data. Ecography 29 129 151

17. McPhersonJM

JetzW

RogersDJ

2004 The effects of species' range sizes on the accuracy of distribution models: ecological phenomenon or statistical artefact? J Appl Ecol 41 811 823

18. MarmionM

LuotoM

HeikkinenRK

ThuillerW

2009 The performance of state-of-the-art modelling techniques depends on geographical distribution of species. Ecol Model 220 3512 3520

19. MinhPQ

MorrisRS

SchauerB

StevensonM

BenschopJ

2009 Spatio-temporal epidemiology of highly pathogenic avian influenza outbreaks in the two deltas of Vietnam during 2003–2007. Prev Vet Med 89 16 24

20. YoonH

ParkCK

NamHM

WeeSH

2005 Virus spread pattern within infected chicken farms using regression model: the 2003–2004 HPAI epidemic in the Republic of Korea. J Vet Med B 52 428 431

21. AdhikariD

ChettriA

BarikSK

2009 Modelling the ecology and distribution of highly pathogenic avian influenza (H5N1) in the Indian subcontinent. Cur Sci India 97 73 78

22. WardMP

MafteiDN

ApostuCL

SuruAR

2009 Association Between Outbreaks of Highly Pathogenic Avian Influenza Subtype H5N1 and Migratory Waterfowl (Family Anatidae) Populations. Zoonoses Public Health 56 1 9

23. WardMP

MafteiD

ApostuC

SuruA

2008 Geostatistical visualisation and spatial statistics for evaluation of the dispersion of epidemic highly pathogenic avian influenza subtype H5N1. Vet Res 39 22

24. CecchiG

IlemobadeA

Le BrunY

HogerwerfL

SlingenberghJ

2008 Agro-ecological features of the introduction and spread of the highly pathogenic avian influenza (HPAI) H5N1 in northern Nigeria. Geospatial Health 3 7 16

25. WilliamsRAJ

FasinaFO

PetersonAT

2008 Predictable ecology and geography of avian influenza (H5N1) transmission in Nigeria and West Africa. T Roy Soc Top Med H 102 471 479

26. OyanaTJ

DaiD

ScottKE

2006 Spatiotemporal distributions of reported cases of the avian influenza H5N1 (bird flu) in Southern China in early 2004. Avian Dis 50 508 515

27. Hulse-PostDJ

Sturm-RamirezKM

HumberdJ

SeilerP

GovorkovaEA

2005 Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proc Natl Acad Sci USA 102 10682 10687

28. KimJ

NegovetichNJ

ForrestHL

WebsterRG

2009 Ducks: the “Trojan horses” of H5N1 influenza. Influenza Other Respi. Viruses 3 121 128

29. BrownJD

StallknechtDE

ValeikaS

SwayneDE

2007 Susceptibility of wood ducks to H5N1 Highly pathogenic avian influenza virus. J Wildl Dis 43 660 667

30. ShortridgeKF

1982 Avian influenza A viruses of southern China and Hong Kong: ecological aspects and implications for man. Bull World Health Organ 60 129 135

31. ShortridgeKF

2005 Avian influenza viruses in Hong Kong: zoonotic considerations. Wageningen UR Frontis Series 8 9

32. WallaceRG

2009 Breeding Influenza: The Political Virology of Offshore Farming. Antipode 41 916 951

33. WebsterRG

CampbellCH

GranoffA

1973 The “in vivo” production of “new” influenza viruses: III. Isolation of recombinant influenza viruses under simulated conditions of natural transmission. Virology 51 149 162

34. ChangWK

1969 National influenza experience in Hong Kong, 1968. Bull World Health Organ 41 349 351

35. CheungCL

VijaykrishnaD

SmithGJD

FanXH

ZhangJX

2007 Establishment of influenza A virus (H6N1) in minor poultry in southern China. J Virol 81 10402 10412

36. ShortridgeK

1982 An influenza epicenter ? The Lancet 320 812 813

37. XuKM

SmithGJD

BahlJ

DuanL

TaiH

2007 The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005. J Virol 81 10389 10401

38. MukhtarMM

RasoolST

SongD

ZhuC

HaoQ

2007 Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. J Gen Virol 88 3094 3099

39. ChenH

2009 Avian influenza vaccination: the experience in China. Rev Sci Tech 28 267 274

40. ChenH

2009 H5N1 avian influenza in China. Sci China, C, Life Sci 52 419 427

41. ChenH

BuZ

2009 Development and application of avian influenza vaccines in China. Curr Top Microbiol Immunol 333 153 162

42. RobinsonTP

FranceschiniG

WintW

2007 The Food and Agriculture Organization's Gridded Livestock of the World. Vet Ital 43 745 751

43. CIESIN, IPFRI, CIAT 2005 Global Rural-Urban Mapping Project (GRUMP), Alpha Version. Center for International Earth Science Information Network (CIESIN), Columbia University; International Food Policy Research Institute (IPFRI); The World Bank; Centro Internacional de Agricultura Tropical (CIAT)

44. JiyuanL

MingliangL

XiangzhengD

DafangZ

ZengxiangZ

2002 The land use and land cover change database and its relative studies in China. J Geogr Sci 12 275 282

45. XiaoX

BolesS

LiuJ

ZhuangD

FrolkingS

2005 Mapping paddy rice agriculture in southern China using multi-temporal MODIS images. Remote Sens Environ 95 480 492