Genetic Variation in the Nuclear and Organellar Genomes Modulates Stochastic Variation in the Metabolome, Growth, and Defense

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Systems biology is largely based on the principal that the link between genotype and phenotype is deterministic, and, if we know enough, can be predicted with high accuracy. In contrast, recent work studying transcription within single celled organisms has shown that the genotype to phenotype link is stochastic, i.e. a single genotype actually makes a range of phenotypes even in a single environment. Further, natural variation within genes can lead to each allele displaying a different phenotypic distribution. To test if multi-cellular organisms also display natural genetic variation in the stochastic link between genotype and phenotype, we measured the metabolome, growth and defense metabolism within an Arabidopsis RIL population and mapped quantitative trait loci. We show that genetic variation in the nuclear and organeller genomes influence the stochastic variation in all measured traits. Further, each trait class has distinct genetics underlying the stochastic variance, showing that there are different mechanisms controlling the stochastic genotype to phenotype link for each trait. Further work is necessary to identify the mechanisms underpinning the stochastic nature of the genotype to phenotype link.

Vyšlo v časopise: Genetic Variation in the Nuclear and Organellar Genomes Modulates Stochastic Variation in the Metabolome, Growth, and Defense. PLoS Genet 11(1): e32767. doi:10.1371/journal.pgen.1004779
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004779

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