Muscle-Strengthening and Conditioning Activities and Risk of Type 2 Diabetes: A Prospective Study in Two Cohorts of US Women


Background:
It is well established that aerobic physical activity can lower the risk of type 2 diabetes (T2D), but whether muscle-strengthening activities are beneficial for the prevention of T2D is unclear. This study examined the association of muscle-strengthening activities with the risk of T2D in women.

Methods and Findings:
We prospectively followed up 99,316 middle-aged and older women for 8 years from the Nurses' Health Study ([NHS] aged 53–81 years, 2000–2008) and Nurses' Health Study II ([NHSII] aged 36–55 years, 2001–2009), who were free of diabetes, cancer, and cardiovascular diseases at baseline. Participants reported weekly time spent on resistance exercise, lower intensity muscular conditioning exercises (yoga, stretching, toning), and aerobic moderate and vigorous physical activity (MVPA) at baseline and in 2004/2005. Cox regression with adjustment for major determinants for T2D was carried out to examine the influence of these types of activities on T2D risk. During 705,869 person years of follow-up, 3,491 incident T2D cases were documented. In multivariable adjusted models including aerobic MVPA, the pooled relative risk (RR) for T2D for women performing 1–29, 30–59, 60–150, and >150 min/week of total muscle-strengthening and conditioning activities was 0.83, 0.93, 0.75, and 0.60 compared to women reporting no muscle-strengthening and conditioning activities (p<0.001 for trend). Furthermore, resistance exercise and lower intensity muscular conditioning exercises were each independently associated with lower risk of T2D in pooled analyses. Women who engaged in at least 150 min/week of aerobic MVPA and at least 60 min/week of muscle-strengthening activities had substantial risk reduction compared with inactive women (pooled RR = 0.33 [95% CI 0.29–0.38]). Limitations to the study include that muscle-strengthening and conditioning activity and other types of physical activity were assessed by a self-administered questionnaire and that the study population consisted of registered nurses with mostly European ancestry.

Conclusions:
Our study suggests that engagement in muscle-strengthening and conditioning activities (resistance exercise, yoga, stretching, toning) is associated with a lower risk of T2D. Engagement in both aerobic MVPA and muscle-strengthening type activity is associated with a substantial reduction in the risk of T2D in middle-aged and older women.

Please see later in the article for the Editors' Summary


Vyšlo v časopise: Muscle-Strengthening and Conditioning Activities and Risk of Type 2 Diabetes: A Prospective Study in Two Cohorts of US Women. PLoS Med 11(1): e32767. doi:10.1371/journal.pmed.1001587
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1001587

Souhrn

Background:
It is well established that aerobic physical activity can lower the risk of type 2 diabetes (T2D), but whether muscle-strengthening activities are beneficial for the prevention of T2D is unclear. This study examined the association of muscle-strengthening activities with the risk of T2D in women.

Methods and Findings:
We prospectively followed up 99,316 middle-aged and older women for 8 years from the Nurses' Health Study ([NHS] aged 53–81 years, 2000–2008) and Nurses' Health Study II ([NHSII] aged 36–55 years, 2001–2009), who were free of diabetes, cancer, and cardiovascular diseases at baseline. Participants reported weekly time spent on resistance exercise, lower intensity muscular conditioning exercises (yoga, stretching, toning), and aerobic moderate and vigorous physical activity (MVPA) at baseline and in 2004/2005. Cox regression with adjustment for major determinants for T2D was carried out to examine the influence of these types of activities on T2D risk. During 705,869 person years of follow-up, 3,491 incident T2D cases were documented. In multivariable adjusted models including aerobic MVPA, the pooled relative risk (RR) for T2D for women performing 1–29, 30–59, 60–150, and >150 min/week of total muscle-strengthening and conditioning activities was 0.83, 0.93, 0.75, and 0.60 compared to women reporting no muscle-strengthening and conditioning activities (p<0.001 for trend). Furthermore, resistance exercise and lower intensity muscular conditioning exercises were each independently associated with lower risk of T2D in pooled analyses. Women who engaged in at least 150 min/week of aerobic MVPA and at least 60 min/week of muscle-strengthening activities had substantial risk reduction compared with inactive women (pooled RR = 0.33 [95% CI 0.29–0.38]). Limitations to the study include that muscle-strengthening and conditioning activity and other types of physical activity were assessed by a self-administered questionnaire and that the study population consisted of registered nurses with mostly European ancestry.

Conclusions:
Our study suggests that engagement in muscle-strengthening and conditioning activities (resistance exercise, yoga, stretching, toning) is associated with a lower risk of T2D. Engagement in both aerobic MVPA and muscle-strengthening type activity is associated with a substantial reduction in the risk of T2D in middle-aged and older women.

Please see later in the article for the Editors' Summary


Zdroje

1. HuFB, LeitzmannMF, StampferMJ, ColditzGA, WillettWC, et al. (2001) Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 161: 1542–1548.

2. HuFB, LiTY, ColditzGA, WillettWC, MansonJE (2003) Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289: 1785–1791.

3. SigalRJ, KennyGP, BoulÇNG, WellsGA, Prud'hommeD, et al. (2007) Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes. Ann Intern Med 147: 357–369.

4. ChurchTS, BlairSN, CocrehamS, JohannsenN, JohnsonW, et al. (2010) Effects of aerobic and resistance training on hemoglobin a1c levels in patients with type 2 diabetes. JAMA 304: 2253–2262.

5. DunstanDW, DalyRM, OwenN, JolleyD, deC, et al. (2002) High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care 25: 1729–1736.

6. BacchiE, NegriC, ZanolinME, MilaneseC, FaccioliN, et al. (2012) Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects. Diabetes Care 35: 676–682.

7. BalducciSZSNA, et al. (2010) Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian diabetes and exercise study (ides). Arch Intern Med 170: 1794–1803.

8. CastanedaC, LayneJE, Munoz-OriansL, GordonPL, WalsmithJ, et al. (2002) A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 25: 2335–2341.

9. UmpierreD, RibeiroPAB, KramerCK, LeitaoCB, ZucattiATN, et al. (2011) Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes. JAMA 305: 1790–1799.

10. GrøntvedA, RimmEB, WillettWC, AndersenLB, HuFB (2012) A prospective study of weight training and risk of type 2 diabetes in men. Arch Intern Med 172: 1306–1312.

11. RolandKP, JakobiJM, JonesGR (2011) Does yoga engender fitness in older adults? A critical review. J Aging Phys Activ 19: 62–79.

12. Cruz-FerreiraA, FernandesJ, LaranjoL, BernardoLM, SilvaA (2011) A systematic review of the effects of pilates method of exercise in healthy people. Arch Phys Med Rehab 92: 2071–2081.

13. ColbergSR, SigalRJ, FernhallB, RegensteinerJG, BlissmerBJ, et al. (2010) Exercise and type 2 diabetes. Diabetes Care 33: e147–e167.

14. (2008) Physical Activity Guidelines Advisory Committee Report. Washington, DC: USDepartment of Health and Human Services and 2008 Physical activity guidelines for Americans (http://www.health.gov/paguidelines/guidelines/default.aspx (accessed Oct 21st, 2013)).

15. World Health Organization (2010) Global recommendations on physical activity for health. Geneva: WHO Press.

16. WolfAM, HunterDJ, ColditzGA, MansonJE, StampferMJ, et al. (1994) Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol 23: 991–999.

17. Chasan-TaberS, RimmEB, StampferMJ, SpiegelmanD, ColditzGA, et al. (1995) Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals. Epidemiology 7: 81–86.

18. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20: 1183–1197.

19. MansonJE, StampferMJ, ColditzGA, WillettWC, RosnerB, et al. (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338: 774–778.

20. FieldAE, CoakleyEH, MustA, SpadanoJL, LairdN, et al. (2001) Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 161: 1581–1586.

21. WillettWC, SampsonL, StampferMJ, RosnerB, BainC, et al. (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122: 51–65.

22. HuFB, MansonJE, StampferMJ, ColditzG, LiuS, et al. (2001) Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. New Engl J Med 345: 790–797.

23. GreenlandS (1995) Dose-response and trend analysis in epidemiology: alternatives to categorical analysis. Epidemiology 6: 356–365.

24. MingesKE, MaglianoDJ, OwenN, DalyRM, SalmonJ, et al. (2012) Associations of strength training with impaired glucose metabolism: the AusDiab Study. Med Sci Sports Exerc 45: 299–303.

25. van DijkJW, MandersR, TummersK, BonomiA, StehouwerC, et al. (2011) Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients. Diabetologia 1–10.

26. Skoro-KondzaL, TaiS, GadelrabR, DrincevicD, GreenhalghT (2009) Community based yoga classes for type 2 diabetes: an exploratory randomised controlled trial. BMC Health Serv Res 9: 33.

27. MonroR, PowerJ, CoumarA, NagarathnaR, DandonaP (1992) Yoga therapy for NIDDM: A controlled trial. Complementary Medical Research 6: 66–68.

28. GordonL, MorrisonE, McGrowderD, YoungR, FraserY, et al. (2008) Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC Complem Altern M 8: 21.

29. HegdeSV, AdhikariP, KotianS, PintoVJ, D'SouzaS, et al. (2011) Effect of 3-month yoga on oxidative stress in type 2 diabetes with or without complications. Diabetes Care 34: 2208–2210.

30. HaginsM, MooreW, RundleA (2007) Does practicing hatha yoga satisfy recommendations for intensity of physical activity which improves and maintains health and cardiovascular fitness? BMC Complem Altern M 7: 40.

31. LeBrasseurNK, WalshK, AranyZ (2011) Metabolic benefits of resistance training and fast glycolytic skeletal muscle. Am J Physiol Endocrinol Metab 300: E3–E10.

32. HoltenMK, ZachoM, GasterM, JuelC, WojtaszewskiJFP, et al. (2004) Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes 53: 294–305.

33. CornelissenVA, FagardRH, CoeckelberghsE, VanheesL (2011) Impact of resistance training on blood pressure and other cardiovascular risk factors. Hypertension 58: 950–958.

Štítky
Interné lekárstvo

Článok vyšiel v časopise

PLOS Medicine


2014 Číslo 1
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa