Influence of Early Postnatal Nutrition in Preterm Infants on Their Anthropometric and Hormonal Characteristics at the Age of 10 Years
Vliv časné postnatální výživy u předčasně narozených dětí na jejich antropometrické a hormonální charakteristiky ve věku 10 let
Východisko.
Ochranný vliv kojení na rozvoj obezity byl jasně prokázán. Četné studie spojují vyšší příjem proteinů v postnatálním období s časnějším nástupem „adiposity rebound“ a vyšším body mass indexem v pozdějším věku.
Metody a výsledky.
Longitudinální studie se zúčastnilo 28 dívek narozených ve 34. týdnu těhotenství (porodní hmotnost: 2,2±0,3 kg, délka: 45,2±2,5 cm, body mass index (BMI): 11,0±1,5 kg/m²). Podle významně odlišného příjmu bílkovin v prvním měsíci po narození byly dívky rozděleny do dvou skupin (příjem bílkovin dívky kojené: 113,5±18,7 g/měsíc vs. příjem bílkovin dívky s náhradní mléčnou výživou: 174,0±14,3 g/měsíc; p
Závěry.
Časná postnatální výživa by mohla ovlivňovat hladinu IGF-1 v pozdějším věku a ovlivňovat tak tělesný rozvoj. Faktorová analýza ukázala IGF-1 jako pojítko mezi postnatálním příjmem energie a makronutrientů, antropometrických parametrů a hladiny leptinu v deseti letech.
Klíčová slova:
postnatální příjem bílkovin, antropometrické parametry, tuková tkáň, leptin, IGF-1, předčasně narozené děti.
Authors:
H. Zamrazilová; V. Hainer; M. Černá 1; M. Kunešová; R. Braunerová; J. Štěpán 2; J. Nedvídková; M. Hill; J. Pařízková
Authors‘ workplace:
Endokrinologický ústav, Praha
; Ústav pro péči o matku a dítě, Praha
1; III. interní klinika 1. LF UK a VFN, Praha
2
Published in:
Čas. Lék. čes. 2007; 146: 278-283
Category:
Original Article
Overview
Backround.
A protective effect of breast feeding on the development of obesity has been clearly demonstrated. Several studies associated higher protein intake in postnatal period with the earlier “adiposity rebound” and the higher BMI in later life.
Methods and Results. Twenty eight girls born at 34th week of pregnancy (weight:
2.22±0.31 kg, length: 45.2±2.5 cm, BMI: 11.0±1.5 kg/m²), were subdivided in two groups differing in protein intake during the first postnatal month due to either breast feeding or formula feeding (113.5±18.7 g/month vs. 174.00±14.3 g/month; p
Conclusions.
Early postnatal nutrition could encode IGF-1 in later life and this way may be involved in body size programming. Factor analysis revealed IGF-1 as a link between the postnatal energy and macronutrient intake and anthropometric indices and leptin at the age of 10 years.
Key words:
postnatal protein intake, anthropometric indices, fat mass, leptin, IGF-1, preterm infants.
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