Leptin and Body Mass Indexes in Nutritional Disorders in Girls
Leptín a indexy telesnej hmotnosti pri poruchách výživy u dievčat
Leptín je hormón tukového tkaniva, ktorý predstavuje signál pre reguláciu príjmu potravy a tým aj telesnejhmotnosti. Presné mechanizmy, ktoré regulujú hladinu leptínu, doteraz nie sú známe. Cieľom našej práce bolosledovať hladiny leptínu u detí s dvoma protikladnými poruchami výživy - mentálnou anorexiou a obezitou vovzťahu k ich indexom telesnej hmotnosti.U dievčat s mentálnou anorexiou (n = 26, vek 15,18 ± 0,45 rokov, deficit hmotnosti - 23,96 ± 1,59 %) a obezitou(n = 26, vek 14,53 ± 0,63 rokov, nadhmotnosť 54,94 ± 3,29 % oproti norme pre daný vek a výšku) sme odobralikrv na vyšetrenie bazálnych hladín leptínu. Kontrolnú skupinu tvorilo 15 zdravých dievčat (n = 15, vek 14,41 ±0,52 rokov, hmotnosť 2,77 ± 2,03 %). Hladiny leptínu sme stanovovali RIA metodikou a navzájom sme ichporovnali.Priemerné hladiny leptínu u pacientok s mentálnou anorexiou boli signifikantne nižš ie (1,91 ± 0,23 ng/ml)v porovnaní so zdravými deťmi (6,07 ± 0,91 ng/ml, p
Klíčová slova:
leptín, mentálna anorexia, obezita, indexy telesnej hmotnosti
Authors:
Ľ. Tichá 1; L. Kovács 1; E. Tomečková 2; A. Gondová 1; J. Birčák 1; M. Benedeková 1
Authors‘ workplace:
1. detská klinika LFUK a DFNsP, Bratislava
1
Published in:
Čes-slov Pediat 2000; (5): 296-299.
Category:
Overview
Leptin is an adipose tissue hormone which is a signal for the regulation of food intake and thus of body weight.Precise mechanisms which regulate leptin levels are not known so far. The objective of the presented work was toinvestigate leptin levels in children with two controversial nutritional disorders - anorexia nervosa and obesity, inrelation to their body mass index.In girls with anorexia nervosa (n = 26, age 15.18 ± 0.45 years, weight deficit 23.96 ± 1.59%), obesity (n = 26, age14.53 ± 0.63 years, overweight 54.94 ± 3.29% as compared with normal for the given age group) blood specimenswere take to examine basal leptin levels. The control group was formed by 15 healthy girls (n = 15, age 14.41 ± 0.52years, body weight 2.77 ± 2.03%). The leptin levels were assessed by the RIA method and compared mutually.The mean leptin values in patients with anorexia nervosa were significantly lower (1.91 ± 0.23 ng/ml) ascompared with healthy children (6.07 ± 0.91 ng/ml, p
Key words:
leptin, anorexia nervosa, obesity, body mass indexes
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2000 Issue 5
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