The Use of the Concept of the Pharmacophore in Drug Design
VYUŽITIE KONCEPCIE FARMAKOFÓRU PRIPROJEKTOVANÍ LIEČIV
V práci sa diskutuje využitie koncepcie farmakofóru pri projektovaní nových liečiv. Hlavná pozor-nosť sa venuje aplikácii počítačovo podporovaných metód racionálneho projektovania liečiv (CADD)pri objavovaní nových nosných štruktúr.
Klíčová slova:
projektovanie liečiv – farmakofór – databáza – molekulové modelovanie –MEP – konformačná analýza
Authors:
M. Smieško; M. Remko
Authors‘ workplace:
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 1999; , 247-251
Category:
Overview
The application of the pharmacophore concept to design new drugs is discussed. The focus is on theapplication of computer–assisted drug design methods (CADD) in the discovery of new leads.
Key words:
drug design – pharmacophore – database – molecular modelling – conformationalanalysis
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
1999 Issue 6
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