#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Incidence of post-stroke depression in hospitalized patients after ischemic stroke


Authors: P. Migaľová 1;  O. Volný 1;  T. Skřont 2;  E. Hurtíková 1
Authors‘ workplace: Neurologická klinika FN Ostrava 1;  Psychiatrické oddělení FN Ostrava 2
Published in: Cesk Slov Neurol N 2025; 88(6): 377-381
Category: Original Paper
doi: https://doi.org/10.48095/cccsnn2025377

Overview

Background: Stroke is the second most common cause of death in the Czech Republic. Ischemic stroke accounts for more than ¾ of all strokes. In 2020, the incidence of ischemic stroke was 211 cases per 100,000 people per year, and the prevalence is estimated at 240,000 cases. Post-stroke depression (PSD) affects approximately one third of patients after ischemic stroke and significantly affects rehabilitation and quality of life. The aim of our work was to determine the frequency of PSD after the first ischemic stroke in our department and to evaluate the interest of patients in drug and experimental treatments. Methodology: The study included patients hospitalized after the first ischemic stroke without previous depression and aphasia. Depression screening was performed using the Beck Depression Inventory (BDI-II) first after 3 months in the outpatient clinic, and later during hospitalization after protocol modification. Results: 40 patients were examined in the outpatient phase, out of whom 12 (30%) were depressed. Only 3 patients agreed to a psychiatric examination. After the protocol change, 300 patients were examined during hospitalization, 51 (17%) were screened as depressed, and 43 patients (14.3%) were treated with antidepressants. Conclusions: The prevalence of PSD reached 17–30% depending on the timing of screening. A fundamental problem is the low compliance of patients with psychiatric care due to stigmatization. Screening during hospitalization appears to be more practical than outpatient monitoring.

Keywords:

ischemic stroke – pharmacotherapy – post-stroke depression – Beck Depression Scale


Sources

1. Tomek A, Bar M, Neumann J et al. Ischemická cévní mozková příhoda nebo tranzitorní ischemická ataka nekardioembolické etiologie a jejich sekundární prevence. 2020 [online]. Dostupné z: https: //kdp.uzis.cz/index.php?pg=kdp&id=14.

2. Dafer RM, Rao M, Shareef A et al. Poststroke depression. Top Stroke Rehabil 2008; 15 (1): 13–21. doi: 10.1310/tsr1501-13.

3. Šilhán P, Perníčková D, Hosák L. Deprese vzniklá po cévní mozkové příhodě. Čes a slov Psychiatr 2012; 108 (6): 291–297.

4. Novák T. Depresivní porucha po cévní mozkové příhodě. Neurol praxi 2019; 20 : 377–382.

5. Pohjasvaara J, Vataja R, Leppävuori A et al. Depression is an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol 2001; 8 (4): 315–319. doi: 10.1046/j.1468-1331.2001.00182.x.

6. Preiss M, Vacíř K. Beckova sebeposuzovací škála depresivity pro dospělé. BDI-II. Příručka. Brno: Psychodiagnostika s. r. o. 1999.

7. Ayerbe L, Ayis S, Wolfe CD et al. Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis. Br J Psychiatry 2013; 202 : 14–21. doi: 10.1192/bjp.bp.111.107664.

8. Wei N, Yong W, Li X et al. Post-stroke depression and lesion location: a systematic review. J Neurol 2015; 262 (1): 81–90. doi: 10.1007/s00415-014-7534-1.

9. Robinson RG, Jorge RE. Post-stroke depression: a review. Am J Psychiatry 2016; 173 (3): 221–231. doi: 10.1176/appi.ajp.2015.15030363.

10. Canadian Stroke Best Practices. Post-stroke depression. [online]. Available form: https: //www.strokebestpractices.ca/recommendations/mood-cognition-and-fatigue-following-stroke/post-stroke-depression.

11. Towfighi A, Ovbiagele B, El Husseini N et al. Poststroke depression: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2017; 48 (2): e30–e43. doi: 10.1161/STR.0000000000000113.

12. Preiss M, Vacíř K. BDI-II: Beckova sebeposuzovací škála pro dospělé. Brno: Psychodiagnostika 1999.

13. Hackett ML, Pickles K. Frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies. Int J Stroke 2014; 9 (8): 1017–1025. doi: 10.1111/ijs.12357.

14. Whooley MA, Stone B, Soghikian K. Randomized trial of case-finding for depression in elderly primary care patients. J Gen Intern Med 2000; 15 (5): 293–300. doi: 10.1046/j.1525-1497.2000.04319.x.

15. Lipsey JR, Robinson RG, Pearlson GD et al. Nortriptyline treatment of post-stroke depression: a double-blind study. Lancet 1984; 1 (8372): 297–300. doi: 10.1016/S0140-6736 (84) 90356-8.

16. Andersen G, Vestergaard K, Lauritzen L. Effective treatment of poststroke depression with the selective serotonin reuptake inhibitor citalopram. Stroke 1994; 25 (6): 1099–1104. doi: 10.1161/01.STR.25. 6.1099.

17. Andersen G, Vestergaard K, Lauritzen L. Effective treatment of depression following apoplexy with citalopram. Ugeskr Laeger 1995; 157 : 2341–2344.

18. Wiart L, Petit H, Joseph PA et al. Fluoxetine in early poststroke depression: a double-blind placebo-controlled study. Stroke 2000; 31 (8): 1829–1832. doi: 10.1161/01.STR.31.8.1829.

19. Robinson RG, Schultz SK, Castillo C et al. Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled double-blind study. Am J Psychiatry 2000; 157 (3): 351–359. doi: 10.1176/appi.ajp.157.3.351.

20. Jorge RE, Robinson RG, Arndt S et al. Mortality and poststroke depression: a placebo-controlled trial of antidepressants. Am J Psychiatry 2003; 160 (10): 1823–1829. doi: 10.1176/appi.ajp.160.10.1823.

21. Ried LD, Jia H, Feng H et al. Selective serotonin reuptake inhibitor treatment and depression are associated with poststroke mortality. Ann Pharmacother 2011; 45 (7–8): 888–897. doi: 10.1345/aph.1P478.

22. Jorge RE, Acion L, Moser D et al. Escitalopram and enhancement of cognitive recovery following stroke. Arch Gen Psychiatry 2010; 67 (2): 187–196. doi: 10.1001/ archgenpsychiatry.2009.185.

23. Johnson ML, Roberts MD, Ross AR et al. Methylphenidate in stroke patient depression. Am J Phys Med Rehabil 1992; 71 (4): 212–216. doi: 10.1097/00002060-199208000-00008.

24. Taragano FE, Allegri R, Vicario A et al. Augmentation of antidepressant therapy with nimodipine in vascular depression: a randomized double-blind study. Int J Geriatr Psychiatry 2001; 16 (3): 254–260. doi: 10.1002/gps.340.

25. Espárrago Llorca G, Castilla-Guerra L, Fernández Moreno MC et al. Post-stroke depression: an update. Neurología 2015; 30 (1): 23–31. doi: 10.1016/j.nrleng.2012.06.006.

26. Wang G, Xu F, Yang B et al. Repetitive transcranial magnetic stimulation for post-stroke depression: an overview of systematic reviews. Front Neurol 2023; 14 : 930558. doi: 10.3389/fneur.2023.930558.

27. Robinson RG, Spalletta G. Poststroke depression: a review. Can J Psychiatry 2010; 55 (6): 341–349. doi: 10.1177/070674371005500602.

Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 6

2025 Issue 6
Popular this week
Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#