The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016

Autoři: Sofie Holmquist aff001;  Anna Nordström aff001;  Peter Nordström aff004
Působiště autorů: Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden aff001;  Department of Applied Educational Science, Umeå University, Umeå, Sweden aff002;  Department of Community Medicine, Arctic University of Norway, Tromsø, Norway aff003;  Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden aff004
Vyšlo v časopise: The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016. PLoS Med 17(1): e1003016. doi:10.1371/journal.pmed.1003016
Kategorie: Research Article
prolekare.web.journal.doi_sk: 10.1371/journal.pmed.1003016



Depression is associated with an increased risk of dementia. However, short follow-up times and lack of adjustment for familial factors in previous studies could influence this association. The purpose of the present study was to investigate the association between depression and subsequent dementia, while controlling for familial factors and with a follow-up of over 35 years.

Methods and findings

Two cohorts were formed from all individuals aged 50 years or older living in Sweden as of 31 December 2005 (n = 3,341,010). The Swedish National Patient Register was searched from 1964 through 2016 to identify diagnosis of depression and dementia. In the first cohort, individuals diagnosed with depression (n = 119,386) were matched 1:1 with controls without depression diagnosis. The second cohort was a sibling cohort (n = 50,644) consisting of same-sex full sibling pairs with discordant depression status. In the population matched cohort study, a total of 9,802 individuals were diagnosed with dementia during a mean follow-up time of 10.41 (range 0–35) years (5.5% of those diagnosed with depression and 2.6% of those without depression diagnosis (adjusted odds ratio [aOR] 2.47, 95% CI 2.35–2.58; p < 0.001), with a stronger association for vascular dementia (aOR 2.68, 95% CI 2.44–2.95; p < 0.001) than for Alzheimer disease (aOR 1.79, 95% CI 1.68–1.92; p < 0.001). The association with dementia diagnosis was strongest in the first 6 months after depression diagnosis (aOR 15.20, 95% CI 11.85–19.50; p < 0.001), then decreased rapidly but persisted over follow-up of more than 20 years (aOR 1.58, 95% CI 1.27–1.98; p < 0.001). Also in the sibling cohort, the association was strongest in the first 6 months (aOR 20.85, 95% CI 9.63–45.12; p < 0.001), then decreased rapidly but persisted over follow-up of more than 20 years (aOR 2.33, 95% CI 1.32–4.11; p < 0.001). The adjusted models included sex, age at baseline, citizenship, civil status, household income, and diagnoses at baseline. The main limitation of the study methodology is the use of observational data; hence, the associations found are not proof of causal effects.


Depression is associated with increased odds of dementia, even more than 20 years after diagnosis of depression, and the association remains after adjustment for familial factors. Further research is needed to investigate whether successful prevention and treatment of depression decrease the risk of dementia.

Klíčová slova:

Alzheimer's disease – Alzheimer's disease diagnosis and management – Dementia – Depression – Diabetes mellitus – Intoxication – Swedish people – Vascular dementia


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