Acute pancreatitis as a complication of childhood cancer treatment

Acute pancreatitis (AP) is now well recognized as a possible complication of childhood cancer treatment, interrupting the chemotherapy regimen, and requiring prolonged hospitalization, possibly with intensive care and surgical intervention, thereby compromising the effect of chemotherapy and the remission of the underlying malignant disease. This review summarizes the current literature and presents the various etiological factors for AP during chemotherapy as well as modern trends in the diagnosis and therapy of AP in children.

Acute pancreatitis, childhood cancer, L-asparaginase, diagnosis, management

Autoři: Milica Stefanović 1,*;  Janez Jazbec 1;  Fredrik Lindgren 2;  Milutin Bulajić 3,4;  Matthias Löhr 5
Působiště autorů: Division of Pediatrics, Unit of Hemato-oncology, University Medical Centre Ljubljana, Ljubljana, Slovenia 1;  Department of Pediatric, Karolinska University Hospital, Stockholm, Sweden 2;  Department of Gastroenterology, University Hospital Center “Santa Maria della Misericordia”, Udine, Italy 3;  Faculty of Medicine, University of Belgrade, Belgrade, Serbia 4;  Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden 5
Vyšlo v časopise: Cancer Medicine 2016; 5(5)
Kategorie: Review
prolekare.web.journal.doi_sk: 10.1002/cam4.649

© 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.


Acute pancreatitis (AP) is now well recognized as a possible complication of childhood cancer treatment, interrupting the chemotherapy regimen, and requiring prolonged hospitalization, possibly with intensive care and surgical intervention, thereby compromising the effect of chemotherapy and the remission of the underlying malignant disease. This review summarizes the current literature and presents the various etiological factors for AP during chemotherapy as well as modern trends in the diagnosis and therapy of AP in children.

Acute pancreatitis, childhood cancer, L-asparaginase, diagnosis, management


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