Acute pancreatitis as a complication of childhood cancer treatment


Acute pancreatitis (AP) is now well recognized as a possible complication of childhood cancer treatment, interrupting the chemotherapy regimen, and requiring prolonged hospitalization, possibly with intensive care and surgical intervention, thereby compromising the effect of chemotherapy and the remission of the underlying malignant disease. This review summarizes the current literature and presents the various etiological factors for AP during chemotherapy as well as modern trends in the diagnosis and therapy of AP in children.

Keywords:
Acute pancreatitis, childhood cancer, L-asparaginase, diagnosis, management


Autoři: Milica Stefanović 1,*;  Janez Jazbec 1;  Fredrik Lindgren 2;  Milutin Bulajić 3,4;  Matthias Löhr 5
Působiště autorů: Division of Pediatrics, Unit of Hemato-oncology, University Medical Centre Ljubljana, Ljubljana, Slovenia 1;  Department of Pediatric, Karolinska University Hospital, Stockholm, Sweden 2;  Department of Gastroenterology, University Hospital Center “Santa Maria della Misericordia”, Udine, Italy 3;  Faculty of Medicine, University of Belgrade, Belgrade, Serbia 4;  Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden 5
Vyšlo v časopise: Cancer Medicine 2016; 5(5)
Kategorie: Review
prolekare.web.journal.doi_sk: 10.1002/cam4.649

© 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Souhrn

Acute pancreatitis (AP) is now well recognized as a possible complication of childhood cancer treatment, interrupting the chemotherapy regimen, and requiring prolonged hospitalization, possibly with intensive care and surgical intervention, thereby compromising the effect of chemotherapy and the remission of the underlying malignant disease. This review summarizes the current literature and presents the various etiological factors for AP during chemotherapy as well as modern trends in the diagnosis and therapy of AP in children.

Keywords:
Acute pancreatitis, childhood cancer, L-asparaginase, diagnosis, management


Zdroje

1 Mekitarian Filho, E., W. B. Carvalho, and F. D. Silva. 2012. Acute pancreatitis in pediatrics: a systematic review of the literature. J. Pediatr. 88:101–114.

2 Velasco-Benítez, C. A. 2011. Pancreatitis in children. Rev. Col. Gastroenterol. 26:48–53.

3 Bradley, E. L., 3rd. 1993. A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, GA, September 11 through 13, 1992. Arch. Surg. 128:586–590.

4 Werlin, S. L., S. Kugathasan, and B. C. Frautschy. 2003. Pancreatitis in children. J. Pediatr. Gastroenterol. Nutr. 37:591–595.

5 Tiao, M. M., J. H. Chuang, S. F. Ko, H. W. Kuo, C. D. Liang, and C. L. Chen. 2002. Pancreatitis in children: clinical analysis of 61 cases in southern Taiwan. Chang Gung Med. J. 25:162–168.

6 Park, A., S. U. Latif, A. U. Shah, J. Tian, S. Werlin, A. Hsiao, et al. 2009. Changing referral trends of acute pancreatitis in children: A 12-year single-center analysis. J. Pediatr. Gastroenterol. Nutr. 49:316–322.

7 Löhr, M., and Å. Andrén-Sandberg. eds. 2011. Pancreatitis - diagnosis and therapy. UNI-MED Science, Uni-Med isbn: 978-3-8374-1317-5.

8 Trivedi, C. D., and C. S. Pitchumoni. 2005. Drug-induced pancreatitis an update. J. Clin. Gastroenterol. 39:709–716.

9 Gullo, L., M. Migliori, A. Olah, G. Farkas, P. Levy, C. Arvanitakis, et al. 2002. Acute pancreatitis in five European countries: etiology and mortality. Pancreas 24:223–227.

10 Steer, M. 2002. Pancreatitis severity: who calls the shots? Gastroenterology 122:1168–1172.

11 Knoderer, H. M., J. Robarge, and D. A. Flockhart. 2007. Predicting asparaginase-associated pancreatitis. Pediatr. Blood Cancer 49:634–639.

12 Alvarez, O. A., and G. Zimmerman. 2000. Pegaspargase-induced pancreatitis. Med. Pediatr. Oncol. 34:200–205.

13 Sikorska-Fic, B., E. Stan'czak, M. Matysiak, and A. Kamin'ski. 2000. Acute pancreatitis during chemotherapy of acute lymphoblastic leukaemia complicated with pseudocyst. Med. Wieku Rozwoj. 12:1051–1055.

14 Kearney, S. L., S. E. Dahlberg, D. E. Levy, S. D. Voss, S. E. Sallan, and L. B. Silverman. 2009. Clinical course and outcome in children with acute lymphoblastic leukemia and asparaginase-associated pancreatitis. Pediatr. Blood Cancer 53:162–167.

15 Earl, M. 2009. Incidence and management of asparaginase-associated adverse events in patients with acute lymphoblastic leukemia. Clin. Adv. Hematol. Oncol. 7:600–606.

16 Flores-Calderón, J., E. Exiga-Gonzaléz, S. Morán-Villota, J. Martín-Trejo, and A. Yamamoto-Nagano. 2009. Acute pancreatitis in children with acute lymphoblastic leukemia treated with L-asparaginase. J. Pediatr. Hematol. Oncol. 31:790–793.

17 Yu, C. H., K. H. Lin, D. T. Lin, R. L. Chen, Y. C. Horng, and M. H. Chang. 1994. L-asparaginase-related pancreatic pseudocyst: report of a case. J. Formos. Med. Assoc. 93:441–444.

18 Karabulut, R., K. Sönmez, C. Afşarlar, A. Can Başaklar, and N. Kale. 2005. Pancreas pseudocyst associated with L-asparaginase treatment: a case report. Acta Chir. Belg. 105:667–669.

19 Caniano, D. A., A. F. Browne, and E. T. Boles, Jr. 1985. Pancreatic pseudocyst complicating treatment of acute lymphoblastic leukemia. J. Pediatr. Surg. 20:452–455.

20 Sadoff, J., S. Hwang, D. Rosenfeld, L. Ettinger, and N. Spigland. 1997. Surgical pancreatic complications induced by L-asparaginase. J. Pediatr. Surg. 32:860–863.

21 McLean, R., S. Martin, and P. R. Lam-Po-Tang. 1982. Fatal case of L-asparaginase induced pancreatitis. Lancet 2:1401–1402.

22 Carter, M. J., A. J. Lobo, and S. P. Travis; IBD Section, British Society of Gastroenterology. 2004. Guidelines for the management of inflammatory bowel disease in adults. Gut 53(Suppl 5):V1–V16.

23 van Geenen, E. J., N. K. de Boer, P. Stassen, R. K. Linskens, M. J. Bruno, C. J. Mulder, et al. 2010. Azathioprine or mercaptopurine-induced acute pancreatitis is not a disease-specific phenomenon. Aliment. Pharmacol. Ther. 31:1322–1329.

24 Willert, J. R., G. V. Dahl, and N. M. Marina. 2002. Recurrent mercaptopurine-induced acute pancreatitis: a rare complication of chemotherapy for acute lymphoblastic leukemia in children. Med. Pediatr. Oncol. 38:73–74.

25 McGrail, L. H., L. H. Sehn, R. B. Weiss, M. R. Robson, J. H. Antin, and J. C. Byrd. 1999. Pancreatitis during therapy of acute myeloid leukemia: cytarabine related? Ann. Oncol. 10:1373–1376.

26 Altman, A. J., P. Dinndorf, and J. J. Quinn. 1982. Acute pancreatitis in association with cytosine arabinoside therapy. Cancer 49:1384–1386.

27 Kudo, K., A. Hama, S. Kojima, R. Ishii, A. Morimoto, F. Bessho, et al. 2010. Mosaic Down syndrome-associated acute myeloid leukemia does not require high-dose cytarabine treatment for induction and consolidation therapy. Int. J. Hematol. 91:630–635.

28 Kawasaki, H., K. Isoyama, M. Eguchi, S. Hibi, N. Kinukawa, Y. Kosaka, et al. 2001. Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group. Blood 98:3589–3594.

29 Badalov, N., R. Baradarian, K. Iswara, J. Li, W. Steinberg, and S. Tenner. 2007. Drug induced acute pancreatitis: an evidence-based review. Clin. Gastroenterol. Hepatol. 5:648–661.

30 Garg, R., S. Agarwala, and V. Bhatnagar. 2010. Acute pancreatitis induced by ifosfamide therapy. J. Pediatr. Surg. 45:2071–2073.

31 Hung, M. C., G. Y. Hung, P. C. Lin, C. M. Tiu, and Y. C. Tien. 2007. Acute pancreatitis associated with ifosfamide. J. Chin. Med. Assoc. 70:176–179.

32 Bunin, N., W. H. Meyer, M. Christensen, and C. B. Pratt. 1985. Pancreatitis following cisplatin: a case report. Cancer Treat. Rep. 69:236–237.

33 Shrikiran, A. 2011. A rare case of methotrextate induced pancreatitis in acute leaukemia patient. Webmed Central Paediatr. 2:WMC002820.

34 Teuffel, O., S. P. Kuster, S. P. Hunger, V. Conter, J. Hitzler, M. C. Ethier, et al. 2011. Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Leukemia 25:1232–1238.

35 Bai, H. X., M. H. Ma, A. I. Orabi, A. Park, S. U. Latif, V. Bhandari, et al. 2011. Novel characterization of drug-associated pancreatitis in children. J. Pediatr. Gastroenterol. Nutr. 53:423–428.

36 Park, T. Y., H.-C. Oh, and J. H. Do. 2010. A case of recurrent pancreatitis induced by trimethoprim-sulfamethoxazole re-exposure. Gut. Liv. 4:250–252.

37 Brett, A. S., and S. V. Shaw. 1999. Simultaneous pancreatitis and hepatitis associated with trimethoprim-sulfamethoxazole. Am. J. Gastroenterol. 94:267–268.

38 Gottschling, S., R. Larsen, S. Meyer, N. Graf, and H. Reinhard. 2005. Acute pancreatitis induced by short-term propofol administration. Paediatr Anaesth. 15:1006–1008.

39 Bustamante, S. E., and E. Appachi. 2006. Acute pancreatitis after anesthesia with propofol in a child with glycogen storage disease type IA. Paediatr. Anaesth. 16:680–683.

40 Crawford, M. W., C. Pehora, and A. V. Lopez. 2009. Drug- induced acute pancreatitis in children receiving chemotherapy for acute leukemia: does propofol increase the risk? Anesth. Analg. 109:379–381.

41 Youssef, S. S., S. B. Iskandar, J. Scruggs, and T. M. Roy. 2005. Acute pancreatitis associated with omeprazole. Int. J. Clin. Pharmacol. Ther. 43:558–561.

42 Eland, I. A., C. H. Alvarez, B. H. Stricker, and L. A. Rodríguez. 2000. The risk of acute pancreatitis associated with acid-suppressing drugs. Br. J. Clin. Pharmacol. 49:473–478.

43 Fernandes, R. 2009. Acute pancreatitis following paracetamol overdose. BMJ Case Rep. doi: 10.1136/bcr.08.2009.2224.

44 Schmidt, L. E., and K. Dalhoff. 2004. Hyperamylasaemia and acute pancreatitis in paracetamol poisoning. Aliment. Pharmacol. Ther. 20:173–179.

45 Werlin, S. L., J. Casper, D. Antonson, and C. Calabro. 1992. Pancreatitis associated with bone marrow transplantation in children. Bone Marrow Transplant. 10:65–69.

46 Ko, C. W., T. Gooley, H. G. Schoch, D. Myerson, R. C. Hackman, H. M. Shulman, et al. 1997. Acute pancreatitis in marrow transplant patients: prevalence at autopsy and risk factor analysis. Bone Marrow Transplant. 20:1081–1086.

47 Sastry, J., S. Young, and P. J. Shaw. 2004. Acute pancreatitis due to tacrolimus in a case of allogeneic bone marrow transplantation. Bone Marrow Transplant. 33:867–868.

48 Nieto, Y., P. Russ, G. Everson, S. I. Bearman, P. J. Cagnoni, R. B. Jones, et al. 2000. Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation. Bone Marrow Transplant. 26:109–111.

49 Ito, T., T. Kimura, H. Yamaguchi, M. Kinjo, T. Sumii, I. Nakano, et al. 1993. Acute pancreatitis induced by cyclosporin A under stimulation of pancreas by caerulein. Pancreas 8:693–699.

50 Niemann, T. H., M. E. Trigg, N. Winick, and G. D. Penick. 1993. Disseminated adenoviral infection presenting as acute pancreatitis. Hum. Pathol. 24:1145–1148.

51 Tomonari, A., S. Takahashi, K. Takasugi, J. Ooi, N. Tsukada, T. Konuma, et al. 2006. Pancreatic hyperamylasemia and hyperlipasemia in association with cytomegalovirus infection following unrelated cord blood transplantation for acute myelogenous leukemia. Int. J. Hematol. 84:438–440.

52 Bateman, C. M., A. M. Kesson, and P. J. Shaw. 2006. Pancreatitis and adenoviral infection in children after blood and marrow transplantation. Bone Marrow Transplant. 38:807–811.

53 Shifrin, A. L., N. Chirmule, G. P. Gao, J. M. Wilson, and S. E. Raper. 2005. Innate immune responses to adenoviral vector-mediated acute pancreatitis. Pancreas 30:122–129.

54 Salomone, T., P. Tosi, C. Raiti, M. Stanzani, G. Leopardi, F. Miglio, et al. 1999. Clinical relevance of acute pancreatitis in allogeneic hemopoietic stem cell (bone marrow or peripheral blood) transplants. Dig. Dis. Sci. 44:1124–1127.

55 Schiller, G. J., S. D. Nimer, J. L. Gajewski, and D. W. Golde. 1991. Abdominal presentation of varicella-zoster infection in recipients of allogeneic bone marrow transplantation. Bone Marrow Transplant. 7:489–491.

56 Ladrière, M., B. Bibes, C. Rabaud, P. Delaby, T. May, and P. Canton. 2001. Varicella zoster virus infection after bone marrow transplant. Unusual presentation and importance of prevention. Presse Med. 30:1151–1154.

57 Morinville, V. D., S. Z. Husain, H. Bai, B. Barth, R. Alhosh, P. R. Dure, et al.; On behalf of the INSPPIRE Group. 2012. Definitions of pediatric pancreatitis and survey of present clinical practices. J. Pediatr. Gastroenterol. Nutr. 55:261–265.

58 Bai, H. X., M. E. Lowe, and S. Z. Husain. 2011. What have we learned about acute pancreatitis in children? J. Pediatr. Gastroenterol. Nutr. 52:262–270.

59 Consuelo Sánchez, A., and J. A. García Aranda. 2012. Acute pancreatitis. Bol. Med. Hosp. Infant Mex. 69:3–9.

60 Nydegger, A., R. T. L. Couper, and M. R. Olive. 2006. Childhood pancreatitis. J. Gastroenterol. Hepatol. 21:499–509.

61 Frank, B., and K. Gottlieb. 1999. Amylase normal, lipase elevated: is it pancreatitis? A case series and review of the literature. Am. J. Gastroenterol. 94:463–469.

62 Muddana, V., D. C. Whitcomb, A. Khalid, A. Slivka, and G. I. Papachristou. 2009. Elevated serum creatinine as a marker of pancreatic necrosis in acute pancreatitis. Am. J. Gastroenterol. 104:164–170.

63 Darge, K., and S. Anupindi. 2009. Pancreatitis and the role of US, MRCP and ERCP. Pediatr. Radiol. 39:S153–S157.

64 UK Working Party on Acute Pancreatitis. 2005. UK guidelines for the management of acute pancreatitis. Gut 54(Suppl. III):iii1–iii9.

65 Tsuji, Y., K. Hamaguchi, Y. Watanabe, A. Okumura, H. Isoda, N. Yamamoto, et al. 2010. Perfusion CT is superior to angiography in predicting pancreatic necrosis in patients with severe acute pancreatitis. J. Gastroenterol. 45:1155–1162.

66 Tsuji, Y., H. Yamamoto, S. Yazumi, Y. Watanabe, K. Matsueda, H. Yamamoto, et al. 2007. Perfusion computerized tomography can predict pancreatic necrosis in early stages of severe acute pancreatitis. Clin. Gastroenterol. Hepatol. 5:1484–1492.

67 Tsuji, Y., N. Takahashi, and C. Tsutomu. 2012. Pancreatic perfusion CT in early stage of severe acute pancreatitis. Int. J. Inflam. 2012:497386. doi: 10.1155/2012/497386.

68 Amano, H., T. Takada, S. Isaji, Y. Takeyama, K. Hirata, M. Yoshida, et al. 2010. Therapeutic intervention and surgery of acute pancreatitis. J. Hepatobiliary Pancreat. Sci. 17:53–59.

69 Dambrauskas, Z., A. Gulbinas, J. Pundzius, and G. Barauskas. 2007. Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis. Medicina (Kaunas) 43:291–300.

70 García-Barrasa, A., F. G. Borobia, R. Pallares, R. Jorba, I. Poves, J. Busquets, et al. 2009. A double-blind, placebo-controlled trial of ciprofloxacin prophylaxis in patients with acute necrotizing pancreatitis. J. Gastrointest. Surg. 13:768–774.

71 Spraker, H. L., G. P. Spyridis, C. H. Pui, and S. C. Howard. 2009. Conservative management of pancreatic pseudocysts in children with acute lymphoblastic leukemia. J. Pediatr. Hematol. Oncol. 31:957–959.

72 Banks, P.A., M. L. Freeman; the Practice Parameters Committee of the American College of Gastroenterology. 2006. Practice guidelines in acute pancreatitis. Am. J. Gastroenterol. 101:2379–400.

73 Takeda, K., T. Takada, and Y. Kawarada. 2006. JPN Guidelines for the management of acute pancreatitis: medical management of acute pancreatitis. J. Hepatobiliary Pancreat. Surg. 13:42–47.

74 Isenmann, R., M. Rünzi, M. Kron, S. Kahl, D. Kraus, N. Jung, et al. 2004. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double blind trial. Gastroenterology 126:997–1004.

75 Heinrich, S., M. Schäfer, V. Rousson, and P. A. Clavien. 2006. Evidence-based treatment of acute pancreatitis: a look at established paradigms. Ann. Surg. 243:154–168.

76 Bai, Y., J. Gao, D. W. Zou, and Z. Li. 2008. Prophylactic antibiotics cannot reduce infected pancreatic necrosis and mortality in acute necrotizing pancreatitis: evidence from a meta-analysis of randomized controlled trials. Am. J. Gastroenterol. 103:104–110.

77 Bang, U. C., S. Semb, C. Nojgaard, and F. Bendtsen. 2008. Pharmacological approach to acute pancreatitis. World J. Gastroenterol. 14:2968–2976.

78 Morimoto, A., T. Imamura, R. Ishii, Y. Nakabayashi, T. Nakatani, J. Sakagami, et al. 2008. Successful management of severe L-asparaginase-associated pancreatitis by continuous regional arterial infusion of protease inhibitor and antibiotic. Cancer 113:1362–1369.

79 Wu, S. F., A. C. Chen, C. T. Peng, and K. H. Wu. 2008. Octreotide therapy in asparaginase-associated pancreatitis in childhood acute lymphoblastic leukemia. Pediatr. Blood Cancer 51:824–825.

80 Tokimasa, S., and K. Yamato. 2012. Does ocreotide prevent L-asparaginase associated pancreatitis in children with acute lymphoblastic leukaemia? Br. J. Haematol. 157:381–382.

81 Sax, H. C., B. W. Warner, M. A. Talamini, F. N. Hamilton, R. H. Bell Jr., J. E. Fischer, et al.1987. Early total parenteral nutrition in acute pancreatitis: lack of beneficial effects. Am. J. Surg. 153:117–124.

82 Petrov, M. S., R. D. Pylypchuk, and N. V. Emelyanov. 2008. Systematic review: nutritional support in acute pancreatitis. Aliment. Pharmacol. Ther. 28:704–712.

83 Thompson, D. R. 2001. Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis. Am. J. Gastroenterol. 96:1266–1272.

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