Biological Mechanisms of Aging
Biologické mechanizmy stárnutí
Článek přináší přehled současných představ o mechanizmu stárnutí a jeho odchylek – progerie a dlouhověkosti. Důraz je kladen na replikativní stárnutí, roli glykace a volných radikálů a na genetickou podmíněnost progerie i dlouhověkosti.
Klíčová slova:
stárnutí, stáří, involuce, progerie, dlouhověkost.
Authors:
B. Otová 1; Z. Kalvach 2; M. Šnejdrlová 2
Authors‘ workplace:
Ústav biologie a lékařské genetiky 1. LF UK a VFN, Praha
1; III. interní klinika 1. LF UK a VFN, Praha
2
Published in:
Čas. Lék. čes. 2006; 145: 688-694
Category:
Review Article
Overview
Contemporary views on the mechanisms of aging and aging variations – progeria and longevity are presented. Replicative aging, the roles of glycation and free radicals on the genetical determination of progeria and longevity are discussed.
Key words:
aging, senescence, involution, progeria, longevity.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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