Pancreatic Hormones and Hormonal Regulation of Insulin Secretion
Pankreatické hormony a hormonální regulace sekrece inzulínu
Endokrinní část pankreatu produkující inzulín, glukagon, somatostatin a pankreatický polypeptid podléhá mnoha typům regulací, z nichž regulační úloha enteropankreatické osy zaujímá přední místo. Inkretinový účinek glukózodependentního inzulínotropního peptidu (GIP) a glukagonu podobnému peptidu 1 (GLP-1) se významně účastní regulace sekrece inzulínu, která je pod modulačním vlivem mnoha dalších hormonů. Diabetes mellitus podobně jako poruchy jiných hormonů mohou být proto příčinou porušené regulace inzulínu i ostatních pankreatických hormonů.
Klíčová slova:
pankreatické hormony, sekrece inzulínu, inkretinové hormony.
Authors:
J. Škrha
Authors‘ workplace:
III. interní klinika 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 2006; 145: 599-605
Category:
Review Article
Overview
Endocrine pancreas producing insulin, glucagon, somatostatin and pancreatic polypeptide is under the influence of different types of regulation; among them the regulatory role of enteropancreatic axis plays an important role. Incretin effect of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide 1 (GLP-1) is significantly involved in the insulin secretion which is modulated by many other hormones. Diabetes mellitus, similarly to disturbances of other hormones, can cause impaired regulation of insulin and other pancreatic hormones.
Key words:
pancreatic hormones, insulin secretion, incretin hormones.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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