Antibiotic Resistance and Serotypes of Invasive Pneumococciin the Czech Republic
Antibiotická rezistence invazivních pneumokokůa jejich sérotypy v České republice
Východisko.
Kmeny S. pneumoniae (pneumokoky) izolované z krve nebo mozkomíšního moku 483 pacientův období leden 2001 – říjen 2003 byly v 5,2 % necitlivé k penicilinu (PNSP, penicillin-non-susceptible S. pneumoniae).Metody a výsledky. Frekvence výskytu PNSP byla nejvyšší u dětí v nejmladší věkové kategorii (12,7 %). K cefotaximubylo necitlivých 2,7 % kmenů. Rezistence pneumokoků ke ko-trimoxazolu byla zjištěna v 9,9 %, k tetracyklinuv 8,9 %, k chloramfenikolu v 4,6 %, k erytromycinu ve 2,3 %, ke klindamycinu v 1,4 %, k levofloxacinuv 0,6 %, k rifampicinu v 0,2 %, žádný kmen nebyl rezistentní k linezolidu. Srovnání s výsledky z let 1996–1999svědčí o trvalém výskytu invazivních kmenů PNSP oscilujícím kolem 5 %. Kmeny PNSP patřily k 7 sérotypům,nejčastěji se vyskytoval sérotyp 9V. Náš soubor kmenů je 5x menší než soubory invazivních pneumokoků izolovanéve stejně dlouhém období v jiných zemích Evropy se srovnatelným počtem obyvatel.Závěry. Tato skutečnost, pravděpodobně způsobená podceněním významu hemokultur, znemožňuje získat v některýchlokalitách České republiky validní údaje nezbytné pro léčbu antibiotiky bezpečnou z hlediska účinnostia prevence vývoje rezistence.
Klíčová slova:
invazivní pneumokoky, antibiotická rezistence, sérotypy.
Authors:
P. Urbášková; J. Motlová; H. Žemličková; Cz-Earss 1
Authors‘ workplace:
Centrum epidemiologie a mikrobiologie – Státní zdravotní ústav, Praha 1Účastníci European Antimicrobial Surveillance Resistance System, ČR
Published in:
Čas. Lék. čes. 2004; : 178-183
Category:
Overview
Background.
Among strains of S. pneumoniae (pneumococci), isolated from blood or cerebrospinal fluid of 483patients between January 2001 and October 2003 as many as 5.2 % strains were penicillin-non-susceptible.Methods and Results. Incidence of penicillin-non-susceptible S. pneumoniae (PNSP) strains was highest in childrenof the youngest age group (12.7 %). Cefotaxim-non-susceptibility was detected in 2.7 % of strains. Pneumococcitested were resistant to co-trimoxazol (9.9 %), tetracycline (8.9 %), chloramphenicol (4.6 %), erythromycin (2.3 %),clindamycin (1.4 %), levofloxacin (0.6 %) and rifampicin (0.2 %); none of the strains was resistant to linezolid.Comparison of the results from 1996–1999 shows a permanent occurrence of invasive PNSP strains ranging about5 %. The PNSP strains were of 7 serotypes, with serotype 9V being the most frequent. The Czech collection ofinvasive pneumococcal strains is five times smaller than that of any other European country with comparablepopulations over the same period of time.Conclusions. Low incidence of invasive S. pneumoniae strains seems to be related to the underestimated significanceof blood culturing. Valid data necessary for the safety of antibiotic therapy in terms of efficacy and prevention ofresistance development cannot be obtained from some localities of the Czech Republic.
Key words:
invasive pneumococci, antibiotic resistance, serotypes.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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