Importance of Assessment of the Osteocalcin Level in Patients with Differentiated Thyroid Carcinoma
Význam stanovení koncentrace osteokalcinu u pacientů s diferencovaným karcinomem štítné žlázy
Autoři sledovali změny koncentrace sérového osteokalcinu u pacientů s diferencovaným karcinomem štítné žlázy po totální tyroidektomii a léčbě radiojodem isil.Osteokalcin jako marker kostní přestavby byl u sledované skupiny pacientů vyšší proti kontrolní skupině, statisticky na hranici významnosti. Využití markeru kostní remodelace k průkazu metastatického postižení je však málo průkazné. Rovněž vliv supresní léčby tyroideálními hormony na hodnoty sérového osteokalcinu, které by signalizovaly při zvýšení metabolického obratu kostní tkáně riziko vzniku osteopenie a osteoporózy u sledovaných pacientů, nebyly dostatečně významné.
Klíčová slova:
osteokalcin - karcinom štítné žlázy - tyroideální hormony.
Authors:
J. Heresová; M. ~j'neradilová; R. Bílek; P. Racek; M. Hill; J. Němec; O. Nývltová
Authors‘ workplace:
Endokrinologický ústav, Praha
Published in:
Prakt. Lék. 2002; (5): 273-276
Category:
Overview
The authors investigated changes of sernm osteocalcin levels is patients with differentiated thyroid Carcinoma after total thyroidectomy and treatment with radioiodinelsl.Osteocalcin as a marker of bone reconstruction was in the investigated group of patients higher as compared with a control group, on the borderline of statistical significance. The use of a marker of bone remodelling to prove metastatic affection is however not sufficient evidence. Also the influence of suppressive treatment with thyroid hormones on values of serum osteocalcin which would signalize in tase of an increased metabolic turnover of bony tissue the risk of osteopenia and osteoporosis in the investigated patients was not sufficiently significant.
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General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2002 Issue 5
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