Gynecological Aspects of Thyroid Disorders. A Review
Gynekologické aspekty poruch štítné žlázy. Přehled
Cíl studie.
Nejčastější syndromy spojené s dysfunkcí štítné žlázy, hypotyreóza a hypertyreóza, se často projevují poruchami menstruačního cyklu. Cílem práce bylo shrnutí poznatků o fyziologii, patologii a klinických aspektech interakce tyreoidální a gonadální osy.
Typ práce.
Souhrnný článek.
Název a sídlo pracoviště. Ústav patologické fyziologie 1. lékařské fakulty Univerzity Karlovy, Praha.
Závěr.
Okolo 25 % případů infertility u žen a 15 % poruch menstruačního cyklu je v příčinné souvislosti s poruchami štítné žlázy. Ukazuje se, že zejména subklinická hypotyreóza má vysokou prevalenci v populaci a je třeba na ni třeba vždy pomyslet u žen s poruchami fertility a menstruačního cyklu. Další z oblastí, kde se problematika poruch štítné žlázy dotýká gynekologie, je použití radiojodu u žen s diferencovaným karcinomem štítné žlázy ve fertilním věku – zejména ve vztahu k poškození gonád a k těhotenskému riziku.
Klíčová slova:
estrogeny, hypotyreóza, menstruace, prolaktin, štítná žláza, tyreotoxikóza, tyroxin
Authors:
P. Maruna
Authors‘ workplace:
Ústav patologické fyziologie 1. LF UK, Praha, přednosta prof. MUDr. E. Nečas, DrSc.
Published in:
Ceska Gynekol 2006; 71(4): 332-338
Category:
Original Article
Overview
Objective.
The most frequent thyroid syndromes – hypothyroidism and thyrotoxicosis - are often accompanied with menstrual disturbances. The aim of this study was to summarize knowledge of physiology, pathology and clinical aspects of both thyroidal and gonadal axis interactions.
Subject.
A review.
Setting.
Department of Pathological Physiology, 1st Faculty of Medicine, Charles University, Prague.
Conclusion.
About 25% female infertility and 15% menstrual cycle disorders result from thyroid dysfunction. Particularly, the subclinical hypothyroidism has a high prevalence in the population; therefore, thyroid function must be examined in female with unclear infertility or menstrual disturbances. The next overlap of thyroid disorders and gynaecology represents iodine-131 use for differentiated thyroid carcinoma in fertile age with aspects to ovarian failure and gestational risk.
Key words:
estrogens, hypothyroidism, menstrual cycle, prolactin, thyroid gland, thyrotoxicosis, thyroxin.
Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2006 Issue 4
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