Xanthium spinosum L. – a Phytochemical Study
Xanthium spinosum L. – fytochemická studie
Práce se zabývá izolací obsahových látek Xanthium spinosum L. a určení biologické aktivity (toxicity). Taxon vyskytující se také v naší flóře nebyl dosud z tohoto pohledu studován. Použitá metodika má charakter „bioassay-guided separace“. Jako základní biologický test byl použit Tubifex tubifex test (TT test). Z methanolového extraktu natě byl vyizolován ent-kauranový diterpen atraktylosid, z acetonového extraktu byly vyizolovány dva deriváty xanthanolidů – seskviterpenických laktonů: xanthumin a deacetylxanthumin a z ethanolového extraktu fytosteroly: ß-sitosterol a stigmasterol. Z acetonového extraktu plodů byly získány mastné kyseliny.
Klíčová slova:
Xanthium spinosum L. – Asteraceae – bioassay-guided separace – atraktylosid – xanthanolidy – Tubifex tubifex test
Authors:
J. Klečáková- Karlíčková; L. Jahodář
Authors‘ workplace:
Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické botaniky a ekologie
Published in:
Čes. slov. Farm., 2005; 54, 141-144
Category:
Original Articles
Overview
The paper deals with the isolation of the constituents of Xanthium spinosum L. and the determination of its biological activity (toxicity). The taxon which is found also in our flora has not been studied from this aspect yet. The used methodology is of a bioassay-guided separation character. The Tubifex tubifex test (TT test) served as the basic biological test. From the methanol extract of the aerial part, ent-kaurane diterpene atractyloside was isolated, from the acetone extract of the aerial part, xanthumin and deacetylxanthumin, two derivatives of xanthanolides – sesquiterpene lactones, were isolated, and from the ethanol extract, phytosterols – β-sitosterol and stigmasterol. From the acetone extract of fruits, fatty acids were obtained.
Key words:
Xanthium spinosum L. – Asteraceae – bioassay-guided separation – atractyloside – xanthanolides – Tubifex tubifex test
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2005 Issue 3
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