Pre-Formulation Studies of the H₁-Antihistamine Loratadine for a Topical Dosage Form
Predformulačné štúdie H₁ – antihistaminika loratadínu do topickej liekovej formy
Práca je zameraná na formuláciu antihistaminika – loratadínu do hydrogélov. V prvej etape tejto štúdie bol hodnoteným polymérom na prípravu hydrogélov Carbopol® 980 o koncentrácii 0,5; 0,8 a 1,0 %. Cieľom príspevku bolo stanovenie optimálnej koncentrácie Carbopolu® 980 pri formulácii hydrogélu na základe hodnotenia reologických vlastností a farmaceutickej dostupnosti loratadínu z pripravených hydrogélov. Z výsledkov štúdie vyplýva, že z hľadiska topickej aplikácie je pre loratadín optimálny 0,5% hydrogél z Carbopolu® 980.
Kľúčové slová:
hydrogély – Carbopol® 980 – loratadín – liberácia – reologické vlastnosti
Authors:
Z. Capková; Z. Vitková; V. Vysokaiová
Authors‘ workplace:
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie
Published in:
Čes. slov. Farm., 2005; 54, 109-113
Category:
Original Articles
Overview
The paper focuses on the formulation of the antihistamine loratadine for hydrogels. In the first stage of this study, the evaluated polymer for the preparation of hydrogels was Carbopol® 980 of concentrations of 0.5, 0.8, and 1.0 %. The paper aimed to determine the optimal concentration of Carbopol® 980 in hydrogel formulation on the basis of the evaluation of the rheological properties and biological availability of loratadine from prepared hydrogels. The results of the study show 0.5% hydrogel of Carbopol® 980 to be optimal for loratadine from the standpoint of topical administration.
Key words:
hydrogels – Carbopol® 980 – loratadine – liberation – rheological properties
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2005 Issue 3
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