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Current view on lipoprotein(a): diagnosis and treatment

Czech version

Authors: Martin Čaprnda 1;  Matej Jantošík 1;  Peter Kromka 1,2
Authors‘ workplace: I. interná klinika LF UK a UNB, Nemocnica Staré Mesto, Bratislava 1;  III. interná klinika LF UK a UNB, Nemocnica akad. L. Dérera, Bratislava 2
Published in: AtheroRev 2026; 11(1): 33-39
Category: Reviews

Overview

Elevated lipoprotein(a)/Lp(a) levels occur in 20–25% of the global population, with prevalence varying across ethnic groups. Lp(a) is a lipoprotein particle consisting of a spherical part similar to an LDL particle containing apolipoprotein B-100, to which a chain of apolipoprotein(a) is bound by a covalent disulfide bond. Structurally, it is 70–85% identical to the plasminogen molecule. The clinical significance of Lp(a) lies in its atherogenic, thrombogenic, and pro-inflammatory properties, which make it an independent risk factor for atherosclerotic cardiovascular disease. In this article, we focus on the investigation, risk assessment, and new treatment options for patients with high Lp(a) levels.

Keywords:

lipoprotein(a) – atherosclerotic cardiovascular disease – apolipoprotein B-100

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