Coronary events are preventable – so don't miss this opportunity: case report
Authors:
Martin Šatný
Authors‘ workplace:
Centrum preventivní kardiologie, III. interní klinika – endokrinologie a metabolismu 1. LF UK a VFN v Praze
Published in:
AtheroRev 2025; 10(2): 121-124
Category:
Overview
Although the incidence of acute coronary events has been declining over the past two decades, cardiovascular disease – predominantly atherosclerotic CVD – remains the leading cause of morbidity and mortality not only in our country, but also in most developed countries. Currently, as in the treatment of arterial hypertension, rapid escalation of therapy is recommended, in particular the early use of appropriate combination therapy, including modern injectable medications. The presented case study documents current trends in the management of patients at very high cardiovascular risk and emphasizes the importance of lipoprotein(a) testing and early use of PCSK9 inhibitors.
Keywords:
acute coronary syndrome – lipoprotein(a) – cardiovascular risk – PCSK9 inhibitors – atherosclerotic cardiovascular disease
Sources
Cífková R, Bruthans J, Wolhlfahrt P et al. Prevalence hlavních rizikových faktorů kardiovaskulárních onemocnění v české populaci v letech 2015–2018. Studie Czech post-MONICA. Cor et Vasa 2020; 62(1): 6–16. Dostupné z DOI: <http://DX.doi.org/10.33678/cor.2020.010>.
Zdravotnická ročenka 2021. ÚZIS ČR: 2021. Dostupné z WWW: <https://www.uzis.cz/res/f/008435/zdrroccz2021.pdf>.
Národní kardiovaskulární plán 2025. MZ ČR: 2025. Dostupné z WWW: <https://mzd.gov.cz/wp-content/uploads/2025/01/Priloha-3_NKV_plan-souhrnna-analyticka-studie.pdf>.
Roth G, Mensah G, Johnson C et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019. J Am Coll Cardiol 2020; 76(25): 2982–3021. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2020.11.010>.
Borén J, Williams KJ. The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity. Curr Opin Lipidol 2016; 27(5): 473–483. Dostupné z DOI: <http://dx.doi.org/10.1097/MOL.0000000000000330>.
Češka R. Číslo LDL žije! AtheroRev 2021; 6(2): 84–89.
Šatný M. Dyslipidemie – známá neznámá. Vnitr Lek 2023; 69(5): 305–311. Dostupné z DOI: <http://doi.org/10.36290/vnl.2023.060>.
Mach F, Baigent C, Catapano AL et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2020; 41(1): 111–188. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehz455>.
Visseren FL, Mach F, Smulders YM et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 2021; 42(34): 3227–3337. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehab484>.
Björnson E, Adiels M, Taskinen MR et al. Lipoprotein(a) Is Markedly More Atherogenic Than LDL: An Apolipoprotein B-Based Genetic Analysis. J Am Coll Cardiol 2024; 83(3): 385–395. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2023.10.039>.
[SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration]. SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe. Eur Heart J 2023 Jul; 44(28): 2544–2556. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/ehad260>.
Parhofer KG, Aguiar C, Banach M et al. Expert opinion on the integration of combination therapy into the treatment algorithm for the management of dyslipidaemia: the integration of ezetimibe and bempedoic acid may enhance goal attainment. Eur Heart J Cardiovasc Pharmacother 2025 11(4): 367–379. Dostupné z DOI: <http://dx.doi.org/10.1093/ehjcvp/pvaf007>.
Informace dostupné z WWW: www.sukl.cz.
Praluent (alirokumab). Souhrn údajů o přípravku. Dostupné z WWW: <https://www.ema.europa.eu/cs/documents/product-information/praluent-epar-product-information_cs.pdf>.
Repatha (evolocumabum). Souhrn údajů o přípravku. Dostupné z WWW: <https://www.ema.europa.eu/cs/documents/product-information/repatha-epar-product-information_cs.pdf.>
Leqvio (inclisiranum natricum). Souhrn údajů o přípravku. Dostupné z WWW: <https://www.ema.europa.eu/cs/documents/product-information/leqvio-epar-product-information_cs.pdf>.
Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adultsArticle was published in
Athero Review
2025 Issue 2
- Advances in the Treatment of Myasthenia Gravis on the Horizon
- Memantine in Dementia Therapy – Current Findings and Possible Future Applications
- Memantine Eases Daily Life for Patients and Caregivers
- Possibilities of Using Metamizole in the Treatment of Acute Primary Headaches
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
-
All articles in this issue
- Editorial
- Bempedoic acid – an efficient and safe lipid-lowering treatment in the light of the latest findings
- Factors influencing hypolipidemic treatment of patients after acute coronary syndrome, ischemic stroke, and transient ischemic attack in cardiological and neurological outpatient care in Slovakia
- Fats and oils from the perspective of scientific studies, the media and the internet
- Evinacumab in the treatment of homozygous familial hypercholesterolemia: data from real-world clinical practice and case report
- Effect of once-weekly semaglutide on functional capacity in patients with peripheral arterial disease and type 2 diabetes: results from the STRIDE study
- Coronary events are preventable – so don't miss this opportunity: case report
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) – the current challenges for its management
- Where does the Czech Republic have a head start, and where does it need to catch up? International Summit on Lipoprotein(a) – Brussels, March 2025
- Research on remarkable articles from international literature
- XXXIXth conference on hyperlipoproteinemias – Šobraʼs Day 2025
- Athero Review
- Journal archive
- Current issue
- About the journal
Most read in this issue
- Bempedoic acid – an efficient and safe lipid-lowering treatment in the light of the latest findings
- Factors influencing hypolipidemic treatment of patients after acute coronary syndrome, ischemic stroke, and transient ischemic attack in cardiological and neurological outpatient care in Slovakia
- Fats and oils from the perspective of scientific studies, the media and the internet
- Where does the Czech Republic have a head start, and where does it need to catch up? International Summit on Lipoprotein(a) – Brussels, March 2025