Dienogest – reliable progestin with unique attribute

Česká verzia

Authors: Miloslav Maule
Published in the journal: Prakt Gyn 2014; 18(4): 254-258
Category: Gynekologie a porodnictví

Summary

Dienogest, progestin was synthesized for the first time in Jena, Germany in 1979 and still has an important role among contraceptives. This fact is based on its marked positive effects – progestagenic and antiandrogenic. Other therapeutic application as well as favorable pharmacological and metabolic profile of agent provides that dienogest, especially in combined form, has a good perspective among oral contraceptives.

Key words:
contraception – dienogest – progestins – combined oral contraceptives

Zdroje

1. Barták A. Dienogest – zajímavý a perspektivní progestin pro orální kontracepci, Gynekolog 2007; 16(5): 184–186.

2. Barták A. Dienogest jako unikátní antiandrogenní norsteroid pro orální kontraceptiva. New EU Magazine of Medicine 2011; 4(1–2): 23–25.

3. Gudermann T. Endokrinopharmakologie. In: Leidenberger F. Strowitzki T, Ortmann O. Klinische Endokrinologie für Frauenärzte. 4th ed. Springer: Berlin-Heidelberg 2009: 217–248. ISBN 978–3-540–89760–6.

4. Oettel M, Kaufmann G, Kurischko A. The endocrinologic profile of metabolites of the progestin dienogest. [Article in German]. Pharmazie 1993; 48(7): 541–545.

5. Oettel M, Carol W, Elger W. A 19-norprogestin without 17 α-ethinyl group II: dienogest from a pharmacodynamic point of view. Drugs Today 1995; 31(7): 517–536.

6. Oettel M, Breibarth H, Elger W et al. The pharmacological profile of dienogest. Eur J Contracept Reprod Health Care 1999; 4(Suppl 2): 9–15.

7. Sitruk-Ware R. Pharmacological profile of progestins. Maturitas 2004; 47(4): 277–283.

8. Strowitzki T, Marr J, Gerlinger C et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Hum Reprod 2010; 25(3): 633–641.

9. Teichmann A. Pharmacology of estradiol valerate/dienogest. Climacteric 2003; 6(Suppl 2): 17–23.

10. Wiegratz I, Lee JH, Kutschera E et al. Effect of dienogest-containing oral contraceptives on lipid metabolism. Contraception 2002; 65(3): 223–229.

11. Zimmermann T, Dietrich H, Wisser KH et al. The efficacy and tolerability of Valette: a postmarketing surveillance study. Eur J Contracept Reprod Health Care 1999; 4(3): 155–164.