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Towards control of the global HIV epidemic: Addressing the middle-90 challenge in the UNAIDS 90–90–90 target


In a Perspective, Collins Iwuji and Marie-Louise Newell discuss early findings from Richard Hayes and colleagues' PopART study on HIV testing and treatment.


Vyšlo v časopise: Towards control of the global HIV epidemic: Addressing the middle-90 challenge in the UNAIDS 90–90–90 target. PLoS Med 14(5): e32767. doi:10.1371/journal.pmed.1002293
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pmed.1002293

Souhrn

In a Perspective, Collins Iwuji and Marie-Louise Newell discuss early findings from Richard Hayes and colleagues' PopART study on HIV testing and treatment.


Zdroje

1. UNAIDS. Global AIDS Update 2016 2016 [cited 2016 7 Jan]. http://www.unaids.org/sites/default/files/media_asset/global-AIDS-update-2016_en.pdf.

2. Group ISS, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B, et al. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. N Engl J Med. 2015;373(9):795–807. doi: 10.1056/NEJMoa1506816 26192873

3. Group TAS, Danel C, Moh R, Gabillard D, Badje A, Le Carrou J, et al. A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa. N Engl J Med. 2015;373(9):808–22. doi: 10.1056/NEJMoa1507198 26193126

4. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505. doi: 10.1056/NEJMoa1105243 21767103

5. UNAIDS. 90-90-90. An ambitious treatment target to help end the AIDS epidemic, 2014 [cited 2017, 14 March]. http://www.unaids.org/sites/default/files/media_asset/90-90-90_en_0.pdf

6. Hayes R, Floyd S, Schaap A, Shanaube K, Bock P, Sabapathy K, et al. A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial. PLoS Med. 2017.

7. Iwuji C, Orne-Gliemann J, Balestre E, Larmarange J, Thiebaut R, Tanser F, et al. The impact of universal test and treat on HIV incidence in a rural South African population: ANRS 12249 TasP trial, 2012–2016. International AIDS Conference; July 18–22; Durban, South Africa 2016.

8. Petersen M, Balzer L, Kwarsiima D, Sang N, Chamie G, Ayieko J, et al. SEARCH test and treat study in Uganda and Kenya exceeds the UNAIDS 90-90-90 cascade target by achieving 81% population-level viral suppression after 2 years. International AIDS Conference; July 18–22, 2016; Durban, South Africa.

9. Gaolathe T, Wirth KE, Holme MP, Makhema J, Moyo S, Chakalisa U, et al. Botswana's progress toward achieving the 2020 UNAIDS 90-90-90 antiretroviral therapy and virological suppression goals: a population-based survey. Lancet HIV. 2016;3(5):e221–30. doi: 10.1016/S2352-3018(16)00037-0 27126489

10. Iwuji CC, Orne-Gliemann J, Larmarange J, Okesola N, Tanser F, Thiebaut R, et al. Uptake of Home-Based HIV Testing, Linkage to Care, and Community Attitudes about ART in Rural KwaZulu-Natal, South Africa: Descriptive Results from the First Phase of the ANRS 12249 TasP Cluster-Randomised Trial. PLoS Med. 2016;13(8):e1002107. doi: 10.1371/journal.pmed.1002107 27504637

11. Plazy M, Farouki KE, Iwuji C, Okesola N, Orne-Gliemann J, Larmarange J, et al. Access to HIV care in the context of universal test and treat: challenges within the ANRS 12249 TasP cluster-randomized trial in rural South Africa. J Int AIDS Soc. 2016;19(1):20913. doi: 10.7448/IAS.19.1.20913 27258430

12. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373(9657):48–57. doi: 10.1016/S0140-6736(08)61697-9 19038438

13. Kates J, Wexler A, Lief E. Financing the response to HIV in Low- and Middle-Income Countries: International Assistance from Donor Governments in 2014. Washington: Kaiser Family Foundation & UNAIDS 2015 [cited 2017, 14 March]. http://www.unaids.org/sites/default/files/media_asset/financing-the-response-to-HIV-in-low-and-middle-income-countries_en.pdf.

14. Mikkelsen E, Hontelez JA, Jansen MP, Barnighausen T, Hauck K, Johansson KA, et al. Evidence for scaling up HIV treatment in sub-Saharan Africa: A call for incorporating health system constraints. PLoS Med. 2017;14(2):e1002240. doi: 10.1371/journal.pmed.1002240 28222126

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Interné lekárstvo

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PLOS Medicine


2017 Číslo 5
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