A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial

1. Joint United Nations Programme on HIV/AIDS. The gap report: beginning of the end of the AIDS epidemic. Geneva: Joint United Nations Programme on HIV/AIDS; 2014 [cited 2016 Jan 17]. Available from: http://www.unaids.org/sites/default/files/media_asset/UNAIDS_Gap_report_en.pdf.

2. Attia S, Egger M, Muller M, Zwahlen M, Low N. Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS. 2009;23(11):1397–404. doi: 10.1097/QAD.0b013e32832b7dca 19381076

3. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505. doi: 10.1056/NEJMoa1105243 21767103

4. Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Li X, Laeyendecker O, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis. 2005;191(9):1403–9. doi: 10.1086/429411 15809897

5. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med. 2000;342(13):921–9. doi: 10.1056/NEJM200003303421303 10738050

6. Cori A, Ayles H, Beyers N, Schaap A, Floyd S, Sabapathy K, et al. HPTN 071 (PopART): a cluster-randomized trial of the population impact of an HIV combination prevention intervention including universal testing and treatment: mathematical model. PLoS ONE. 2014;9(1):e84511. doi: 10.1371/journal.pone.0084511 24454728

7. Dodd PJ, Garnett GP, Hallett TB. Examining the promise of HIV elimination by ‘test and treat’ in hyperendemic settings. AIDS. 2010;24(5):729–35. doi: 10.1097/QAD.0b013e32833433fe 20154580

8. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009;373(9657):48–57. doi: 10.1016/S0140-6736(08)61697-9 19038438

9. Lima VD, Johnston K, Hogg RS, Levy AR, Harrigan PR, Anema A, et al. Expanded access to highly active antiretroviral therapy: a potentially powerful strategy to curb the growth of the HIV epidemic. J Infect Dis. 2008;198(1):59–67. doi: 10.1086/588673 18498241

10. Granich R, Gupta S, Hersh B, Williams B, Montaner J, Young B, et al. Trends in AIDS deaths, new infections and ART coverage in the top 30 countries with the highest AIDS mortality burden; 1990–2013. PLoS ONE. 2015;10(7):e0131353. doi: 10.1371/journal.pone.0131353 26147987

11. Montaner JS, Lima VD, Barrios R, Yip B, Wood E, Kerr T, et al. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet. 2010;376(9740):532–9. doi: 10.1016/S0140-6736(10)60936-1 20638713

12. Montaner JS, Lima VD, Harrigan PR, Lourenco L, Yip B, Nosyk B, et al. Expansion of HAART coverage is associated with sustained decreases in HIV/AIDS morbidity, mortality and HIV transmission: the “HIV treatment as prevention” experience in a Canadian setting. PLoS ONE. 2014;9(2):e87872. doi: 10.1371/journal.pone.0087872 24533061

13. Tanser F, Barnighausen T, Grapsa E, Zaidi J, Newell ML. High coverage of ART associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa. Science. 2013;339(6122):966–71. doi: 10.1126/science.1228160 23430656

14. Joint United Nations Programme on HIV/AIDS. Treatment 2015. Geneva: Joint United Nations Programme on HIV/AIDS; 2012 [cited 2016 Jan 11]. Available from: http://www.unaids.org/sites/default/files/media_asset/JC2484_treatment-2015_en_1.pdf.

15. Joint United Nations Programme on HIV/AIDS. 90-90-90: an ambitious treatment target to help end the AIDS epidemic. Geneva: Joint United Nations Programme on HIV/AIDS; 2014 [cited 2016 Jan 11]. Available from: http://www.unaids.org/sites/default/files/media_asset/90-90-90_en_0.pdf.

16. Joint United Nations Programme on HIV/AIDS. Fast-track: ending the AIDS epidemic by 2030. Geneva: Joint United Nations Programme on HIV/AIDS; 2014 [cited 2016 Jan 11]. Available from: http://www.unaids.org/sites/default/files/media_asset/JC2686_WAD2014report_en.pdf.

17. Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, et al. HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment—a study protocol for a cluster randomised trial. Trials. 2014;15:57. doi: 10.1186/1745-6215-15-57 24524229

18. Iwuji CC, Orne-Gliemann J, Tanser F, Boyer S, Lessells RJ, Lert F, et al. Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a cluster randomised controlled trial. Trials. 2013;14:230. doi: 10.1186/1745-6215-14-230 23880306

19. Barnabas R, van Rooyen H, Tumwisigye E, Brantley J, Baeten J, van Heerden A, et al. Uptake of antiretroviral therapy and male circumcision after community-based HIV testing and strategies for linkage to care versus standard clinic referral: a multisite, open-label, randomised controlled trial in South Africa and Uganda. Lancet HIV. 2016;3(5):e212–20. doi: 10.1016/S2352-3018(16)00020-5 27126488

20. McNairy ML, El-Sadr WM. The HIV care continuum: no partial credit given. AIDS. 2012;26(14):1735–8. doi: 10.1097/QAD.0b013e328355d67b 22614888

21. Rosen S, Fox MP. Retention in HIV care between testing and treatment in sub-Saharan Africa: a systematic review. PLoS Med. 2011;8(7):e1001056. doi: 10.1371/journal.pmed.1001056 21811403

22. Sabapathy K, Hayes R. Linkage to care: a step on the path, but not the destination. Lancet HIV. 2016;3(5):e193–4. doi: 10.1016/S2352-3018(16)00038-2 27126481

23. Maman D, Chilima B, Masiku C, Ayouba A, Masson S, Szumilin E, et al. Closer to 90-90-90. The cascade of care after 10 years of ART scale-up in rural Malawi: a population study. J Int AIDS Soc. 2016;19(1):20673. doi: 10.7448/IAS.19.1.20673 26894388

24. Levira F, Agnarson AM, Masanja H, Zaba B, Ekstrom AM, Thorson A. Antiretroviral treatment coverage in a rural district in Tanzania—a modeling study using empirical data. BMC Public Health. 2015;15:195. doi: 10.1186/s12889-015-1460-8 25884639

25. Levi J, Raymond A, Pozniak A, Vernazza P, Kohler P, Hill A. Can the UNAIDS 90-90-90 target be achieved? A systematic analysis of national HIV treatment cascades. BMJ Global Health. 2016;1:e000010.

26. Gaolathe T, Wirth KE, Holme MP, Makhema J, Moyo S, Chakalisa U, et al. Botswana’s progress toward achieving the 2020 UNAIDS 90-90-90 antiretroviral therapy and virological suppression goals: a population-based survey. Lancet HIV. 2016;3(5):e221–30. doi: 10.1016/S2352-3018(16)00037-0 27126489

27. Iwuji CC, Orne-Gliemann J, Larmarange J, Okesola N, Tanser F, Thiebaut R, et al. Uptake of home-based HIV testing, linkage to care, and community attitudes about ART in Rural KwaZulu-Natal, South Africa: descriptive results from the first phase of the ANRS 12249 TasP cluster-randomised trial. PLoS Med. 2016;13(8):e1002107. doi: 10.1371/journal.pmed.1002107 27504637

28. Petersen M, Balzer L, Kwarsiima D, Sang N, Chamie G, Ayieko J, et al. SEARCH test and treat study in Uganda and Kenya exceeds the UNAIDS 90-90-90 cascade target by achieving 81% population-level viral suppression after 2 years. Abstract WEAC0106LB2016. 21st International AIDS Conference; 18–22 Jul 2016; Durban, South Africa. Geneva: International AIDS Society; 2016 [cited 2017 Mar 28]. Available from: http://programme.aids2016.org/Abstract/Abstract/10514.

29. Sabapathy K, Van den Bergh R, Fidler S, Hayes R, Ford N. Uptake of home-based voluntary HIV testing in sub-Saharan Africa: a systematic review and meta-analysis. PLoS Med. 2012;9(12):e1001351. doi: 10.1371/journal.pmed.1001351 23226107

30. Dellar RC, Dlamini S, Karim QA. Adolescent girls and young women: key populations for HIV epidemic control. J Int AIDS Soc. 2015;18(2 Suppl 1):19408.

31. Sharma M, Ying R, Tarr G, Barnabas R. Systematic review and meta-analysis of community and facility-based HIV testing to address linkage to care gaps in sub-Saharan Africa. Nature. 2015;528(7580):S77–85. doi: 10.1038/nature16044 26633769

32. Barnabas RV, van Rooyen H, Tumwesigye E, Murnane PM, Baeten JM, Humphries H, et al. Initiation of antiretroviral therapy and viral suppression after home HIV testing and counselling in KwaZulu-Natal, South Africa, and Mbarara district, Uganda: a prospective, observational intervention study. Lancet HIV. 2014;1(2):e68–76. doi: 10.1016/S2352-3018(14)70024-4 25601912

33. Hoffmann C, Mabuto T, Ginindza S, Fielding K, Kubeka G, Dowdy D, et al. A randomized trial to accelerate HIV care and art initiation following HIV diagnosis. Abstract 113LB. 23rd Conference on Retroviruses and Opportunistic Infections; 22–25 Feb 2016; Boston, Massachusetts, US. San Francisco: CROI Foundation; 2016 [cited 2017 Mar 28]. Available from: http://www.croiconference.org/sessions/randomized-trial-accelerate-hiv-care-and-art-initiation-following-hiv-diagnosis.

34. Feldacker C, Johnson D, Hosseinipour M, Phiri S, Tweya H. Who starts? Factors associated with starting antiretroviral therapy among eligible patients in two, public HIV clinics in Lilongwe, Malawi. PLoS ONE. 2012;7(11):e50871. doi: 10.1371/journal.pone.0050871 23226413

35. Chamie G, Clark TD, Kabami J, Kadede K, Ssemmondo E, Steinfeld R, et al. A hybrid mobile approach for population-wide HIV testing in rural east Africa: an observational study. Lancet HIV. 2016;3(3):e111–9. doi: 10.1016/S2352-3018(15)00251-9 26939734

36. Iwuji C, Orne-Gliemann J, Balestre E, Larmarange J, Thiebaut R, Tanser F, et al. The impact of universal test and treat on HIV incidence in a rural South African population: ANRS 12249 TasP trial, 2012–2016. Abstract FRAC0105LB2016. 21st International AIDS Conference; 18–22 Jul 2016; Durban, South Africa. Geneva: International AIDS Society; 2016 [cited 2017 Mar 28]. Available from: http://programme.aids2016.org/Abstract/Abstract/10537.