Primary laryngeal B lymphoma with plasmocyoid diff erentiation – a case report

Czech version

Authors: M. Bonaventurová ¹; P. Lukeš ¹; D. Kalfeřt ¹; L. Galiyeva ¹; T. Dekojová ²; V. Campr ³; J. Plzák ¹
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku 1. LF UK a FN v Motole, Praha ¹; Hematologicko-onkologické oddělení, FN Plzeň ²; Ústav patologie a molekulární medicíny 2. LF UK a FN v Motole, Praha ³
Published in: Otorinolaryngol Foniatr, 73, 2024, No. 4, pp. 246-250.
Category: Case Reports
doi: https://doi.org/10.48095/ccorl2024246

Overview

Primary non-Hodgkin laryngeal lymphoma is a rare disease with a prevalence under 1% of all tumors of the larynx. It originates mostly in the supraglottis region and presents itself as a nonulcerative solid tumor. Patient can suffer from dysphonia, dysphagia, foreign body sensation, dyspnea or even suffocation. Diagnosis is based on microlaryngoscopy and histopathology. The treatment options are chemotherapy, immunotherapy, radiotherapy or their combination. In our report, we present the case of an 86-year-old woman with a history of over a year of progressive dysphonia and dyspnea. Samples were taken during direct microlaryngoscopy under general anesthesia. In frozen sections, there was a high suspicion of lymphoma, and that was also confirmed from definitive histopathology. The patient was given over to the hemato-oncologist. There was a prompt response to chemotherapy, with relief from the symptoms even after the first dose. The aim of our study is to highlight this condition in the differential diagnosis of laryngeal tumors and the causes of dyspnea, summarize the knowledge of the disorder and the modality of treatment according to recent literature.

Sources

1. Kim KH, Kim RB, Woo SH. Individual participant data meta-analysis of primary laryngeal lymphoma: Focusing on the clinical characteristics and prognosis. Laryngoscope 2015; 125 (12): 2741–2748. Doi: 10.1002/lary.25391.

2. Singh R, Shaik S, Negi BS et al. Non-Hodgkin’s Lymphoma: A review. J Fam Med Prim Care 2020; 9 (4): 1834–1840.

3. Morgan DAL, MacLennan K, Narula A. Non-Hodgkin’s Lymphoma of the Larynx (Stage IE). Cancer 1989; 64 : 1123–1127.

4. Anderson HA, Maisel RH, Cantrell RW. Isolated laryngeal lymphoma. Laryngoscope 1976; 86 (8): 1251–1257. Doi: 10.1288/00005537-197 608000-00016.

5. Markou K, Goudakos J, Constantinidis J et al. Primary laryngeal lymphoma: Report of 3 cases and review of the literature. Head Neck 2010; 32 (4): 541–549. Doi: 10.1002/HED.21104.

6. Horny HP, Kaiserling E. Involvement of the Larynx by Hemopoietic Neoplasms: An Investigation of Autopsy Cases and Review of the Literature. Pathol Res Pract 1995; 191 (2): 130–138. Doi: 10.1016/S0344-0338 (11) 80562-5.

7. Hong SA, Tajudeen BA, Choi S et al. Epidemiology and prognostic indicators in laryngeal lymphoma: A population-based analysis. Laryngoscope 2018; 128 (9): 2044–2049. Doi: 10.1002/lary.27074.

8. Picard A, Cardinne C, Denoux Y et al. Extranodal lymphoma of the head and neck: A 67-case series. Eur Ann Otorhinolaryngol Head Neck Dis 2015; 132 (2): 71–75. Doi: 10.1016/j.anorl. 2014.07.005.

9. MacKenty J, Faulkner E, Ross E. Malignant disease of the larynx: rare types, premalignant conditions and conditions simulating malignancy. Arch Otolaryngol 1934; 20 (3): 297–328. Doi: 10.1001/ARCHOTOL.1934.0360 0030002001.

10. Izadi F, Parvas E, Derakhshandeh V. Lymphoma of larynx presented with hoarseness: Case report. Med J Islam Repub Iran 2014; 28 : 21.

11. Rahman B, Bilal J, Sipra QUAR et al. All That Wheezes Is Not Asthma: A Case of Diffuse Large B-Cell Lymphoma of the Larynx. Case Rep Oncol Med 2017; 2017 : 1–4. Doi: 10.1155/2017/ 7072615.

12. King AD., Yuen EHY., Lei KIK., Ahuja AT., van Hasselt A. Non-Hodgkin Lymphoma of the Larynx: CT and MR Imaging Findings. Am J Neuroradiol 2004; 25 (1).

13. Bonaventurova M, Zabrodsky M, Plzak J. Léčba kombinované laryngokély endoskopickým přístupem –⁠ kazuistické sdělení. Otorinolaryngol Foniatr 2023; 72 (4): 215-220. Doi: 10.48095/ccorl2023215

14. Nazaroglu H, Üniversitesi O. A Rare Cause of Dysphonia: Laryngeal Lipoma: Differential Diagnosis. Artic Turkiye Klin J Med Sci 2009. 2009 [online]. Dostupné z: https: //www.semanticscholar.org/paper/A-Rare-Cause-of-Dysphonia%3A-Laryngeal-Lipoma%3A-Ozmen-Nazaro%C7%A7lu/2dafe278681f67b9c3d87fed4517e69831b01507.

15. Myssiorek D, Rinaldo A, Barnes L et al. Laryngeal paraganglioma: An updated critical review. Acta Otolaryngol 2004; 124 (9): 995–999. Doi: 10.1080/00016480410017576.

16. Saleh EM, Mancuso AA, Stringer SP. CT of submucosal and occult laryngeal masses. J Comput Assist Tomogr 1992; 16 (1): 87–93. Doi: 10.1097/00004728-199201000-00016.

17. Musshoff K. Clinical staging classification of non-Hodgkin’s lymphomas. Strahlentherapie 1977; 153 (4): 218–221.

18. Shipp MA. Prognostic factors in aggressive non-Hodgkin’s lymphoma: who has high -⁠ risk disease? Blood 1994; 83 (5): 1165–1173. Doi: 10.1182/BLOOD.V83.5.1165.1165.

19. Sýkorová A, Belada D, Smolej L et al. Určování rozsahu onemocnění u non-Hodgkinových lymfomů-doporučení Kooperativní lymfomové skupiny Staging of Non-Hodgkin’ s Lymphoma-Recommendations of the Czech Lymphoma Study Group. Klin Onkol 2010; 23 (3): 146–154.

20. Kato S, Sakura M, Takooda S et al. Primary non-Hodgkin’s lymphoma of the larynx. J Laryngol Otol 1997; 111 (6): 571–574. Doi: 10.1017/S0022215100137946.

21. Pisani P, Dosdegani R, Policarpo M et al. Non-Hodgkin’s lymphoma of the larynx: clinical cases. Acta Otorhinolaryngol Ital 1999; 19 (2): 97–101.

22. Ferjaoui M, Kolsi N, Bergaoui E et al. B-cell non-Hodgkin lymphoma of the larynx: Case report and review of literature. Asian J Oncol 2023; 9 (December): 17. Doi: 10.25259/asjo-2022-33.

23. Coiffier B, Lepage E, Brière J et al. CHOP Chemotherapy plus Rituximab Compared with CHOP Alone in Elderly Patients with Diffuse Large-B-Cell Lymphoma. N Engl J Med 2002; 346 (4): 235–242. Doi: 10.1056/NEJMOA 011795/ASSET/123FAC68-22CE-4D83-9337-C26 1227D7454/ASSETS/IMAGES/LARGE/NEJMOA 011795_T4.JPG.

24. Dabaja B, Illidge TM. Re-Examining the Role of Radiation Therapy for Diffuse Large B-Cell Lymphoma in the Modern Era SEE PROFILE. Artic J Clin Oncol 2016. Doi: 10.1200/JCO. 2015.64.9418.

25. Dědečková K, Móciková H, Belada D et al. The role of radiotherapy in the treatment of malignant lymphomas –⁠ recommendations of the Czech Lymphoma Study Group. Klin Onkol 2013; 26 (2): 99–109. Doi: 10.14735/AMKO 201 399.

26. Sorrentino A, Ferragina F, Barca I et al. Extra-Nodal Lymphomas of the Head and Neck and Oral Cavity: A Retrospective Study. Curr Oncol 2022; 29 (10): 7189–7197. Doi: 10.3390/CURRONCOL29100566.

ORCID autorů

M. Bonaventurová 0000-0003-3283-0503,

P. Lukeš 0000-0001-8007-8083,

D. Kalfeřt 0000-0003-4369-4113,

L. Galiyeva 0009-0002-0870-5286,

J. Plzák 0000-0003-3710-4455.

Přijato k recenzi: 29. 7. 2024

Přijato k tisku: 25. 9. 2024

MUDr. Markéta Bonaventurová

Klinika otorinolaryngologie a chirurgie hlavy a krku

1. LF UK a FN v Motole

V Úvalu 84