Indicators of the Action of Free Radicals in Incipient Forms of Pneumoconiosis
Ukazatele působení volných radikálů u počínajících forem pneumokonióz
Vyšetřili jsme ukazatele působení volných radikálů u 30 nemocných s počínajícími formami pneumokoniózy (12 horníků, 7 dělníků v keramických závodech a 11 ostatních). Při srovnání s ostatními zjišťujeme u keramiků sníženou aktivitu superoxiddismutázy. Aktivita superoxiddismutázy v celém souboru klesá s věkem, aktivita glutathionperoxidázy stoupá s expozicí. Proti kontrolnímu souboru zjišťujeme zvýšenou aktivitu glutathionperoxidázy, nižší koncentraci glutathionu a vyšší aktivitu superoxiddismutázy. Výsledky svědčí pro jistý stupeň aktivity volných radikálů, k dalšímu upřesnění však bude nutné doplnit sledování jiných markerů poškození
Klíčová slova:
pneumokonióza, horníci, keramici, volné radikály
Authors:
J. Kohout 1; J. Racek 2; V. Machartová 1; L. Treňl 2; F. Šefrna 3
Authors‘ workplace:
IKlinika pracovního lékařství Fakultní nemocnice v Plzni, přednosta doc. MUDr. Josef Kohout, CSc. 2Ústav klinické biochemie a laboratorní diagnostiky Fakultní nemocnice v Plzni, přednosta prof. MUDr. Jaroslav Racek, DrSc. 30dde~lení informatiky a statisti
Published in:
Pracov. Lék., , 2002, No. 2, s. 53-54.
Category:
Overview
The authors examined indicators of the action of free radicals in 30 patients with incipient forms of pneumoconiosis (12 miners, 7 workers from pottery planu and 11 others), in those working with pottery they found as compared with the others an elevated aktivity of superoxide dismutase. The aktivity of superoxide dismutase in the whole group declines with age, the aktivity of glutathione peroxidase rises with exposure. As compared with controls, there is an increased aktivity of glutathione peroxidase, a lower concentration of glutathione and higher aktivity of superoxide dismutase. The results suggest a certain degree of free radical aktivity. To obtain more detailed data it will
Key words:
pneumoconiosis, miners, pottery workers, free radicals
Labels
Hygiene and epidemiology Hyperbaric medicine Occupational medicineArticle was published in
Occupational Medicine
2002 Issue 2
-
All articles in this issue
- Indicators of the Action of Free Radicals in Incipient Forms of Pneumoconiosis
- Textile Dust and Occupational Diseases of the Airways - Experience of the Clinic of Occupational
- Contagious and Parasitic Occupational Diseases in the Czech Republic
- Zoonoses with Dermatological Symptoms as Occupational Dermatoses
- Scabies, a Contemporary Occupational Disease
- Are Herpetic Viruses a Frequent Cause of Occupational Infections?
- Contemporary View on the Problem of Chronic Víral Hepatitis B
- Contemporary View on the Problem of Chronic Víral Hepatitis C
- Clinical Picture and Diagnostic Principles in Lyme Borreliosis
- Specific Features in Evaluation of Contagious and Parasitic Occupational Diseases
- Possible Manifestations of Malaria and Its Appraisal as an Occupational Disease
- Risk of Occupational Diseases - Medical and Legal Problems
- Recommended Criteria for Termination of an Occupational Disease according to the List of Occupational Diseases
- Occupational Medicine
- Journal archive
- Current issue
- About the journal
Most read in this issue
- Contagious and Parasitic Occupational Diseases in the Czech Republic
- Zoonoses with Dermatological Symptoms as Occupational Dermatoses
- Risk of Occupational Diseases - Medical and Legal Problems
- Scabies, a Contemporary Occupational Disease